Perforin and granzymes: function, dysfunction and human pathology von Voskoboinik, Ilia, Whisstock, James C., Trapani, Joseph A.

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Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion von Voli, Florida, Valli, Emanuele, Lerra, Luigi, Kimpton, Kathleen, Saletta, Federica, Giorgi, Federico M., Mercatelli, Daniele, Rouaen, Jourdin R. C., Shen, Sylvie, Murray, Jayne E., Ahmed-Cox, Aria, Cirillo, Giuseppe, Mayoh, Chelsea, Beavis, Paul A., Haber, Michelle, Trapani, Joseph A., Kavallaris, Maria, Vittorio, Orazio

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TRAIL+ NK Cells Control CD4+ T Cell Responses during Chronic Viral Infection to Limit Autoimmunity von Schuster, Iona S., Wikstrom, Matthew E., Brizard, Geraldine, Coudert, Jerome D., Estcourt, Marie J., Manzur, Mitali, O’Reilly, Lorraine A., Smyth, Mark J., Trapani, Joseph A., Hill, Geoffrey R., Andoniou, Christopher E., Degli-Esposti, Mariapia A.

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Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time von Jenkins, Misty R, Rudd-Schmidt, Jesse A, Lopez, Jamie A, Ramsbottom, Kelly M, Mannering, Stuart I, Andrews, Daniel M, Voskoboinik, Ilia, Trapani, Joseph A

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Lipid order and charge protect killer T cells from accidental death von Rudd-Schmidt, Jesse A., Hodel, Adrian W., Noori, Tahereh, Lopez, Jamie A., Cho, Hyun-Jung, Verschoor, Sandra, Ciccone, Annette, Trapani, Joseph A., Hoogenboom, Bart W., Voskoboinik, Ilia

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Functional significance of the perforin/granzyme cell death pathway von Trapani, Joseph A, Smyth, Mark J

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Revisiting T Cell Tolerance as a Checkpoint Target for Cancer Immunotherapy von Nussing, Simone, Trapani, Joseph A., Parish, Ian A.

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Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance von Fareh, Mohamed, Zhao, Wei, Hu, Wenxin, Casan, Joshua M. L., Kumar, Amit, Symons, Jori, Zerbato, Jennifer M., Fong, Danielle, Voskoboinik, Ilia, Ekert, Paul G., Rudraraju, Rajeev, Purcell, Damian F. J., Lewin, Sharon R., Trapani, Joseph A.

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Conformational changes during pore formation by the perforin-related protein pleurotolysin von Lukoyanova, Natalya, Kondos, Stephanie C, Farabella, Irene, Law, Ruby H P, Reboul, Cyril F, Caradoc-Davies, Tom T, Spicer, Bradley A, Kleifeld, Oded, Traore, Daouda A K, Ekkel, Susan M, Voskoboinik, Ilia, Trapani, Joseph A, Hatfaludi, Tamas, Oliver, Katherine, Hotze, Eileen M, Tweten, Rodney K, Whisstock, James C, Topf, Maya, Saibil, Helen R, Dunstone, Michelle A

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Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack von Lopez, Jamie A., Susanto, Olivia, Jenkins, Misty R., Lukoyanova, Natalya, Sutton, Vivien R., Law, Ruby H.P., Johnston, Angus, Bird, Catherina H., Bird, Phillip I., Whisstock, James C., Trapani, Joseph A., Saibil, Helen R., Voskoboinik, Ilia

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Real-time visualization of perforin nanopore assembly von Leung, Carl, Hodel, Adrian W., Brennan, Amelia J., Lukoyanova, Natalya, Tran, Sharon, House, Colin M., Kondos, Stephanie C., Whisstock, James C., Dunstone, Michelle A., Trapani, Joseph A., Voskoboinik, Ilia, Saibil, Helen R., Hoogenboom, Bart W.

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Perforinopathy: a spectrum of human immune disease caused by defective perforin delivery or function von Voskoboinik, Ilia, Trapani, Joseph A

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Perforin: structure, function, and role in human immunopathology von Voskoboinik, Ilia, Dunstone, Michelle A, Baran, Katherine, Whisstock, James C, Trapani, Joseph A

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Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer von Dushyanthen, Sathana, Teo, Zhi Ling, Caramia, Franco, Savas, Peter, Mintoff, Christopher P., Virassamy, Balaji, Henderson, Melissa A., Luen, Stephen J., Mansour, Mariam, Kershaw, Michael H., Trapani, Joseph A., Neeson, Paul J., Salgado, Roberto, McArthur, Grant A., Balko, Justin M., Beavis, Paul A., Darcy, Phillip K., Loi, Sherene

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PVRIG is a novel natural killer cell immune checkpoint receptor in acute myeloid leukemia von Li, Jessica, Whelan, Sarah, Kotturi, Maya F., Meyran, Deborah, D'Souza, Criselle, Hansen, Kyle, Liang, Spencer, Hunter, John, Trapani, Joseph A., Neeson, Paul J.

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The structural basis for membrane binding and pore formation by lymphocyte perforin von Trapani, Joseph A, Saibil, Helen R, Whisstock, James C, Law, Ruby H. P, Lukoyanova, Natalya, Voskoboinik, Ilia, Caradoc-Davies, Tom T, Baran, Katherine, Dunstone, Michelle A, D'Angelo, Michael E, Orlova, Elena V, Coulibaly, Fasséli, Verschoor, Sandra, Browne, Kylie A, Ciccone, Annette, Kuiper, Michael J, Bird, Phillip I

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Natural killer cells kill extracellular Pseudomonas aeruginosa using contact-dependent release of granzymes B and H von Feehan, David D, Jamil, Khusraw, Polyak, Maria J, Ogbomo, Henry, Hasell, Mark, Li, Shu Shun, Xiang, Richard F, Parkins, Michael, Trapani, Joseph A, Harrison, Joe J, Mody, Christopher H

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Differential effects of BTK inhibitors ibrutinib and zanubrutinib on NK-cell effector function in patients with mantle cell lymphoma von Flinsenberg, Thijs W. H., Tromedjo, Charnelle C., Hu, Nan, Liu, Ye, Guo, Yin, Thia, Kevin Y. T., Noori, Tahereh, Song, Xiaomin, Aw Yeang, Han X., Tantalo, Daniela G., Handunnetti, Sasanka, Seymour, John F., Roberts, Andrew W., Ritchie, David, Koldej, Rachel, Neeson, Paul J., Wang, Lai, Trapani, Joseph A., Tam, Constantine S., Voskoboinik, Ilia

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Functional crosstalk between type I and II interferon through the regulated expression of STAT1 von Gough, Daniel J, Messina, Nicole L, Hii, Linda, Gould, Jodee A, Sabapathy, Kanaga, Robertson, Ashley P S, Trapani, Joseph A, Levy, David E, Hertzog, Paul J, Clarke, Christopher J P, Johnstone, Ricky W

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The immunostimulatory effect of lenalidomide on NK-cell function is profoundly inhibited by concurrent dexamethasone therapy von Hsu, Andy K., Quach, Hang, Tai, Tsin, Prince, H. Miles, Harrison, Simon J., Trapani, Joseph A., Smyth, Mark J., Neeson, Paul, Ritchie, David S.

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