Pneumococcal capsule expression is controlled through a conserved, distal cis-regulatory element during infection von Glanville, David G, Gazioglu, Ozcan, Marra, Michela, Tokars, Valerie L, Kushnir, Tatyana, Habtom, Medhanie, Croucher, Nicholas J, Nebenzahl, Yaffa Mizrachi, Mondragón, Alfonso, Yesilkaya, Hasan, Ulijasz, Andrew T

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Structures of an active type III-A CRISPR effector complex von Smith, Eric M., Ferrell, Sé, Tokars, Valerie L., Mondragón, Alfonso

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Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction von Watterson, D Martin, Grum-Tokars, Valerie L, Roy, Saktimayee M, Schavocky, James P, Bradaric, Brinda Desai, Bachstetter, Adam D, Xing, Bin, Dimayuga, Edgardo, Saeed, Faisal, Zhang, Hong, Staniszewski, Agnieszka, Pelletier, Jeffrey C, Minasov, George, Anderson, Wayne F, Arancio, Ottavio, Van Eldik, Linda J

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Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 von El-Shennawy, Lamiaa, Hoffmann, Andrew D., Dashzeveg, Nurmaa Khund, McAndrews, Kathleen M., Mehl, Paul J., Cornish, Daphne, Yu, Zihao, Tokars, Valerie L., Nicolaescu, Vlad, Tomatsidou, Anastasia, Mao, Chengsheng, Felicelli, Christopher J., Tsai, Chia-Feng, Ostiguin, Carolina, Jia, Yuzhi, Li, Lin, Furlong, Kevin, Wysocki, Jan, Luo, Xin, Ruivo, Carolina F., Batlle, Daniel, Hope, Thomas J., Shen, Yang, Chae, Young Kwang, Zhang, Hui, LeBleu, Valerie S., Shi, Tujin, Swaminathan, Suchitra, Luo, Yuan, Missiakas, Dominique, Randall, Glenn C., Demonbreun, Alexis R., Ison, Michael G., Kalluri, Raghu, Fang, Deyu, Liu, Huiping

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Machine learning-assisted elucidation of CD81-CD44 interactions in promoting cancer stemness and extracellular vesicle integrity von Ramos, Erika K, Tsai, Chia-Feng, Jia, Yuzhi, Cao, Yue, Manu, Megan, Taftaf, Rokana, Hoffmann, Andrew D, El-Shennawy, Lamiaa, Gritsenko, Marina A, Adorno-Cruz, Valery, Schuster, Emma J, Scholten, David, Patel, Dhwani, Liu, Xia, Patel, Priyam, Wray, Brian, Zhang, Youbin, Zhang, Shanshan, Moore, Ronald J, Mathews, Jeremy V, Schipma, Matthew J, Liu, Tao, Tokars, Valerie L, Cristofanilli, Massimo, Shi, Tujin, Shen, Yang, Dashzeveg, Nurmaa K, Liu, Huiping

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Energetic landscape of polycystin channel gating von Ng, Leo CT, Harris, Brandon J, Larmore, Megan, Ta, My C, Vien, Thuy N, Tokars, Valerie L, Yarov‐Yarovoy, Vladimir, DeCaen, Paul G

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Synthesis, Characterization, and Simulation of Four-Armed Megamolecules von Zhou, Shengwang, He, Peng, Dhindwal, Sonali, Grum-Tokars, Valerie L, Li, Ying, Parker, Kelly, Modica, Justin A, Bleher, Reiner, dos Reis, Roberto, Zuchniarz, Joshua, Dravid, Vinayak P, Voth, Gregory A, Roux, Benoît, Mrksich, Milan

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LRRK2 at Striatal Synapses: Cell-Type Specificity and Mechanistic Insights von Skelton, Patrick D, Tokars, Valerie, Parisiadou, Loukia

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Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer’s Disease Mouse Models von Roy, Saktimayee M, Grum-Tokars, Valerie L, Schavocky, James P, Saeed, Faisal, Staniszewski, Agnieszka, Teich, Andrew F, Arancio, Ottavio, Bachstetter, Adam D, Webster, Scott J, Van Eldik, Linda J, Minasov, George, Anderson, Wayne F, Pelletier, Jeffrey C, Watterson, D. Martin

