A Hierarchical Combination of Factors Shapes the Genome-wide Topography of Yeast Meiotic Recombination Initiation von Pan, Jing, Sasaki, Mariko, Kniewel, Ryan, Murakami, Hajime, Blitzblau, Hannah G., Tischfield, Sam E., Zhu, Xuan, Neale, Matthew J., Jasin, Maria, Socci, Nicholas D., Hochwagen, Andreas, Keeney, Scott

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The Landscape of Mouse Meiotic Double-Strand Break Formation, Processing, and Repair von Lange, Julian, Yamada, Shintaro, Tischfield, Sam E., Pan, Jing, Kim, Seoyoung, Zhu, Xuan, Socci, Nicholas D., Jasin, Maria, Keeney, Scott

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Structural and functional characterization of the Spo11 core complex von Claeys Bouuaert, Corentin, Tischfield, Sam E., Pu, Stephen, Mimitou, Eleni P., Arias-Palomo, Ernesto, Berger, James M., Keeney, Scott

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Genomic and transcriptomic analysis of a library of small cell lung cancer patient-derived xenografts von Caeser, Rebecca, Egger, Jacklynn V., Chavan, Shweta, Socci, Nicholas D., Jones, Caitlin Byrne, Kombak, Faruk Erdem, Asher, Marina, Roehrl, Michael H., Shah, Nisargbhai S., Allaj, Viola, Manoj, Parvathy, Tischfield, Sam E., Kulick, Amanda, Meneses, Maximiliano, Iacobuzio-Donahue, Christine A., Lai, W. Victoria, Bhanot, Umeshkumar, Baine, Marina K., Rekhtman, Natasha, Hollmann, Travis J., de Stanchina, Elisa, Poirier, John T., Rudin, Charles M., Sen, Triparna

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The ectonucleotidase CD39 identifies tumor-reactive CD8+ T cells predictive of immune checkpoint blockade efficacy in human lung cancer von Chow, Andrew, Uddin, Fathema Z., Liu, Michael, Dobrin, Anton, Nabet, Barzin Y., Mangarin, Levi, Lavin, Yonit, Rizvi, Hira, Tischfield, Sam E., Quintanal-Villalonga, Alvaro, Chan, Joseph M., Shah, Nisargbhai, Allaj, Viola, Manoj, Parvathy, Mattar, Marissa, Meneses, Maximiliano, Landau, Rebecca, Ward, Mariana, Kulick, Amanda, Kwong, Charlene, Wierzbicki, Matthew, Yavner, Jessica, Egger, Jacklynn, Chavan, Shweta S., Farillas, Abigail, Holland, Aliya, Sridhar, Harsha, Ciampricotti, Metamia, Hirschhorn, Daniel, Guan, Xiangnan, Richards, Allison L., Heller, Glenn, Mansilla-Soto, Jorge, Sadelain, Michel, Klebanoff, Christopher A., Hellmann, Matthew D., Sen, Triparna, de Stanchina, Elisa, Wolchok, Jedd D., Merghoub, Taha, Rudin, Charles M.

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Multiomic Analysis of Lung Tumors Defines Pathways Activated in Neuroendocrine Transformation von Quintanal-Villalonga, Alvaro, Taniguchi, Hirokazu, Zhan, Yingqian A., Hasan, Maysun M., Chavan, Shweta S., Meng, Fanli, Uddin, Fathema, Manoj, Parvathy, Donoghue, Mark T. A., Won, Helen H., Chan, Joseph M., Ciampricotti, Metamia, Chow, Andrew, Offin, Michael, Chang, Jason C., Ray-Kirton, Jordana, Tischfield, Sam E., Egger, Jacklynn, Bhanot, Umesh K., Linkov, Irina, Asher, Marina, Sinha, Sonali, Silber, Joachim, Iacobuzio-Donahue, Christine A., Roehrl, Michael H., Hollmann, Travis J., Yu, Helena A., Qiu, Juan, de Stanchina, Elisa, Baine, Marina K., Rekhtman, Natasha, Poirier, John T., Loomis, Brian, Koche, Richard P., Rudin, Charles M., Sen, Triparna

