Rational Targeting of Active-Site Tyrosine Residues Using Sulfonyl Fluoride Probes von Hett, Erik C, Xu, Hua, Geoghegan, Kieran F, Gopalsamy, Ariamala, Kyne, Robert E, Menard, Carol A, Narayanan, Arjun, Parikh, Mihir D, Liu, Shenping, Roberts, Lee, Robinson, Ralph P, Tones, Michael A, Jones, Lyn H

Volltext

In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels von Cherry, Jonathan J, DiDonato, Christine J, Androphy, Elliot J, Calo, Alessandro, Potter, Kyle, Custer, Sara K, Du, Sarah, Foley, Timothy L, Gopalsamy, Ariamala, Reedich, Emily J, Gordo, Susana M, Gordon, William, Hosea, Natalie, Jones, Lyn H, Krizay, Daniel K, LaRosa, Gregory, Li, Hongxia, Mathur, Sachin, Menard, Carol A, Patel, Paraj, Ramos-Zayas, Rebeca, Rietz, Anne, Rong, Haojing, Zhang, Baohong, Tones, Michael A

Volltext

Ca2+-Independent Alterations in Diastolic Sarcomere Length and Relaxation Kinetics in a Mouse Model of Lipotoxic Diabetic Cardiomyopathy von Flagg, Thomas P, Cazorla, Olivier, Remedi, Maria S, Haim, Todd E, Tones, Michael A, Bahinski, Anthony, Numann, Randal E, Kovacs, Attila, Schaffer, Jean E, Nichols, Colin G, Nerbonne, Jeanne M

Volltext

A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS von Xu, Hua, Hett, Erik C, Gopalsamy, Ariamala, Parikh, Mihir D, Geoghegan, Kieran F, Kyne, Jr, Robert E, Menard, Carol A, Narayanan, Arjun, Robinson, Ralph P, Johnson, Douglas S, Tones, Michael A, Jones, Lyn H

Volltext

Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure von Baliga, Reshma S., Preedy, Michael E. J., Dukinfield, Matthew S., Chu, Sandy M., Aubdool, Aisah A., Bubb, Kristen J., Moyes, Amie J., Tones, Michael A., Hobbs, Adrian J.

Volltext

Transcript profiling of functionally related groups of genes during conditional differentiation of a mammalian cochlear hair cell line von Rivolta, Marcelo N, Halsall, Antony, Johnson, Claire M, Tones, Michael A, Holley, Matthew C

Volltext

Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular A... von Gopalsamy, Ariamala, Narayanan, Arjun, Liu, Shenping, Parikh, Mihir D, Kyne, Robert E, Fadeyi, Olugbeminiyi, Tones, Michael A, Cherry, Jonathan J, Nabhan, Joseph F, LaRosa, Gregory, Petersen, Donna N, Menard, Carol, Foley, Timothy L, Noell, Stephen, Ren, Yong, Loria, Paula M, Maglich-Goodwin, Jodi, Rong, Haojing, Jones, Lyn H

Volltext

The human decapping scavenger enzyme DcpS modulates microRNA turnover von Meziane, Oussama, Piquet, Sandra, Bossé, Gabriel D., Gagné, Dominic, Paquet, Eric, Robert, Claude, Tones, Michael A., Simard, Martin J.

Volltext

DPP-4 inhibitors sitagliptin and PF-00734,200 mitigate dopaminergic neurodegeneration, neuroinflammation and behavioral impairment in the rat 6-OHDA model of Parkinson’s disease von Yu, Seong-Jin, Wang, Yun, Shen, Hui, Bae, Eun-Kyung, Li, Yazhou, Sambamurti, Kumar, Tones, Michael A., Zaleska, Margaret M., Hoffer, Barry J., Greig, Nigel H.