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Discovery, Synthesis, And Structure-Based Optimization of a Series of N‑(tert-Butyl)-2‑(N‑arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibi... von Jacobs, Jon, Grum-Tokars, Valerie, Zhou, Ya, Turlington, Mark, Saldanha, S. Adrian, Chase, Peter, Eggler, Aimee, Dawson, Eric S, Baez-Santos, Yahira M, Tomar, Sakshi, Mielech, Anna M, Baker, Susan C, Lindsley, Craig W, Hodder, Peter, Mesecar, Andrew, Stauffer, Shaun R

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Closing the structure-to-function gap for LRRK2 von Tokars, Valerie, Chen, Chuyu, Parisiadou, Loukia

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Mutation of Membrane Type-1 Metalloproteinase, MT1-MMP, Causes the Multicentric Osteolysis and Arthritis Disease Winchester Syndrome von Evans, Brad R., Mosig, Rebecca A., Lobl, Mollie, Martignetti, Chiara R., Camacho, Catalina, Grum-Tokars, Valerie, Glucksman, Marc J., Martignetti, John A.

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Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors von Ghosh, Arun K., Gong, Gangli, Grum-Tokars, Valerie, Mulhearn, Debbie C., Baker, Susan C., Coughlin, Melissa, Prabhakar, Bellur S., Sleeman, Katrina, Johnson, Michael E., Mesecar, Andrew D.

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Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors von Ghosh, Arun K., Xi, Kai, Grum-Tokars, Valerie, Xu, Xiaoming, Ratia, Kiira, Fu, Wentao, Houser, Katherine V., Baker, Susan C., Johnson, Michael E., Mesecar, Andrew D.

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Mutations in Capillary Morphogenesis Gene-2 Result in the Allelic Disorders Juvenile Hyaline Fibromatosis and Infantile Systemic Hyalinosis von Dowling, Oonagh, Difeo, Analisa, Ramirez, Maria C., Tukel, Turgut, Narla, Goutham, Bonafe, Luisa, Kayserili, Hulya, Yuksel-Apak, Memnune, Paller, Amy S., Norton, Karen, Teebi, Ahmad S., Grum-Tokars, Valerie, Martin, Gail S., Davis, George E., Glucksman, Marc J., Martignetti, John A.

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Infantile systemic hyalinosis: Case report and review of the literature von Lindvall, Lisa E., MS, Kormeili, Tanya, MD, Chen, Elaine, BA, Ramirez, Maria Celeste M., PhD, Grum-Tokars, Valerie, PhD, Glucksman, Marc J., PhD, Martignetti, John A., MD, PhD, Zaragoza, Michael V., MD, PhD, Dyson, Senait W., MD

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A Platform for Delivery of Isoform Selective Inhibitors with In Vivo Efficacy and Safety: Case Study That Revised Prevailing Perspectives on Active Site Targeting and Delivered a N... von Roy, Saktimayee Mira, Tokars, Valerie, Watterson, Daniel Martin

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Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of... von Turlington, Mark, Chun, Aspen, Tomar, Sakshi, Eggler, Aimee, Grum-Tokars, Valerie, Jacobs, Jon, Daniels, J. Scott, Dawson, Eric, Saldanha, Adrian, Chase, Peter, Baez-Santos, Yahira M., Lindsley, Craig W., Hodder, Peter, Mesecar, Andrew D., Stauffer, Shaun R.

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MnSOD Lysine 68 acetylation leads to cisplatin and doxorubicin resistance due to aberrant mitochondrial metabolism von Gao, Yucheng, Zhu, Yueming, Tran, Elizabeth L, Tokars, Valerie, Dean, Angela E, Quan, Songhua, Gius, David

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Evaluating the 3C-like protease activity of SARS-Coronavirus: Recommendations for standardized assays for drug discovery von Grum-Tokars, Valerie, Ratia, Kiira, Begaye, Adrian, Baker, Susan C., Mesecar, Andrew D.

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