Characterization of Alisertib (MLN8237), an Investigational Small-Molecule Inhibitor of Aurora A Kinase Using Novel In Vivo Pharmacodynamic Assays von MANFREDI, Mark G, ECSEDY, Jeffrey A, WYSONG, Deborah R, JANOWICK, David A, HYER, Marc L, LEROY, Patrick J, GERSHMAN, Rachel E, SILVA, Matthew D, GERMANOS, Melissa S, BOLEN, Joseph B, CLAIBORNE, Christopher F, SELLS, Todd B, CHAKRAVARTY, Arijit, SILVERMAN, Lee, MENGKUN ZHANG, HOAR, Kara M, STROUD, Stephen G, WEI CHEN, SHINDE, Vaishali, HUCK, Jessica J

Volltext

Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ von Brownell, James E., Sintchak, Michael D., Gavin, James M., Liao, Hua, Bruzzese, Frank J., Bump, Nancy J., Soucy, Teresa A., Milhollen, Michael A., Yang, Xiaofeng, Burkhardt, Anne L., Ma, Jingya, Loke, Huay-Keng, Lingaraj, Trupti, Wu, Dongyun, Hamman, Kristin B., Spelman, James J., Cullis, Courtney A., Langston, Steven P., Vyskocil, Stepan, Sells, Todd B., Mallender, William D., Visiers, Irache, Li, Ping, Claiborne, Christopher F., Rolfe, Mark, Bolen, Joseph B., Dick, Lawrence R.

Volltext

Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase von Manfredi, Mark G, Ecsedy, Jeffrey A, Meetze, Kristan A, Balani, Suresh K, Burenkova, Olga, Chen, Wei, Galvin, Katherine M, Hoar, Kara M, Huck, Jessica J, LeRoy, Patrick J, Ray, Emily T, Sells, Todd B, Stringer, Bradley, Stroud, Stephen G, Vos, Tricia J, Weatherhead, Gabriel S, Wysong, Deborah R, Zhang, Mengkun, Bolen, Joseph B, Claiborne, Christopher F

Volltext

Treatment-Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 von Milhollen, Michael A., Thomas, Michael P., Narayanan, Usha, Traore, Tary, Riceberg, Jessica, Amidon, Benjamin S., Bence, Neil F., Bolen, Joseph B., Brownell, James, Dick, Lawrence R., Loke, Huay-Keng, McDonald, Alice A., Ma, Jingya, Manfredi, Mark G., Sells, Todd B., Sintchak, Mike D., Yang, Xiaofeng, Xu, Qing, Koenig, Erik M., Gavin, James M., Smith, Peter G.

Volltext

MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors von Sells, Todd B., Chau, Ryan, Ecsedy, Jeffrey A., Gershman, Rachel E., Hoar, Kara, Huck, Jessica, Janowick, David A., Kadambi, Vivek J., LeRoy, Patrick J., Stirling, Matthew, Stroud, Stephen G., Vos, Tricia J., Weatherhead, Gabriel S., Wysong, Deborah R., Zhang, Mengkun, Balani, Suresh K., Bolen, Joseph B., Manfredi, Mark G., Claiborne, Christopher F.

Volltext

Discovery of a Potent and Orally Bioavailable Benzolactam-Derived Inhibitor of Polo-Like Kinase 1 (MLN0905) von Duffey, Matthew O, Vos, Tricia J, Adams, Ruth, Alley, Jennifer, Anthony, Justin, Barrett, Cynthia, Bharathan, Indu, Bowman, Douglas, Bump, Nancy J, Chau, Ryan, Cullis, Courtney, Driscoll, Denise L, Elder, Amy, Forsyth, Nancy, Frazer, Jonathan, Guo, Jianping, Guo, Luyi, Hyer, Marc L, Janowick, David, Kulkarni, Bheemashankar, Lai, Su-Jen, Lasky, Kerri, Li, Gang, Li, Jing, Liao, Debra, Little, Jeremy, Peng, Bo, Qian, Mark G, Reynolds, Dominic J, Rezaei, Mansoureh, Scott, Margaret Porter, Sells, Todd B, Shinde, Vaishali, Shi, Qiuju Judy, Sintchak, Michael D, Soucy, Francois, Sprott, Kevin T, Stroud, Stephen G, Nestor, Michelle, Visiers, Irache, Weatherhead, Gabriel, Ye, Yingchun, D’Amore, Natalie

Volltext

Synthetic approaches to novel cis and trans dideoxynucleosides of the apiose family von Sells, Todd B., Nair, Vasu

Volltext

Copper mediated reactions in nucleoside synthesis von Nair, Vasu, Sells, Todd B

Volltext

AURORA KINASE INHIBITORS FOR INHIBITING MITOTIC PROGRESSION von Stroud, Stephen G, Claiborne, Christopher F, Sells, Todd B

Volltext bestellen

Aurora kinase inhibitors for inhibiting mitotic progression von Stroud, Stephen G, Claiborne, Christopher F, Sells, Todd B

Volltext bestellen

Synthesis of congeners of adenosine resistant to deamination by adenosine deaminase von VASU NAIR, PURDY, D. F, SELLS, T. B

Volltext

AURORA KINASE INHIBITORS FOR INHIBITING MITOTIC PROGRESSION von Stroud, Stephen G, Claiborne, Christopher F, Sells, Todd B

Volltext bestellen

Aurora kinase inhibitors for inhibiting mitotic progression von Stroud, Stephen G, Claiborne, Christopher F, Sells, Todd B

Volltext bestellen

COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION von Travers, Stuart, Payne, Lloyd J, Boyce, Richard J, Stroud, Stephen G, Claiborne, Christopher F, Vos, Tricia J, Sells, Todd B, Weatherhead, Gabriel S

Volltext bestellen

Novel isomeric dideoxynucleosides of the D- and L-apiose family von Sells, Todd B., Nair, Vasu

Volltext

AURORA KINASE INHIBITORS FOR INHIBITING MITOTIC PROGRESSION von Stroud, Stephen G, Claiborne, Christopher F, Sells, Todd B

Volltext bestellen

Novel isomeric dideoxynucleosides as potential antiviral agents von Bolon, Pascal J., Sells, Todd B., Nuesca, Zoraida M., Purdy, David F., Nair, Vasu

Volltext

Aurora kinase inhibitors for inhibiting mitotic progression von Stroud, Stephen G, Claiborne, Christopher F, Sells, Todd B

Volltext bestellen

COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION von Travers, Stuart, Payne, Lloyd J, Boyce, Richard J, Stroud, Stephen G, Claiborne, Christopher F, Vos, Tricia J, Sells, Todd B, Weatherhead, Gabriel S

Volltext bestellen

Aurora kinase inhibitors for inhibiting mitotic progression von Claiborne Christopher F, Stroud Stephen G, Sells Todd B

Volltext bestellen