Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial von Aung, Kyaw L, Fischer, Sandra E, Denroche, Robert E, Jang, Gun-Ho, Dodd, Anna, Creighton, Sean, Southwood, Bernadette, Liang, Sheng-Ben, Chadwick, Dianne, Zhang, Amy, O'Kane, Grainne M, Albaba, Hamzeh, Moura, Shari, Grant, Robert C, Miller, Jessica K, Mbabaali, Faridah, Pasternack, Danielle, Lungu, Ilinca M, Bartlett, John M S, Ghai, Sangeet, Lemire, Mathieu, Holter, Spring, Connor, Ashton A, Moffitt, Richard A, Yeh, Jen Jen, Timms, Lee, Krzyzanowski, Paul M, Dhani, Neesha, Hedley, David, Notta, Faiyaz, Wilson, Julie M, Moore, Malcolm J, Gallinger, Steven, Knox, Jennifer J

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Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories von Taylor, Renea A., Fraser, Michael, Livingstone, Julie, Espiritu, Shadrielle Melijah G., Thorne, Heather, Huang, Vincent, Lo, Winnie, Shiah, Yu-Jia, Yamaguchi, Takafumi N., Sliwinski, Ania, Horsburgh, Sheri, Meng, Alice, Heisler, Lawrence E., Yu, Nancy, Yousif, Fouad, Papargiris, Melissa, Lawrence, Mitchell G., Timms, Lee, Murphy, Declan G., Frydenberg, Mark, Hopkins, Julia F., Bolton, Damien, Clouston, David, McPherson, John D., van der Kwast, Theodorus, Boutros, Paul C., Risbridger, Gail P., Bristow, Robert G.

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A Double-Sided Stator Type Axial Bearingless Motor Development for Total Artificial Heart von Kurita, Nobuyuki, Ishikawa, Takeo, Saito, Naoki, Masuzawa, Toru, Timms, Daniel Lee

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Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer‐associated variants von Peltekova, Vanya D., Lemire, Mathieu, Qazi, Aamer M., Zaidi, Syed H. E., Trinh, Quang M., Bielecki, Ryszard, Rogers, Marianne, Hodgson, Lyndsey, Wang, Mike, D'Souza, David J. A., Zandi, Sasan, Chong, Taryne, Kwan, Jennifer Y. Y., Kozak, Krystian, Borja, Richard, Timms, Lee, Rangrej, Jagadish, Volar, Milica, Chan‐Seng‐Yue, Michelle, Beck, Timothy, Ash, Colleen, Lee, Shawna, Wang, Jianxin, Boutros, Paul C., Stein, Lincoln D., Dick, John E., Gryfe, Robert, McPherson, John D., Zanke, Brent W., Pollett, Aaron, Gallinger, Steven, Hudson, Thomas J.

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Use of Sequenom sample ID Plus® SNP genotyping in identification of FFPE tumor samples von Miller, Jessica K, Buchner, Nicholas, Timms, Lee, Tam, Shirley, Luo, Xuemei, Brown, Andrew M K, Pasternack, Danielle, Bristow, Robert G, Fraser, Michael, Boutros, Paul C, McPherson, John D

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Prediction of acute myeloid leukaemia risk in healthy individuals von Abelson, Sagi, Collord, Grace, Ng, Stanley W. K., Weissbrod, Omer, Mendelson Cohen, Netta, Niemeyer, Elisabeth, Barda, Noam, Zuzarte, Philip C., Heisler, Lawrence, Sundaravadanam, Yogi, Luben, Robert, Hayat, Shabina, Wang, Ting Ting, Zhao, Zhen, Cirlan, Iulia, Pugh, Trevor J., Soave, David, Ng, Karen, Latimer, Calli, Hardy, Claire, Raine, Keiran, Jones, David, Hoult, Diana, Britten, Abigail, McPherson, John D., Johansson, Mattias, Mbabaali, Faridah, Eagles, Jenna, Miller, Jessica K., Pasternack, Danielle, Timms, Lee, Krzyzanowski, Paul, Awadalla, Philip, Costa, Rui, Segal, Eran, Bratman, Scott V., Beer, Philip, Behjati, Sam, Martincorena, Inigo, Wang, Jean C. Y., Bowles, Kristian M., Quirós, J. Ramón, Karakatsani, Anna, La Vecchia, Carlo, Trichopoulou, Antonia, Salamanca-Fernández, Elena, Huerta, José M., Barricarte, Aurelio, Travis, Ruth C., Tumino, Rosario, Masala, Giovanna, Boeing, Heiner, Panico, Salvatore, Kaaks, Rudolf, Krämer, Alwin, Sieri, Sabina, Riboli, Elio, Vineis, Paolo, Foll, Matthieu, McKay, James, Polidoro, Silvia, Sala, Núria, Khaw, Kay-Tee, Vermeulen, Roel, Campbell, Peter J., Papaemmanuil, Elli, Minden, Mark D., Tanay, Amos, Balicer, Ran D., Wareham, Nicholas J., Gerstung, Moritz, Dick, John E., Brennan, Paul, Vassiliou, George S., Shlush, Liran I.

