Central and Eastern European constitutionalism a quarter century after the fall of the Berlin Wall: Introduction to the symposium von Rosenfeld, M., Sadurski, W., Toniatti, R.

Volltext

El poder ejecutivo en los sistemas presidenciales de gobierno von Toniatti, R

Volltext

The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies von Vangamudi, Bhavatarini, Paul, Thomas A, Shah, Parantu K, Kost-Alimova, Maria, Nottebaum, Lisa, Shi, Xi, Zhan, Yanai, Leo, Elisabetta, Mahadeshwar, Harshad S, Protopopov, Alexei, Futreal, Andrew, Tieu, Trang N, Peoples, Mike, Heffernan, Timothy P, Marszalek, Joseph R, Toniatti, Carlo, Petrocchi, Alessia, Verhelle, Dominique, Owen, Dafydd R, Draetta, Giulio, Jones, Philip, Palmer, Wylie S, Sharma, Shikhar, Andersen, Jannik N

Volltext

The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial von Sandhu, Shahneen K, MD, Schelman, William R, MD, Wilding, George, MD, Moreno, Victor, MD, Baird, Richard D, PhD, Miranda, Susana, BSc, Hylands, Lucy, BSc, Riisnaes, Ruth, FIBMS, Forster, Martin, PhD, Omlin, Aurelius, MD, Kreischer, Nathan, MSc, Thway, Khin, MD, Gevensleben, Heidrun, MD, Sun, Linda, PhD, Loughney, John, PhD, Chatterjee, Manash, PhD, Toniatti, Carlo, PhD, Carpenter, Christopher L, MD, Iannone, Robert, MD, Kaye, Stan B, Prof, de Bono, Johann S, Prof, Wenham, Robert M

Volltext

An inhibitor of oxidative phosphorylation exploits cancer vulnerability von Molina, Jennifer R., Sun, Yuting, Protopopova, Marina, Gera, Sonal, Bandi, Madhavi, Bristow, Christopher, McAfoos, Timothy, Morlacchi, Pietro, Ackroyd, Jeffrey, Agip, Ahmed-Noor A., Al-Atrash, Gheath, Asara, John, Bardenhagen, Jennifer, Carrillo, Caroline C., Carroll, Christopher, Chang, Edward, Ciurea, Stefan, Cross, Jason B., Czako, Barbara, Deem, Angela, Daver, Naval, de Groot, John Frederick, Dong, Jian-Wen, Feng, Ningping, Gao, Guang, Gay, Jason, Do, Mary Geck, Greer, Jennifer, Giuliani, Virginia, Han, Jing, Han, Lina, Henry, Verlene K., Hirst, Judy, Huang, Sha, Jiang, Yongying, Kang, Zhijun, Khor, Tin, Konoplev, Sergej, Lin, Yu-Hsi, Liu, Gang, Lodi, Alessia, Lofton, Timothy, Ma, Helen, Mahendra, Mikhila, Matre, Polina, Mullinax, Robert, Peoples, Michael, Petrocchi, Alessia, Rodriguez-Canale, Jaime, Serreli, Riccardo, Shi, Thomas, Smith, Melinda, Tabe, Yoko, Theroff, Jay, Tiziani, Stefano, Xu, Quanyun, Zhang, Qi, Muller, Florian, DePinho, Ronald A., Toniatti, Carlo, Draetta, Giulio F., Heffernan, Timothy P., Konopleva, Marina, Jones, Philip, Di Francesco, M. Emilia, Marszalek, Joseph R.

Volltext

Identification of potent and selective MTH1 inhibitors von Petrocchi, Alessia, Leo, Elisabetta, Reyna, Naphtali J., Hamilton, Matthew M., Shi, Xi, Parker, Connor A., Mseeh, Faika, Bardenhagen, Jennifer P., Leonard, Paul, Cross, Jason B., Huang, Sha, Jiang, Yongying, Cardozo, Mario, Draetta, Giulio, Marszalek, Joseph R., Toniatti, Carlo, Jones, Philip, Lewis, Richard T.

