Genomic context of NTRK1/2/3 fusion-positive tumours from a large real-world population von Westphalen, C. B., Krebs, M. G., Le Tourneau, C., Sokol, E. S., Maund, S. L., Wilson, T. R., Jin, D. X., Newberg, J. Y., Fabrizio, D., Veronese, L., Thomas, M., de Braud, F.

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Statistical controversies in clinical research: requiem for the 3 + 3 design for phase I trials von Paoletti, X., Ezzalfani, M., Le Tourneau, C.

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Randomized phase II trial comparing molecularly targeted therapy based on tumor molecular profiling versus conventional therapy in patients with refractory cancer: cross-over analy... von Belin, L., Kamal, M., Mauborgne, C., Plancher, C., Mulot, F., Delord, J.-P., Gonçalves, A., Gavoille, C., Dubot, C., Isambert, N., Campone, M., Trédan, O., Ricci, F., Alt, M., Loirat, D., Sablin, M.-P., Paoletti, X., Servois, V., Le Tourneau, C.

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Pembrolizumab versus methotrexate, docetaxel, or cetuximab in recurrent or metastatic head and neck squamous cell carcinoma (KEYNOTE-040): Subgroup analysis by pattern of disease r... von Harrington, K.J., Cohen, E.E.W., Soulières, D., Dinis, J., Licitra, L., Ahn, M.-J., Soria, A., Machiels, J.-P., Mach, N., Mehra, R., Burtness, B., Swaby, R.F., Lin, J., Ge, J., Lerman, N., Tourneau, C. Le

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Safety and clinical activity of the Notch inhibitor, crenigacestat (LY3039478), in an open-label phase I trial expansion cohort of advanced or metastatic adenoid cystic carcinoma von Even, C., Lassen, U., Merchan, J., Le Tourneau, C., Soria, J-C, Ferte, C., Ricci, F., Diener, J. T., Yuen, E., Smith, C., Oakley, G. J., Benhadji, K. A., Massard, Christophe

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Comprehensive genomic profiling of head and neck squamous cell carcinoma reveals FGFR1 amplifications and tumour genomic alterations burden as prognostic biomarkers of survival von Dubot, C., Bernard, V., Sablin, M.P., Vacher, S., Chemlali, W., Schnitzler, A., Pierron, G., Ait Rais, K., Bessoltane, N., Jeannot, E., Klijanienko, J., Mariani, O., Jouffroy, T., Calugaru, V., Hoffmann, C., Lesnik, M., Badois, N., Berger, F., Le Tourneau, C., Kamal, M., Bieche, I.

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Efficacy and Tolerance of Carboplatin plus Cetuximab (Simplified EXTREME Regimen) in Patients with Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma von Le Roy, C., Vernerey, D., Evin, C., Richard, S., Crespel, C., Samaille, T., Le Tourneau, C., Huguet, F.

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Novel patterns of response under immunotherapy von Borcoman, E., Kanjanapan, Y., Champiat, S., Kato, S., Servois, V., Kurzrock, R., Goel, S., Bedard, P., Le Tourneau, C.

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Review of clinical applications of radiation-enhancing nanoparticles von Scher, N., Bonvalot, S., Le Tourneau, C., Chajon, E., Verry, C., Thariat, J., Calugaru, V.

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Hyperprogression during anti-PD-1/PD-L1 therapy in patients with recurrent and/or metastatic head and neck squamous cell carcinoma von Saâda-Bouzid, E., Defaucheux, C., Karabajakian, A., Coloma, V.P., Servois, V., Paoletti, X., Even, C., Fayette, J., Guigay, J., Loirat, D., Peyrade, F., Alt, M., Gal, J., Le Tourneau, C.

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Paving the path towards tissue-agnostic drug approval in oncology von Le Tourneau, C., Bieche, I., Kamal, M.

