Silyl Radical-Mediated Activation of Sulfamoyl Chlorides Enables Direct Access to Aliphatic Sulfonamides from Alkenes von Hell, Sandrine M, Meyer, Claudio F, Laudadio, Gabriele, Misale, Antonio, Willis, Michael C, Noël, Timothy, Trabanco, Andrés A, Gouverneur, Véronique

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Late-stage difluoromethylation: concepts, developments and perspective von Sap, Jeroen B. I, Meyer, Claudio F, Straathof, Natan J. W, Iwumene, Ndidi, am Ende, Christopher W, Trabanco, Andrés A, Gouverneur, Véronique

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Hydrodifluoromethylation of Alkenes with Difluoroacetic Acid von Meyer, Claudio F., Hell, Sandrine M., Misale, Antonio, Trabanco, Andrés A., Gouverneur, Véronique

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Organophotoredox Hydrodefluorination of Trifluoromethylarenes with Translational Applicability to Drug Discovery von Sap, Jeroen B. I, Straathof, Natan J. W, Knauber, Thomas, Meyer, Claudio F, Médebielle, Maurice, Buglioni, Laura, Genicot, Christophe, Trabanco, Andrés A, Noël, Timothy, am Ende, Christopher W, Gouverneur, Véronique

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Hydrosulfonylation of Alkenes with Sulfonyl Chlorides under Visible Light Activation von Hell, Sandrine M., Meyer, Claudio F., Misale, Antonio, Sap, Jeroen B. I., Christensen, Kirsten E., Willis, Michael C., Trabanco, Andrés A., Gouverneur, Véronique

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Application of Free Energy Perturbation for the Design of BACE1 Inhibitors von Ciordia, Myriam, Pérez-Benito, Laura, Delgado, Francisca, Trabanco, Andrés A, Tresadern, Gary

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Photoredox Nucleophilic (Radio)fluorination of Alkoxyamines von Ortalli, Sebastiano, Ford, Joseph, Trabanco, Andrés A., Tredwell, Matthew, Gouverneur, Véronique

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Acylguanidine Beta Secretase 1 Inhibitors: A Combined Experimental and Free Energy Perturbation Study von Keränen, Henrik, Pérez-Benito, Laura, Ciordia, Myriam, Delgado, Francisca, Steinbrecher, Thomas B, Oehlrich, Daniel, van Vlijmen, Herman W. T, Trabanco, Andrés A, Tresadern, Gary

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Hydrogen Bonding Phase-Transfer Catalysis with Ionic Reactants: Enantioselective Synthesis of γ‑Fluoroamines von Roagna, Giulia, Ascough, David M. H, Ibba, Francesco, Vicini, Anna Chiara, Fontana, Alberto, Christensen, Kirsten E, Peschiulli, Aldo, Oehlrich, Daniel, Misale, Antonio, Trabanco, Andrés A, Paton, Robert S, Pupo, Gabriele, Gouverneur, Véronique

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Benzazaborinines as Novel Bioisosteric Replacements of Naphthalene: Propranolol as an Example von Rombouts, Frederik J. R, Tovar, Fulgencio, Austin, Nigel, Tresadern, Gary, Trabanco, Andrés A

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Bench-Stable Transfer Reagent Facilitates the Generation of Trifluoromethyl-sulfonimidamides von Wright, Miranda, Martínez-Lamenca, Carolina, Leenaerts, Joseph E, Brennan, Paul E, Trabanco, Andrés A, Oehlrich, Daniel

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[18F]Difluorocarbene for positron emission tomography von Sap, Jeroen B. I., Meyer, Claudio F., Ford, Joseph, Straathof, Natan J. W., Dürr, Alexander B., Lelos, Mariah J., Paisey, Stephen J., Mollner, Tim A., Hell, Sandrine M., Trabanco, Andrés A., Genicot, Christophe, am Ende, Christopher W., Paton, Robert S., Tredwell, Matthew, Gouverneur, Véronique

