SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage von Clifford, Ruth, Louis, Tania, Robbe, Pauline, Ackroyd, Sam, Burns, Adam, Timbs, Adele T., Wright Colopy, Glen, Dreau, Helene, Sigaux, Francois, Judde, Jean Gabriel, Rotger, Margalida, Telenti, Amalio, Lin, Yea-Lih, Pasero, Philippe, Maelfait, Jonathan, Titsias, Michalis, Cohen, Dena R., Henderson, Shirley J., Ross, Mark T., Bentley, David, Hillmen, Peter, Pettitt, Andrew, Rehwinkel, Jan, Knight, Samantha J.L., Taylor, Jenny C., Crow, Yanick J., Benkirane, Monsef, Schuh, Anna

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Multiplex Ligation-Dependent Probe Amplification Identification of 17 Different β-Globin Gene Deletions (Including Four Novel Mutations) in the Uk Population von Gallienne, Alice E., Dréau, Hélène M., McCarthy, Janice, Timbs, Adele T., Hampson, Janet M., Schuh, Anna, Old, John M., Henderson, Shirley J.

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Towards Response Prediction Using Integrated Genomics in Chronic Lymphocytic Leukaemia: Results on 250 First-Line FCR Treated Patients from UK Clinical Trials von Clifford, Ruth M, Robbe, Pauline, Weller, Susanne, Timbs, Adele T, Titsias, Michalis, Burns, Adam, Cabes, Maite, Alsolami, Reem, Yau, Christopher, Hamblin, Angela, Mason, Joanne, Oates, Melanie, Pettitt, Andrew, Holmes, Chris, Hillmen, Peter, Taylor, Jenny, Knight, Samantha JL, Schuh, Anna

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The Identification of Further Minimal Regions of Overlap in Chronic Lymphocytic Leukemia Using High-Resolution SNP Arrays von Knight, Samantha JL, Clifford, Ruth, Robbe, Pauline, Ramos, Sara DC, Burns, Adam, Timbs, Adele T, Alsolami, Reem, Weller, Susanne, Hamblin, Angela, Mason, Joanne, Oates, Melanie, Titsias, Michalis, Yau, Christopher, Holmes, Chris C, Pettitt, Andrew R, Hillmen, Peter, Taylor, Jenny, Shuh, Anna

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Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns von Schuh, Anna, Becq, Jennifer, Humphray, Sean, Alexa, Adrian, Burns, Adam, Clifford, Ruth, Feller, Stephan M., Grocock, Russell, Henderson, Shirley, Khrebtukova, Irina, Kingsbury, Zoya, Luo, Shujun, McBride, David, Murray, Lisa, Menju, Toshi, Timbs, Adele, Ross, Mark, Taylor, Jenny, Bentley, David

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The Light Chain IgLV3-21 Defines a New Poor Prognostic Subgroup in Chronic Lymphocytic Leukemia: Results of a Multicenter Study von Stamatopoulos, Basile, Smith, Thomas, Crompot, Emerence, Pieters, Karlien, Clifford, Ruth, Mraz, Marek, Robbe, Pauline, Burns, Adam, Timbs, Adele, Bruce, David, Hillmen, Peter, Meuleman, Nathalie, Mineur, Philippe, Firescu, Radu, Maerevoet, Marie, De Wilde, Virginie, Efira, André, Philippé, Jan, Verhasselt, Bruno, Offner, Fritz, Sims, David, Heger, Andreas, Dreau, Hélène, Schuh, Anna

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Mutational analysis of disease relapse in patients allografted for acute myeloid leukemia von Quek, Lynn, Ferguson, Paul, Metzner, Marlen, Ahmed, Ikhlaaq, Kennedy, Alison, Garnett, Catherine, Jeffries, Sally, Walter, Claudia, Piechocki, Kim, Timbs, Adele, Danby, Robert, Raghavan, Manoj, Peniket, Andrew, Griffiths, Mike, Bacon, Andrew, Ward, Janice, Wheatley, Keith, Vyas, Paresh, Craddock, Charles

