Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers von Koundinya, Malvika, Sudhalter, Judith, Courjaud, Albane, Lionne, Bruno, Touyer, Gaetan, Bonnet, Luc, Menguy, Isabelle, Schreiber, Isabelle, Perrault, Christelle, Vougier, Stephanie, Benhamou, Brigitte, Zhang, Bailin, He, Timothy, Gao, Qiang, Gee, Patricia, Simard, Daniel, Castaldi, M. Paola, Tomlinson, Ronald, Reiling, Stephan, Barrague, Matthieu, Newcombe, Richard, Cao, Hui, Wang, Yanjun, Sun, Fangxian, Murtie, Joshua, Munson, Mark, Yang, Eric, Harper, David, Bouaboula, Monsif, Pollard, Jack, Grepin, Claudine, Garcia-Echeverria, Carlos, Cheng, Hong, Adrian, Francisco, Winter, Christopher, Licht, Stuart, Cornella-Taracido, Ivan, Arrebola, Rosalia, Morris, Aaron

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Mechanistic Insights into a CDK9 Inhibitor Via Orthogonal Proteomics Methods von Hendricks, J. Adam, Beaton, Nigel, Chernobrovkin, Alexey, Miele, Eric, Hamza, Ghaith M, Ricchiuto, Piero, Tomlinson, Ronald C, Friman, Tomas, Borenstain, Cassandra, Barlaam, Bernard, Hande, Sudhir, Lamb, Michelle L, De Savi, Chris, Davies, Rick, Main, Martin, Hellner, Joakim, Beeler, Kristina, Feng, Yuehan, Bruderer, Roland, Reiter, Lukas, Molina, Daniel Martinez, Castaldi, M. Paola

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Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron‑2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA) von Cheung, Atwood K, Hurley, Brian, Kerrigan, Ryan, Shu, Lei, Chin, Donovan N, Shen, Yiping, O’Brien, Gary, Sung, Moo Je, Hou, Ying, Axford, Jake, Cody, Emma, Sun, Robert, Fazal, Aleem, Tomlinson, Ronald C, Jain, Monish, Deng, Lin, Hoffmaster, Keith, Song, Cheng, Van Hoosear, Mailin, Shin, Youngah, Servais, Rebecca, Towler, Christopher, Hild, Marc, Curtis, Daniel, Dietrich, William F, Hamann, Lawrence G, Briner, Karin, Chen, Karen S, Kobayashi, Dione, Sivasankaran, Rajeev, Dales, Natalie A

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Optimization of a series of potent, selective and orally bioavailable SYK inhibitors von Grimster, Neil P., Gingipalli, Lakshmaiah, Barlaam, Bernard, Su, Qibin, Zheng, XiaoLan, Watson, David, Wang, Haixia, Simpson, Iain, Pike, Andy, Balazs, Amber, Boiko, Scott, Ikeda, Timothy P., Impastato, Anna C., Jones, Natalie H., Kawatkar, Sameer, Kemmitt, Paul, Lamont, Scott, Patel, Joe, Read, Jon, Sarkar, Ujjal, Sha, Li, Tomlinson, Ronald C., Wang, Haiyun, Wilson, David M., Zehnder, Troy E., Wang, Lianghe, Wang, Peng, Goldberg, Frederick W., Shao, Wenlin, Fawell, Stephen, Dry, Hannah, Dowling, James E., Edmondson, Scott D.

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One-Pot C–N/C–C Cross-Coupling of Methyliminodiacetic Acid Boronyl Arenes Enabled by Protective Enolization von Grob, Jonathan E, Dechantsreiter, Michael A, Tichkule, Ritesh B, Connolly, Michael K, Honda, Ayako, Tomlinson, Ronald C, Hamann, Lawrence G

