Insulin-regulated aminopeptidase is required for water excretion in response to acute hypotonic stress von Zuchowski, Yvonne, Carty, Joshua, Terker, Andrew S, Bock, Fabian, Trapani, Jonathan B, Bhave, Gautam, Watts, Jason A, Keller, Susanna, Zhang, Mingzhi, Zent, Roy, Harris, Raymond C, Arroyo, Juan Pablo

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Disruption of mitochondrial electron transport impairs urinary concentration via AMPK-dependent suppression of aquaporin 2 von Carty, Joshua S, Bessho, Ryoichi, Zuchowski, Yvonne, Trapani, Jonathan B, Davidoff, Olena, Kobayashi, Hanako, Roland, Joseph T, Watts, Jason A, Terker, Andrew S, Bock, Fabian, Arroyo, Juan Pablo, Haase, Volker H

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Jedi‐1/MEGF12‐mediated phagocytosis controls the pro‐neurogenic properties of microglia in the ventricular‐subventricular zone von Morrison, Vivianne E, Houpert, Matthew G, Trapani, Jonathan B, Brockman, Asa A, Kingsley, Philip J, Katdare, Ketaki A., Layden, Hillary M, Hiebert, Scott W, Nguena‐Jones, Gabriela, Trevisan, Alexandra J, Maguire‐Zeiss, Kathleen A, Marnett, Lawrence J, Bix, Gregory J, Ihrie, Rebecca A, Carter, Bruce D

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BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition von Hofmann, Marco H, Gmachl, Michael, Ramharter, Juergen, Savarese, Fabio, Gerlach, Daniel, Marszalek, Joseph R, Sanderson, Michael P, Kessler, Dirk, Trapani, Francesca, Arnhof, Heribert, Rumpel, Klaus, Botesteanu, Dana-Adriana, Ettmayer, Peter, Gerstberger, Thomas, Kofink, Christiane, Wunberg, Tobias, Zoephel, Andreas, Fu, Szu-Chin, Teh, Jessica L, Böttcher, Jark, Pototschnig, Nikolai, Schachinger, Franziska, Schipany, Katharina, Lieb, Simone, Vellano, Christopher P, O'Connell, Jonathan C, Mendes, Rachel L, Moll, Jurgen, Petronczki, Mark, Heffernan, Timothy P, Pearson, Mark, McConnell, Darryl B, Kraut, Norbert

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Prehospital Tranexamic Acid for Severe Trauma von Gruen, Russell L, Mitra, Biswadev, Bernard, Stephen A, McArthur, Colin J, Burns, Brian, Gantner, Dashiell C, Maegele, Marc, Cameron, Peter A, Dicker, Bridget, Forbes, Andrew B, Hurford, Sally, Martin, Catherine A, Mazur, Stefan M, Medcalf, Robert L, Murray, Lynnette J, Myles, Paul S, Ng, Sze J, Pitt, Veronica, Rashford, Stephen, Reade, Michael C, Swain, Andrew H, Trapani, Tony, Young, Paul J

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Pathological Computed Tomography Features Associated With Adverse Outcomes After Mild Traumatic Brain Injury: A TRACK-TBI Study With External Validation in CENTER-TBI von Yuh, Esther L, Jain, Sonia, Sun, Xiaoying, Pisica, Dana, Harris, Mark H, Taylor, Sabrina R, Markowitz, Amy J, Mukherjee, Pratik, Verheyden, Jan, Giacino, Joseph T, Levin, Harvey S, McCrea, Michael, Stein, Murray B, Temkin, Nancy R, Diaz-Arrastia, Ramon, Robertson, Claudia S, Lingsma, Hester F, Okonkwo, David O, Maas, Andrew I.R, Manley, Geoffrey T, Adeoye, Opeolu, Badjatia, Neeraj, Boase, Kim, Bodien, Yelena, Corrigan, John D, Crawford, Karen, Dikmen, Sureyya, Duhaime, Ann-Christine, Ellenbogen, Richard, Feeser, V. Ramana, Ferguson, Adam R, Foreman, Brandon, Gardner, Raquel, Gaudette, Etienne, Gonzalez, Luis, Gopinath, Shankar, Gullapalli, Rao, Hemphill, J. Claude, Hotz, Gillian, Keene, C. Dirk, Kramer, Joel, Kreitzer, Natalie, Lindsell, Chris, Machamer, Joan, Madden, Christopher, Martin, Alastair, McAllister, Thomas, Merchant, Randall, Nelson, Lindsay, Ngwenya, Laura B, Noel, Florence, Nolan, Amber, Palacios, Eva, Perl, Daniel, Rabinowitz, Miri, Rosand, Jonathan, Sander, Angelle, Satris, Gabriella, Schnyer, David, Seabury, Seth, Toga, Arthur, Valadka, Alex, Vassar, Mary, Zafonte, Ross

