Multiplexed Size Separation of Intact Proteins in Solution Phase for Mass Spectrometry von Tran, John C, Doucette, Alan A

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Mapping intact protein isoforms in discovery mode using top-down proteomics von Tran, John C., Zamdborg, Leonid, Ahlf, Dorothy R., Lee, Ji Eun, Catherman, Adam D., Durbin, Kenneth R., Tipton, Jeremiah D., Vellaichamy, Adaikkalam, Kellie, John F., Li, Mingxi, Wu, Cong, Sweet, Steve M. M., Early, Bryan P., Siuti, Nertila, LeDuc, Richard D., Compton, Philip D., Thomas, Paul M., Kelleher, Neil L.

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Large-scale Top-down Proteomics of the Human Proteome: Membrane Proteins, Mitochondria, and Senescence von Catherman, Adam D., Durbin, Kenneth R., Ahlf, Dorothy R., Early, Bryan P., Fellers, Ryan T., Tran, John C., Thomas, Paul M., Kelleher, Neil L.

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Optimizing capillary electrophoresis for top-down proteomics of 30-80 kDa proteins von Li, Yihan, Compton, Philip D., Tran, John C., Ntai, Ioanna, Kelleher, Neil L.

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High-throughput antibody screening from complex matrices using intact protein electrospray mass spectrometry von Sawyer, William S., Srikumar, Neha, Carver, Joseph, Chu, Phillip Y., Shen, Amy, Xu, Ankai, Williams, Ambrose J., Spiess, Christoph, Wu, Cong, Liu, Yichin, Tran, John C.

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Automated Affinity Capture and On-Tip Digestion to Accurately Quantitate in Vivo Deamidation of Therapeutic Antibodies von Tran, John C, Tran, Daniel, Hilderbrand, Amy, Andersen, Nisana, Huang, Tao, Reif, Karin, Hotzel, Isidro, Stefanich, Eric G, Liu, Yichin, Wang, Jianyong

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Gel-Eluted Liquid Fraction Entrapment Electrophoresis:  An Electrophoretic Method for Broad Molecular Weight Range Proteome Separation von Tran, John C, Doucette, Alan A

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A Cross Company Perspective on the Assessment of Therapeutic Protein Biotransformation von Walles, Markus, Berna, Michael J, Jian, Wenying, Hauri, Simon, Hengel, Shawna, King, Lloyd, Tran, John C, Wei, Cong, Xu, Keyang, Zhu, Xiaochun

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Mechanism of Plasmid-Mediated Quinolone Resistance von Tran, John H., Jacoby, George A.

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Interaction of the Plasmid-Encoded Quinolone Resistance Protein Qnr with Escherichia coli DNA Gyrase von TRAN, John H, JACOBY, George A, HOOPER, David C

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Novel Interface for High-Throughput Analysis of Biotherapeutics by Electrospray Mass Spectrometry von Park, Hae-Min, Winton, Valerie J, Drader, Jared J, Manalili Wheeler, Sheri, Lazar, Greg A, Kelleher, Neil L, Liu, Yichin, Tran, John C, Compton, Philip D

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Plasmid-Mediated Quinolone Resistance in Clinical Isolates of Escherichia coli from Shanghai, China von MINGGUI WANG, TRAN, John H, JACOBY, George A, YINGYUAN ZHANG, FU WANG, HOOPER, David C

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Top Down Proteomics of Human Membrane Proteins from Enriched Mitochondrial Fractions von Catherman, Adam D, Li, Mingxi, Tran, John C, Durbin, Kenneth R, Compton, Philip D, Early, Bryan P, Thomas, Paul M, Kelleher, Neil L

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Translatability of In Vitro Stress for Predicting Deamidation and Oxidation Biotransformation on Biotherapeutics von Chu, Phillip Y., Wang, Hui, Ross, Emily, Stephens, Nicole, Zhang, Hui-Min, Andersen, Nisana, Chan, Wayman, Shivva, Vittal, Crowell, Susan R., Spiess, Christoph, Holder, Patrick G., Agard, Nicholas J., Ji, Chengjie, Chen, John, Sreedhara, Alavattam, Wang, Jianyong, Wu, Cong, Liu, Yichin, Tran, John C.

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Assessment of KRAS G12C Target Engagement by a Covalent Inhibitor in Tumor Biopsies Using an Ultra-Sensitive Immunoaffinity 2D-LC–MS/MS Approach von Meng, Lingyao, Chan, Emily W., Ng, Carl, Aimi, Junko, Tran, John C., Oh, Angela J., Merchant, Mark, Purkey, Hans E., Heffron, Timothy P., Kaur, Surinder, Xu, Keyang, Shi, Zhen, He, Jintang

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Analysis of Intact Protein Isoforms by Mass Spectrometry von Tipton, Jeremiah D., Tran, John C., Catherman, Adam D., Ahlf, Dorothy R., Durbin, Kenneth R., Kelleher, Neil L.

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Evaluation of the Compact High-Field Orbitrap for Top-Down Proteomics of Human Cells von Ahlf, Dorothy R, Compton, Philip D, Tran, John C, Early, Bryan P, Thomas, Paul M, Kelleher, Neil L

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Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors von Taylor, Alexander M., Williams, Bret R., Giordanetto, Fabrizio, Kelley, Elizabeth H., Lescarbeau, André, Shortsleeves, Kelley, Tang, Yong, Walters, W. Patrick, Arrazate, Alfonso, Bowman, Christine, Brophy, Erin, Chan, Emily W., Deshmukh, Gauri, Greisman, Jack B., Hunsaker, Thomas L., Kipp, D. Randal, Saenz Lopez-Larrocha, Pablo, Maddalo, Danilo, Martin, Iain J., Maragakis, Paul, Merchant, Mark, Murcko, Mark, Nisonoff, Hunter, Nguyen, Vi, Nguyen, Vy, Orozco, Olivia, Owen, Christopher, Pierce, Levi, Schmidt, Molly, Shaw, David E., Smith, Sherri, Therrien, Eric, Tran, John C., Watters, Jim, Waters, Nigel J., Wilbur, Jeremy, Willmore, Lindsay

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Characterizing and Quantitating Therapeutic Tethered Multimeric Antibody Degradation Using Affinity Capture Mass Spectrometry von Li, Wenjing, Srikumar, Neha, Forrest, William F, Ellerman, Diego, Gu, Chen, Tchelepi, Robert, Lazar, Greg A, Liu, Yichin, Tran, John C

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High-Throughput Analyses of Therapeutic Antibodies Using High-Field Asymmetric Waveform Ion Mobility Spectrometry Combined with SampleStream and Intact Protein Mass Spectrometry von Shi, Rachel Liuqing, Dillon, Michael A, Compton, Philip D, Sawyer, William S, Thorup, John R, Kwong, Mandy, Chan, Pamela, Chiu, Cecilia P C, Li, Ran, Yadav, Rajbharan, Lee, Genee Y, Gober, Joshua G, Li, Zhiyu, ElSohly, Adel M, Ovacik, Ayse Meric, Koerber, James T, Spiess, Christoph, Josephs, Jonathan L, Tran, John C

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