2021 ESC/EACTS Guidelines for the management of valvular heart disease von Vahanian, Alec, Beyersdorf, Friedhelm, Praz, Fabien, Milojevic, Milan, Baldus, Stephan, Bauersachs, Johann, Capodanno, Davide, Conradi, Lenard, De Bonis, Michele, De Paulis, Ruggero, Delgado, Victoria, Freemantle, Nick, Gilard, Martine, Haugaa, Kristina H, Jeppsson, Anders, Jüni, Peter, Pierard, Luc, Prendergast, Bernard D, Sádaba, J Rafael, Tribouilloy, Christophe, Wojakowski, Wojtek

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620 Normalized stroke volume in severe aortic stenosis with preserved ejection fraction: reference values and outcome implications von Bohbot, Y, Rusinaru, D, Rietzschel, E, De Buyzere, M, Buicuic, O, Marechaux, S, Gilebert, T, Tribouilloy, T

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2021 ESC/EACTS Guidelines for the management of valvular heart disease von Beyersdorf, Friedhelm, Vahanian, Alec, Milojevic, Milan, Praz, Fabien, Baldus, Stephan, Bauersachs, Johann, Capodanno, Davide, Conradi, Lenard, De Bonis, Michele, De Paulis, Ruggero, Delgado, Victoria, Freemantle, Nick, Gilard, Martine, Haugaa, Kristina H, Jeppsson, Anders, Jüni, Peter, Pierard, Luc, Prendergast, Bernard D, Sádaba, J Rafael, Tribouilloy, Christophe, Wojakowski, Wojtek

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Transcatheter aortic valve implantation: early results of the FRANCE (FRench Aortic National CoreValve and Edwards) registry von ELTCHANINOFF, Hélène, PRAT, Alain, PAVIE, Alain, GUERET, Pascal, GILARD, Martine, LEGUERRIER, Alain, BLANCHARD, Didier, FOURNIAL, Gérard, LUNG, Bernard, DONZEAU-GOUGE, Patrick, TRIBOUILLOY, Christophe, DEBRUX, Jean-Louis

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A Machine-Learning Framework to Identify Distinct Phenotypes of Aortic Stenosis Severity von Sengupta, Partho P., Shrestha, Sirish, Kagiyama, Nobuyuki, Hamirani, Yasmin, Kulkarni, Hemant, Yanamala, Naveena, Bing, Rong, Chin, Calvin W.L., Pawade, Tania A., Messika-Zeitoun, David, Tastet, Lionel, Shen, Mylène, Newby, David E., Clavel, Marie-Annick, Pibarot, Phillippe, Dweck, Marc R., Larose, Éric, Guzzetti, Ezequiel, Bernier, Mathieu, Beaudoin, Jonathan, Arsenault, Marie, Côté, Nancy, Everett, Russell, Jenkins, William S.A., Tribouilloy, Christophe, Dreyfus, Julien, Mathieu, Tiffany, Renard, Cedric, Gun, Mesut, Macron, Laurent, Sechrist, Jacob W., Lacomis, Joan M., Nguyen, Virginia, Gay, Laura Galian, Calabria, Hug Cuéllar, Ntalas, Ioannis, Prendergast, Bernard, Rajani, Ronak, Evangelista, Arturo, Cavalcante, João L.

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Long-Term Implications of Atrial Fibrillation in Patients With Degenerative Mitral Regurgitation von Grigioni, Francesco, Benfari, Giovanni, Vanoverschelde, Jean-Louis, Tribouilloy, Christophe, Avierinos, Jean-Francois, Bursi, Francesca, Suri, Rakesh M., Guerra, Federico, Pasquet, Agnés, Rusinaru, Dan, Marcelli, Emanuela, Théron, Alexis, Barbieri, Andrea, Michelena, Hector, Lazam, Siham, Szymanski, Catherine, Nkomo, Vuyisile T., Capucci, Alessandro, Thapa, Prabin, Enriquez-Sarano, Maurice, Suri, R., Clavel, M.A, Maalouf, J., Michelena, H., Nkomo, Vuyisile T., Enriquez-Sarano, M., Tribouilloy, C., Trojette, F., Szymanski, C., Rusinaru, D., Touati, G., Remadi, J.P., Guerra, F., Capucci, A., Grigioni, F., Russo, A., Biagini, E., Pasquale, F., Ferlito, M., Rapezzi, C., Savini, C., Marinelli, G., Pacini, D., Gargiulo, G.D., Di Bartolomeo, R., Boulif, J., de Meester, C., El Khoury, G., Gerber, B., Lazam, S., Pasquet, A., Noirhomme, P., Vancraeynest, D., Vanoverschelde, J-L., Avierinos, J.F., Collard, F., Théron, A., Habib, G., Barbieri, A., Bursi, F., Mantovani, F., Lugli, R., Modena, M.G., Boriani, G., Bacchi-Reggiani, L.