Volltext

Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities von Skoulidis, Ferdinandos, Byers, Lauren A, Diao, Lixia, Papadimitrakopoulou, Vassiliki A, Tong, Pan, Izzo, Julie, Behrens, Carmen, Kadara, Humam, Parra, Edwin R, Canales, Jaime Rodriguez, Zhang, Jianjun, Giri, Uma, Gudikote, Jayanthi, Cortez, Maria A, Yang, Chao, Fan, Youhong, Peyton, Michael, Girard, Luc, Coombes, Kevin R, Toniatti, Carlo, Heffernan, Timothy P, Choi, Murim, Frampton, Garrett M, Miller, Vincent, Weinstein, John N, Herbst, Roy S, Wong, Kwok-Kin, Zhang, Jianhua, Sharma, Padmanee, Mills, Gordon B, Hong, Waun K, Minna, John D, Allison, James P, Futreal, Andrew, Wang, Jing, Wistuba, Ignacio I, Heymach, John V

Volltext

Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation von Sun, Yuting, Bandi, Madhavi, Lofton, Timothy, Smith, Melinda, Bristow, Christopher A., Carugo, Alessandro, Rogers, Norma, Leonard, Paul, Chang, Qing, Mullinax, Robert, Han, Jing, Shi, Xi, Seth, Sahil, Meyers, Brooke A., Miller, Meredith, Miao, Lili, Ma, Xiaoyan, Feng, Ningping, Giuliani, Virginia, Geck Do, Mary, Czako, Barbara, Palmer, Wylie S., Mseeh, Faika, Asara, John M., Jiang, Yongying, Morlacchi, Pietro, Zhao, Shuping, Peoples, Michael, Tieu, Trang N., Warmoes, Marc O., Lorenzi, Philip L., Muller, Florian L., DePinho, Ronald A., Draetta, Giulio F., Toniatti, Carlo, Jones, Philip, Heffernan, Timothy P., Marszalek, Joseph R.

Volltext

Gene therapy progress and prospects: transcription regulatory systems von Toniatti, C, Bujard, H, Cortese, R, Ciliberto, G

Volltext

Discovery of IPN60090, a Clinical Stage Selective Glutaminase‑1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties von Soth, Michael J, Le, Kang, Di Francesco, Maria Emilia, Hamilton, Matthew M, Liu, Gang, Burke, Jason P, Carroll, Chris L, Kovacs, Jeffrey J, Bardenhagen, Jennifer P, Bristow, Christopher A, Cardozo, Mario, Czako, Barbara, de Stanchina, Elisa, Feng, Ningping, Garvey, Jill R, Gay, Jason P, Do, Mary K. Geck, Greer, Jennifer, Han, Michelle, Harris, Angela, Herrera, Zachary, Huang, Sha, Giuliani, Virginia, Jiang, Yongying, Johnson, Sarah B, Johnson, Troy A, Kang, Zhijun, Leonard, Paul G, Liu, Zhen, McAfoos, Timothy, Miller, Meredith, Morlacchi, Pietro, Mullinax, Robert A, Palmer, Wylie S, Pang, Jihai, Rogers, Norma, Rudin, Charles M, Shepard, Hannah E, Spencer, Nakia D, Theroff, Jay, Wu, Qi, Xu, Alan, Yau, Ju Anne, Draetta, Giulio, Toniatti, Carlo, Heffernan, Timothy P, Jones, Philip

Volltext

Discovery of I-0436650, a potent and selective SHP2 allosteric inhibitor for the treatment of RAS driven solid tumors von Puca, F., Fodale, V., Randazzo, P., Fabbrini, D., Missineo, A., Bisbocci, M., Esposito, S., Nibbio, M., Amaudrut, J., Colaceci, F., Sasso, R., Scalabrì, F., Loponte, S., Alli, C., Pucci, V., Montalbetti, C., Di Fabio, R., Petrocchi, A., Carugo, A., Toniatti, C.

