DJ‐927, a novel oral taxane, overcomes P‐glycoprotein‐mediated multidrug resistance in vitro and in vivo von Shionoya, Motoko, Jimbo, Takeshi, Kitagawa, Mayumi, Soga, Tsunehiko, Tohgo, Akiko

Volltext

Circumvention of Breast Cancer Resistance Protein (BCRP)-mediated Resistance to Camptothecins in Vitro Using Non-Substrate Drugs or the BCRP Inhibitor GF120918 von MALIEPAARD, Marc, VAN GASTELEN, Margot A, TOHGO, Akiko, HAUSHEER, Frederick H, VAN WAARDENBURG, Robert C. A. M, DE JONG, Laurina A, PLUIM, Dick, BEIJNEN, Jos H, SCHELLENS, Jan H. M

Volltext

Potent and broad antitumor effects of DX-8951f, a water-soluble camptothecin derivative, against various human tumors xenografted in nude mice von KUMAZAWA, E, JIMBO, T, OCHI, Y, TOHGO, A

Volltext

DX‐8951F, a water‐soluble camptothecin analog, exhibits potent antitumor activity against a human lung cancer cell line and its SN‐38‐resistant variant von Joto, Noriko, Ishii, Mineko, Minami, Megumi, Kuga, Hiroshi, Mitsui, Ikuo, Tohgo, Akiko

Volltext

Growth inhibitory effect of a new camptothecin analog, DX-8951f, on various drug-resistant sublines including BCRP-mediated camptothecin derivative-resistant variants derived from... von Ishii, Mineko, Iwahana, Michio, Mitsui, Ikuo, Minami, Megumi, Imagawa, Setsuko, Tohgo, Akiko, Ejima, Akio

Volltext

Antitumour activity of DX-8951f: a new camptothecin derivative von Kumazawa, Eiji, Tohgo, Akiko

Volltext

Antitumor Effect of DX‐8951, a Novel Camptothecin Analog, on Human Pancreatic Tumor Cells and Their CPT‐11‐resistant Variants Cultured in vitro and Xenografted into Nude Mice von Takiguchi, Soichi, Kumazawa, Eiji, Shimazoe, Takao, Tohgo, Akiko, Kono, Akira

Volltext

Efficacy of camptothecin analog DX-8951f (exatecan mesylate) on human pancreatic cancer in an orthotopic metastatic model von SUN, Fang-Xian, TOHGO, Akiko, BOUVET, Michael, YAGI, Shigeo, NASSIRPOUR, Rounak, MOOSSA, Abdoul R, HOFFMAN, Robert M

Volltext

Antitumor Effect of DT-5461, a Lipid a Derivative, Against Human Tumor Xenografts Is Mediated by Intratumoral Production of Tumor Necrosis Factor and Affected by Host Immunosuppres... von Kumazawa, Eiji, Jimbo, Takeshi, Akimoto, Toshihiko, Joto, Noriko, Tohgo, Akiko

Volltext

The activity profile of the hexacyclic camptothecin derivative DX-8951f in experimental human colon cancer and ovarian cancer von van Hattum, Annemarie H, Pinedo, Herbert M, Schlüper, Hennie M.M, Erkelens, Caroline A.M, Tohgo, Akiko, Boven, Epie

Volltext

Excretion into gastrointestinal tract of irinotecan lactone and carboxylate forms and their pharmacodynamics in rodents von ARIMORI, Kazuhiko, KUROKI, Noriaki, KUMAMOTO, Ayumi, TANOUE, Naomi, NAKANO, Masahiro, KUMAZAWA, Eiji, TOHGO, Akiko, KIKUCHI, Masahiko

Volltext

Anticancer drugs that induce cancer-associated cachectic syndromes von Tohgo, Akiko, Kumazawa, Eiji, Akahane, Kouichi, Asakawa, Akihiro, Inui, Akio

Volltext

Effect of combined administration of a synthetic low-toxicity lipid A derivative, DT-5461a, and indomethacin in various experimental tumor models of colon 26 carcinoma in mice von Jimbo, T, Akimoto, T, Tohgo, A

Volltext

Comparison of DX-8951f and topotecan effects on tumor colony formation from freshly explanted adult and pediatric human tumor cells von Lawrence, Richard A, Izbicka, Elzbieta, De Jager, Robert L, Tohgo, Akiko, Clark, Gary M, Weitman, Steven D, Rowinsky, Eric K, Von Hoff, Daniel D

Volltext

Production of tumor necrosis factor induced by synthetic low-toxicity lipid a analog, DT-5461a, is mediated by LPS receptor sites and tyrosine kinase—MAP kinase signaling pathway i... von Joto, Noriko, Akimoto, Toshihiko, Someya, Kazuhiko, Tohgo, Akiko

Volltext

Significant antitumor effect of a synthetic lipid A analogue, DT-5461, on murine syngeneic tumor models von KUMAZAWA, E, TOHGO, A, SOGA, T, KUSAMA, T, OSADA, Y

Volltext

Intratumoral production of tumor necrosis factor augmented by endogenous interferons results in potent antitumor effects of DT-5461, a synthetic lipid A analog von KUMAZAWA, E, AKIMOTO, T, KITA, Y, JIMBO, T, JOTO, N, TOHGO, A

Volltext

Antitumor Synthetic Lipid A Analog DT-5461a Upregulates Cytokine Expression in a Murine Macrophage Cell Line through LPS Pathway von Akahane, Kouichi, Someya, Kazuhiko, Tsutomi, Yumi, Akimoto, Toshihiko, Tohgo, Akiko

Volltext

CYTOSTATIC ACTION OF HUMAN FIBROBLAST INTERFERON IN DIRECT GROWTH INHIBITION: EFFECT ON HUMAN MALIGNANT MELANOMA von NAGAO, Shin'ichi, TOHGO, Akiko, KOHNO, Morihiro, OGAWA, Hidemasa

Volltext

EFFECTS OF HUMAN FIBROBLAST INTERFERON ON HUMAN GLIOMAS TRANSPLANTED INTO NUDE MICE von TANAKA, Noriko, NAGAO, Shin'ichi, TOHGO, Akiko, SEKIGUCHI, Fujio, KOHNO, Morihiro, OGAWA, Hidemasa, MATSUI, Takane, MATSUTANI, Masao

Volltext