Volltext

Selectivity Determination of a Small Molecule Chemical Probe Using Protein Microarray and Affinity Capture Techniques von Hett, Erik C, Kyne, Robert E, Gopalsamy, Ariamala, Tones, Michael A, Xu, Hua, Thio, Guene L, Nolan, Edward, Jones, Lyn H

Volltext

Sitagliptin elevates plasma and CSF incretin levels following oral administration to nonhuman primates: relevance for neurodegenerative disorders von Li, Yazhou, Vaughan, Kelli L., Wang, Yun, Yu, Seong-Jin, Bae, Eun-Kyung, Tamargo, Ian A., Kopp, Katherine O., Tweedie, David, Chiang, Cheng-Chuan, Schmidt, Keith T., Lahiri, Debomoy K., Tones, Michael A., Zaleska, Margaret M., Hoffer, Barry J., Mattison, Julie A., Greig, Nigel H.

Volltext

Oral Administration of Soluble Guanylate Cyclase Agonists to Rats Results in Osteoclastic Bone Resorption and Remodeling with New Bone Formation in the Appendicular and Axial Skele... von Homer, Bruce L., Morton, Daniel, Bagi, Cedo M., Warneke, James A., Andresen, Catharine J., Whiteley, Laurence O., Morris, Dale L., Tones, Michael A.

Volltext

Palmitate attenuates myocardial contractility through augmentation of repolarizing Kv currents von Haim, Todd E, Wang, Wei, Flagg, Thomas P, Tones, Michael A, Bahinski, Anthony, Numann, Randal E, Nichols, Colin G, Nerbonne, Jeanne M

Volltext

Acidic triazoles as soluble guanylate cyclase stimulators von Roberts, Lee R., Bradley, Paul A., Bunnage, Mark E., England, Katherine S., Fairman, David, Fobian, Yvette M., Fox, David N.A., Gymer, Geoff E., Heasley, Steven E., Molette, Jerome, Smith, Graham L., Schmidt, Michelle A., Tones, Michael A., Dack, Kevin N.

Volltext

A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpSElectronic supplementary information (ESI) available: Additional experimental... von Xu, Hua, Hett, Erik C, Gopalsamy, Ariamala, Parikh, Mihir D, Geoghegan, Kieran F, Kyne, Robert E, Menard, Carol A, Narayanan, Arjun, Robinson, Ralph P, Johnson, Douglas S, Tones, Michael A, Jones, Lyn H

Volltext

Ca 2+ -Independent Alterations in Diastolic Sarcomere Length and Relaxation Kinetics in a Mouse Model of Lipotoxic Diabetic Cardiomyopathy von Flagg, Thomas P., Cazorla, Olivier, Remedi, Maria S., Haim, Todd E., Tones, Michael A., Bahinski, Anthony, Numann, Randal E., Kovacs, Attila, Schaffer, Jean E., Nichols, Colin G., Nerbonne, Jeanne M.

Volltext

Characterization of a Metabotropic Glutamate Receptor Type 5-Green Fluorescent Protein Chimera (mGluR5–GFP): Pharmacology, Surface Expression, and Differential Effects of Homer-1a... von Coutinho, Victoria, Kavanagh, Irene, Sugiyama, Hiroyuki, Tones, Michael A., Henley, Jeremy M.

Volltext

Alpha-adrenoceptor stimulation, lysophosphoglycerides, and lipid peroxidation in reoxygenation induced calcium uptake in rabbit myocardium von TONES, MICHAEL A, POOLE-WILSON, PHILIP A

Volltext

Binding of [3H]BAY 58-2667 to purified bovine lung soluble guanylate cyclase by scintillation proximity assay von Garner-Hamrick, Peggy A, Mathis, Karl, Emmons, Tom, Tones, Michael A

Volltext

The effect of heparin on the inositol 1,4,5-trisphosphate receptor in rat liver microsomes Dependence on sulphate content and chain length von Tones, Michael A., Bootman, Martin D., Higgins, Bernard F., Lane, David A., Pay, Graham F., Lindahl, Ulf

Volltext