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Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia von Shlush, Liran I., Zandi, Sasan, Mitchell, Amanda, Chen, Weihsu Claire, Brandwein, Joseph M., Gupta, Vikas, Kennedy, James A., Schimmer, Aaron D., Schuh, Andre C., Yee, Karen W., McLeod, Jessica L., Doedens, Monica, Medeiros, Jessie J. F., Marke, Rene, Kim, Hyeoung Joon, Lee, Kwon, McPherson, John D., Hudson, Thomas J., Pan-Leukemia Gene Panel Consortium, The HALT, Brown, Andrew M. K., Yousif, Fouad, Trinh, Quang M., Stein, Lincoln D., Minden, Mark D., Wang, Jean C. Y., Dick, John E.

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A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns von Notta, Faiyaz, Chan-Seng-Yue, Michelle, Lemire, Mathieu, Li, Yilong, Wilson, Gavin W., Connor, Ashton A., Denroche, Robert E., Liang, Sheng-Ben, Brown, Andrew M. K., Kim, Jaeseung C., Wang, Tao, Simpson, Jared T., Beck, Timothy, Borgida, Ayelet, Buchner, Nicholas, Chadwick, Dianne, Hafezi-Bakhtiari, Sara, Dick, John E., Heisler, Lawrence, Hollingsworth, Michael A., Ibrahimov, Emin, Jang, Gun Ho, Johns, Jeremy, Jorgensen, Lars G. T., Law, Calvin, Ludkovski, Olga, Lungu, Ilinca, Ng, Karen, Pasternack, Danielle, Petersen, Gloria M., Shlush, Liran I., Timms, Lee, Tsao, Ming-Sound, Wilson, Julie M., Yung, Christina K., Zogopoulos, George, Bartlett, John M. S., Alexandrov, Ludmil B., Real, Francisco X., Cleary, Sean P., Roehrl, Michael H., McPherson, John D., Stein, Lincoln D., Hudson, Thomas J., Campbell, Peter J., Gallinger, Steven

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Spatial genomic heterogeneity within localized, multifocal prostate cancer von Boutros, Paul C, Fraser, Michael, Harding, Nicholas J, de Borja, Richard, Trudel, Dominique, Lalonde, Emilie, Meng, Alice, Hennings-Yeomans, Pablo H, McPherson, Andrew, Sabelnykova, Veronica Y, Zia, Amin, Fox, Natalie S, Livingstone, Julie, Shiah, Yu-Jia, Wang, Jianxin, Beck, Timothy A, Have, Cherry L, Chong, Taryne, Sam, Michelle, Johns, Jeremy, Timms, Lee, Buchner, Nicholas, Wong, Ada, Watson, John D, Simmons, Trent T, P'ng, Christine, Zafarana, Gaetano, Nguyen, Francis, Luo, Xuemei, Chu, Kenneth C, Prokopec, Stephenie D, Sykes, Jenna, Dal Pra, Alan, Berlin, Alejandro, Brown, Andrew, Chan-Seng-Yue, Michelle A, Yousif, Fouad, Denroche, Robert E, Chong, Lauren C, Chen, Gregory M, Jung, Esther, Fung, Clement, Starmans, Maud H W, Chen, Hanbo, Govind, Shaylan K, Hawley, James, D'Costa, Alister, Pintilie, Melania, Waggott, Daryl, Hach, Faraz, Lambin, Philippe, Muthuswamy, Lakshmi B, Cooper, Colin, Eeles, Rosalind, Neal, David, Tetu, Bernard, Sahinalp, Cenk, Stein, Lincoln D, Fleshner, Neil, Shah, Sohrab P, Collins, Colin C, Hudson, Thomas J, McPherson, John D, van der Kwast, Theodorus, Bristow, Robert G

