Identification of Novel Substrates for cGMP Dependent Protein Kinase (PKG) through Kinase Activity Profiling to Understand Its Putative Role in Inherited Retinal Degeneration von Roy, Akanksha, Groten, John, Marigo, Valeria, Tomar, Tushar, Hilhorst, Riet

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Combined Inhibition of SHP2 and MEK Is Effective in Models of NF1-Deficient Malignant Peripheral Nerve Sheath Tumors von Wang, Jiawan, Pollard, Kai, Allen, Amy N., Tomar, Tushar, Pijnenburg, Dirk, Yao, Zhan, Rodriguez, Fausto J., Pratilas, Christine A.

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Kinase activity profiling identifies putative downstream targets of cGMP/PKG signaling in inherited retinal neurodegeneration von Roy, Akanksha, Tolone, Arianna, Hilhorst, Riet, Groten, John, Tomar, Tushar, Paquet-Durand, François

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Kinome Array Profiling of Patient-Derived Pancreatic Ductal Adenocarcinoma Identifies Differentially Active Protein Tyrosine Kinases von Creeden, Justin F., Alganem, Khaled, Imami, Ali S., Brunicardi, F. Charles, Liu, Shi-He, Shukla, Rammohan, Tomar, Tushar, Naji, Faris, McCullumsmith, Robert E.

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Integrative Kinase Activity Profiling and Phosphoproteomics of rd10 Mouse Retina during cGMP-Dependent Retinal Degeneration von Roy, Akanksha, Zhou, Jiaming, Nolet, Merijn, Welinder, Charlotte, Zhu, Yu, Paquet-Durand, François, Groten, John, Tomar, Tushar, Ekström, Per

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The PKG Inhibitor CN238 Affords Functional Protection of Photoreceptors and Ganglion Cells against Retinal Degeneration von Tolone, Arianna, Haq, Wadood, Fachinger, Alexandra, Roy, Akanksha, Kesh, Sandeep, Rentsch, Andreas, Wucherpfennig, Sophie, Zhu, Yu, Groten, John, Schwede, Frank, Tomar, Tushar, Herberg, Friedrich W, Nache, Vasilica, Paquet-Durand, François

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KRSA: An R package and R Shiny web application for an end-to-end upstream kinase analysis of kinome array data von DePasquale, Erica A. K., Alganem, Khaled, Bentea, Eduard, Nawreen, Nawshaba, McGuire, Jennifer L., Tomar, Tushar, Naji, Faris, Hilhorst, Riet, Meller, Jaroslaw, McCullumsmith, Robert E.

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Integrative Kinome Profiling Identifies mTORC1/2 Inhibition as Treatment Strategy in Ovarian Clear Cell Carcinoma von Caumanns, Joseph J, Berns, Katrien, Wisman, G Bea A, Fehrmann, Rudolf S N, Tomar, Tushar, Klip, Harry, Meersma, Gert J, Hijmans, E Marielle, Gennissen, Annemiek M C, Duiker, Evelien W, Weening, Desiree, Itamochi, Hiroaki, Kluin, Roelof J C, Reyners, Anna K L, Birrer, Michael J, Salvesen, Helga B, Vergote, Ignace, van Nieuwenhuysen, Els, Brenton, James, Braicu, E Ioana, Kupryjanczyk, Jolanta, Spiewankiewicz, Beata, Mittempergher, Lorenza, Bernards, René, van der Zee, Ate G J, de Jong, Steven

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Emerging Kinase Therapeutic Targets in Pancreatic Ductal Adenocarcinoma and Pancreatic Cancer Desmoplasia von Creeden, Justin F., Alganem, Khaled, Imami, Ali S., Henkel, Nicholas D., Brunicardi, F. Charles, Liu, Shi-He, Shukla, Rammohan, Tomar, Tushar, Naji, Faris, McCullumsmith, Robert E.