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Surgery versus conservative treatment for traumatic acute subdural haematoma: a prospective, multicentre, observational, comparative effectiveness study von Lingsma, Hester F, Ribbers, Gerard M, Hutchinson, Peter, Åkerlund, Cecilia, Amrein, Krisztina, Anke, Audny, Audibert, Gérard, Azzolini, Maria Luisa, Bartels, Ronald, Barzó, Pál, Bellander, Bo-Michael, Benali, Habib, Beretta, Luigi, Blaabjerg, Morten, Brazinova, Alexandra, Brinck, Vibeke, Brooker, Joanne, Bullinger, Monika, Caccioppola, Alessio, Calappi, Emiliana, Castaño-León, Ana M., Chieregato, Arturo, Czosnyka, Marek, De Keyser, Véronique, Della Corte, Francesco, Dixit, Abhishek, Donoghue, Emma, Dreier, Jens, Ezer, Erzsébet, Fabricius, Martin, Feigin, Valery L., Frisvold, Shirin, Gomez, Pedro A., Grossi, Francesca, Haagsma, Juanita A., Helseth, Eirik, Jankowski, Stefan, Jarrett, Mike, Jiang, Ji-yao, Johnson, Faye, Kondziella, Daniel, Lagares, Alfonso, Ledoux, Didier, Lefering, Rolf, Legrand, Valerie, Lejeune, Aurelie, Lightfoot, Roger, Maegele, Marc, Majdan, Marek, Maréchal, Hugues, Mattern, Julia, Melegh, Béla, Menovsky, Tomas, Mikolic, Ana, Muraleedharan, Visakh, Ortolano, Fabrizio, Payen, Jean-François, Perlbarg, Vincent, Pirinen, Matti, Polinder, Suzanne, Pomposo, Inigo, Posti, Jussi P., Rădoi, Andreea, Ragauskas, Arminas, Rehorčíková, Veronika, Richardson, Sylvia, Ripatti, Samuli, Rocka, Saulius, Rosand, Jonathan, Rosenthal, Guy, Sandor, Janos, Schäfer, Nadine, Schoonman, Guus, Skandsen, Toril, Smielewski, Peter, Sorinola, Abayomi, Kowark, Ana, Stewart, William, Tamás, Viktória, Taylor, Mark Steven, Tenovuo, Olli, Tibboel, Dick, van der Naalt, Joukje, van Dijck, Jeroen T.J.M., Van Hecke, Wim, van Heugten, Caroline, Van Veen, Ernest, van Wijk, Roel, Vande Vyvere, Thijs, Verheyden, Jan, Vespa, Paul M., Vulekovic, Petar, Wang, Kevin K.W., Wiegers, Eveline, Winzeck, Stefan, Wolf, Stefan, Yang, Zhihui, Ylén, Peter, Ziverte, Agate, Zoerle, Tommaso

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Biomarkers for Traumatic Brain Injury: Data Standards and Statistical Considerations von Huie, J Russell, Mondello, Stefania, Lindsell, Christopher J, Antiga, Luca, Yuh, Esther L, Zanier, Elisa R, Masson, Serge, Rosario, Bedda L, Ferguson, Adam R

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Missing Data in Prediction Research: A Five-Step Approach for Multiple Imputation, Illustrated in the CENTER-TBI Study von Gravesteijn, Benjamin Yaël, Sewalt, Charlie Aletta, Venema, Esmee, Nieboer, Daan, Steyerberg, Ewout W

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The effect of recombinant erythropoietin on long-term outcome after moderate-to-severe traumatic brain injury von Skrifvars, Markus B., Luethi, Nora, Bailey, Michael, French, Craig, Nichol, Alistair, Trapani, Tony, McArthur, Colin, Arabi, Yaseen M., Bendel, Stepani, Cooper, David J., Bellomo, Rinaldo

