Cryo-electron microscopy structure of a human PRMT5:MEP50 complex von Timm, David E, Bowman, Valorie, Madsen, Russell, Rauch, Charles

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Reconstruction of 3D structures of MET antibodies from electron microscopy 2D class averages von Chen, Qi, Vieth, Michal, Timm, David E, Humblet, Christine, Schneidman-Duhovny, Dina, Chemmama, Ilan E, Sali, Andrej, Zeng, Wei, Lu, Jirong, Liu, Ling

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Merestinib (LY2801653) inhibits neurotrophic receptor kinase (NTRK) and suppresses growth of NTRK fusion bearing tumors von Konicek, Bruce W, Capen, Andrew R, Credille, Kelly M, Ebert, Philip J, Falcon, Beverly L, Heady, Gary L, Patel, Bharvin K R, Peek, Victoria L, Stephens, Jennifer R, Stewart, Julie A, Stout, Stephanie L, Timm, David E, Um, Suzane L, Willard, Melinda D, Wulur, Isabella H, Zeng, Yi, Wang, Yong, Walgren, Richard A, Betty Yan, Sau-Chi

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Preparation and biological evaluation of conformationally constrained BACE1 inhibitors von Winneroski, Leonard L., Schiffler, Matthew A., Erickson, Jon A., May, Patrick C., Monk, Scott A., Timm, David E., Audia, James E., Beck, James P., Boggs, Leonard N., Borders, Anthony R., Boyer, Robert D., Brier, Richard A., Hudziak, Kevin J., Klimkowski, Valentine J., Garcia Losada, Pablo, Mathes, Brian M., Stout, Stephanie L., Watson, Brian M., Mergott, Dustin J.

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Pyrithiamine as a Substrate for Thiamine Pyrophosphokinase von Liu, Jing-Yuan, Timm, David E., Hurley, Thomas D.

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Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor von May, Patrick C, Dean, Robert A, Lowe, Stephen L, Martenyi, Ferenc, Sheehan, Scott M, Boggs, Leonard N, Monk, Scott A, Mathes, Brian M, Mergott, Dustin J, Watson, Brian M, Stout, Stephanie L, Timm, David E, Smith Labell, Elizabeth, Gonzales, Celedon R, Nakano, Masako, Jhee, Stanford S, Yen, Mark, Ereshefsky, Larry, Lindstrom, Terry D, Calligaro, David O, Cocke, Patrick J, Greg Hall, D, Friedrich, Stuart, Citron, Martin, Audia, James E

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Discovery of a First-in-Class Inhibitor of the PRMT5–Substrate Adaptor Interaction von McKinney, David C, McMillan, Brian J, Ranaghan, Matthew J, Moroco, Jamie A, Brousseau, Merissa, Mullin-Bernstein, Zachary, O’Keefe, Meghan, McCarren, Patrick, Mesleh, Michael F, Mulvaney, Kathleen M, Robinson, Foxy, Singh, Ritu, Bajrami, Besnik, Wagner, Florence F, Hilgraf, Robert, Drysdale, Martin J, Campbell, Arthur J, Skepner, Adam, Timm, David E, Porter, Dale, Kaushik, Virendar K, Sellers, William R, Ianari, Alessandra

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The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans von May, Patrick C, Willis, Brian A, Lowe, Stephen L, Dean, Robert A, Monk, Scott A, Cocke, Patrick J, Audia, James E, Boggs, Leonard N, Borders, Anthony R, Brier, Richard A, Calligaro, David O, Day, Theresa A, Ereshefsky, Larry, Erickson, Jon A, Gevorkyan, Hykop, Gonzales, Celedon R, James, Douglas E, Jhee, Stanford S, Komjathy, Steven F, Li, Linglin, Lindstrom, Terry D, Mathes, Brian M, Martényi, Ferenc, Sheehan, Scott M, Stout, Stephanie L, Timm, David E, Vaught, Grant M, Watson, Brian M, Winneroski, Leonard L, Yang, Zhixiang, Mergott, Dustin J

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Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor von McKinzie, David L, Winneroski, Leonard L, Green, Steven J, Hembre, Erik J, Erickson, Jon A, Willis, Brian A, Monk, Scott A, Aluise, Christopher D, Baker, Thomas K, Lopez, Jose E, Hendle, Jörg, Beck, James P, Brier, Richard A, Boggs, Leonard N, Borders, Anthony R, Cocke, Patrick J, Garcia-Losada, Pablo, Lowe, Stephen L, Mathes, Brian M, May, Patrick C, Porter, Warren J, Stout, Stephanie L, Timm, David E, Watson, Brian M, Yang, Zhixiang, Mergott, Dustin J

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Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints von Winneroski, Leonard L., Erickson, Jon A., Green, Steven J., Lopez, Jose E., Stout, Stephanie L., Porter, Warren J., Timm, David E., Audia, James E., Barberis, Mario, Beck, James P., Boggs, Leonard N., Borders, Anthony R., Boyer, Robert D., Brier, Richard A., Hembre, Erik J., Hendle, Jörg, Garcia-Losada, Pablo, Minguez, Jose Miguel, Mathes, Brian M., May, Patrick C., Monk, Scott A., Rankovic, Zoran, Shi, Yuan, Watson, Brian M., Yang, Zhixiang, Mergott, Dustin J.

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Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation von Timm, David E, Benveniste, Morris, Weeks, Autumn M, Nisenbaum, Eric S, Partin, Kathryn M

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Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: kinetics, crystal structure and pharmacokinetics von Bateman, Raynard L, Ashworth, Justin, Witte, John F, Baker, L-J, Bhanumoorthy, Pullooru, Timm, David E, Hurley, Thomas D, Grompe, Markus, McClard, Ronald W

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Crystal structure of human homogentisate dioxygenase von Timm, David E, Titus, Greg P, Mueller, Heather A, Burgner, John, Rodríguez de Córdoba, Santiago, Peñalva, Miguel A

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Conformational stability of dimeric proteins: Quantitative studies by equilibrium denaturation von Neet, Kenneth E., Timm, David E.

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Structural basis of pheromone binding to mouse major urinary protein (MUP‐I) von Timm, David E., Baker, L.J., Mueller, Heather, Zidek, Lukas, Novotny, Milos V.

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ESR and X-ray Structure Investigations on the Binding and Mechanism of Inhibition of the Native State of Myeloperoxidase with Low Molecular Weight Fragments von Chavali, Balagopalakrishna, Masquelin, Thierry, Nilges, Mark J., Timm, David E., Stout, Stephanie L., Matter, William F., Jin, Najia, Jadhav, Prabhakar K., Deng, Gary G.

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Structural and functional analysis of mutations in alkaptonuria von RODRIGUEZ, José M, TIMM, David E, TITUS, Gregory P, BELTRAN-VALERO DE BERNABE, D, CRIADO, O, MUELLER, Heather A, RODRIGUEZ DE CORDOBA, S, PENALVA, M. A

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Asymmetries in the nucleosome core particle at 2.5 Å resolution von Harp, Joel M., Hanson, B. Leif, Timm, David E., Bunick, Gerard J.

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Crystal structure and mechanism of a carbon–carbon bond hydrolase von Timm, David E, Mueller, Heather A, Bhanumoorthy, P, Harp, Joel M, Bunick, Gerard J

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Structural and Functional Analysis of Missense Mutations in Fumarylacetoacetate Hydrolase, the Gene Deficient in Hereditary Tyrosinemia Type 1 von Bergeron, Anne, D'Astous, Myreille, Timm, David E., Tanguay, Robert M.

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