Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926) von Tremblay, Martin R, Lescarbeau, André, Grogan, Michael J, Tan, Eddy, Lin, Grace, Austad, Brian C, Yu, Lin-Chen, Behnke, Mark L, Nair, Somarajan J, Hagel, Margit, White, Kerry, Conley, James, Manna, Joseph D, Alvarez-Diez, Teresa M, Hoyt, Jennifer, Woodward, Caroline N, Sydor, Jens R, Pink, Melissa, MacDougall, John, Campbell, Matthew J, Cushing, Jill, Ferguson, Jeanne, Curtis, Michael S, McGovern, Karen, Read, Margaret A, Palombella, Vito J, Adams, Julian, Castro, Alfredo C

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Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy von Tremblay, Martin R, Nesler, Michael, Weatherhead, Robin, Castro, Alfredo C

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In Vitro and In Vivo Anticancer Activities of Synthetic (-)-Laulimalide, a Marine Natural Product Microtubule Stabilizing Agent von JUNKE LIU, TOWLE, Murray J, HONGJUAN ZHAO, PESANT, Marc, FANG, Francis G, VERMEULEN, Mary W, GALLAGHER, Brian M, LITTLEFIELD, Bruce A, HONGSHENG CHENG, SAXTON, Philip, REARDON, Cathy, JIAYI WU, MURPHY, Erin A, KUZNETSOV, Galina, JOHANNES, Charles W, TREMBLAY, Martin R

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Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme von Hamilton, Matthew M, Mseeh, Faika, McAfoos, Timothy J, Leonard, Paul G, Reyna, Naphtali J, Harris, Angela L, Xu, Alan, Han, Michelle, Soth, Michael J, Czako, Barbara, Theroff, Jay P, Mandal, Pijus K, Burke, Jason P, Virgin-Downey, Brett, Petrocchi, Alessia, Pfaffinger, Dana, Rogers, Norma E, Parker, Connor A, Yu, Simon S, Jiang, Yongying, Krapp, Stephan, Lammens, Alfred, Trevitt, Graham, Tremblay, Martin R, Mikule, Keith, Wilcoxen, Keith, Cross, Jason B, Jones, Philip, Marszalek, Joseph R, Lewis, Richard T

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Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1R von Czako, Barbara, Marszalek, Joseph. R, Burke, Jason P, Mandal, Pijus, Leonard, Paul G, Cross, Jason B, Mseeh, Faika, Jiang, Yongying, Chang, Edward Q, Suzuki, Erika, Kovacs, Jeffrey J, Feng, Ningping, Gera, Sonal, Harris, Angela L, Liu, Zhen, Mullinax, Robert A, Pang, Jihai, Parker, Connor A, Spencer, Nakia D, Yu, Simon S, Wu, Qi, Tremblay, Martin R, Mikule, Keith, Wilcoxen, Keith, Heffernan, Timothy P, Draetta, Giulio F, Jones, Philip

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Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)‑γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate von Evans, Catherine A, Liu, Tao, Lescarbeau, André, Nair, Somarajan J, Grenier, Louis, Pradeilles, Johan A, Glenadel, Quentin, Tibbitts, Thomas, Rowley, Ann M, DiNitto, Jonathan P, Brophy, Erin E, O’Hearn, Erin L, Ali, Janid A, Winkler, David G, Goldstein, Stanley I, O’Hearn, Patrick, Martin, Christian M, Hoyt, Jennifer G, Soglia, John R, Cheung, Culver, Pink, Melissa M, Proctor, Jennifer L, Palombella, Vito J, Tremblay, Martin R, Castro, Alfredo C

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Synthetic Silvestrol Analogues as Potent and Selective Protein Synthesis Inhibitors von Liu, Tao, Nair, Somarajan J, Lescarbeau, André, Belani, Jitendra, Peluso, Stéphane, Conley, James, Tillotson, Bonnie, O’Hearn, Patrick, Smith, Sherri, Slocum, Kelly, West, Kip, Helble, Joseph, Douglas, Mark, Bahadoor, Adilah, Ali, Janid, McGovern, Karen, Fritz, Christian, Palombella, Vito J, Wylie, Andrew, Castro, Alfredo C, Tremblay, Martin R