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TRI-SCORE and benefit of intervention in patients with severe tricuspid regurgitation von Dreyfus, Julien, Galloo, Xavier, Taramasso, Maurizio, Heitzinger, Gregor, Benfari, Giovanni, Kresoja, Karl-Patrick, Juarez-Casso, Fernando, Omran, Hazem, Bohbot, Yohann, Iliadis, Christos, Russo, Giulio, Topilsky, Yan, Weber, Marcel, Nombela-Franco, Luis, Sala, Alessandra, Eixerés-Esteve, Andrea, Iung, Bernard, Obadia, Jean-François, Estevez Loureiro, Rodrigo, Riant, Elisabeth, Donal, Erwan, Hausleiter, Jörg, Badano, Luigi, Le Tourneau, Thierry, Coisne, Augustin, Modine, Thomas, Latib, Azeem, Praz, Fabien, Windecker, Stephan, Zamorano, Jose Luis, von Bardeleben, Ralph Stephan, Tang, Gilbert H L, Hahn, Rebecca, Webb, John, Muraru, Denisa, Nejjari, Mohammed, Chan, Vincent, De Bonis, Michele, Carnero-Alcazar, Manuel, Nickenig, Georg, Pfister, Roman, Tribouilloy, Christophe, Rudolph, Volker, Crestanello, Juan, Lurz, Philipp, Bartko, Philipp, Maisano, Francesco, Bax, Jeroen, Enriquez-Sarano, Maurice, Messika-Zeitoun, David

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Prognostic and therapeutic implications of pulmonary hypertension complicating degenerative mitral regurgitation due to flail leaflet: A Multicenter Long-term International Study von BARBIERI, Andrea, BURSI, Francesca, BACCHI REGGIANI, Maria Letizia, BRANZI, Angelo, GRAZIA MODENA, Maria, ENRIQUEZ-SARANO, Maurice, GRIGIONI, Francesco, TRIBOUILLOY, Christophe, FRANCOIS AVIERINOS, Jean, MICHELENA, Hector I, RUSINARU, Dan, SZYMANSKY, Catherine, RUSSO, Antonio, SURI, Rakesh

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The MIDA Mortality Risk Score: development and external validation of a prognostic model for early and late death in degenerative mitral regurgitation von Grigioni, Francesco, Clavel, Marie-Annick, Vanoverschelde, Jean-Louis, Tribouilloy, Christophe, Pizarro, Rodolfo, Huebner, Marianne, Avierinos, Jean-Francois, Barbieri, Andrea, Suri, Rakesh, Pasquet, Agnés, Rusinaru, Dan, Gargiulo, Gaetano D, Oberti, Pablo, Théron, Alexis, Bursi, Francesca, Michelena, Hector, Lazam, Siham, Szymanski, Catherine, Nkomo, Vuyisile T, Schumacher, Martin, Bacchi-Reggiani, Letizia, Enriquez-Sarano, Maurice

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The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: an individual patient data meta-analysis von Berry, C, Doughty, R.N., Granger, C, Kober, L, Massie, B, McAlister, F, McMurray, J, Pocock, S, Poppe, K, Swedberg, Karl, Andersson, Bert

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The obesity paradox in heart failure patients with preserved versus reduced ejection fraction: a meta-analysis of individual patient data von Padwal, R, McAlister, F A, McMurray, J J V, Cowie, M R, Rich, M, Pocock, S, Swedberg, K, Maggioni, A, Gamble, G, Ariti, C, Earle, N, Whalley, G, Poppe, K K, Doughty, R N, Bayes-Genis, A

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Indoxyl-sulfate activation of the AhR- NF-κB pathway promotes interleukin-6 secretion and the subsequent osteogenic differentiation of human valvular interstitial cells from the ao... von Candellier, Alexandre, Issa, Nervana, Grissi, Maria, Brouette, Théo, Avondo, Carine, Gomila, Cathy, Blot, Gérémy, Gubler, Brigitte, Touati, Gilles, Bennis, Youssef, Caus, Thierry, Brazier, Michel, Choukroun, Gabriel, Tribouilloy, Christophe, Kamel, Saïd, Boudot, Cédric, Hénaut, Lucie, Eltchaninoff, Hélène, Bellien, Jérémy, Bertrand, Benjamin, Beygui, Farzin, Béziau-Gasnier, Delphine, Brakenhielm, Ebba, Caligiuri, Giuseppina, Chevreul, Karine, Debroucker, Frédérique, Durand, Eric, Fraschini, Christophe, Gilard, Martine, Iung, Bernard, Kamel, Said, Laschet, Jamila, Manrique, Alain, Messas, Emmanuel, Messika-Zeitoun, David, Pinet, Florence, Richard, Vincent, Saloux, Eric, Thoenes, Martin, Tribouilloy, Christophe, Vézier, Claire

