Mapping intact protein isoforms in discovery mode using top-down proteomics von Tran, John C., Zamdborg, Leonid, Ahlf, Dorothy R., Lee, Ji Eun, Catherman, Adam D., Durbin, Kenneth R., Tipton, Jeremiah D., Vellaichamy, Adaikkalam, Kellie, John F., Li, Mingxi, Wu, Cong, Sweet, Steve M. M., Early, Bryan P., Siuti, Nertila, LeDuc, Richard D., Compton, Philip D., Thomas, Paul M., Kelleher, Neil L.

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Multiplexed Size Separation of Intact Proteins in Solution Phase for Mass Spectrometry von Tran, John C, Doucette, Alan A

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Large-scale Top-down Proteomics of the Human Proteome: Membrane Proteins, Mitochondria, and Senescence von Catherman, Adam D., Durbin, Kenneth R., Ahlf, Dorothy R., Early, Bryan P., Fellers, Ryan T., Tran, John C., Thomas, Paul M., Kelleher, Neil L.

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Optimizing capillary electrophoresis for top-down proteomics of 30-80 kDa proteins von Li, Yihan, Compton, Philip D., Tran, John C., Ntai, Ioanna, Kelleher, Neil L.

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Automated Affinity Capture and On-Tip Digestion to Accurately Quantitate in Vivo Deamidation of Therapeutic Antibodies von Tran, John C, Tran, Daniel, Hilderbrand, Amy, Andersen, Nisana, Huang, Tao, Reif, Karin, Hotzel, Isidro, Stefanich, Eric G, Liu, Yichin, Wang, Jianyong

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Top Down Proteomics of Human Membrane Proteins from Enriched Mitochondrial Fractions von Catherman, Adam D, Li, Mingxi, Tran, John C, Durbin, Kenneth R, Compton, Philip D, Early, Bryan P, Thomas, Paul M, Kelleher, Neil L

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Analysis of Intact Protein Isoforms by Mass Spectrometry von Tipton, Jeremiah D., Tran, John C., Catherman, Adam D., Ahlf, Dorothy R., Durbin, Kenneth R., Kelleher, Neil L.

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Evaluation of the Compact High-Field Orbitrap for Top-Down Proteomics of Human Cells von Ahlf, Dorothy R, Compton, Philip D, Tran, John C, Early, Bryan P, Thomas, Paul M, Kelleher, Neil L

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Improved translation of stability for conjugated antibodies using an in vitro whole blood assay von Fourie-O'Donohue, Aimee, Chu, Phillip Y, Dela Cruz Chuh, Josefa, Tchelepi, Robert, Tsai, Siao Ping, Tran, John C, Sawyer, William S, Su, Dian, Ng, Carl, Xu, Keyang, Yu, Shang-Fan, Pillow, Thomas H, Sadowsky, Jack, Dragovich, Peter S, Liu, Yichin, Kozak, Katherine R

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A Robust Two-Dimensional Separation for Top-Down Tandem Mass Spectrometry of the Low-Mass Proteome von Lee, Ji Eun, Kellie, John F., Tran, John C., Tipton, Jeremiah D., Catherman, Adam D., Thomas, Haylee M., Ahlf, Dorothy R., Durbin, Kenneth R., Vellaichamy, Adaikkalam, Ntai, Ioanna, Marshall, Alan G., Kelleher, Neil L.

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Intact mass detection, interpretation, and visualization to automate Top-Down proteomics on a large scale von Durbin, Kenneth R, Tran, John C, Zamdborg, Leonid, Sweet, Steve M.M, Catherman, Adam D, Lee, Ji Eun, Li, Mingxi, Kellie, John F, Kelleher, Neil L

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High-throughput antibody screening from complex matrices using intact protein electrospray mass spectrometry von Sawyer, William S., Srikumar, Neha, Carver, Joseph, Chu, Phillip Y., Shen, Amy, Xu, Ankai, Williams, Ambrose J., Spiess, Christoph, Wu, Cong, Liu, Yichin, Tran, John C.