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Genomic and chromatin features shaping meiotic double-strand break formation and repair in mice von Yamada, Shintaro, Kim, Seoyoung, Tischfield, Sam E., Jasin, Maria, Lange, Julian, Keeney, Scott

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Developmental chromatin programs determine oncogenic competence in melanoma von Baggiolini, Arianna, Callahan, Scott J., Montal, Emily, Weiss, Joshua M., Trieu, Tuan, Tagore, Mohita M., Tischfield, Sam E., Walsh, Ryan M., Suresh, Shruthy, Fan, Yujie, Campbell, Nathaniel R., Perlee, Sarah C., Saurat, Nathalie, Hunter, Miranda, Simon-Vermot, Theresa, Huang, Ting-Hsiang, Ma, Yilun, Hollmann, Travis, Tickoo, Satish K., Taylor, Barry S., Khurana, Ekta, Koche, Richard P., Studer, Lorenz, White, Richard M.

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Meiotic recombination initiation in and around retrotransposable elements in Saccharomyces cerevisiae von Sasaki, Mariko, Tischfield, Sam E, van Overbeek, Megan, Keeney, Scott

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Scale matters: The spatial correlation of yeast meiotic DNA breaks with histone H3 trimethylation is driven largely by independent colocalization at promoters von Tischfield, Sam E., Keeney, Scott

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Combination Therapy With MDM2 and MEK Inhibitors Is Effective in Patient-Derived Models of Lung Adenocarcinoma With Concurrent Oncogenic Drivers and MDM2 Amplification von Elkrief, Arielle, Odintsov, Igor, Markov, Vladimir, Caeser, Rebecca, Sobczuk, Pawel, Tischfield, Sam E., Bhanot, Umesh, Vanderbilt, Chad M., Cheng, Emily H., Drilon, Alexander, Riely, Gregory J., Lockwood, William W., de Stanchina, Elisa, Tirunagaru, Vijaya G., Doebele, Robert C., Quintanal-Villalonga, Álvaro, Rudin, Charles M., Somwar, Romel, Ladanyi, Marc

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Genomic and transcriptomic analysis of a diffuse pleural mesothelioma patient-derived xenograft library von Offin, Michael, Sauter, Jennifer L, Tischfield, Sam E, Egger, Jacklynn V, Chavan, Shweta, Shah, Nisargbhai S, Manoj, Parvathy, Ventura, Katia, Allaj, Viola, de Stanchina, Elisa, Travis, William, Ladanyi, Marc, Rimner, Andreas, Rusch, Valerie W, Adusumilli, Prasad S, Poirier, John T, Zauderer, Marjorie G, Rudin, Charles M, Sen, Triparna

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ATR inhibition activates cancer cell cGAS/STING-interferon signaling and promotes antitumor immunity in small-cell lung cancer von Taniguchi, Hirokazu, Chakraborty, Subhamoy, Takahashi, Nobuyuki, Banerjee, Avisek, Caeser, Rebecca, Zhan, Yingqian A, Tischfield, Sam E, Chow, Andrew, Nguyen, Evelyn M, Villalonga, Álvaro Quintanal, Manoj, Parvathy, Shah, Nisargbhai S, Rosario, Samantha, Hayatt, Omar, Qu, Rui, de Stanchina, Elisa, Chan, Joseph, Mukae, Hiroshi, Thomas, Anish, Rudin, Charles M, Sen, Triparna

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MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer von Caeser, Rebecca, Hulton, Christopher, Costa, Emily, Durani, Vidushi, Little, Megan, Chen, Xiaoping, Tischfield, Sam E., Asher, Marina, Kombak, Faruk Erdem, Chavan, Shweta S., Shah, Nisargbhai S., Ciampricotti, Metamia, de Stanchina, Elisa, Poirier, John T., Rudin, Charles M., Sen, Triparna