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Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival von Zaidi, Syed H., Harrison, Tabitha A., Phipps, Amanda I., Steinfelder, Robert, Trinh, Quang M., Qu, Conghui, Banbury, Barbara L., Georgeson, Peter, Grasso, Catherine S., Giannakis, Marios, Adams, Jeremy B., Alwers, Elizabeth, Amitay, Efrat L., Barfield, Richard T., Berndt, Sonja I., Borozan, Ivan, Brenner, Hermann, Brezina, Stefanie, Buchanan, Daniel D., Cao, Yin, Chan, Andrew T., Chang-Claude, Jenny, Connolly, Charles M., Drew, David A., Farris, Alton Brad, Figueiredo, Jane C., French, Amy J., Fuchs, Charles S., Garraway, Levi A., Gruber, Steve, Guinter, Mark A., Hamilton, Stanley R., Harlid, Sophia, Heisler, Lawrence E., Hidaka, Akihisa, Hopper, John L., Huang, Wen-Yi, Huyghe, Jeroen R., Jenkins, Mark A., Krzyzanowski, Paul M., Lemire, Mathieu, Lin, Yi, Luo, Xuemei, Mardis, Elaine R., McPherson, John D., Miller, Jessica K., Moreno, Victor, Mu, Xinmeng Jasmine, Nishihara, Reiko, Papadopoulos, Nickolas, Pasternack, Danielle, Quist, Michael J., Rafikova, Adilya, Reid, Emma E. G., Shinbrot, Eve, Shirts, Brian H., Stein, Lincoln D., Teney, Cherie D., Timms, Lee, Um, Caroline Y., Van Guelpen, Bethany, Van Tassel, Megan, Wang, Xiaolong, Wheeler, David A., Yung, Christina K., Hsu, Li, Ogino, Shuji, Gsur, Andrea, Newcomb, Polly A., Gallinger, Steven, Hoffmeister, Michael, Campbell, Peter T., Thibodeau, Stephen N., Sun, Wei, Hudson, Thomas J., Peters, Ulrike

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Genome-wide germline correlates of the epigenetic landscape of prostate cancer von Houlahan, Kathleen E., Shiah, Yu-Jia, Gusev, Alexander, Yuan, Jiapei, Ahmed, Musaddeque, Shetty, Anamay, Ramanand, Susmita G., Yao, Cindy Q., Bell, Connor, O’Connor, Edward, Huang, Vincent, Fraser, Michael, Heisler, Lawrence E., Livingstone, Julie, Yamaguchi, Takafumi N., Rouette, Alexandre, Foucal, Adrien, Espiritu, Shadrielle Melijah G., Sinha, Ankit, Sam, Michelle, Timms, Lee, Johns, Jeremy, Wong, Ada, Murison, Alex, Orain, Michèle, Picard, Valérie, Hovington, Hélène, Bergeron, Alain, Lacombe, Louis, Lupien, Mathieu, Fradet, Yves, Têtu, Bernard, McPherson, John D., Pasaniuc, Bogdan, Kislinger, Thomas, Chua, Melvin L. K., Pomerantz, Mark M., van der Kwast, Theodorus, Freedman, Matthew L., Mani, Ram S., He, Housheng H., Bristow, Robert G., Boutros, Paul C.

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Development and Manufacture of a Curtius Rearrangement Using Continuous Flow towards the Large-Scale Manufacture of AZD7648 von Mallia, Carl J., McCreanor, Niall G., Legg, Daniel H., Stewart, Craig R., Coppock, Sarah, Ashworth, Ian W., Le Bars, Joël, Clarke, Adam, Clemens, Graeme, Fisk, Heidi, Benson, Helen, Oke, Samantha, Churchill, Trevor, Hoyle, Mark, Timms, Lee, Vare, Kevin, Sims, Martin, Knight, Steven

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Hypoxia-inducible factor expression in human RPE cells von Forooghian, Farzin, Razavi, Rozita, Timms, Lee

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Expedited Kilolab Development of AZD7624 Using Kulinkovich-de Meijere Cyclopropanation von Ashok, Mithun, J, Ashwini D., Leuser, Helena, Malapati, Ajaya K., Parker, Jeremy S., Rowley, Naomi A., Steven, Alan, Timms, Lee, Tyler, Simon N. G., Whitmarsh, Samuel

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Targeted sequencing in a phase III trial of luminal breast cancer: Identification of novel targets von Bartlett, John, Kalatskaya, Irina, Yousif, Fouad, Bayani, Jane, Trinh, Quang M, Heisler, Lawrence, Timms, Lee, Lee, Shawna, Buchner, Nicholas, Milacic, Marija, Rothfels, Karen, Crozier, Cheryl, Drake, Camilla, Hasenburg, Annette, Kieback, Dirk G, Rea, Daniel, McPherson, John, Boutros, Paul Christopher, Stein, Lincoln D

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Prospective genomic/transcriptomic profiling of advanced pancreatic ductal adenocarcinoma (PDAC) for personalized therapy: Feasibility and preliminary results from the COMPASS stud... von Aung, Kyaw Lwin, Fischer, Sandra, Denroche, Rob, Jang, Gun Ho, Dodd, Anna, Creighton, Sean, Chadwick, Dianne, Timms, Lee, O'Kane, Grainne M., Albaba, Hamzeh, Southwood, Bernadette M., Ghai, Sangeet, Moore, Malcolm J., Miller, Jessica, Notta, Faiyaz, Wilson, Julie, Hedley, David W., Dhani, Neesha C., Gallinger, Steven, Knox, Jennifer J.