Volltext

Role of IL-6 and Its Soluble Receptor in Induction of Chemokines and Leukocyte Recruitment von Romano, Maria, Sironi, Marina, Toniatti, Carlo, Polentarutti, Nadia, Fruscella, Paolo, Ghezzi, Pietro, Faggioni, Raffaella, Luini, Walter, van Hinsbergh, Victor, Sozzani, Silvano, Bussolino, Federico, Poli, Valeria, Ciliberto, Gennaro, Mantovani, Alberto

Volltext

Unique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibition von Guertin, Amy D, Martin, Melissa M, Roberts, Brian, Hurd, Melissa, Qu, Xianlu, Miselis, Nathan R, Liu, Yaping, Li, Jing, Feldman, Igor, Benita, Yair, Bloecher, Andrew, Toniatti, Carlo, Shumway, Stuart D

Volltext

Abstract 1655: Discovery and development of IACS-010759, a novel inhibitor of Complex I currently in phase I studies to exploit oxidative phosphorylation dependency in acute myeloi... von Francesco, Maria Emilia Di, Marszalek, Joseph R., McAfoos, Timothy, Carroll, Christopher L., Kang, Zhijun, Liu, Gang, Theroff, Jay P., Bardenhager, Jennifer P., Bandi, Madhavi L., Molina, Jennifer R., Gera, Sonal, Protopopova, Marina, Sun, Yuting, Do, Mary K. Geck, Feng, Ningping, Gay, Jason P., Muller, Florian, Konopleva, Marina, Meric-Bernstam, Funda, Toniatti, Carlo, Heffernan, Timothy P., Draetta, Giulio F., Jones, Philip

Volltext

A zinc finger nuclease assay to rapidly quantitate homologous recombination proficiency in human cell lines von Yuan, Jing, Strack, Peter R., Toniatti, Carlo, Pelletier, Marc

Volltext

Site-Specific Integration Mediated by a Hybrid Adenovirus/Adeno-associated Virus Vector von Recchia, Alessandra, Parks, Robin J., Lamartina, Stefania, Toniatti, Carlo, Pieroni, Luisa, Palombo, Fabio, Ciliberto, Gennaro, Graham, Frank L., Cortese, Riccardo, La Monica, Nicola, Colloca, Stefano

Volltext

Intratumor RNA interference of cell cycle genes slows down tumor progression von Dharmapuri, S, Peruzzi, D, Marra, E, Palombo, F, Bett, A J, Bartz, S R, Yong, M, Ciliberto, G, La Monica, N, Buser, C A, Toniatti, C, Aurisicchio, L

Volltext

Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans von Romani, L, Mencacci, A, Cenci, E, Spaccapelo, R, Toniatti, C, Puccetti, P, Bistoni, F, Poli, V

Volltext

Abstract PR01: IACS-010759 a novel inhibitor of oxidative phosphorylation advancing into first-in-human studies to exploit metabolic vulnerabilities von Jones, Philip, Francesco, M Emilia Di, Molina, Jennifer M., Protopopova, Marina, Bandi, Madhavi, Bardenhagen, Jennifer, Bristow, Christopher A., Carroll, Christopher L., Feng, Ningping, Gay, Jason P., Do, Mary K. Geck, Greer, Jennifer M., Konopleva, Marina, Kang, Zhijun, Liu, Gang, McAfoos, Timothy, Morlacchi, Pietro, Smith, Melinda G., Fnu, Sonal, Theroff, Jay P., Draetta, Giulio, Toniatti, Carlo, Marszalek, Joseph R.

Volltext

Abstract 4971: IACS-010759, a novel inhibitor of complex I in Phase I clinical development to target OXPHOS dependent tumors von Molina, Jennifer, Bandi, Madhavi, Bardenhagen, Jennifer, Bristow, Christopher, Carroll, Christopher, Chang, Edward, Cross, Jason, Daver, Naval, Feng, Ningping, Gay, Jason, Do, Mary Geck, Greer, Jennifer, Han, Jing, Hirst, Judy, Huang, Sha, Jiang, Yongying, Kang, Zhijun, Konopleva, Marina, Liu, Gang, Ma, Helen, Matre, Polina, McAfoos, Timothy, Meric-Bernstam, Funda, Morlacchi, Pietro, Muller, Florian, Protopopova, Marina, Smith, Melinda, Sonal, Sonal, Sun, Yuting, Theroff, Jay, Viale, Andrea, Xu, Quanyun, Toniatti, Carlo, Draetta, Giulio, Jones, Philip, Francesco, M. Emilia Di, Marszalek, Joseph R.

Volltext