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Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies von Keating, Brendan J, Tischfield, Sam, Murray, Sarah S, Bhangale, Tushar, Price, Thomas S, Glessner, Joseph T, Galver, Luana, Barrett, Jeffrey C, Grant, Struan F A, Farlow, Deborah N, Chandrupatla, Hareesh R, Hansen, Mark, Ajmal, Saad, Papanicolaou, George J, Guo, Yiran, Li, Mingyao, Derohannessian, Stephanie, de Bakker, Paul I W, Bailey, Swneke D, Montpetit, Alexandre, Edmondson, Andrew C, Taylor, Kent, Gai, Xiaowu, Wang, Susanna S, Fornage, Myriam, Shaikh, Tamim, Groop, Leif, Boehnke, Michael, Hall, Alistair S, Hattersley, Andrew T, Frackelton, Edward, Patterson, Nick, Chiang, Charleston W K, Kim, Cecelia E, Fabsitz, Richard R, Ouwehand, Willem, Price, Alkes L, Munroe, Patricia, Caulfield, Mark, Drake, Thomas, Boerwinkle, Eric, Reich, David, Whitehead, A Stephen, Cappola, Thomas P, Samani, Nilesh J, Lusis, A Jake, Schadt, Eric, Wilson, James G, Koenig, Wolfgang, McCarthy, Mark I, Kathiresan, Sekar, Gabriel, Stacey B, Hakonarson, Hakon, Anand, Sonia S, Reilly, Muredach, Engert, James C, Nickerson, Deborah A, Rader, Daniel J, Hirschhorn, Joel N, Fitzgerald, Garret A

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Article MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer von Caeser, Rebecca, Hulton, Christopher, Costa, Emily, Durani, Vidushi, Little, Megan, Chen, Xiaoping, Tischfield, Sam E., Asher, Marina, Kombak, Faruk Erdem, Chavan, Shweta S., Shah, Nisargbhai S., Ciampricotti, Metamia, de Stanchina, Elisa, Poirier, John T., Rudin, Charles M., Sen, Triparna

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Meiotic Recombination Initiation in and around Retrotransposable Elements in Saccharomyces cerevisiae: e1003732 von Sasaki, Mariko, Tischfield, Sam E, Overbeek, Megan van, Keeney, Scott

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Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals von Guo, Yiran, Lanktree, Matthew B, Taylor, Kira C, Hakonarson, Hakon, Lange, Leslie A, Keating, Brendan J

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Multi-omic analysis of lung tumors defines pathways activated in neuroendocrine transformation von Quintanal-Villalonga, Alvaro, Taniguchi, Hirokazu, Zhan, Yingqian A., Hasan, Maysun M., Chavan, Shweta S., Meng, Fanli, Uddin, Fathema, Manoj, Parvathy, Donoghue, Mark T.A., Won, Helen H., Chan, Joseph M., Ciampricotti, Metamia, Chow, Andrew, Offin, Michael, Chang, Jason C., Ray-Kirton, Jordana, Tischfield, Sam E., Egger, Jacklynn, Bhanot, Umesh K., Linkov, Irina, Asher, Marina, Sinha, Sonali, Silber, Joachim, Iacobuzio-Donahue, Christine A., Roehrl, Michael H., Hollmann, Travis J., Yu, Helena A., Qiu, Juan, de Stanchina, Elisa, Baine, Marina K., Rekhtman, Natasha, Poirier, John T., Loomis, Brian, Koche, Richard P., Rudin, Charles M., Sen, Triparna

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Abstract 3858: Exploring Exportin-1 as a therapeutic vulnerability in squamous cell carcinoma von Durani, Vidushi, Caeser, Rebecca, Rudin, Charles M., Quintanal-Villalonga, Alvaro, Sridhar, Harsha, Manoj, Parvathy, Tischfield, Sam E., Asher, Marina, Bhanot, Umeshkumar, Egger, Jacklynn V., Socci, Nicholas D. Socci D., Shah, Nisargbhai S S., de Stanchina, Elisa, Rekhtman, Natasha

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