Tumor dynamics in patients with solid tumors treated with pembrolizumab beyond disease progression von Topp, Brian G., Channavazzala, Madhav, Mayawala, Kapil, De Alwis, Dinesh P., Rubin, Eric, Snyder, Alexandra, Wolchok, Jedd D., Ribas, Antoni

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Incorporating lesion-to-lesion heterogeneity into early oncology decision making von Kumar, Rukmini, Qi, Timothy, Cao, Yanguang, Topp, Brian

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A bootstrapping method to optimize go/no‐go decisions from single‐arm, signal‐finding studies in oncology von Dutta, Raunak, Mohan, Aparna, Buros‐Novik, Jacqueline, Goldmacher, Gregory, Akala, Omobolaji O., Topp, Brian

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Applications of Quantitative Systems Pharmacology in Model‐Informed Drug Discovery: Perspective on Impact and Opportunities von Bradshaw, Erica L., Spilker, Mary E., Zang, Richard, Bansal, Loveleena, He, Handan, Jones, Rhys D.O., Le, Kha, Penney, Mark, Schuck, Edgar, Topp, Brian, Tsai, Alice, Xu, Christine, Nijsen, Marjoleen J.M.A., Chan, Jason R.

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Preclinical QSP Modeling in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape von Nijsen, Marjoleen J.M.A., Wu, Fan, Bansal, Loveleena, Bradshaw‐Pierce, Erica, Chan, Jason R., Liederer, Bianca M., Mettetal, Jerome T., Schroeder, Patricia, Schuck, Edgar, Tsai, Alice, Xu, Christine, Chimalakonda, Anjaneya, Le, Kha, Penney, Mark, Topp, Brian, Yamada, Akihiro, Spilker, Mary E.

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Beyond the single average tumor: Understanding IO combinations using a clinical QSP model that incorporates heterogeneity in patient response von Kumar, Rukmini, Thiagarajan, Kannan, Jagannathan, Lakshmanan, Liu, Liming, Mayawala, Kapil, Alwis, Dinesh, Topp, Brian

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Biomarker development for PD-(L)1 axis inhibition: a consensus view from the SITC Biomarkers Committee von Monette, Anne, Warren, Sarah, Barrett, J Carl, Garnett-Benson, Charlie, Schalper, Kurt A, Taube, Janis M, Topp, Brian, Snyder, Alexandra

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P1067: ESTIMATING THE RELATIVE EFFICACY OF FAVEZELIMAB WHEN USED IN COMBINATION WITH PEMBROLIZUMAB IN PATIENTS WITH PD‐1–REFRACTORY CLASSICAL HODGKIN LYMPHOMA von Armand, Philippe, Luigi Zinzani, Pier, Timmerman, John, Johnson, Nathalie, Lavie, David, Thiagarajan, Kannan, Topp, Brian, Pillai, Pallavi, Herrera, Alex F.

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β-cell mass dynamics in Zucker diabetic fatty rats rosiglitazone prevents the rise in net cell death von FINEGOOD, Diane T, DAWN MCARTHUR, M, KOJWANG, David, THOMAS, Marion J, TOPP, Brian G, LEONARD, Thomas, BUCKINGHAM, Robin E

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Industrialization of Quantitative Systems Pharmacology von Topp, Brian, Trujillo, Maria E., Sinha, Vikram

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RECISTv1.1 progression in oncology: Shades of gray von Topp, Brian, Snyder, Alexandra, Wolchok, Jedd

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Abstract 4384: Does progressive disease justify pembrolizumab discontinuation: a simulation analysis von Thiagarajan, Kannan, Channavazzala, Madhav, Topp, Brian Gregory

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Abstract PO-131: Inter-tumoral heterogeneity of progressive disease in melanoma patients treated with pembrolizumab von Topp, Brian, Kumar, Rukmini, Mayawala, Kapil, de Alwis, Dinesh, Hellmann, Matt D., Snyder, Alexandra

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Treatment with Sitagliptin or Metformin Does Not Increase Body Weight despite Predicted Reductions in Urinary Glucose Excretion von Waters, Steven B., Topp, Brian G., Siler, Scott Q., Alexander, Charles M.

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Abstract 4375: A bootstrapping method to optimize go/no-go decisions from single-arm, signal-finding studies in oncology von Mohan, Aparna, Dutta, Raunak, Buros-Novik, Jacqueline, Akala, Omobolaji, Topp, Brian Gregory

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Modulation of intratumoural myeloid cells, the hallmark of the anti-tumour efficacy induced by a triple combination: tumour-associated peptide, TLR-3 ligand and α-PD-1 von Zalba, Sara, Belsúe, Virginia, Topp, Brian, de Alwis, Dinesh, Alvarez, Maite, Trocóniz, Iñaki F., Berraondo, Pedro, Garrido, María J.

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β-cell deterioration - prospects for reversal or prevention von Finegood, Diane T., Topp, Brian G.

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Dynamics of insulin sensitivity, β-cell function, and β-cell mass during the development of diabetes in fa / fa rats von Topp, Brian G., Atkinson, Laura L., Finegood, Diane T.

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Semi-Mechanistic Model for the Antitumor Response of a Combination Cocktail of Immuno-Modulators in Non-Inflamed (Cold) Tumors von Sancho-Araiz, Aymara, Zalba, Sara, Garrido, Maria J., Berraondo, Pedro, Topp, Brian, de Alwis, Dinesh, Parra-Guillen, Zinnia P., Mangas-Sanjuan, Victor, Troconiz, Inaki F.

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A Model of β -Cell Mass, Insulin, and Glucose Kinetics: Pathways to Diabetes von TOPP, BRIAN, PROMISLOW, KEITH, DEVRIES, GERDA, MIURA, ROBERT M, FINEGOOD, DIANE T

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