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Rehabilitation and outcomes after complicated vs uncomplicated mild TBI: results from the CENTER-TBI study von Howe, Emilie Isager, Zeldovich, Marina, Andelic, Nada, von Steinbuechel, Nicole, Fure, Silje C R, Borgen, Ida M H, Forslund, Marit V, Hellstrøm, Torgeir, Søberg, Helene L, Sveen, Unni, Rasmussen, Mari, Kleffelgaard, Ingerid, Tverdal, Cathrine, Helseth, Eirik, Løvstad, Marianne, Lu, Juan, Arango-Lasprilla, Juan Carlos, Tenovuo, Olli, Azouvi, Philippe, Dawes, Helen, Roe, Cecilie

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A genome-wide association study of outcome from traumatic brain injury von Anderson, Christopher D., Temkin, Nancy, Steyerberg, Ewout W., Stein, Murray B., Manley, Geoff T., Beer, Ronny, Berardino, Maurizio, Bragge, Peter, Bullinger, Monika, Cabeleira, Manuel, Calappi, Emiliana, Cameron, Peter, Citerio, Giuseppe, Clusmann, Hans, Coles, Jonathan P., Correia, Marta, Čović, Amra, Curry, Nicola, Czeiter, Endre, Czosnyka, Marek, Boogert, Hugo den, Depreitere, Bart, Frisvold, Shirin, Furmanov, Alex, Gagliardo, Pablo, Gantner, Dashiell, Ghuysen, Alexandre, Giga, Lelde, Gravesteijn, Benjamin, Gupta, Deepak, Haagsma, Juanita A., Haitsma, Iain, Helbok, Raimund, Huijben, Jilske, Jiang, Jiyao, Karan, Mladen, Kompanje, Erwin, Kondziella, Daniel, Kornaropoulos, Evgenios, Ledoux, Didier, CastañoLeón, Ana M., Maegele, Marc, Misset, Benoit, Murray, Lynnette, Negru, Ancuta, Nelson, David, Persona, Paolo, Peul, Wilco, Piippo-Karjalainen, Anna, Pisica, Dana, Rambadagalla, Malinka, Roe, Cecilie, Rosenfeld, Jeffrey V., Rosenthal, Guy, Rueckert, Daniel, Sahuquillo, Juan, Schmidt, Silke, Schoechl, Herbert, Schwendenwein, Elisabeth, Sorinola, Abayomi, Steyerberg, Ewout W., Sundström, Nina, Taylor, Mark Steven, Theadom, Alice, Thomas, Matt, Tibboel, Dick, Trapani, Tony, Vajkoczy, Peter, Valeinis, Egils, van der Jagt, Mathieu, van der Steen, Gregory, van Dijck, Jeroen T.J.M., Vargiolu, Alessia, Velt, Kimberley, Vilcinis, Rimantas, Volovici, Victor, von Steinbüchel, Nicole, Wilson, Lindsay, Zeiler, Frederick A., Zoerle, Tommaso, Katila, Ari, Adeoye, Opeolu, Boase, Kim, Barber, Jason, Chesnut, Randall, Corrigan, John D., Dikmen, Sureyya, Gaudette, Etienne, Gopinath, Shankar, Jain, Sonia, Keene, Dirk, Martin, Alastair, Noel, Florence, Palacios, Eva, Perl, Daniel, Sander, Angelle, Satris, Gabriella, Seabury, Seth, Temkin, Nancy, Toga, Arthur

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Abstract C133: Effective targeting of KRAS-driven tumors by the first-in-class, orally bioavailable SOS1::KRAS inhibitor BI-3406 von Hofmann, Marco H, Gmachl, Michael, Ramharter, Jürgen, Savarese, Fabio, Sanderson, Michael P, Gerlach, Daniel, Trapani, Francesca, Botesteanu, Dana-Adriana, Kessler, Dirk, Ettmayer, Peter, Arnhof, Heribert, Gerstberger, Thomas, Schnitzer, Renate, Kofink, Christiane, Stadtmueller, Heinz, Wunberg, Tobias, O’Connell, Jonathan C., Mendes, Rachel L, Richard, David, Saldanha, Adrian S, Moll, Juergen, Pearson, Mark, McConnell, Darryl B, Kraut, Norbert

