Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4 von Fairhurst, Robin A, Knoepfel, Thomas, Buschmann, Nicole, Leblanc, Catherine, Mah, Robert, Todorov, Milen, Nimsgern, Pierre, Ripoche, Sebastien, Niklaus, Michel, Warin, Nicolas, Luu, Van Huy, Madoerin, Mario, Wirth, Jasmin, Graus-Porta, Diana, Weiss, Andreas, Kiffe, Michael, Wartmann, Markus, Kinyamu-Akunda, Jacqueline, Sterker, Dario, Stamm, Christelle, Adler, Flavia, Buhles, Alexandra, Schadt, Heiko, Couttet, Philippe, Blank, Jutta, Galuba, Inga, Trappe, Jörg, Voshol, Johannes, Ostermann, Nils, Zou, Chao, Berghausen, Jörg, Del Rio Espinola, Alberto, Jahnke, Wolfgang, Furet, Pascal

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7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes von Huber, Kilian, Brault, Laurent, Fedorov, Oleg, Gasser, Christelle, Filippakopoulos, Panagis, Bullock, Alex N, Fabbro, Doriano, Trappe, Jörg, Schwaller, Jürg, Knapp, Stefan, Bracher, Franz

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Tetra-Substituted Pyridinylimidazoles As Dual Inhibitors of p38α Mitogen-Activated Protein Kinase and c‑Jun N‑Terminal Kinase 3 for Potential Treatment of Neurodegenerative Disease... von Muth, Felix, Günther, Marcel, Bauer, Silke M., Döring, Eva, Fischer, Sabine, Maier, Julia, Drückes, Peter, Köppler, Jürgen, Trappe, Jörg, Rothbauer, Ulrich, Koch, Pierre, Laufer, Stefan A.

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Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes von Sutton, Jon M., Clark, David E., Dunsdon, Stephen J., Fenton, Garry, Fillmore, Amanda, Harris, Neil V., Higgs, Chris, Hurley, Chris A., Krintel, Sussie L., MacKenzie, Robert E., Duttaroy, Alokesh, Gangl, Eric, Maniara, Wiesia, Sedrani, Richard, Namoto, Kenji, Ostermann, Nils, Gerhartz, Bernd, Sirockin, Finton, Trappe, Jörg, Hassiepen, Ulrich, Baeschlin, Daniel K.

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A Novel Class of Oral Direct Renin Inhibitors: Highly Potent 3,5-Disubstituted Piperidines Bearing a Tricyclic P3 –P1 Pharmacophore von Ostermann, Nils, Ruedisser, Simon, Ehrhardt, Claus, Breitenstein, Werner, Marzinzik, Andreas, Jacoby, Edgar, Vangrevelinghe, Eric, Ottl, Johannes, Klumpp, Martin, Hartwieg, J. Constanze D, Cumin, Frederic, Hassiepen, Ulrich, Trappe, Jörg, Sedrani, Richard, Geisse, Sabine, Gerhartz, Bernd, Richert, Paul, Francotte, Eric, Wagner, Trixie, Krömer, Markus, Kosaka, Takatoshi, Webb, Randy L, Rigel, Dean F, Maibaum, Jürgen, Baeschlin, Daniel K

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Correction to Tetra-Substituted Pyridinylimidazoles As Dual Inhibitors of p38α Mitogen-Activated Protein Kinase and c‑Jun N‑Terminal Kinase 3 for Potential Treatment of Neurodegene... von Muth, Felix, Günther, Marcel, Bauer, Silke M, Döring, Eva, Fischer, Sabine, Maier, Julia, Drückes, Peter, Köppler, Jürgen, Trappe, Jörg, Rothbauer, Ulrich, Koch, Pierre, Laufer, Stefan A

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Kinase Inhibition by Deoxy Analogues of the Resorcylic Lactone L-783277 von Liniger, Marc, Neuhaus, Christian, Hofmann, Tatjana, Fransioli-Ignazio, Luca, Jordi, Michel, Drueckes, Peter, Trappe, Jörg, Fabbro, Doriano, Altmann, Karl-Heinz

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A high‐throughput screening for inhibitors of riboflavin synthase identifies novel antimicrobial compounds to treat brucellosis von Serer, María Inés, Carrica, Mariela del Carmen, Trappe, Jörg, López Romero, Sandra, Bonomi, Hernán Ruy, Klinke, Sebastián, Cerutti, María Laura, Goldbaum, Fernando Alberto

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Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV von Namoto, Kenji, Sirockin, Finton, Ostermann, Nils, Gessier, Francois, Flohr, Stefanie, Sedrani, Richard, Gerhartz, Bernd, Trappe, Jörg, Hassiepen, Ulrich, Duttaroy, Alokesh, Ferreira, Suzie, Sutton, Jon M., Clark, David E., Fenton, Garry, Beswick, Mandy, Baeschlin, Daniel K.