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Reducing length of stay after transfemoral transcatheter aortic valve implantation: the FAST-TAVI II trial von Durand, Eric, Beziau-Gasnier, Delphine, Michel, Morgane, Iung, Bernard, Tchetche, Didier, Bonnet, Guillaume, Lhermusier, Thibault, Gilard, Martine, Souteyrand, Geraud, Bouleti, Claire, Ohlmann, Patrick, Lefevre, Thierry, Beygui, Farzin, Chassaing, Stephan, Chevreul, Karine, Eltchaninoff, Hélène

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Prognostic Implications of Residual Tricuspid Regurgitation Grading After Transcatheter Tricuspid Valve Repair von Dreyfus, Julien, Taramasso, Maurizio, Kresoja, Karl-Patrik, Iliadis, Christos, Russo, Giulio, Weber, Marcel, Nombela-Franco, Luis, Estevez Loureiro, Rodrigo, Stolz, Lukas, Praz, Fabien, Windecker, Stephan, Zamorano, Jose Luis, von Bardeleben, Ralph Stephan, Hahn, Rebecca, Webb, John, Fam, Neil, Lauten, Alexander, Rodés-Cabau, Josep, Nejjari, Mohammed, Alessandrini, Hannes, Himbert, Dominique, Sievert, Horst, Piayda, Kerstin, Donal, Erwan, Modine, Thomas, Nickenig, Georg, Pfister, Roman, Bernick, Jordan, Wells, George A., Bax, Jeroen, Lurz, Philipp, Enriquez-Sarano, Maurice, Maisano, Francesco, Messika-Zeitoun, David, Ajmone-Marsan, Nina, Badano, Luigi, Bartko, Philipp, Bax, Jeroen, Bazire, Baptiste, Bernick, Jordan, Bohbot, Yohan, Carnero-Alcazar, Manuel, Chan, Vincent, Crestanello, Juan, De Bonis, Michele, Doguet, Fabien, Donal, Erwan, Dreyfus, Julien, Enriquez-Sarano, Maurice, Eixerés-Esteve, Andrea, Loureiro, Rodrigo Estevez, Fam, Neil, Flagiello, Michele, Galloo, Xavier, Gavazzoni, Mara, Hahn, Rebecca, Hausleiter, Jörg, Himbert, Dominique, Iliadis, Christos, Iung, Bernard, Juarez-Casso, Fernando, Kresoja, Karl-Patrick, Latib, Azeem, Lauten, Alexander, Le Tourneau, Thierry, Lim, Pascal, Lubos, Edith, Lurz, Philipp, Maisano, Francesco, Mbaki, Yannick, Messika-Zeitoun, David, Muraru, Denisa, Nejjari, Mohammed, Nicol, Martin, Nombela-Franco, Luis, Obadia, Jean-François, Omran, Hazem, Pedrazzini, Giovanni, Pfister, Roman, Piayda, Kerstin, Praz, Fabien, Radu, Costin, Riant, Elisabeth, Rodés-Cabau, Josep, Ruf, Tobias, Russo, Giulio, Sala, Alessandra, Sievert, Horst, Stolz, Lukas, Tang, Gilbert H.L., Taramasso, Maurizio, Tomasi, Jacques, Topilsky, Yan, Tribouilloy, Christophe, Viau, Florence, Webb, John, Weber, Marcel, Wells, George A., Windecker, Stephan, Zamorano, Jose Luis

