Neutrophil-derived alpha defensins control inflammation by inhibiting macrophage mRNA translation von Brook, Matthew, Tomlinson, Gareth H., Miles, Katherine, Smith, Richard W. P., Rossi, Adriano G., Hiemstra, Pieter S., van ’t Wout, Emily F. A., Dean, Jonathan L. E., Gray, Nicola K., Lu, Wuyuan, Gray, Mohini

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11βHSD1 Inhibition with AZD4017 Improves Lipid Profiles and Lean Muscle Mass in Idiopathic Intracranial Hypertension von Hardy, Rowan S, Botfield, Hannah, Markey, Keira, Mitchell, James L, Alimajstorovic, Zerin, Westgate, Connar S J, Sagmeister, Michael, Fairclough, Rebecca J, Ottridge, Ryan S, Yiangou, Andreas, Storbeck, Karl-Heinz H, Taylor, Angela E, Gilligan, Lorna C, Arlt, Wiebke, Stewart, Paul M, Tomlinson, Jeremy W, Mollan, Susan P, Lavery, Gareth G, Sinclair, Alexandra J

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Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology von Hughes, David J, Tiede, Christian, Penswick, Natalie, Tang, Anna Ah-San, Trinh, Chi H, Mandal, Upasana, Zajac, Katarzyna Z, Gaule, Thembaninskosi, Howell, Gareth, Edwards, Thomas A, Duan, Jianxin, Feyfant, Eric, McPherson, Michael J, Tomlinson, Darren C, Whitehouse, Adrian

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Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk von Broderick, Peter, Chubb, Daniel, Johnson, David C, Weinhold, Niels, Försti, Asta, Lloyd, Amy, Olver, Bianca, Ma, Yussanne P, Dobbins, Sara E, Walker, Brian A, Davies, Faith E, Gregory, Walter A, Child, J Anthony, Ross, Fiona M, Jackson, Graham H, Neben, Kai, Jauch, Anna, Hoffmann, Per, Mühleisen, Thomas W, Nöthen, Markus M, Moebus, Susanne, Tomlinson, Ian P, Goldschmidt, Hartmut, Hemminki, Kari, Morgan, Gareth J, Houlston, Richard S

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Effect of Short-Term Hormone Replacement Therapy on Breast Cancer Risk Reduction After Bilateral Prophylactic Oophorectomy in BRCA1 and BRCA2 Mutation Carriers: The PROSE Study Gro... von REBBECK, Timothy R, FRIEBEL, Tara, EELES, Rosalind, EVANS, D. Gareth, TOMLINSON, Gail, MATLOFF, Ellen, NAROD, Steven A, EISEN, Andrea, DOMCHEK, Susan, ARMSTRONG, Katrma, WEBER, Barbara L, WAGNER, Theresa, LYNCH, Henry T, GARBER, Judy E, DALY, Mary B, ISAACS, Claudine, OLOPADE, Olufunmilayo I, NEUHAUSEN, Susan L, VAN 'T VEER, Laura

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Mortality after bilateral salpingo-oophorectomy in BRCA1 and BRCA2 mutation carriers: a prospective cohort study von Domchek, Susan M, Friebel, Tara M, Neuhausen, Susan L, Wagner, Theresa, Evans, Gareth, Isaacs, Claudine, Garber, Judy E, Daly, Mary B, Eeles, Rosalind, Matloff, Ellen, Tomlinson, Gail E, Van't Veer, Laura, Lynch, Henry T, Olopade, Olufunmilayo I, Weber, Barbara L, Rebbeck, Timothy R