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Extended kinase profile and properties of the protein kinase inhibitor nilotinib von Manley, Paul W., Drueckes, Peter, Fendrich, Gabriele, Furet, Pascal, Liebetanz, Janis, Martiny-Baron, Georg, Mestan, Jürgen, Trappe, Jörg, Wartmann, Markus, Fabbro, Doriano

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Transfection of mitochondria: strategy towards a gene therapy of mitochondrial DNA diseases von Seibel, Peter, Trappe, Jörg, Villani, Gaetano, Klopstock, Thomas, Papa, Sergio, Reichmann, Heinz

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Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing von Fedorov, Oleg, Huber, Kilian, Eisenreich, Andreas, Filippakopoulos, Panagis, King, Oliver, Bullock, Alex N., Szklarczyk, Damian, Jensen, Lars J., Fabbro, Doriano, Trappe, Jörg, Rauch, Ursula, Bracher, Franz, Knapp, Stefan

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Approaches to selective fibroblast growth factor receptor 4 inhibition through targeting the ATP-pocket middle-hinge region von Fairhurst, Robin A, Knoepfel, Thomas, Leblanc, Catherine, Buschmann, Nicole, Gaul, Christoph, Blank, Jutta, Galuba, Inga, Trappe, Jörg, Zou, Chao, Voshol, Johannes, Genick, Christine, Brunet-Lefeuvre, Peggy, Bitsch, Francis, Graus-Porta, Diana, Furet, Pascal

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Inhibition of murine cytomegalovirus and human cytomegalovirus by a novel non-nucleosidic compound in vivo von Weber, Olaf, Bender, Wolfgang, Eckenberg, Peter, Goldmann, Siegfried, Haerter, Michael, Hallenberger, Sabine, Henninger, Kerstin, Reefschläger, Jürgen, Trappe, Jörg, Witt-Laido, Astrid, Ruebsamen-Waigmann, Helga

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A Novel Class of Oral Direct Renin Inhibitors: Highly Potent 3,5-Disubstituted Piperidines Bearing a Tricyclic P 3 – P 1 Pharmacophore von Ostermann, Nils, Ruedisser, Simon, Ehrhardt, Claus, Breitenstein, Werner, Marzinzik, Andreas, Jacoby, Edgar, Vangrevelinghe, Eric, Ottl, Johannes, Klumpp, Martin, Hartwieg, J. Constanze D., Cumin, Frederic, Hassiepen, Ulrich, Trappe, Jörg, Sedrani, Richard, Geisse, Sabine, Gerhartz, Bernd, Richert, Paul, Francotte, Eric, Wagner, Trixie, Krömer, Markus, Kosaka, Takatoshi, Webb, Randy L., Rigel, Dean F., Maibaum, Jürgen, Baeschlin, Daniel K.

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A nomenclature system for granular phosphate rocks according to depositional texture von Trappe, Jörg

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Approaches to selective fibroblast growth factor receptor 4 inhibition through targeting the ATP-pocket middle-hinge regionThe authors declare no competing interests.Electronic sup... von Fairhurst, Robin A, Knoepfel, Thomas, Leblanc, Catherine, Buschmann, Nicole, Gaul, Christoph, Blank, Jutta, Galuba, Inga, Trappe, Jörg, Zou, Chao, Voshol, Johannes, Genick, Christine, Brunet-Lefeuvre, Peggy, Bitsch, Francis, Graus-Porta, Diana, Furet, Pascal

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Approaches to selective fibroblast growth factor receptor 4 inhibition through targeting the ATP-pocket middle-hinge region† †The authors declare no competing interests. ‡ ‡Electro... von Fairhurst, Robin A., Knoepfel, Thomas, Leblanc, Catherine, Buschmann, Nicole, Gaul, Christoph, Blank, Jutta, Galuba, Inga, Trappe, Jörg, Zou, Chao, Voshol, Johannes, Genick, Christine, Brunet-Lefeuvre, Peggy, Bitsch, Francis, Graus-Porta, Diana, Furet, Pascal

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2-Amino-aryl-7-aryl-benzoxazoles as potent, selective and orally available JAK2 inhibitors von Gerspacher, Marc, Furet, Pascal, Pissot-Soldermann, Carole, Gaul, Christoph, Holzer, Philipp, Vangrevelinghe, Eric, Lang, Marc, Erdmann, Dirk, Radimerski, Thomas, Regnier, Catherine H., Chene, Patrick, Pover, Alain De, Hofmann, Francesco, Baffert, Fabienne, Buhl, Thomas, Aichholz, Reiner, Blasco, Francesca, Endres, Ralf, Trappe, Jörg, Drueckes, Peter

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Crystal Structure of an Activation Intermediate of Cathepsin E von Ostermann, Nils, Gerhartz, Bernd, Worpenberg, Susanne, Trappe, Jörg, Eder, Jörg

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