CRISPR/Cas9-Mediated Trp53 and Brca2 Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous Carcinoma von Walton, Josephine, Blagih, Julianna, Ennis, Darren, Leung, Elaine, Dowson, Suzanne, Farquharson, Malcolm, Tookman, Laura A, Orange, Clare, Athineos, Dimitris, Mason, Susan, Stevenson, David, Blyth, Karen, Strathdee, Douglas, Balkwill, Frances R, Vousden, Karen, Lockley, Michelle, McNeish, Iain A

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RAD51 and BRCA2 Enhance Oncolytic Adenovirus Type 5 Activity in Ovarian Cancer von Tookman, Laura A, Browne, Ashley K, Connell, Claire M, Bridge, Gemma, Ingemarsdotter, Carin K, Dowson, Suzanne, Shibata, Atsushi, Lockley, Michelle, Martin, Sarah A, McNeish, Iain A

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Paclitaxel resistance increases oncolytic adenovirus efficacy via upregulated CAR expression and dysfunctional cell cycle control von Ingemarsdotter, Carin K., Tookman, Laura A., Browne, Ashley, Pirlo, Katrina, Cutts, Rosalind, Chelela, Claude, Khurrum, Karisma F., Leung, Elaine Y.L., Dowson, Suzanne, Webber, Lee, Khan, Iftekhar, Ennis, Darren, Syed, Nelofer, Crook, Tim R., Brenton, James D., Lockley, Michelle, McNeish, Iain A.

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The Genomic Landscape of Early-Stage Ovarian High-Grade Serous Carcinoma von Cheng, Zhao, Mirza, Hasan, Ennis, Darren P, Smith, Philip, Morrill Gavarró, Lena, Sokota, Chishimba, Giannone, Gaia, Goranova, Theodora, Bradley, Thomas, Piskorz, Anna, Lockley, Michelle, Kaur, Baljeet, Singh, Naveena, Tookman, Laura A, Krell, Jonathan, McDermott, Jacqueline, Macintyre, Geoffrey, Markowetz, Florian, Brenton, James D, McNeish, Iain A

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The genomic trajectory of ovarian high‐grade serous carcinoma can be observed in STIC lesions von Cheng, Zhao, Ennis, Darren P, Lu, Bingxin, Mirza, Hasan B, Sokota, Chishimba, Kaur, Baljeet, Singh, Naveena, Le Saux, Olivia, Russo, Giorgia, Giannone, Gaia, Tookman, Laura A, Krell, Jonathan, Barnes, Chris, McDermott, Jackie, McNeish, Iain A

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Pharmacological Inhibition of β3 Integrin Reduces the Inflammatory Toxicities Caused by Oncolytic Adenovirus without Compromising Anticancer Activity von Browne, Ashley, Tookman, Laura A, Ingemarsdotter, Carin K, Bouwman, Russell D, Pirlo, Katrina, Wang, Yaohe, McNeish, Iain A, Lockley, Michelle

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Failure of Translation of Human Adenovirus mRNA in Murine Cancer Cells Can be Partially Overcome by L4-100K Expression In Vitro and In Vivo von Young, Anna-Mary, Archibald, Kyra M, Tookman, Laura A, Pool, Alexander, Dudek, Kate, Jones, Carolyn, Williams, Sarah L, Pirlo, Katrina J, Willis, Anne E, Lockley, Michelle, McNeish, Iain A

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Genomic DNA damage and ATR-Chk1 signaling determine oncolytic adenoviral efficacy in human ovarian cancer cells von Connell, Claire M, Shibata, Atsushi, Tookman, Laura A, Archibald, Kyra M, Flak, Magdalena B, Pirlo, Katrina J, Lockley, Michelle, Wheatley, Sally P, McNeish, Iain A