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1,4-Oxazine β‑Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads von Rombouts, Frederik J. R, Tresadern, Gary, Delgado, Oscar, Martínez-Lamenca, Carolina, Van Gool, Michiel, García-Molina, Aránzazu, Alonso de Diego, Sergio A, Oehlrich, Daniel, Prokopcova, Hana, Alonso, José Manuel, Austin, Nigel, Borghys, Herman, Van Brandt, Sven, Surkyn, Michel, De Cleyn, Michel, Vos, Ann, Alexander, Richard, Macdonald, Gregor, Moechars, Dieder, Gijsen, Harrie, Trabanco, Andrés A

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Continuous Flow α‑Arylation of N,N‑Dialkylhydrazones under Visible-Light Photoredox Catalysis von Vega, Juan A, Alonso, José Manuel, Méndez, Gabriela, Ciordia, Myriam, Delgado, Francisca, Trabanco, Andrés A

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[1,2,4]Triazolo[1,5‑a]pyrimidine Phosphodiesterase 2A Inhibitors: Structure and Free-Energy Perturbation-Guided Exploration von Tresadern, Gary, Velter, Ingrid, Trabanco, Andrés A, Van den Keybus, Frans, Macdonald, Gregor J, Somers, Marijke V. F, Vanhoof, Greet, Leonard, Philip M, Lamers, Marieke B. A. C, Van Roosbroeck, Yves E. M, Buijnsters, Peter J. J. A

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Discovery of 3‑Cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3‑a]pyridine (JNJ-42153605): A Positive Allosteric Modulator of the Metabotropic Glut... von Cid, Jose María, Tresadern, Gary, Vega, Juan Antonio, de Lucas, Ana Isabel, Matesanz, Encarnación, Iturrino, Laura, Linares, María Lourdes, Garcia, Aránzazu, Andrés, José Ignacio, Macdonald, Gregor J, Oehlrich, Daniel, Lavreysen, Hilde, Megens, Anton, Ahnaou, Abdellah, Drinkenburg, Wilhelmus, Mackie, Claire, Pype, Stefan, Gallacher, David, Trabanco, Andrés A

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Discovery and Kinetic Profiling of 7‑Aryl-1,2,4-triazolo[4,3‑a]­pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 von Doornbos, Maarten L. J, Cid, José María, Haubrich, Jordi, Nunes, Alexandro, van de Sande, Jasper W, Vermond, Sophie C, Mulder-Krieger, Thea, Trabanco, Andrés A, Ahnaou, Abdellah, Drinkenburg, Wilhelmus H, Lavreysen, Hilde, Heitman, Laura H, IJzerman, Adriaan P, Tresadern, Gary

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Diazaspirononane Nonsaccharide Inhibitors of O‑GlcNAcase (OGA) for the Treatment of Neurodegenerative Disorders von Martínez-Viturro, Carlos M, Trabanco, Andrés A, Royes, Jordi, Fernández, Elena, Tresadern, Gary, Vega, Juan A, del Cerro, Alcira, Delgado, Francisca, García Molina, Aránzazu, Tovar, Fulgencio, Shaffer, Paul, Ebneth, Andreas, Bretteville, Alexis, Mertens, Liesbeth, Somers, Marijke, Alonso, Jose M, Bartolomé-Nebreda, José M

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Discovery of 8‑Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)­methyl]-1,2,4-triazolo[4,3‑a]pyridine (JNJ-46356479), a Selective and Orally Bioavailab... von Cid, Jose María, Tresadern, Gary, Vega, Juan Antonio, de Lucas, Ana Isabel, del Cerro, Alcira, Matesanz, Encarnación, Linares, María Lourdes, García, Aránzazu, Iturrino, Laura, Pérez-Benito, Laura, Macdonald, Gregor J, Oehlrich, Daniel, Lavreysen, Hilde, Peeters, Luc, Ceusters, Marc, Ahnaou, Abdellah, Drinkenburg, Wilhelmus, Mackie, Claire, Somers, Marijke, Trabanco, Andrés A

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Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological Characterization von Doornbos, Maarten L. J, Wang, Xuesong, Vermond, Sophie C, Peeters, Luc, Pérez-Benito, Laura, Trabanco, Andrés A, Lavreysen, Hilde, Cid, José María, Heitman, Laura H, Tresadern, Gary, IJzerman, Adriaan P

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