Community surveillance of complications after hernia surgery von Bailey, I. S., Karran, S. E., Toyn, K., Brough, P., Ranaboldo, C., Karran, S. J.

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The Swi5 transcription factor of Saccharomyces cerevisiae has a role in exit from mitosis through induction of the cdk-inhibitor Sic1 in telophase von Toyn, J.H. (National Institute for Medical Research, London, UK.), Johnson, A.L, Donovan, J.D, Toone, W.M, Johnston, L.H

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The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers von Soares, Holly D., Gasior, Maciej, Toyn, Jeremy H., Wang, Jun-Sheng, Hong, Quan, Berisha, Flora, Furlong, Michael T., Raybon, Joseph, Lentz, Kimberley A., Sweeney, Francis, Zheng, Naiyu, Akinsanya, Billy, Berman, Robert M., Thompson, Lorin A., Olson, Richard E., Morrison, John, Drexler, Dieter M., Macor, John E., Albright, Charlie F., Ahlijanian, Michael K., AbuTarif, Malaz

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Synthesis of functionalized derivatives of the gamma-secretase modulator BMS-932481 and identification of its major metabolite von Zhang, Yunhui, Boy, Kenneth M., Wu, Yong-Jin, Ramirez, Antonio, Toyn, Jeremy H., Ahlijanian, Michael K., Albright, Charles F., Zhuo, Xiaoliang, Johnson, Benjamin M., Denton, R. Rex, Olson, Richard E., Thompson, Lorin A., Macor, John E.

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Discovery of S3-Truncated, C‑6 Heteroaryl Substituted Aminothiazine β‑Site APP Cleaving Enzyme‑1 (BACE1) Inhibitors von Wu, Yong-Jin, Guernon, Jason, Shi, Jianliang, Marcin, Lawrence, Higgins, Mendi, Rajamani, Ramkumar, Muckelbauer, Jodi, Lewis, Hal, Chang, ChiehYing, Camac, Dan, Toyn, Jeremy H, Ahlijanian, Michael K, Albright, Charles F, Macor, John E, Thompson, Lorin A

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Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors von Wu, Yong-Jin, Guernon, Jason, Rajamani, Ramkumar, Toyn, Jeremy H., Ahlijanian, Michael K., Albright, Charles F., Muckelbauer, Jodi, Chang, ChiehYing, Camac, Dan, Macor, John E., Thompson, Lorin A.

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Interpreting Alzheimer's disease clinical trials in light of the effects on amyloid-β von Toyn, Jeremy H, Ahlijanian, Michael K

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Effect of vitamin d2 supplementation on serum 25 hydroxy-vitamin d3 levels: a systematic review and meta-analysis von Toyn, C., Darling, A.L., Hart, K., Tripkovic, L., Smith, C.P., Mathers, J.C., Lanham-New, S.A., Elliott, R.M.

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Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects von Toyn, Jeremy H., Boy, Kenneth M., Raybon, Joseph, Meredith, Jere E., Robertson, Alan S., Guss, Valerie, Hoque, Nina, Sweeney, Francis, Zhuo, Xiaoliang, Clarke, Wendy, Snow, Kimberly, Denton, R. Rex, Zuev, Dmitry, Thompson, Lorin A., Morrison, John, Grace, James, Berisha, Flora, Furlong, Michael, Wang, Jun-Sheng, Lentz, Kimberly A., Padmanabha, Ramesh, Cook, Lynda, Wei, Cong, Drexler, Dieter M., Macor, John E., Albright, Charlie F., Gasior, Maciej, Olson, Richard E., Hong, Quan, Soares, Holly D., AbuTarif, Malaz, Ahlijanian, Michael K.

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Acyl Guanidine Inhibitors of β‑Secretase (BACE-1): Optimization of a Micromolar Hit to a Nanomolar Lead via Iterative Solid- and Solution-Phase Library Synthesis von Gerritz, Samuel W, Zhai, Weixu, Shi, Shuhao, Zhu, Shirong, Toyn, Jeremy H, Meredith, Jere E, Iben, Lawrence G, Burton, Catherine R, Albright, Charles F, Good, Andrew C, Tebben, Andrew J, Muckelbauer, Jodi K, Camac, Daniel M, Metzler, William, Cook, Lynda S, Padmanabha, Ramesh, Lentz, Kimberley A, Sofia, Michael J, Poss, Michael A, Macor, John E, Thompson, Lorin A

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Synergistic inhibition of Aβ production by combinations of γ-secretase modulators von Robertson, Alan S., Iben, Lawrence G., Wei, Cong, Meredith, Jere E., Drexler, Dieter M., Banks, Martyn, Vite, Gregory D., Olson, Richard E., Thompson, Lorin A., Albright, Charles F., Ahlijanian, Michael K., Toyn, Jeremy H.