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Atezolizumab and chemotherapy for advanced or recurrent endometrial cancer (AtTEnd): a randomised, double-blind, placebo-controlled, phase 3 trial von Colombo, Nicoletta, Biagioli, Elena, Harano, Kenichi, Galli, Francesca, Hudson, Emma, Antill, Yoland, Choi, Chel Hun, Rabaglio, Manuela, Marth, Christian, Parma, Gabriella, Fariñas-Madrid, Lorena, Nishio, Shin, Allan, Karen, Lee, Yeh Chen, Piovano, Elisa, Pardo, Beatriz, Nakagawa, Satoshi, McQueen, John, Zamagni, Claudio, Manso, Luis, Takehara, Kazuhiro, Ferrero, Annamaria, Tognon, Germana, Lissoni, Andrea Alberto, Petrella, Mariacristina, Laudani, Maria Elena, Uggeri, Sara, Barretina Ginesta, M Pilar, Casanova, Claudia, Arcangeli, Valentina, Antonuzzo, Lorenzo, Gadducci, Angiolo, Cosio, Stefania, McNeish, Ian, Tookman, Laura, Redondo Sanchez, Andrés, Choi, Chel Hun, Baldini, Editta, Palaia, Innocenza, Benedetti Panici, Pierluigi, Takahashi, Nobutaka, Lombard, Janine, Ardizzoia, Antonio, Bologna, Alessandra, Herrero Ibáñez, Ana Maria, Musolino, Antonino, Márquez Vázquez, Raúl, Pietzner, Klaus, Braicu, Elena, Heinzelmann-Schwarz, Viola A., Powell, Melanie, Yokoyama, Yoshihito, Abeni, Chiara, Cueva, Juan Fernando, Trillsch, Fabian, Ataseven, Beyhan, Petru, Edgar, Heubner, MartinLeonhard, Sadozye, Azmat Hassanq, Dubey, Sidharth, Tiley, Susan, Chrystal, Kathryn, Kim, Sang Wun, Fehr, Mathias, Scatchard, Kate, Anand, Anjana, Taylor, Alexandra, Enomoto, Takayuki, Yoshihara, Kosuke, Selva-Nayagam, Sudarsha, Karki, Bhaskar, Wilkinson, Kate, Chantrill, Lorraine, Lee, Chulmin, Bertolini, Alessandro, Narducci, Filomena, Bellotti, Giovanna, Fusco, Vittorio, Aebi, Stefan, Del Grande, Maria, Tokunaga, Hideki, Shigeta, Shogo, Goss, Geraldine, Siow, Zhen Rong, Steer, Christopher, Lee, Kwang-Beom, Di Meglio, Giovanni, Massa, Elena, De Marino, Elvira, Tortora, Vincenzo, Palacio Vazquez, Isabel, Tsuji, Kosuke, Tominaga, Eiichiro, Black, Allison, So, Kyeong A, Suh, Dong Hoon, Lee, Keun Ho, Fossati, Roldano, Carlucci, Luciano, Barberis, Massimo

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Abstract AP24: CRISPR/CAS9–MEDIATED TRP53 , BRCA1 , BRCA2 AND PTEN KNOCKOUT TO GENERATE IMPROVED MURINE MODELS OF OVARIAN HIGH GRADE SEROUS CARCINOMA von Walton, Josephine, Blagih, Julianna, Farquharson, Malcolm, Ennis, Darren, Leung, Elaine, Dowson, Suzanne, Tookman, Laura A., Orange, Clare, Athineos, Dimitris, Mason, Susan, Stevenson, David, Blyth, Karen, Strathdee, Douglas, Balkwill, Frances R., Vousden, Karen, Lockley, Michelle, McNeish, Iain A.

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Abstract 53: The copy number landscape of early stage ovarian high grade serous carcinoma von Cheng, Zhao, Mirza, Hasan B., Ennis, Darren P., Smith, Philip, Gavarró, Lena Morrill, Sokota, Chishimba, Giannone, Gaia, Goranova, Teodora, Bradley, Thomas, Piskorz, Anna, Lockley, Michelle, Kaur, Baljeet, Singh, Naveena, Tookman, Laura A., Krell, Jonathan, McDermott, Jackie, Macintyre, Geoff, Markowetz, Florian, Brenton, James D., McNeish, Iain A.

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The genomic trajectory of ovarian high-grade serous carcinoma can be observed in STIC lesions von Cheng, Zhao, Ennis, Darren P, Lu, Bingxin, Mirza, Hasan B, Sokota, Chishimba, Kaur, Baljeet, Singh, Naveena, Le Saux, Olivia, Russo, Giorgia, Giannone, Gaia, Tookman, Laura A, Krell, Jonathan, Barnes, Chris, McDermott, Jackie, McNeish, Iain A

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The Genomic Landscape of Early-Stage Ovarian High-Grade Serous Carcinoma von Cheng, Zhao, Mirza, Hasan, Ennis, Darren P, Smith, Philip, Morrill Gavarró, Lena, Sokota, Chishimba, Giannone, Gaia, Goranova, Theodora, Bradley, Thomas, Piskorz, Anna, Lockley, Michelle, BriTROC-1 Investigators, Kaur, Baljeet, Singh, Naveena, Tookman, Laura A, Krell, Jonathan, McDermott, Jacqueline, Macintyre, Geoffrey, Markowetz, Florian, Brenton, James D, McNeish, Iain A

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ESR Bridges: imaging and treatment of ovarian cancer-a multidisciplinary view von Bryan, Stacey, Rockall, Andrea, Tookman, Laura