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Identification of NVP-TNKS656: The Use of Structure–Efficiency Relationships To Generate a Highly Potent, Selective, and Orally Active Tankyrase Inhibitor von Shultz, Michael D, Cheung, Atwood K, Kirby, Christina A, Firestone, Brant, Fan, Jianmei, Chen, Christine Hiu-Tung, Chen, Zhouliang, Chin, Donovan N, DiPietro, Lucian, Fazal, Aleem, Feng, Yun, Fortin, Pascal D, Gould, Ty, Lagu, Bharat, Lei, Huangshu, Lenoir, Francois, Majumdar, Dyuti, Ochala, Etienne, Palermo, M. G, Pham, Ly, Pu, Minying, Smith, Troy, Stams, Travis, Tomlinson, Ronald C, Touré, B. Barry, Visser, Michael, Wang, Run Ming, Waters, Nigel J, Shao, Wenlin

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DOSCHEDA: a web application for interactive chemoproteomics data analysis von Contrino, Bruno, Miele, Eric, Tomlinson, Ronald, Castaldi, M. Paola, Ricchiuto, Piero

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EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex von Hsu, Jessie Hao-Ru, Rasmusson, Timothy, Robinson, James, Pachl, Fiona, Read, Jon, Kawatkar, Sameer, O’ Donovan, Daniel H., Bagal, Sharan, Code, Erin, Rawlins, Philip, Argyrou, Argyrides, Tomlinson, Ronald, Gao, Ning, Zhu, Xiahui, Chiarparin, Elisabetta, Jacques, Kelly, Shen, Minhui, Woods, Haley, Bednarski, Emma, Wilson, David M., Drew, Lisa, Castaldi, M. Paola, Fawell, Stephen, Bloecher, Andrew

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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling von Bauer, Andreas, Myer, Vic, Fawell, Stephen, Ghidelli, Sonja, Shi, Xiaoying, Rau, Christina, Schirle, Markus, Serluca, Fabrizio, Zhang, Yue, Bouwmeester, Tewis, Charlat, Olga, Mickanin, Craig, Curtis, Daniel, Stegmeier, Frank, Hild, Marc, Cong, Feng, Mishina, Yuji M, Wilson, Christopher J, Liu, Shanming, Wiessner, Stephanie, Tomlinson, Ronald, Fazal, Aleem, Shao, Wenlin, Shultz, Michael, Wiellette, Elizabeth, Michaud, Gregory A, Cheng, Hong, Schlegl, Judith, Finan, Peter M, Porter, Jeffery A, Lu, Chris, Cheung, Atwood, Lengauer, Christoph, Tallarico, John A, Kirschner, Marc W, Huang, Shih-Min A

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Chemical Biology Approaches Confirm MCT4 as the Therapeutic Target of a Cellular Optimized Hit von Kawatkar, Aarti, Clark, Roger A., Hopcroft, Lorna, Roaquin, Debora Ann, Tomlinson, Ronald, Zuhl, Andrea M., Lamont, Gillian M., Kettle, Jason G., Critchlow, Susan E., Castaldi, M. Paola, Goldberg, Frederick W., Zhang, Andrew X.

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Structure‐Based Design of Selective Noncovalent CDK12 Inhibitors von Johannes, Jeffrey W., Denz, Christopher R., Su, Nancy, Wu, Allan, Impastato, Anna C., Mlynarski, Scott, Varnes, Jeffrey G., Prince, D. Bryan, Cidado, Justin, Gao, Ning, Haddrick, Malcolm, Jones, Natalie H., Li, Shaobin, Li, Xiuwei, Liu, Yang, Nguyen, Toan B., O'Connell, Nichole, Rivers, Emma, Robbins, Daniel W., Tomlinson, Ronald, Yao, Tieguang, Zhu, Xiahui, Ferguson, Andrew D., Lamb, Michelle L., Manchester, John I., Guichard, Sylvie

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Abstract LB-A09: EED targeted PROTACs degrade EED, EZH2, and SUZ12 in the PRC2 complex von Hsu, Jessie Hao-Ru, Rasmusson, Timothy, Robinson, James, Pachl, Fiona, Read, Jon, Kawatkar, Sameer, O'Donovan, Daniel H, Bagal, Sharan, Code, Erin, Rawlins, Philip, Argyrou, Argyrides, Tomlinson, Ronald, Gao, Ning, Zhu, Xiahui, Chiarparin, Elisabetta, Jacques, Kelly, Shen, Minhui, Woods, Haley, Bednarski, Emma, Wilson, David M., Drew, Lisa, Castaldi, M. Paola, Fawell, Stephen, Bloecher, Andrew