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Gel-Eluted Liquid Fraction Entrapment Electrophoresis:  An Electrophoretic Method for Broad Molecular Weight Range Proteome Separation von Tran, John C, Doucette, Alan A

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A Cross Company Perspective on the Assessment of Therapeutic Protein Biotransformation von Walles, Markus, Berna, Michael J, Jian, Wenying, Hauri, Simon, Hengel, Shawna, King, Lloyd, Tran, John C, Wei, Cong, Xu, Keyang, Zhu, Xiaochun

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Novel Interface for High-Throughput Analysis of Biotherapeutics by Electrospray Mass Spectrometry von Park, Hae-Min, Winton, Valerie J, Drader, Jared J, Manalili Wheeler, Sheri, Lazar, Greg A, Kelleher, Neil L, Liu, Yichin, Tran, John C, Compton, Philip D

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Translatability of In Vitro Stress for Predicting Deamidation and Oxidation Biotransformation on Biotherapeutics von Chu, Phillip Y., Wang, Hui, Ross, Emily, Stephens, Nicole, Zhang, Hui-Min, Andersen, Nisana, Chan, Wayman, Shivva, Vittal, Crowell, Susan R., Spiess, Christoph, Holder, Patrick G., Agard, Nicholas J., Ji, Chengjie, Chen, John, Sreedhara, Alavattam, Wang, Jianyong, Wu, Cong, Liu, Yichin, Tran, John C.

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Assessment of KRAS G12C Target Engagement by a Covalent Inhibitor in Tumor Biopsies Using an Ultra-Sensitive Immunoaffinity 2D-LC–MS/MS Approach von Meng, Lingyao, Chan, Emily W., Ng, Carl, Aimi, Junko, Tran, John C., Oh, Angela J., Merchant, Mark, Purkey, Hans E., Heffron, Timothy P., Kaur, Surinder, Xu, Keyang, Shi, Zhen, He, Jintang

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Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors von Taylor, Alexander M., Williams, Bret R., Giordanetto, Fabrizio, Kelley, Elizabeth H., Lescarbeau, André, Shortsleeves, Kelley, Tang, Yong, Walters, W. Patrick, Arrazate, Alfonso, Bowman, Christine, Brophy, Erin, Chan, Emily W., Deshmukh, Gauri, Greisman, Jack B., Hunsaker, Thomas L., Kipp, D. Randal, Saenz Lopez-Larrocha, Pablo, Maddalo, Danilo, Martin, Iain J., Maragakis, Paul, Merchant, Mark, Murcko, Mark, Nisonoff, Hunter, Nguyen, Vi, Nguyen, Vy, Orozco, Olivia, Owen, Christopher, Pierce, Levi, Schmidt, Molly, Shaw, David E., Smith, Sherri, Therrien, Eric, Tran, John C., Watters, Jim, Waters, Nigel J., Wilbur, Jeremy, Willmore, Lindsay

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Characterizing and Quantitating Therapeutic Tethered Multimeric Antibody Degradation Using Affinity Capture Mass Spectrometry von Li, Wenjing, Srikumar, Neha, Forrest, William F, Ellerman, Diego, Gu, Chen, Tchelepi, Robert, Lazar, Greg A, Liu, Yichin, Tran, John C

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High-Throughput Analyses of Therapeutic Antibodies Using High-Field Asymmetric Waveform Ion Mobility Spectrometry Combined with SampleStream and Intact Protein Mass Spectrometry von Shi, Rachel Liuqing, Dillon, Michael A, Compton, Philip D, Sawyer, William S, Thorup, John R, Kwong, Mandy, Chan, Pamela, Chiu, Cecilia P C, Li, Ran, Yadav, Rajbharan, Lee, Genee Y, Gober, Joshua G, Li, Zhiyu, ElSohly, Adel M, Ovacik, Ayse Meric, Koerber, James T, Spiess, Christoph, Josephs, Jonathan L, Tran, John C

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