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Outcome and molecular landscape of patients with PIK3CA-mutated metastatic breast cancer von Mosele, F., Stefanovska, B., Lusque, A., Tran Dien, A., Garberis, I., Droin, N., Le Tourneau, C., Sablin, M.-P., Lacroix, L., Enrico, D., Miran, I., Jovelet, C., Bièche, I., Soria, J.-C., Bertucci, F., Bonnefoi, H., Campone, M., Dalenc, F., Bachelot, T., Jacquet, A., Jimenez, M., André, F.

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CinéBreast-factors influencing the time to first metastatic recurrence in breast cancer: Analysis of real-life data from the French ESME MBC database von Gougis, P., Carton, M., Tchokothe, C., Campone, M., Dalenc, F., Mailliez, A., Levy, C., Jacot, W., Debled, M., Leheurteur, M., Bachelot, T., Hennequin, A., Perrin, C., Gonçalves, A., Uwer, L., Eymard, J.C., Petit, T., Mouret-Reynier, M.A., Chamorey, E., Simon, G., Saghatchian, M., Cailliot, C., Le Tourneau, C.

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Author Correction: Genomic context of NTRK1/2/3 fusion-positive tumours from a large real-world population von Westphalen, C. B., Krebs, M. G., Le Tourneau, C., Sokol, E. S., Maund, S. L., Wilson, T. R., Jin, D. X., Newberg, J. Y., Fabrizio, D., Veronese, L., Thomas, M., de Braud, F.

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Phase I study of emactuzumab single agent or in combination with paclitaxel in patients with advanced/metastatic solid tumors reveals depletion of immunosuppressive M2-like macroph... von Gomez-Roca, C.A., Italiano, A., Le Tourneau, C., Cassier, P.A., Toulmonde, M., D’Angelo, S.P., Campone, M., Weber, K.L., Loirat, D., Cannarile, M.A., Jegg, A.-M., Ries, C., Christen, R., Meneses-Lorente, G., Jacob, W., Klaman, I., Ooi, C.-H., Watson, C., Wonde, K., Reis, B., Michielin, F., Rüttinger, D., Delord, J.-P., Blay, J.-Y.

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The European Society for Medical Oncology (ESMO) Precision Medicine Glossary von Yates, L.R., Seoane, J., Le Tourneau, C., Siu, L.L., Marais, R., Michiels, S., Soria, J.C., Campbell, P., Normanno, N., Scarpa, A., Reis-Filho, J.S., Rodon, J., Swanton, C., Andre, F.

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SP-035: Is there still a role for targeted signaling agents in head and neck cancer? von Le Tourneau, C

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First-in-human study of LY3039478, an oral Notch signaling inhibitor in advanced or metastatic cancer von Massard, C., Azaro, A., Soria, J.-C., Lassen, U., Le Tourneau, C., Sarker, D., Smith, C., Ohnmacht, U., Oakley, G., Patel, B.K.R., Yuen, E.S.M., Benhadji, K.A., Rodon, J.

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Precision cancer medicine: Concepts, current practice, and future developments von Edsjö, Anders, Holmquist, Louise, Geoerger, Birgit, Nowak, Frédérique, Gomon, Georgy, Alix‐Panabières, Catherine, Staaf, Johan, Ploeger, Carolin, Lassen, Ulrik, Le Tourneau, Christophe, Lehtiö, Janne, Ott, Patrick A., von Deimling, Andreas, Fröhling, Stefan, Voest, Emile, Klauschen, Frederick, Dienstmann, Rodrigo, Alshibany, Aisha, Siu, Lillian L., Stenzinger, Albrecht

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Personalized biomarker-based treatment strategy for patients with squamous cell carcinoma of the head and neck: EORTC position and approach von Galot, R., Le Tourneau, C., Guigay, J., Licitra, L., Tinhofer, I., Kong, A., Caballero, C., Fortpied, C., Bogaerts, J., Govaerts, A.-S., Staelens, D., Raveloarivahy, T., Rodegher, L., Laes, J.-F., Saada-Bouzid, E., Machiels, J.-P.

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