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New developments in the discovery of small molecule Hedgehog pathway antagonists von Tremblay, Martin R, McGovern, Karen, Read, Margaret A, Castro, Alfredo C

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Semisynthetic Cyclopamine Analogues as Potent and Orally Bioavailable Hedgehog Pathway Antagonists von Tremblay, Martin R, Nevalainen, Marta, Nair, Somarajan J, Porter, James R, Castro, Alfredo C, Behnke, Mark L, Yu, Lin-Chen, Hagel, Margit, White, Kerry, Faia, Kerrie, Grenier, Louis, Campbell, Matthew J, Cushing, Jill, Woodward, Caroline N, Hoyt, Jennifer, Foley, Michael A, Read, Margaret A, Sydor, Jens R, Tong, Jeffrey K, Palombella, Vito J, McGovern, Karen, Adams, Julian

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A Sequential Application of Kinetic Resolution and Polymer-Supported Scavenging for the Isolation of Chiral Secondary Alcohols von Córdova, Armando, Tremblay, Martin R, Clapham, Bruce, Janda, Kim D

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Development of a Multi Kilogram-Scale, Tandem Cyclopropanation Ring-Expansion Reaction en Route to Hedgehog Antagonist IPI-926 von Austad, Brian C, Hague, Andrew B, White, Priscilla, Peluso, Stéphane, Nair, Somarajan J, Depew, Kristopher M, Grogan, Michael J, Charette, André B, Yu, Lin-Chen, Lory, Caroline D, Grenier, Louis, Lescarbeau, André, Lane, Benjamin S, Lombardy, Richard, Behnke, Mark L, Koney, Nii, Porter, James R, Campbell, Matthew J, Shaffer, Jeanne, Xiong, Jimin, Helble, Joseph C, Foley, Michael A, Adams, Julian, Castro, Alfredo C, Tremblay, Martin R

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Estradiol−Adenosine Hybrid Compounds Designed to Inhibit Type 1 17β-Hydroxysteroid Dehydrogenase von Poirier, Donald, Boivin, Roch P, Tremblay, Martin R, Bérubé, Marie, Qiu, Wei, Lin, Sheng-Xiang

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Advances in Antibody Catalysis of Cycloaddition Reactions von Tremblay, Martin R., Dickerson, Tobin J., Janda, Kim D.

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A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity von Qiu, Wei, Campbell, Robert L, Gangloff, Anne, Dupuis, Philippe, Boivin, Roch P, Tremblay, Martin R, Poirier, Donald, Lin, Sheng-Xiang

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Overview of a rational approach to design type I 17 β-hydroxysteroid dehydrogenase inhibitors without estrogenic activity: chemical synthesis and biological evaluation von Tremblay, Martin R, Poirier, Donald

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Synthesis and biological evaluation of (−)-laulimalide analogues von Gallagher, Brian M., Fang, Francis G., Johannes, Charles W., Pesant, Marc, Tremblay, Martin R., Zhao, Hongjuan, Akasaka, Kozo, Li, Xiang-yi, Liu, Junke, Littlefield, Bruce A.

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Exploring the Scope of the 29G12 Antibody Catalyzed 1,3-Dipolar Cycloaddition Reaction von Toker, Jonathan D, Tremblay, Martin R, Yli-Kauhaluoma, Jari, Wentworth, Anita D, Zhou, Bin, Wentworth, Paul, Janda, Kim D

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Inhibitors of type II 17β-hydroxysteroid dehydrogenase von Poirier, Donald, Bydal, Patrick, Tremblay, Martin R, Sam, Kay-Mane, Luu-The, Van

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Chemical synthesis of 16β-propylaminoacyl derivatives of estradiol and their inhibitory potency on type 1 17β-hydroxysteroid dehydrogenase and binding affinity on steroid receptors... von Tremblay, Martin R., Lin, Sheng-Xiang, Poirier, Donald

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Catalysis of the Photo-Fries Reaction:  Antibody-Mediated Stabilization of High Energy States von Dickerson, Tobin J, Tremblay, Martin R, Hoffman, Timothy Z, Ruiz, Diana I, Janda, Kim D

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