Nonthermal Activation of Transient Receptor Potential Vanilloid-1 Channels in Abdominal Viscera Tonically Inhibits Autonomic Cold-Defense Effectors von Steiner, Alexandre A, Turek, Victoria F, Almeida, Maria C, Burmeister, Jeffrey J, Oliveira, Daniela L, Roberts, Jennifer L, Bannon, Anthony W, Norman, Mark H, Louis, Jean-Claude, Treanor, James J. S, Gavva, Narender R, Romanovsky, Andrej A

Volltext

The Vanilloid Receptor TRPV1 Is Tonically Activated In Vivo and Involved in Body Temperature Regulation von Gavva, Narender R, Bannon, Anthony W, Surapaneni, Sekhar, Hovland, David N., Jr, Lehto, Sonya G, Gore, Anu, Juan, Todd, Deng, Hong, Han, Bora, Klionsky, Lana, Kuang, Rongzhen, Le, April, Tamir, Rami, Wang, Jue, Youngblood, Brad, Zhu, Dawn, Norman, Mark H, Magal, Ella, Treanor, James J. S, Louis, Jean-Claude

Volltext

Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans von Gavva, Narender R., Treanor, James J.S., Garami, Andras, Fang, Liang, Surapaneni, Sekhar, Akrami, Anna, Alvarez, Francisco, Bak, Annette, Darling, Mary, Gore, Anu, Jang, Graham R., Kesslak, James P., Ni, Liyun, Norman, Mark H., Palluconi, Gabrielle, Rose, Mark J., Salfi, Margaret, Tan, Edward, Romanovsky, Andrej A., Banfield, Christopher, Davar, Gudarz

Volltext

Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux von Rzasa, Robert M., Hu, Essa, Rumfelt, Shannon, Chen, Ning, Andrews, Kristin L., Chmait, Samer, Falsey, James R., Zhong, Wenge, Jones, Adrie D., Porter, Amy, Louie, Steven W., Zhao, Xiaoning, Treanor, James J.S., Allen, Jennifer R.

Volltext

Design of Potent, Orally Available Antagonists of the Transient Receptor Potential Vanilloid 1. Structure−Activity Relationships of 2-Piperazin-1-yl-1H-benzimidazoles von Ognyanov, Vassil I, Balan, Chenera, Bannon, Anthony W, Bo, Yunxin, Dominguez, Celia, Fotsch, Christopher, Gore, Vijay K, Klionsky, Lana, Ma, Vu V, Qian, Yi-Xin, Tamir, Rami, Wang, Xianghong, Xi, Ning, Xu, Shimin, Zhu, Dawn, Gavva, Narender R, Treanor, James J. S, Norman, Mark H

Volltext

Novel Vanilloid Receptor-1 Antagonists:  2. Structure−Activity Relationships of 4-Oxopyrimidines Leading to the Selection of a Clinical Candidate von Doherty, Elizabeth M, Fotsch, Christopher, Bannon, Anthony W, Bo, Yunxin, Chen, Ning, Dominguez, Celia, Falsey, James, Gavva, Narender R, Katon, Jodie, Nixey, Thomas, Ognyanov, Vassil I, Pettus, Liping, Rzasa, Robert M, Stec, Markian, Surapaneni, Sekhar, Tamir, Rami, Zhu, Jiawang, Treanor, James J. S, Norman, Mark H

Volltext

Substituted aryl pyrimidines as potent and soluble TRPV1 antagonists von Stec, Markian M., Bo, Yunxin, Chakrabarti, Partha P., Liao, Lillian, Ncube, Mqhele, Tamayo, Nuria, Tamir, Rami, Gavva, Narender R., Treanor, James J.S., Norman, Mark H.

Volltext

Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility von Rzasa, Robert M., Frohn, Michael J., Andrews, Kristin L., Chmait, Samer, Chen, Ning, Clarine, Jeffrey G., Davis, Carl, Eastwood, Heather A., Horne, Daniel B., Hu, Essa, Jones, Adrie D., Kaller, Matthew R., Kunz, Roxanne K., Miller, Silke, Monenschein, Holger, Nguyen, Thomas, Pickrell, Alexander J., Porter, Amy, Reichelt, Andreas, Zhao, Xiaoning, Treanor, James J.S., Allen, Jennifer R.

Volltext

Trisubstituted pyrimidines as transient receptor potential vanilloid 1 (TRPV1) antagonists with improved solubility von Wang, Xianghong, Chakrabarti, Partha P., Ognyanov, Vassil I., Pettus, Liping H., Tamir, Rami, Tan, Helming, Tang, Phi, Treanor, James J.S., Gavva, Narender R., Norman, Mark H.