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Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas von Palles, Claire, Cazier, Jean-Baptiste, Howarth, Kimberley M, Domingo, Enric, Jones, Angela M, Broderick, Peter, Kemp, Zoe, Spain, Sarah L, Guarino, Estrella, Salguero, Israel, Sherborne, Amy, Chubb, Daniel, Carvajal-Carmona, Luis G, Ma, Yusanne, Kaur, Kulvinder, Dobbins, Sara, Barclay, Ella, Gorman, Maggie, Martin, Lynn, Kovac, Michal B, Humphray, Sean, Lucassen, Anneke, Holmes, Christopher C, Bentley, David, Donnelly, Peter, Taylor, Jenny, Petridis, Christos, Roylance, Rebecca, Sawyer, Elinor J, Kerr, David J, Clark, Susan, Grimes, Jonathan, Kearsey, Stephen E, Thomas, Huw J W, McVean, Gilean, Houlston, Richard S, Tomlinson, Ian

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The impact of the COVID-19 pandemic on cardiovascular disease prevention and management von Dale, Caroline E., Takhar, Rohan, Carragher, Raymond, Katsoulis, Michail, Torabi, Fatemeh, Duffield, Stephen, Kent, Seamus, Mueller, Tanja, Kurdi, Amanj, Le Anh, Thu Nguyen, McTaggart, Stuart, Abbasizanjani, Hoda, Hollings, Sam, Scourfield, Andrew, Lyons, Ronan A., Griffiths, Rowena, Lyons, Jane, Davies, Gareth, Harris, Daniel, Handy, Alex, Mizani, Mehrdad A., Tomlinson, Christopher, Thygesen, Johan H., Ashworth, Mark, Denaxas, Spiros, Banerjee, Amitava, Sterne, Jonathan A. C., Brown, Paul, Bullard, Ian, Priedon, Rouven, Mamas, Mamas A., Slee, Ann, Lorgelly, Paula, Pirmohamed, Munir, Khunti, Kamlesh, Morris, Andrew D., Sudlow, Cathie, Akbari, Ashley, Bennie, Marion, Sattar, Naveed, Sofat, Reecha

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Germline and Somatic Genetic Variants in the p53 Pathway Interact to Affect Cancer Risk, Progression, and Drug Response von Zhang, Ping, Kitchen-Smith, Isaac, Xiong, Lingyun, Stracquadanio, Giovanni, Brown, Katherine, Richter, Philipp H., Wallace, Marsha D., Bond, Elisabeth, Sahgal, Natasha, Moore, Samantha, Nornes, Svanhild, De Val, Sarah, Surakhy, Mirvat, Sims, David, Wang, Xuting, Bell, Douglas A., Zeron-Medina, Jorge, Jiang, Yanyan, Ryan, Anderson J., Selfe, Joanna L., Shipley, Janet, Kar, Siddhartha, Pharoah, Paul D., Loveday, Chey, Jansen, Rick, Grochola, Lukasz F., Palles, Claire, Protheroe, Andrew, Millar, Val, Ebner, Daniel, Pagadala, Meghana, Blagden, Sarah P., Maughan, Timothy S., Domingo, Enric, Tomlinson, Ian, Turnbull, Clare, Carter, Hannah, Bond, Gareth L.

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11 beta HSD1 Inhibition with AZD4017 Improves Lipid Profiles and Lean Muscle Mass in Idiopathic Intracranial Hypertension von Hardy, Rowan S., Botfield, Hannah, Markey, Keira, Mitchell, James L., Alimajstorovic, Zerin, Westgate, Connar S. J., Sagmeister, Michael, Fairclough, Rebecca J., Ottridge, Ryan S., Yiangou, Andreas, Storbeck, Karl-Heinz H., Taylor, Angela E., Gilligan, Lorna C., Arlt, Wiebke, Stewart, Paul M., Tomlinson, Jeremy W., Mollan, Susan P., Lavery, Gareth G., Sinclair, Alexandra J.

