The 2-5A system: modulation of viral and cellular processes through acceleration of RNA degradation von Player, M R, Torrence, P F

Volltext

Combating the threat of pandemic influenza: drug discovery approaches von Torrence, Paul F

Volltext

A study of the interferon antiviral mechanism: apoptosis activation by the 2-5A system von Castelli, J C, Hassel, B A, Wood, K A, Li, X L, Amemiya, K, Dalakas, M C, Torrence, P F, Youle, R J

Volltext

Blockage of NF-κB Signaling by Selective Ablation of an mRNA Target by 2-5A Antisense Chimeras von Maran, Avudaiappan, Maitra, Ratan K., Kumar, Aseem, Dong, Beihua, Xiao, Wei, Li, Guiying, Bryan R. G. Williams, Torrence, Paul F., Silverman, Robert H.

Volltext

Targeted Therapy of Respiratory Syncytial Virus in African Green Monkeys by Intranasally Administered 2-5A Antisense von Leaman, Douglas W., Longano, Frank J., Okicki, James R., Soike, Kenneth F., Torrence, Paul F., Silverman, Robert H., Cramer, Hagen

Volltext

Intrinsic molecular activities of the interferon-induced 2-5A-dependent RNase von BEIHUA DONG, LULU XU, AIMIN ZHOU, HASSEL, B. A, LEE, X, TORRENCE, P. F, SILVERMAN, R. H

Volltext

Potent Inhibition of Respiratory Syncytial Virus Replication using a 2-5A-Antisense Chimera Targeted to Signals within the Virus Genomic RNA von Player, Mark R., Barnard, Dale L., Torrence, Paul F.

Volltext

Targeting RNA Decay with 2′,5′ Oligoadenylate-Antisense in Respiratory Syncytial Virus-Infected Cells von Cirino, Nick M., Li, Guiying, Xiao, Wei, Torrence, Paul F., Silverman, Robert H.

Volltext

Endowing RNase H-Inactive Antisense with Catalytic Activity:  2-5A-Morphants von Zhou, Longhu, Civitello, Edgar R, Gupta, Nidhi, Silverman, Robert H, Molinaro, Ross J, Anderson, David E, Torrence, Paul F

Volltext

Targeting RNA for degradation with a (2'-5')oligoadenylate-antisense chimera von TORRENCE, P. F, MAITRA, R. K, LESIAK, K, SHAHRZAD KHAMNEI, AIMIN ZHOU, SILVERMAN, R. H

Volltext

Synthesis and Properties of Second-Generation 2-5A-Antisense Chimeras with Enhanced Resistance to Exonucleases von Li, Guiying, Xiao, Wei, Torrence, Paul F

Volltext

3-Deazaadenosine analogues of p5′A2′p5′A2′p5′A: synthesis, stereochemistry, and the roles of adenine ring nitrogen-3 in the interaction with RNase L von Kalinichenko, Elena N, Podkopaeva, Tatiana L, Budko, Elena V, Seela, Frank, Dong, Beihua, Silverman, Robert, Vepsäläinen, Jouko, Torrence, Paul F, Mikhailopulo, Igor A

Volltext

[3] Accelerating RNA decay through intervention of RNase L: Alternative synthesis of composite 2′, 5′-oligoadenylate-antisense von Torrence, Paul F., Wang, Zhengfu

Volltext

Discrimination between ribonuclease H- and ribonuclease L-mediated RNA degradation by 2′- O-methylated 2-5A-antisense oligonucleotides von Cramer, Hagen, Player, Mark R., Torrence, Paul F.

Volltext

2-5A-DNA conjugate inhibition of respiratory syncytial virus replication: effects of oligonucleotide structure modifications and RNA target site selection von Barnard, D.L, Sidwell, R.W, Xiao, W, Player, M.R, Adah, S.A, Torrence, P.F

Volltext

2',5'-Oligoadenylate:antisense chimeras. Synthesis and properties von Lesiak, Krystyna, Khamnei, Shahrzad, Torrence, Paul F

Volltext

2′,5′-Oligoadenylate-Antisense Chimeras Cause RNase L to Selectively Degrade bcr/abl mRNA in Chronic Myelogenous Leukemia Cells von Maran, Avudaiappan, Waller, Cornelius F., Paranjape, Jayashree M., Li, Guiying, Xiao, Wei, Zhang, Kerry, Kalaycio, Matt E., Maitra, Ratan K., Lichtin, Alan E., Brugger, Wolfram, Torrence, Paul F., Silverman, Robert H.

Volltext

2,5-oligoadenylate-peptide nucleic acids (2-5A-PNAs) activate RNase L von Verheijen, J C, van der Marel, G A, van Boom, J H, Bayly, S F, Player, M R, Torrence, P F

Volltext

Neighboring Group Catalysis in the Design of Nucleotide Prodrugs von Khamnei, Shahrzad, Torrence, Paul F

Volltext

Phosphorothioate oligodeoxyribonucleotides inhibit ribonuclease L thereby disabling a mechanism of interferon action von Player, Mark R., Torrence, Paul F.

Volltext