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Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma von Au, Lewis, Hatipoglu, Emine, Litchfield, Kevin, Beattie, Gordon, Horswell, Stuart, Nicol, David, Mason, Robert, Del Rosario, Lyra, Edmonds, Kim, Lingard, Karla, Sarker, Sarah, Carlyle, Eleanor, Attig, Jan, Becker, Pablo D., Puccio, Ignazio, Lund, Tom, Ghorani, Ehsan, Xu, Hang, Mitchison, Miriam, Moore, David A., Proctor, Ian, Falzon, Mary, Furness, Andrew J.S., Reading, James L., Marafioti, Teresa, Abbosh, Chris, Bridgewater, John, Hochhauser, Daniel, Forster, Martin, Enfield, Katey, Huebner, Ariana, Enver, Tariq, Sinclair, Ron, Rhodes, Zoe, Moore, David, Khiroya, Reena, Ellery, Peter, Veeriah, Selvaraju, Shaw, Heather, Attard, Gert, Akther, Mita Afroza, Naceur-Lombardelli, Cristina, Manzano, Lizi, Summan, Simranpreet, Kanu, Nnenna, Ward, Sophie, Stone, Paddy, Stirling, Caroline, Spain, Lavinia, Shum, Ben, Carlyle, Eleanor, Korteweg, Justine, Chandra, Ashish, Stewart, Ruby, Iredale, Lara-Rose, Enting, Debra, Ghosh, Sharmistha, Karapagniotou, Lena, Pintus, Elias, Tutt, Andrew, Howlett, Sarah, Michalarea, Vasiliki, Caldas, Carlos, Fitzgerald, Rebecca, Provenzano, Elena, Cluroe, Alison, McDermott, Ultan, Tavare, Simon, Roxburgh, Patricia, Chalmers, Anthony, Fraser, Sioban, Oien, Karin, Krebs, Matt, Blackhall, Fiona, Dransfield, Jo, Le Quesne, John, Tanchel, Bruce, Langman, Gerald, Robinson, Andrew, Kerr, Amy, Middleton, Gary, Webb, Joanne, Ottensmeier, Christian, Harrison, David, Hackshaw, Allan, Ledermann, Jonathan, Sharp, Abby, Farrelly, Laura, Bridger, Hayley, Kassiotis, George, Chain, Benny, Larkin, James, Swanton, Charles, Quezada, Sergio A., Turajlic, Samra, Drake, William, Fernando, Archana, Hazell, Steve, Hill, Peter, O'Brien, Tim

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Oncologist-led BRCA ‘mainstreaming’ in the ovarian cancer clinic: A study of 255 patients and its impact on their management von Rumford, Megan, Lythgoe, Mark, McNeish, Iain, Gabra, Hani, Tookman, Laura, Rahman, Nazneen, George, Angela, Krell, Jonathan

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Diversity of thought: public perceptions of genetic testing across ethnic groups in the UK von Harris, Benjamin H L, McCabe, Caitlin, Shafique, Hana, Lammy, Simon, Tookman, Laura, Flanagan, James, Miron-Barroso, Sofia, Lythgoe, Mark, Clark, James, Walsh, Jason L, Di Giovannantonio, Matteo, Krell, Jonathan

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Practical guidance for the management of side effects during rucaparib therapy in a multidisciplinary UK setting von Tookman, Laura, Krell, Jonathan, Nkolobe, Baleseng, Burley, Laura, McNeish, Iain A.

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Immune modulation and the oral live biotherapeutic product, MRx0518, in treatment-naïve patients with cancer: Updated safety data von Lythgoe, Mark, Dama, Paola, Frampton, Adam Enver, Pickford, Emily, Tookman, Laura, Cunnea, Paula, Fotopoulou, Christina, Liu, Daniel, Clark, James, Lozano-kuehne, Jingky, Badman, Philip David, Clarke, Aaron, Chetal, Sasha, Fyvie, Gayle, Stevenson, Alex, Krell, Jonathan

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Homologous recombination deficiency in newly diagnosed FIGO stage III/IV high-grade epithelial ovarian cancer: a multi-national observational study von Morgan, Robert D, Clamp, Andrew R, Barnes, Bethany M, Timms, Kirsten, Schlecht, Helene, Yarram-Smith, Laura, Wallis, Yvonne, Valganon-Petrizan, Mikel, Macmahon, Suzanne, White, Rhian, Morgan, Sian, Mckenna, Sarah, Hudson, Emma, Tookman, Laura, George, Angela, Manchanda, Ranjit, Sundar, Sudha S, Nicum, Shibani, Brenton, James D, Kristeleit, Rebecca S, Banerjee, Susana, Mcneish, Iain A, Ledermann, Jonathan A, Taylor, Stephen S, Evans, D Gareth, Jayson, Gordon C

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