Volltext

Proton Activation Does Not Alter Antagonist Interaction with the Capsaicin-Binding Pocket of TRPV1 von Gavva, Narender R, Tamir, Rami, Klionsky, Lana, Norman, Mark H, Louis, Jean-Claude, Wild, Kenneth D, Treanor, James J S

Volltext

4-Aminopyrimidine tetrahydronaphthols: A series of novel vanilloid receptor-1 antagonists with improved solubility properties von Doherty, Elizabeth M., Retz, Daniel, Gavva, Narender R., Tamir, Rami, Treanor, James J.S., Norman, Mark H.

Volltext

Characterization of a multicomponent receptor for GDNF von Treanor, James J. S, Goodman, Laurie, de Sauvage, Frederic, Stone, Donna M, Poulsen, Kris T, Beck, Claus D, Gray, Christa, Armanini, Mark P, Pollock, Richard A, Hefti, Franz, Phillips, Heidi S, Goddard, Audry, Moore, Mark W, Buj-Bello, Anna, Davies, Alun M, Asai, Naoya, Takahashi, Masahide, Vandlen, Richard, Henderson, Christopher E, Rosenthal, Arnon

Volltext

Discovery of Potent, Orally Available Vanilloid Receptor-1 Antagonists. Structure−Activity Relationship of N-Aryl Cinnamides von Doherty, Elizabeth M, Fotsch, Christopher, Bo, Yunxin, Chakrabarti, Partha P, Chen, Ning, Gavva, Narender, Han, Nianhe, Kelly, Michael G, Kincaid, John, Klionsky, Lana, Liu, Qingyian, Ognyanov, Vassil I, Tamir, Rami, Wang, Xianghong, Zhu, Jiawang, Norman, Mark H, Treanor, James J. S

Volltext

Novel Vanilloid Receptor-1 Antagonists:  3. The Identification of a Second-Generation Clinical Candidate with Improved Physicochemical and Pharmacokinetic Properties von Wang, Hui-Ling, Katon, Jodie, Balan, Chenera, Bannon, Anthony W, Bernard, Charles, Doherty, Elizabeth M, Dominguez, Celia, Gavva, Narender R, Gore, Vijay, Ma, Vu, Nishimura, Nobuko, Surapaneni, Sekhar, Tang, Phi, Tamir, Rami, Thiel, Oliver, Treanor, James J. S, Norman, Mark H

Volltext

Novel Vanilloid Receptor-1 Antagonists:  1. Conformationally Restricted Analogues of trans-Cinnamides von Norman, Mark H, Zhu, Jiawang, Fotsch, Christopher, Bo, Yunxin, Chen, Ning, Chakrabarti, Partha, Doherty, Elizabeth M, Gavva, Narender R, Nishimura, Nobuko, Nixey, Thomas, Ognyanov, Vassil I, Rzasa, Robert M, Stec, Markian, Surapaneni, Sekhar, Tamir, Rami, Viswanadhan, Vellarkad N, Treanor, James J. S

Volltext

Structure–activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonists von Gore, Vijay K., Ma, Vu V., Tamir, Rami, Gavva, Narender R., Treanor, James J.S., Norman, Mark H.

Volltext

Molecular Determinants of Vanilloid Sensitivity in TRPV1 von Gavva, Narender R, Klionsky, Lana, Qu, Yusheng, Shi, Licheng, Tamir, Rami, Edenson, Steve, Zhang, T J, Viswanadhan, Vellarkad N, Toth, Attila, Pearce, Larry V, Vanderah, Todd W, Porreca, Frank, Blumberg, Peter M, Lile, Jack, Sun, Yax, Wild, Ken, Louis, Jean-Claude, Treanor, James J S

Volltext

Fenchylamine Sulfonamide Inhibitors of Amyloid β Peptide Production by the γ-Secretase Proteolytic Pathway:  Potential Small-Molecule Therapeutic Agents for the Treatment of Alzhei... von Rishton, Gilbert M, Retz, Daniel M, Tempest, Paul A, Novotny, James, Kahn, Steve, Treanor, James J. S, Lile, Jack D, Citron, Martin

Volltext

Synthesis and evaluation of thiazole carboxamides as vanilloid receptor 1 (TRPV1) antagonists von Xi, Ning, Bo, Yunxin, Doherty, Elizabeth M., Fotsch, Christopher, Gavva, Narender R., Han, Nianhe, Hungate, Randall W., Klionsky, Lana, Liu, Qingyian, Tamir, Rami, Xu, Shimin, Treanor, James J.S., Norman, Mark H.

Volltext

Design of Potent, Orally Available Antagonists of the Transient Receptor Potential Vanilloid 1. Structure−Activity Relationships of 2-Piperazin-1-yl-1 H -benzimidazoles von Ognyanov, Vassil I., Balan, Chenera, Bannon, Anthony W., Bo, Yunxin, Dominguez, Celia, Fotsch, Christopher, Gore, Vijay K., Klionsky, Lana, Ma, Vu V., Qian, Yi-Xin, Tamir, Rami, Wang, Xianghong, Xi, Ning, Xu, Shimin, Zhu, Dawn, Gavva, Narender R., Treanor, James J. S., Norman, Mark H.

Volltext