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Lack of Significant Metabolic Abnormalities in Mice with Liver-Specific Disruption of 11β-Hydroxysteroid Dehydrogenase Type 1 von Lavery, Gareth G, Zielinska, Agnieszka E, Gathercole, Laura L, Hughes, Beverly, Semjonous, Nina, Guest, Phillip, Saqib, Khalid, Sherlock, Mark, Reynolds, Gary, Morgan, Stuart A, Tomlinson, Jeremy W, Walker, Elizabeth A, Rabbitt, Elizabeth H, Stewart, Paul M

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Mutations in the genes encoding 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency von Stewart, Paul M, Draper, Nicole, Walker, Elizabeth A, Bujalska, Iwona J, Tomlinson, Jeremy W, Chalder, Susan M, Arlt, Wiebke, Lavery, Gareth G, Bedendo, Oliver, Ray, David W, Laing, Ian, Malunowicz, Ewa, White, Perrin C, Hewison, Martin, Mason, Philip J, Connell, John M, Shackleton, Cedric H L

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Steroid Biomarkers and Genetic Studies Reveal Inactivating Mutations in Hexose-6-Phosphate Dehydrogenase in Patients with Cortisone Reductase Deficiency von Lavery, Gareth G., Walker, Elizabeth A., Tiganescu, Ana, Ride, Jon P., Shackleton, Cedric H. L., Tomlinson, Jeremy W., Connell, John M. C., Ray, David W., Biason-Lauber, Anna, Malunowicz, Ewa M., Arlt, Wiebke, Stewart, Paul M.

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The impact of inversions across 33,924 families with rare disease from a national genome sequencing project von Pagnamenta, Alistair T., Yu, Jing, Walker, Susan, Noble, Alexandra J., Lord, Jenny, Dutta, Prasun, Hashim, Mona, Camps, Carme, Green, Hannah, Devaiah, Smrithi, Nashef, Lina, Parr, Jason, Fratter, Carl, Ibnouf Hussein, Rana, Lindsay, Sarah J., Lalloo, Fiona, Banos-Pinero, Benito, Evans, David, Mallin, Lucy, Waite, Adrian, Evans, Julie, Newman, Andrew, Allen, Zoe, Perez-Becerril, Cristina, Ryan, Gavin, Hart, Rachel, Taylor, John, Bedenham, Tina, Clement, Emma, Blair, Ed, Hay, Eleanor, Forzano, Francesca, Higgs, Jenny, Canham, Natalie, Majumdar, Anirban, McEntagart, Meriel, Lahiri, Nayana, Stewart, Helen, Smithson, Sarah, Calpena, Eduardo, Jackson, Adam, Banka, Siddharth, Titheradge, Hannah, McGowan, Ruth, Rankin, Julia, Shaw-Smith, Charles, Evans, D. Gareth, Burghel, George J., Smith, Miriam J., Anderson, Emily, Madhu, Rajesh, Firth, Helen, Ellard, Sian, Brennan, Paul, Anderson, Claire, Taupin, Doug, Rogers, Mark T., Cook, Jackie A., Durkie, Miranda, East, James E., Fowler, Darren, Wilson, Louise, Igbokwe, Rebecca, Gardham, Alice, Tomlinson, Ian, Baralle, Diana, Uhlig, Holm H., Taylor, Jenny C.