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Abstract 1286: Targeted deep sequencing of colorectal tumor tissues to study associations of tumor subtypes with germline genetic, lifestyle, and environmental risk factors von Zaidi, Syed H., Sun, Wei, Huyghe, Jeroen, Grasso, Catherine S., Trinh, Quang, Connolly, Charles, French, Amy, Mu, Jasmine, Giannakis, Marios, Shinbrot, Eve, Borozan, Ivan, Quist, Michael J., Brenner, Hermann, Buchanan, Daniel, Campbell, Peter, Chan, Andrew, Chang-Claude, Jenny, Ferretti, Vincent, Fuchs, Charles, Gsur, Andrea, Gunter, Marc, Harrison, Tabitha, Hoffmeister, Michael, Huang, Wen-Yi, Krzyzanowski, Paul, Lee, Stephen, Lemire, Mathieu, Miller, Jessica, Pasternack, Danielle, Teney, Cherie, Mardis, Elaine, Newcomb, Polly, Stein, Lincoln, Timms, Lee, Wheeler, David, Yung, Christina, Zubair, Niha, Garraway, Levi, Ogino, Shuji, Hsu, Li, Gallinger, Steven, Thibodeau, Stephen, Hudson, Thomas, Peters, Ulrike

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Prediction of acute myeloid leukaemia risk in healthy individuals von Abelson, Sagi, Collord, Grace, Ng, Stanley W K, Weissbrod, Omer, Mendelson Cohen, Netta, Niemeyer, Elisabeth, Barda, Noam, Zuzarte, Philip C, Heisler, Lawrence, Sundaravadanam, Yogi, Luben, Robert, Hayat, Shabina, Wang, Ting Ting, Zhao, Zhen, Cirlan, Iulia, Pugh, Trevor J, Soave, David, Ng, Karen, Latimer, Calli, Hardy, Claire, Raine, Keiran, Jones, David, Hoult, Diana, Britten, Abigail, McPherson, John D, Johansson, Mattias, Mbabaali, Faridah, Eagles, Jenna, Miller, Jessica K, Pasternack, Danielle, Timms, Lee, Krzyzanowski, Paul, Awadalla, Philip, Costa, Rui, Segal, Eran, Bratman, Scott V, Beer, Philip, Behjati, Sam, Martincorena, Inigo, Wang, Jean C Y, Bowles, Kristian M, Quirós, J Ramón, Karakatsani, Anna, La Vecchia, Carlo, Trichopoulou, Antonia, Salamanca-Fernández, Elena, Huerta, José M, Barricarte, Aurelio, Travis, Ruth C, Tumino, Rosario, Masala, Giovanna, Boeing, Heiner, Panico, Salvatore, Kaaks, Rudolf, Krämer, Alwin, Sieri, Sabina, Riboli, Elio, Vineis, Paolo, Foll, Matthieu, McKay, James, Polidoro, Silvia, Sala, Núria, Khaw, Kay-Tee, Vermeulen, Roel, Campbell, Peter J, Papaemmanuil, Elli, Minden, Mark D, Tanay, Amos, Balicer, Ran D, Wareham, Nicholas J, Gerstung, Moritz, Dick, John E, Brennan, Paul, Vassiliou, George S, Shlush, Liran I

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Abstract 3124: Prognostic biomarkers for pancreatic cancer von Baciu, Cristina, Grant, Robert, He, Hansen, Ahmed, Musaddeque, Denroche, Robert E., Timms, Lee, Jang, Gun Ho, Borgida, Ayelet, Lin, Xihui, Boutros, Paul C., Chadwich, Dianne, Liang, Sheng-Ben, Shahabi, Sagedeh, Roehrl, Michael H.A., Cleary, Sean, Wilson, Julie M., McPherson, John D., Stein, Lincoln, Gallinger, Steven

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A cancer cell-line titration series for evaluating somatic classification von Denroche, Robert E, Mullen, Laura, Timms, Lee, Beck, Timothy, Yung, Christina K, Stein, Lincoln, McPherson, John D, Brown, Andrew M K

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