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Methylome analysis of extreme chemoresponsive patients identifies novel markers of platinum sensitivity in high-grade serous ovarian cancer von Tomar, Tushar, Alkema, Nicolette G, Schreuder, Leroy, Meersma, Gert Jan, de Meyer, Tim, van Criekinge, Wim, Klip, Harry G, Fiegl, Heidi, van Nieuwenhuysen, Els, Vergote, Ignace, Widschwendter, Martin, Schuuring, Ed, van der Zee, Ate G J, de Jong, Steven, Wisman, G Bea A

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Serum-Induced Differentiation of Glioblastoma Neurospheres Leads to Enhanced Migration/Invasion Capacity That Is Associated with Increased MMP9 von Joseph, Justin V, van Roosmalen, Ingrid A M, Busschers, Ellen, Tomar, Tushar, Conroy, Siobhan, Eggens-Meijer, Ellie, Peñaranda Fajardo, Natalia, Pore, Milind M, Balasubramanyian, Veerakumar, Wagemakers, Michiel, Copray, Sjef, den Dunnen, Wilfred F A, Kruyt, Frank A E

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Protective effect of rosiglitazone on kidney function in high-fat challenged human-CRP transgenic mice: a possible role for adiponectin and miR-21? von Morrison, Martine C., Yakala, Gopala K., Liang, Wen, Wielinga, Peter Y., Salic, Kanita, van Koppen, Arianne, Tomar, Tushar, Kleemann, Robert, Heeringa, Peter, Kooistra, Teake

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Genome-wide methylation profiling of ovarian cancer patient-derived xenografts treated with the demethylating agent decitabine identifies novel epigenetically regulated genes and p... von Tomar, Tushar, de Jong, Steven, Alkema, Nicolette G, Hoekman, Rieks L, Meersma, Gert Jan, Klip, Harry G, van der Zee, Ate Gj, Wisman, G Bea A

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Chick fetal organ spheroids as a model to study development and disease von Dakhel, Soran, Davies, Wayne I. L., Joseph, Justin, Tomar, Tushar, Remeseiro, Silvia, Gunhaga, Lena

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Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1α–ZEB1 axis von Joseph, Justin V, Conroy, Siobhan, Pavlov, Kirill, Sontakke, Pallavi, Tomar, Tushar, Eggens-Meijer, Ellie, Balasubramaniyan, Veerakumar, Wagemakers, Michiel, den Dunnen, Wilfred F.A, Kruyt, Frank A.E

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Integrative Kinase Activity Profiling and Phosphoproteomics of Ird10/I Mouse Retina during cGMP-Dependent Retinal Degeneration von Roy, Akanksha, Zhou, Jiaming, Nolet, Merijn, Welinder, Charlotte, Zhu, Yu, Paquet-Durand, François, Groten, John, Tomar, Tushar, Ekström, Per

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Technological advancements to study cellular signaling pathways in inherited retinal degenerative diseases von Roy, Akanksha, Hilhorst, Riet, Groten, John, Paquet-Durand, François, Tomar, Tushar

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KRSA: An R package and R Shiny web application for an end-to-end upstream kinase analysis of kinome array data von DePasquale, Erica A.K, Alganem, Khaled, Bentea, Eduard, Nawreen, Nawshaba, McGuire, Jennifer L, Tomar, Tushar, Naji, Faris, Hilhorst, Riet, Meller, Jaroslaw, McCullumsmith, Robert E

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TGF-β promotes microtube formation in glioblastoma through thrombospondin 1 von Joseph, Justin V, Magaut, Capucine R, Storevik, Simon, Geraldo, Luiz H, Mathivet, Thomas, Latif, Md Abdul, Rudewicz, Justine, Guyon, Joris, Gambaretti, Matteo, Haukas, Frida, Trones, Amalie, Rømo Ystaas, Lars A, Hossain, Jubayer A, Ninzima, Sandra, Cuvellier, Sylvain, Zhou, Wenjing, Tomar, Tushar, Klink, Barbara, Rane, Lalit, Irving, Bronwyn K, Marrison, Joanne, O’Toole, Peter, Wurdak, Heiko, Wang, Jian, Di, Zhang, Birkeland, Even, Berven, Frode S, Winkler, Frank, Kruyt, Frank A E, Bikfalvi, Andreas, Bjerkvig, Rolf, Daubon, Thomas, Miletic, Hrvoje

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Selective targeting of interferon γ to stromal fibroblasts and pericytes as a novel therapeutic approach to inhibit angiogenesis and tumor growth von Bansal, Ruchi, Tomar, Tushar, Ostman, Arne, Poelstra, Klaas, Prakash, Jai

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