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COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records von Thygesen, Johan H, Mizani, Mehrdad A, Banerjee, Amitava, Cooper, Jennifer, Lai, Alvina G, Sudlow, Cathie, Abbasizanjani, Hoda, Ahmed, Nida, Akbari, Ashley, Allery, Freya, Ashworth, Mark, Bacon, Seb, Ball, Steve, Banerjee, Ami, Berry, Colin, Beveridge, Jennifer, Boyle, Jon, Briffa, Norman, Buch, Maya, Canoy, Dexter, Cheema, Kate, Crallan, Rebecca, Curcin, Vasa, Curry, Gwenetta, Denholm, Rachel, Dennis, John, Denniston, Alastair, Deo, Salil, Dhillon, Baljean, Dong, Tim, Downs, Johnny, Dregan, Alexandru, Elwenspoek, Martha, Falter, Florian, Firth, Joseph, Friebel, Rocco, Gilbert, Ruth, Goldacre, Ben, Goldacre, Raph, Grieco, Luca, Handy, Alex, Hardelid, Pia, Hardy, Flavien, Hemingway, Harry, Herz, Naomi, Heyl, Johannes, Hinchliffe, Rosie, Hippisley-Cox, Julia, Hocaoglu, Mevhibe, Hollings, Sam, Inouye, Mike, Jenkins, David, Kadam, Umesh, Kallis, Costas, Khawaja, Anthony, Killick, Richard, Kinnear, Deborah, Kolamunnage-Dona, Ruwanthi, Kurdi, Amanj, Lai, Alvina, Lambarth, Andrew, Larzjan, Milad Nazarzadeh, Li, Qiuju, Lyons, Ronan, Macleod, Mary Joan, Mamouei, Mohammad, Melville, Craig, Moncusi, Marta Pineda, Morales, Daniel, Morris, Carole, Nicholson, George, Norris, Tom, Oliver, Dominic, Oluyase, Adejoke, Pierotti, Livia, Priedon, Rouven, Proudfoot, Alastair, Roberts, Brian, Rossdale, Jennifer, Samani, Nilesh, Sattar, Naveed, Schwartz, Roy, Seminog, Olena, Sinha, Shubhra, Skrypak, Mirek, Sofat, Reecha, Sun, Luanluan, Suseeladevi, Arun Karthikeyan, Tilston, George, Toit, Clea du, Torabi, Fatemeh, Watkinson, Ruth, Whiteley, William, Williams, Michelle, Williams, Richard, Withnell, Eloise, Wright, Lucy, Wu, Jinge, Wu, Jianhua, Zaccardi, Francesco

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11[beta]HSD1 Inhibition with AZD4017 Improves Lipid Profiles and Lean Muscle Mass in Idiopathic Intracranial Hypertension von Hardy, Rowan S, Botfield, Hannah, Markey, Keira, Mitchell, James L, Alimajstorovic, Zerin, Westgate, Connar S.J, Sagmeister, Michael, Fairclough, Rebecca J, Ottridge, Ryan S, Yiangou, Andreas, Storbeck, Karl-Heinz H, Taylor, Angela E, Gilligan, Lorna C, Arlt, Wiebke, Stewart, Paul M, Tomlinson, Jeremy W, Mollan, Susan R, Lavery, Gareth G, Sinclair, Alexandra J

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11 beta HSD1 Inhibition with AZD4017 Improves Lipid Profiles and Lean Muscle Mass in Idiopathic Intracranial Hypertension von Hardy, Rowan S., Botfield, Hannah, Markey, Keira, Mitchell, James L., Alimajstorovic, Zerin, Westgate, Connar S. J., Sagmeister, Michael, Fairclough, Rebecca J., Ottridge, Ryan S., Yiangou, Andreas, Storbeck, Karl-Heinz H., Taylor, Angela E., Gilligan, Lorna C., Arlt, Wiebke, Stewart, Paul M., Tomlinson, Jeremy W., Mollan, Susan P., Lavery, Gareth G., Sinclair, Alexandra J.

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Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis

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Preoperative risk factors for conversion from laparoscopic to open cholecystectomy: a validated risk score derived from a prospective U.K. database of 8820 patients von Sutcliffe, Robert P, Hollyman, Marianne, Hodson, James, Bonney, Glenn, Vohra, Ravi S, Griffiths, Ewen A

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11 beta -Hydroxysteroid Dehydrogenase Type 1 Regulation by Intracellular Glucose 6-Phosphate Provides Evidence for a Novel Link between Glucose Metabolism and Hypothalamo-Pituitary... von Walker, Elizabeth A, Ahmed, Adeeba, Lavery, Gareth G, Tomlinson, Jeremy W, Kim, So Youn, Cooper, Mark S, Ride, Jonathan P, Hughes, Beverly A, Shackleton, Cedric HL, McKiernan, Patrick, Elias, Elwyn, Chou, Janice Y, Stewart, Paul M

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