Low-dose carboplatin modifies the tumor microenvironment to augment CAR T cell efficacy in human prostate cancer models von Porter, L. H., Zhu, J. J., Lister, N. L., Harrison, S. G., Keerthikumar, S., Goode, D. L., Urban, R. Quezada, Byrne, D. J., Azad, A., Vela, I., Hofman, M. S., Neeson, P. J., Darcy, P. K., Trapani, J. A., Taylor, R. A., Risbridger, G. P.

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Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis von Welz, M., Eickhoff, S., Abdullah, Z., Trebicka, J., Gartlan, K. H., Spicer, J. A., Demetris, A. J., Akhlaghi, H., Anton, M., Manske, K., Zehn, D., Nieswandt, B., Kurts, C., Trapani, J. A., Knolle, P., Wohlleber, D., Kastenmüller, W.

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The role of perforin and granzymes in diabetes von Thomas, H E, Trapani, J A, Kay, T W H

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Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen von Peinert, S, Prince, H M, Guru, P M, Kershaw, M H, Smyth, M J, Trapani, J A, Gambell, P, Harrison, S, Scott, A M, Smyth, F E, Darcy, P K, Tainton, K, Neeson, P, Ritchie, D S, Hönemann, D

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Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity von Davenport, A. J., Cross, R. S., Watson, K. A., Liao, Y., Shi, W., Prince, H. M., Beavis, P. A., Trapani, J. A., Kershaw, M. H., Ritchie, D. S., Darcy, P. K., Neeson, P. J., Jenkins, M. R.

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A new quantitative assay for cytochrome c release in apoptotic cells von Waterhouse, N J, Trapani, J A

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Early-phenotype CAR-T cells for the treatment of pediatric cancers von Meyran, D., Terry, R.L., Zhu, J.J., Haber, M., Ziegler, D.S., Ekert, P.G., Trapani, J.A., Darcy, P.K., Neeson, P.J.

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Ex vivo culture of chimeric antigen receptor T cells generates functional CD8+ T cells with effector and central memory-like phenotype von Neeson, P, Shin, A, Tainton, K M, Guru, P, Prince, H M, Harrison, S J, Peinert, S, Smyth, M J, Trapani, J A, Kershaw, M H, Darcy, P K, Ritchie, D S

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Granzymes, cytotoxic granules and cell death: the early work of Dr. Jurg Tschopp von Trapani, J A

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In vitro Activation of CPP32 and Mch3 by Mch4, a Novel Human Apoptotic Cysteine Protease Containing Two FADD-Like Domains von Fernandes-Alnemri, Teresa, Armstrong, Robert C., Krebs, Joseph, Srinivasula, Srinivasa M., Wang, Lijuan, Bullrich, Florencia, Fritz, Lawrence C., Trapani, Joseph A., Tomaselli, Kevin J., Litwack, Gerald, Alnemri, Emad S.

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Perforin deficiency and susceptibility to cancer von Brennan, A J, Chia, J, Trapani, J A, Voskoboinik, I

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Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice von Westwood, J A, Murray, W K, Trivett, M, Shin, A, Neeson, P, MacGregor, D P, Haynes, N M, Trapani, J A, Mayura-Guru, P, Fox, S, Peinert, S, Honemann, D, Prince, H M, Ritchie, D, Scott, A M, Smyth, F E, Smyth, M J, Darcy, P K, Kershaw, M H

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Redirecting mouse CTL against colon carcinoma: superior signaling efficacy of single-chain variable domain chimeras containing TCR-zeta vs Fc epsilon RI-gamma von Haynes, N M, Snook, M B, Trapani, J A, Cerruti, L, Jane, S M, Smyth, M J, Darcy, P K

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Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis von Susanto, O, Stewart, S E, Voskoboinik, I, Brasacchio, D, Hagn, M, Ellis, S, Asquith, S, Sedelies, K A, Bird, P I, Waterhouse, N J, Trapani, J A

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Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma von DEYOUNG, K. L, RAY, M. E, SU, Y. A, ANZICK, S. L, JOHNSTONE, R. W, TRAPANI, J. A, MELTZER, P. S, TRENT, J. M

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A fresh look at tumor immunosurveillance and immunotherapy von Smyth, Mark J, Godfrey, Dale I, Trapani, Joseph A

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A genome scale RNAi screen identifies GLI1 as a novel gene regulating vorinostat sensitivity von Falkenberg, K J, Newbold, A, Gould, C M, Luu, J, Trapani, J A, Matthews, G M, Simpson, K J, Johnstone, R W

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Potent and Selective Non-Peptidic Inhibitors of Endothelin-Converting Enzyme-1 with Sustained Duration of Action von De Lombaert, Stéphane, Blanchard, Louis, Stamford, Lisa B, Tan, Jenny, Wallace, Eli M, Satoh, Yoshitaka, Fitt, John, Hoyer, Denton, Simonsbergen, David, Moliterni, John, Marcopoulos, Nicholas, Savage, Paula, Chou, Mary, Trapani, Angelo J, Jeng, Arco Y

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A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage von Brasacchio, D, Noori, T, House, C, Brennan, A J, Simpson, K J, Susanto, O, Bird, P I, Johnstone, R W, Trapani, J A

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In memoriam: Prof Christopher J Froelich (1951–2015) von Metkar, S S, Pardo, J, Anderluh, G, Salvesen, G, Trapani, J A, Simon, M M

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