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PIKfyve, a Class III PI Kinase, Is the Target of the Small Molecular IL-12/IL-23 Inhibitor Apilimod and a Player in Toll-like Receptor Signaling von Cai, Xinming, Xu, Yongyao, Cheung, Atwood K., Tomlinson, Ronald C., Alcázar-Román, Abel, Murphy, Leon, Billich, Andreas, Zhang, Bailin, Feng, Yan, Klumpp, Martin, Rondeau, Jean-Michel, Fazal, Aleem N., Wilson, Christopher J., Myer, Vic, Joberty, Gerard, Bouwmeester, Tewis, Labow, Mark A., Finan, Peter M., Porter, Jeffrey A., Ploegh, Hidde L., Baird, Daniel, De Camilli, Pietro, Tallarico, John A., Huang, Qian

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Abstract 2924: Target identification, selectivity profiling and mechanistic insights of a Cdk9 inhibitor using complementary proteomics methods von Hendricks, Adam, Beaton, Nigel, Chernobrovkin, Alexey, Miele, Eric, Hamza, Ghaith, Ricchiuto, Piero, Tomlinson, Ronald, Friman, Tomas, Borenstein, Cassandra, Barlaam, Bernard, Hande, Sudhir, De Savi, Chris, Davies, Rick, Main, Martin, Hellner, Joakim, Beeler, Kristina, Feng, Yuehan, Bruderer, Roland, Reiter, Lukas, Molina, Daniel Martinez, Castaldi, Maria Paola

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Abstract 1135: Chemical Proteomics effort identifies PKN1 as a key player in the canonical NF-κB signaling pathway von Tang, Katherine, Lampa, Michael, Le, Tieu-Binh, Barrague, Matthieu, Tomlinson, Ronald, Scott, Brittain, Majid, Tahir, Dorsch, Marion, Cheng, Hong, Lengauer, Christoph, Garcia-Echeverria, Carlos, Adrian, Francisco, Levit, Mikhail, Zhang, Balin, Yu, Kin, Cornella-Taracido, Ivan, Srinivasan, Lakshmi

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Abstract 2243: Clonogenic 3D high throughput screening in mutant KRAS dependent cancer cells - a chemogenomic approach von Koundinya, Malvika, Sudhalter, Judith, Courjaud, Albane, Lionne, Bruno, Touyer, Gaetan, Bonnet, Luc, Menguy, Isabelle, Schreiber, Isabelle, Perrault, Christelle, Vougier, Stephanie, Benhamou, Brigitte, Simard, Daniel, Castaldi, Maria Paola, Tomlinson, Ronald, Reiling, Stephan, Cao, Hui, Harper, David, Bouaboula, Monsif, Pollard, Jack, Grepin, Claudine, Garcia-Echeverria, Carlos, Adrian, Francisco, Cornella-Taracido, Ivan, Arrebola, Rosalia, Morris, Aaron J.

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Enzyme-Activated Antagonists of the Strychnine-Insensitive Glycine/NMDA Receptor von Salituro, Francesco G, Tomlinson, Ronald C, Baron, Bruce M, Palfreyman, Michael G, McDonald, Ian A, Schmidt, Werner, Wu, Hui Qiu, Guidetti, Paolo, Schwarcz, Robert

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ChemInform Abstract: One-Pot C-N/C-C Cross-Coupling of Methyliminodiacetic Acid Boronyl Arenes Enabled by Protective Enolization von Grob, Jonathan E., Dechantsreiter, Michael A., Tichkule, Ritesh B., Connolly, Michael K., Honda, Ayako, Tomlinson, Ronald C., Hamann, Lawrence G.

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Hydrocarbon separation process and apparatus von Terence Ronald Tomlinson, Zac Loftus

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Hydrocarbon separation process and apparatus von Terence Ronald Tomlinson, Zak Richard Loftus, Adrian Joseph Finn

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