Assessment of Drug–drug Interaction and Optimization in Capecitabine and Irinotecan Combination Regimen using a Physiologically Based Pharmacokinetic Model von Sakai, Shuhei, Kobuchi, Shinji, Ito, Yukako, Sakaeda, Toshiyuki

Volltext

Adverse Event Profile of Tigecycline: Data Mining of the Public Version of the U.S. Food and Drug Administration Adverse Event Reporting System von Kadoyama, Kaori, Sakaeda, Toshiyuki, Tamon, Akiko, Okuno, Yasushi

Volltext

Circadian variations in the pharmacokinetics of capecitabine and its metabolites in rats von Kobuchi, Shinji, Yazaki, Yukiko, Ito, Yukako, Sakaeda, Toshiyuki

Volltext

Circadian variations in the pharmacokinetics of the oral anticancer agent tegafur-uracil (UFT) and its metabolites in rats von Kobuchi, Shinji, Ito, Yukako, Takamatsu, Daiki, Sakaeda, Toshiyuki

Volltext

A Physiologically Based Pharmacokinetic–Pharmacodynamic Model for Capecitabine in Colorectal Cancer Rats: Simulation of Antitumor Efficacy at Various Administration Schedules von Sakai, Shuhei, Kobuchi, Shinji, Ito, Yukako, Sakaeda, Toshiyuki

Volltext

MDR1 Genotype-Related Pharmacokinetics and Pharmacodynamics von Sakaeda, Toshiyuki, Nakamura, Tsutomu, Okumura, Katsuhiko

Volltext

Pharmacokinetics of Macrolide Antibiotics and Transport into the Interstitial Fluid: Comparison among Erythromycin, Clarithromycin, and Azithromycin von Kobuchi, Shinji, Kabata, Teruhiko, Maeda, Koki, Ito, Yukako, Sakaeda, Toshiyuki

Volltext

Population Pharmacokinetic–Pharmacodynamic Modeling of 5-Fluorouracil for Toxicities in Rats von Kobuchi, Shinji, Ito, Yukako, Sakaeda, Toshiyuki

Volltext

MDR1 Genotype-related pharmacokinetics of digoxin after single oral administration in healthy japanese subjects von SAKAEDA, Toshiyuki, NAKAMURA, Tsutomu, KASUGA, Masato, OKUMURA, Katsuhiko, HORINOUCHI, Masanori, KAKUMOTO, Mikio, OHMOTO, Nobuko, SAKAI, Toshiyuki, MORITA, Yoshinori, TAMURA, Takao, AOYAMA, Nobuo, HIRAI, Midori

Volltext

Effects of a bolus injection of 5-fluorouracil on dihydropyrimidine dehydrogenase activity in rats receiving continuous infusion of 5-fluorouracil von Kobuchi, Shinji, Hayashi, Asuka, Taniguchi, Mayu, Ito, Yukako, Tamura, Takao, Sakaeda, Toshiyuki

Volltext

Effect of the mutation (C3435T) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects von Nakamura, Tsutomu, Sakaeda, Toshiyuki, Horinouchi, Masanori, Tamura, Takao, Aoyama, Nobuo, Shirakawa, Toshiro, Matsuo, Masafumi, Kasuga, Masato, Okumura, Katsuhiko

Volltext

Proteomic identification of protein targets for 15-deoxy-Δ(12,14)-prostaglandin J2 in neuronal plasma membrane von Yamamoto, Yasuhiro, Takase, Kenkichi, Kishino, Junji, Fujita, Megumi, Okamura, Noboru, Sakaeda, Toshiyuki, Fujimoto, Masafumi, Yagami, Tatsurou

Volltext

Factors affecting sensitivity to antitumor platinum derivatives of human colorectal tumor cell lines von Kitada, Noriaki, Takara, Kohji, Minegaki, Tetsuya, Itoh, Chihiro, Tsujimoto, Masayuki, Sakaeda, Toshiyuki, Yokoyama, Teruyoshi

Volltext

Pharmacokinetic–pharmacodynamic (PK–PD) modeling and simulation of 5-fluorouracil for erythropenia in rats von Kobuchi, Shinji, Ito, Yukako, Hayakawa, Taro, Nishimura, Asako, Shibata, Nobuhito, Takada, Kanji, Sakaeda, Toshiyuki

Volltext

Quantitative Structure−Activity Relationship Analysis and Molecular Dynamics Simulation To Functionally Validate Nonsynonymous Polymorphisms of Human ABC Transporter ABCB1 (P-Glyco... von Sakurai, Aki, Onishi, Yuko, Hirano, Hiroyuki, Seigneuret, Michel, Obanayama, Kazuya, Kim, Gunwoo, Liew, Ei Leen, Sakaeda, Toshiyuki, Yoshiura, Koh-ichiro, Niikawa, Norio, Sakurai, Minoru, Ishikawa, Toshihisa

Volltext

Cytotoxic Effects of 27 Anticancer Drugs in HeLa and MDR1-Overexpressing Derivative Cell Lines von Takara, Kohji, Sakaeda, Toshiyuki, Yagami, Tatsurou, Kobayashi, Hironao, Ohmoto, Nobuko, Horinouchi, Masanori, Nishiguchi, Kohshi, Okumura, Katsuhiko

Volltext

Knock-down of Sorcin Induces Up-regulation of MDR1 in HeLa Cells von Kawakami, Megumi, Nakamura, Tsutomu, Okamura, Noboru, Komoto, Chiho, Markova, Svetlana, Kobayashi, Hironao, Hashimoto, Naofumi, Okumura, Katsuhiko, Sakaeda, Toshiyuki

Volltext

Hsp12.6 expression is inducible by host immunity in adult worms of the parasitic nematode Nippostrongylus brasiliensis von Arizono, Naoki, Yamada, Minoru, Tegoshi, Tatsuya, Takaoka, Yutaka, Ohta, Mika, Sakaeda, Toshiyuki

Volltext

Significant genetic linkage of MDR1 polymorphisms at positions 3435 and 2677: Functional relevance to pharmacokinetics of digoxin von HORINOUCHI, Masanori, SAKAEDA, Toshiyuki, NAKAMURA, Tsutomu, MORITA, Yoshinori, TAMURA, Takao, AOYAMA, Nobuo, KASUGA, Masato, OKUMURA, Katsuhiko

Volltext

Molecular pathology of Sandhoff disease with p.Arg505Gln in HEXB: application of simulation analysis von Yasui, Naoko, Takaoka, Yutaka, Nishio, Hisahide, Nurputra, Dian K, Sekiguchi, Kenji, Hamaguchi, Hirotoshi, Kowa, Hisatomo, Maeda, Eiichi, Sugano, Aki, Miura, Kenji, Sakaeda, Toshiyuki, Kanda, Fumio, Toda, Tatsushi

Volltext