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Tricuspid regurgitation: Frequency, clinical presentation, management and outcome among patients with severe left‐sided valvular heart disease in Europe. Insights from the ESC‐EORP... von Dreyfus, Julien, Ruschitzka, Frank, Messika‐Zeitoun, David, Bax, Jeroen, Price, Susanna, Debonis, Michele, Prendergast, Bernard, Rosenhek, Raphael, Windecker, Stephan, Maggioni, Aldo, Lemaitre, Katell, Authier, Sebastien, Laroche, Cécile, Druais, Hervé, Goda, Artan, Mascherbauer, Julia, Linhartova, Katerina, Ihlemann, Nikolaj, Tribouilloy, Christophe, Katsaros, Andreas, Demarco, Daniela Cassar, Popescu, Bogdan, Bogachev‐Prokophiev, Alexander, Dogan, Sait Mesut, Dado, Elona, Zera, Eliverta, Heger, Maria, Muslumova, Fargana, Jahangirov, Tofig, Pierard, Luc, Van de Veire, Nico, Republic, Czech, Linhartova, Katerina, Branny, Marian, Vondrackova, Dagmar Jungwirtova, Homza, Miroslav, Ostransky, Jiri, Abdelhamid, Magdy, Mostafa, Ahmad Elsayed, Eltobgi, Sherif, Kamal, Diaa, Iung, Bernard, Marechaux, Sylvestre, Donal, Erwan, Habib, Gilbert, Thuny, Franck, Berenfeld, Alain, Lehnert, Kristin, Akin, Ibrahim, Maier, Lars, Nickenig, Georg, Scholtz, Werner, Heintzen, Matthias, Er, Fikret, Kamperidis, Vasileios, Bartha, Elektra, Borsanyi, Tunde, Laahunova, Elmira, Erglis, Andrejs, Radauskaite, Greta, Kostovska, Elizabeta Srbinovska, Bax, Jeroen, Komar, Monika, Tomkiewicz‐Pajak, Lidia, Zaborska, Beata, Almeida, Ines, Freitas, Antonio, Mitre, Adriana, Popescu, Andreea, Onut, Roxana, Eminovici, Gabriela, Arsenescu‐Georgescu, Catalina, Boldyrev, Sergey, Gross, Yuriy, Kulumbegov, Oleg, Jakubov, Ramis, Stefanov, Sergei, Schneider, Yuri, Tsechanovich, Valeriy, Voronova, Tatyana, Safna, Vasilya, Koroleva, Tatyana, Tarasenko, Ivan, Verevetinov, Artem, Ruzicic, Dusan, Milosavljevic, Jelica, Valocik, Gabriel, Gomez, Ariana Gonzalez, Gallego, Irene Menduina, Caballero, Luis, Paton, Ramon Rubio, Mitroi, Cristina, Alberca, Maria Teresa, Molina‐Mora, Maria Jose, Sayar, Nurten, Dogan, Sait Mesut, Bozkurt, Abdi, Gudul, Naile Eris, Mert, Kadir Ugur, Sayin, Muhammet Rasit

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Differing prognostic value of pulse pressure in patients with heart failure with reduced or preserved ejection fraction: results from the MAGGIC individual patient meta-analysis von Jackson, Colette E, Castagno, Davide, Maggioni, Aldo P, Køber, Lars, Squire, Iain B, Swedberg, Karl, Andersson, Bert, Richards, A Mark, Bayes-Genis, Antoni, Tribouilloy, Christophe, Dobson, Joanna, Ariti, Cono A, Poppe, Katrina K, Earle, Nikki, Whalley, Gillian, Pocock, Stuart J, Doughty, Robert N, McMurray, John J V

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Characteristics, management, and outcomes of patients with left‐sided infective endocarditis complicated by heart failure: a substudy of the ESC‐EORP EURO‐ENDO (European infective... von Gale, C.P., Gray, A., Maggioni, A.P., Badano, L.P., Calderon Aranda, E., Chan, K‐L., Sengupta, S., Yamagata, K., Yiangou, K., Filipini, E., Novas, V., Schneider, M., Hoffer, E., D'Emal, C., Weytjens, C., Unger, P., Beauloye, C., Musa, C., Moises, V.A., De Abreu Ferrari, T.C., Rudski, L.G., Vargovic, M., Pelouch, R., Osama, D., Mishriky, M., Assayag, P., El Hatimi, S., Arregle, F., Pierrard, R., Sierra, V., Strady, C., Curlier, E., Le Ven, F., Bohbot, Y., Chevalier, E., Oliver, L., Gohier, S., Börgermann, J., Nickenig, G., Baldenhofer, G., Brecht, A., Venieri, E., Grassos, C., Rallidis, L., Bechlioulis, A., Tomprou, I., Samaras, H., Nagy, A., Bartykowszki, A., Cresti, A., Prota, C., Di Vece, D., Santini, F., Sansoni, S., Miyake, M., Tsujimoto, S., Kitai, T., Staub, T., Farrugia, J., Prisacari, E., Samohvalov, S., Panfile, E., Feodorovici, A., Jimbei, P., Marian, V., Streukens, S.A., Van der Spoel, T., Lokhorst, J., Liesbek, O., Vriend, J., Beitnes, J.O., Skardal, R., Kosmala, W., Lisowska, A., Rodrigues, G., Marques, A., Trofenciuc, N‐M., Bordejevic, A., Onel, M.F., Parvanescu, T., Rosianu, H., Karaulova, J., Pisaryuk, A., Milojevic, P., Kovacevic, M., Poh, K.K., Maisterra, O., Fernandez‐Golfin, C., Navas Elorza, E., Gonzalez Rico, C., Montejo, M., Vidal, B., Marco, F., Bardaji Ruiz, A., Guillen Marzo, M., Gulel, O., Baslib, F., Primus, C., Browne‐Morgan, M., Uzokov, J.