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Abstract PL06-01: Discovery of BI-3406: A potent and selective SOS1::KRAS inhibitor opens a new approach for treating KRAS-driven tumors von Hofmann, Marco H, Gmachl, Michael, Ramharter, Jürgen, Savarese, Fabio, Gerlach, Daniel, Marszalek, Joseph R, Sanderson, Michael P, Trapani, Francesca, Kessler, Dirk, Rumpel, Klaus, Botesteanu, Dana-Adriana, Ettmayer, Peter, Arnhof, Heribert, Gerstberger, Thomas, Kofink, Christiane, Wunberg, Tobias, Fu, Szu-Chin, Teh, Jessica, Vellano, Christopher P., O’Connell, Jonathan C., Mendes, Rachel L, Moll, Juergen, Heffernan, Timothy P., Pearson, Mark, McConnell, Darryl B, Kraut, Norbert

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Frequency and predictors of headache in the first 12 months after traumatic brain injury: results from CENTER-TBI von Howe, Emilie Isager, Andelic, Nada, Brunborg, Cathrine, Zeldovich, Marina, Helseth, Eirik, Skandsen, Toril, Olsen, Alexander, Fure, Silje C. R., Theadom, Alice, Rauen, Katrin, Madsen, Benedikte Å., Jacobs, Bram, van der Naalt, Joukje, Tartaglia, Maria Carmela, Einarsen, Cathrine Elisabeth, Storvig, Gøril, Tronvik, Erling, Tverdal, Cathrine, von Steinbüchel, Nicole, Røe, Cecilie, Hellstrøm, Torgeir

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Parsimonious immune-response endotypes and global outcome in patients with traumatic brain injury von Samanta, Romit J., Needham, Edward, Wang, Kevin K.W., Kobeissy, Firas, Posti, Jussi P., Summers, Charlotte, Tenovuo, Olli, Sanchez, Jean-Charles, Badjatia, Neeraj, Diaz-Arrastia, Ramon, Duhaime, Ann-Christine, Gopinath, Shankar, Ha, Ruchira J., Keene, Dirk, Madden, Christopher, Ngwenya, Laura B., Schnyer, David, Ackerlund, Cecilia, Amrein, Krisztina, Bartels, Ronald, Beer, Ronny, Berardino, Maurizio, Lund, Stine Borgen, Buki, Andras, Caccioppola, Alessio, Calappi, Emiliana, Cameron, Peter, Castaño-León, Ana M., Chieregato, Arturo, Citerio, Giuseppe, Clusmann, Hans, Coles, Jonathan, Dahyot-Fizelier, Claire, De Keyser, Véronique, Degos, Vincent, Della Corte, Francesco, Depreitere, Bart, Dixit, Abhishek, Dreier, Jens, Dulière, Guy-Loup, Furmanov, Alex, Gantner, Dashiell, Ghuysen, Alexandre, Golubović, Jagoš, Gomez, Pedro A., Gravesteijn, Benjamin, Grossi, Francesca, Gupta, Deepak, Haitsma, Iain, Helbok, Raimund, Helseth, Eirik, Huijben, Jilske, Jankowski, Stefan, Johnson, Faye, Kolias, Angelos G., Kondziella, Daniel, Koskinen, Lars-Owe, Kowark, Ana, Laureys, Steven, Maas, Andrew I.R., McMahon, Catherine, Menon, David, Muraleedharan, Visakh, Murray, Lynnette, Nelson, David, Newcombe, Virginia, Nyirádi, József, Payen, Jean-François, Persona, Paolo, Peul, Wilco, Pomposo, Inigo, Posti, Jussi P., Ragauskas, Arminas, Rocka, Saulius, Roise, Olav, Rosenfeld, Jeffrey, Rosenlund, Christina, Rossaint, Rolf, Rossi, Sandra, Sorinola, Abayomi, Stamatakis, Emmanuel, Steyerberg, Ewout W., Stocchetti, Nino, Sundström, Nina, Tenovuo, Olli, Thomas, Matt, Tibboel, Dick, Valeinis, Egils, Vámos, Zoltán, Van der Steen, Gregory, van Dijck, Jeroen T.J.M., van Essen, Thomas A., Vargiolu, Alessia, Vega, Emmanuel, Vik, Anne, Vilcinis, Rimantas, Volovici, Victor, Wiegers, Eveline, Younsi, Alexander, Zeiler, Frederick A.

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