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Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents von Wu, Yong-Jin, Guernon, Jason, Yang, Fukang, Snyder, Lawrence, Shi, Jianliang, Mcclure, Andrea, Rajamani, Ramkumar, Park, Hyunsoo, Ng, Alicia, Lewis, Hal, Chang, ChiehYing, Camac, Dan, Toyn, Jeremy H, Ahlijanian, Michael K, Albright, Charles F, Macor, John E, Thompson, Lorin A

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Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ‑Secretase Modulator BMS-932481 von Boy, Kenneth M, Guernon, Jason M, Zuev, Dmitry S, Xu, Li, Zhang, Yunhui, Shi, Jianliang, Marcin, Lawrence R, Higgins, Mendi A, Wu, Yong-Jin, Krishnananthan, Subramaniam, Li, Jianqing, Trehan, Ashok, Smith, Daniel, Toyn, Jeremy H, Meredith, Jere E, Burton, Catherine R, Kimura, S. Roy, Zvyaga, Tatyana, Zhuo, Xiaoliang, Lentz, Kimberley A, Grace, James E, Denton, Rex, Morrison, John S, Mathur, Arvind, Albright, Charles F, Ahlijanian, Michael K, Olson, Richard E, Thompson, Lorin A, Macor, John E

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A Bub2p‐dependent spindle checkpoint pathway regulates the Dbf2p kinase in budding yeast von Fesquet, Didier, Fitzpatrick, Patrick J., Johnson, Anthony L., Kramer, Kate M., Toyn, Jeremy H., Johnston, Leland H.

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Interpreting Alzheimer's disease clinical trials in light of the effects on amyloid-[beta] von Toyn, Jeremy H, Ahlijanian, Michael K

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Soluble Aβ and cognitive function in aged F-344 rats and Tg2576 mice von Lindner, Mark D., Hogan, John B., Krause, Rudolph G., Machet, Frederic, Bourin, Clotilde, Hodges, Donald B., Corsa, Jason A., Barten, Donna M., Toyn, Jeremy H., Stock, David A., Rose, Gregory M., Gribkoff, Valentin K.

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Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1 von Marcin, Lawrence R., Higgins, Mendi A., Zusi, F. Christopher, Zhang, Yunhui, Dee, Michael F., Parker, Michael F., Muckelbauer, Jodi K., Camac, Daniel M., Morin, Paul E., Ramamurthy, Vidhyashankar, Tebben, Andrew J., Lentz, Kimberley A., Grace, James E., Marcinkeviciene, Jovita A., Kopcho, Lisa M., Burton, Catherine R., Barten, Donna M., Toyn, Jeremy H., Meredith, Jere E., Albright, Charles F., Bronson, Joanne J., Macor, John E., Thompson, Lorin A.

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Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE) von Boy, Kenneth M., Guernon, Jason M., Shi, Jianliang, Toyn, Jeremy H., Meredith, Jere E., Barten, Donna M., Burton, Catherine R., Albright, Charles F., Marcinkeviciene, Jovita, Good, Andrew C., Tebben, Andrew J., Muckelbauer, Jodi K., Camac, Daniel M., Lentz, Kimberley A., Bronson, Joanne J., Olson, Richard E., Macor, John E., Thompson, Lorin A.

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Robust Translation of  -Secretase Modulator Pharmacology across Preclinical Species and Human Subjects von Toyn, J. H., Boy, K. M., Raybon, J., Meredith, J. E., Robertson, A. S., Guss, V., Hoque, N., Sweeney, F., Zhuo, X., Clarke, W., Snow, K., Denton, R. R., Zuev, D., Thompson, L. A., Morrison, J., Grace, J., Berisha, F., Furlong, M., Wang, J.-S., Lentz, K. A., Padmanabha, R., Cook, L., Wei, C., Drexler, D. M., Macor, J. E., Albright, C. F., Gasior, M., Olson, R. E., Hong, Q., Soares, H. D., AbuTarif, M., Ahlijanian, M. K.

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The  -Secretase Modulator, BMS-932481, Modulates A  Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers von Soares, H. D., Gasior, M., Toyn, J. H., Wang, J.-S., Hong, Q., Berisha, F., Furlong, M. T., Raybon, J., Lentz, K. A., Sweeney, F., Zheng, N., Akinsanya, B., Berman, R. M., Thompson, L. A., Olson, R. E., Morrison, J., Drexler, D. M., Macor, J. E., Albright, C. F., Ahlijanian, M. K., AbuTarif, M.

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