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Validated Risk Score for Predicting 6‐Month Mortality in Infective Endocarditis von Bouza, Emilio, Tattevin, Pierre, Habib, Gilbert, Tan, Ren, Fortes, Claudio Querido, Siciliano, Rinaldo Focaccia, Cortes, Claudia, Kogan, Silvia, Spelman, Denis, Jones, Phillip, Harkness, John, Ryan, Suzanne, Jones, Phillip, Post, Jeffrey, Ryan, Suzanne, Gattringer, Rainer, Andrade, Adriana Ribas, Strabelli, Tania Mara Varejao, Oliveira Ramos, Auristela, Weksler, Clara, Fernandez, Ricardo, Bukovski, Suzana, Rudez, Igor, Alla, Francois, Casalta, Jean‐Paul, Fournier, Pierre‐Edouard, Raoult, Didier, Donnio, Pierre Yves, Michelet, Christian, Jeu, Antoine, Tribouilloy, Christophe, Leroy, Joel, Athanasia, Sophia, Deliolanis, Ioannis, Giamarellou, Helen, Thomas, Tsaganos, Paniara, Olga, Papanicolaou, Konstantinos, Paniara, Olga, Pyros, John, Francis, Johnson, Israel, Sarah, Strahilevitz, Jacob, Durante‐Mangoni, Emanuele, Senese, Alessandra, Cecchi, Enrico, De Rosa, Francesco, Forno, Davide, Imazio, Massimo, Toniolo, Antonio, Goglio, Antonio, Rizzi, Marco, Carosi, Giampiero, Signorini, Liana, Kanafani, Zeina, Kanj, Souha S., Abidin, Imran, Tamin, Syahidah Syed, Meer, Jan T.M., Chambers, Stephen, Morris, Arthur, Raymond, Nigel, Butkevich, O.M., Chipigina, Natalia, Vadim, Kulichenko, Liew, Yee‐Yun, Tan, Ru‐San, Logar, Mateja, Hansa, Cass, Almela, Manuel, Armero, Yolanda, Azqueta, Manuel, Cervera, Carlos, Gatell, Jose M., Paré, Carlos, Rovira, Irene, Garcia Fernández, Miguel Angel, Roda, Jorge, Solis, Jorge, Olaison, Lars, Pussadhamma, Burabha, Watkin, Richard, Klein, John L., Mudrick, Daniel, Stryjewski, Martin, Woods, Christopher W., Lerakis, Stamatios, Cantey, Robert, Bonilla, Hector, Salstrom, Sara‐Jane, Corey, G. Ralph, Dixon, Christy C., Fowler, Vance G., Jones‐Richmond, Marian, Stafford, Judy, Stafford, Judy, Cabell, Christopher H., Fowler, Vance G., Bayer, Arnold S., Fowler, Vance G.

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Survival loss linked to guideline-based indications for degenerative mitral regurgitation surgery von Vancraeynest, David, Pouleur, Anne-Catherine, de Meester, Christophe, Pasquet, Agnès, Gerber, Bernhard, Michelena, Hector, Benfari, Giovanni, Essayagh, Benjamin, Tribouilloy, Christophe, Rusinaru, Dan, Grigioni, Francesco, Barbieri, Andrea, Bursi, Francesca, Avierinos, Jean-François, Guerra, Federico, Biagini, Elena, Yeo, Khung Keong, Ewe, See Hooi, Lee, Alex Pui-Wai, Vanoverschelde, Jean-Louis J, Enriquez-Sarano, Maurice

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Left Atrial Size Is a Potent Predictor of Mortality in Mitral Regurgitation Due to Flail Leaflets: Results From a Large International Multicenter Study von RUSINARU, Dan, TRIBOUILLOY, Christophe, BURSI, Francesca, MEZGHANI, Sonia, BRANZI, Angelo, HABIB, Gilbert, MODENA, Maria G, ENRIQUEZ-SARANO, Maurice, GRIGIONI, Francesco, AVIERINOS, Jean François, SURI, Rakesh M, BARBIERI, Andrea, SZYMANSKI, Catherine, FERLITO, Marinella, MICHELENA, Hector, TAFANELLI, Laurence

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