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Presence of multiple recurrent mutations confers poor trial outcome of relapsed/refractory CLL von Guièze, Romain, Robbe, Pauline, Clifford, Ruth, de Guibert, Sophie, Pereira, Bruno, Timbs, Adele, Dilhuydy, Marie-Sarah, Cabes, Maite, Ysebaert, Loïc, Burns, Adam, Nguyen-Khac, Florence, Davi, Frédéric, Véronèse, Lauren, Combes, Patricia, Le Garff-Tavernier, Magali, Leblond, Véronique, Merle-Béral, Hélène, Alsolami, Reem, Hamblin, Angela, Mason, Joanne, Pettitt, Andrew, Hillmen, Peter, Taylor, Jenny, Knight, SamanthaJ.L., Tournilhac, Olivier, Schuh, Anna

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Detection of Clinically Relevant Molecular Alterations in Chronic Lymphocytic Leukemia (CLL) By Nanopore Sequencing von Burns, Adam, Bruce, David Robert, Robbe, Pauline, Timbs, Adele, Stamatopoulos, Basile, Clifford, Ruth, Lopopolo, Maria, Parkes, Duncan, Ridout, Kate E, Schuh, Anna

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Clinical‐grade validation of whole genome sequencing reveals robust detection of low‐frequency variants and copy number alterations in CLL von Klintman, Jenny, Barmpouti, Katerina, Knight, Samantha J. L., Robbe, Pauline, Dreau, Hélène, Clifford, Ruth, Ridout, Kate, Burns, Adam, Timbs, Adele, Bruce, David, Antoniou, Pavlos, Sosinsky, Alona, Becq, Jennifer, Bentley, David, Hillmen, Peter, Taylor, Jenny C., Caulfield, Mark, Schuh, Anna H.

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Next-Generation Deep Sequencing Reveals Multiple Ighv Clones in One Third of CLL Patients Defining New Prognostic Subgroups and Improving Previous Classification von Stamatopoulos, Basile, Timbs, Adele, Dreau, Hélène, Clifford, Ruth, Robbe, Pauline, Burns, Adam, Mason, Joanne, Schuh, Anna

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Application of Genomics to Clinical Practice in Haematological Malignancy von Veenstra, Coen, Bruce, David, Timbs, Adele, Hamblin, Angela

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New Challenges in Diagnosis of Haemoglobinopathies: Migration of Populations von Old, John, Timbs, Adele, McCarthy, Janice, Gallienne, Alice, Proven, Melanie, Rugless, Michelle, Lopez, Herminio, Eglinton, Jennifer, Dziedzic, Dariusz, Beardsall, Matthew, Khalila, Mohamed S.M., Henderson, Shirley

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Incidence of haemoglobinopathies in various populations — The impact of immigration von Henderson, Shirley, Timbs, Adele, McCarthy, Janice, Gallienne, Alice, Van Mourik, Margaretha, Masters, Gillian, May, Alison, Khalil, Mohamed S.M., Schuh, Anna, Old, John

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Development and Evaluation of the Clinical Utility of a Next Generation Sequencing (NGS) Tool for Myeloid Disorders von Hamblin, Angela, Burns, Adam, Tham, Christopher, Clifford, Ruth, Robbe, Pauline, Timbs, Adele, Mason, Joanne, Dreau, Helene, Weller, Andreas, Jithesh, Puthen, Fox, Olivia, Tabiner, Melody, Mead, Adam, Peniket, Andrew, Vyas, Paresh, Henderson, Shirley, Schuh, Anna

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Screening for clinically significant non-deletional alpha thalassaemia mutations by pyrosequencing von Haywood, Anna, Dreau, Helene, Timbs, Adele, Schuh, Anna, Old, John, Henderson, Shirley

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Mutational Landscape of 118 Relapsed Chronic Lymphocytic Leukemia Clinical Trial Samples; Evidence for a Multiple-Hit Profile Using Targeted Next Generation Sequencing von Robbe, Pauline, Guièze, Romain, Clifford, Ruth M, de Guibert, Sophie, Timbs, Adele, Dilhuydy, Marie-Sarah, Cabes, Maite, Ysebaert, Loic, Burns, Adam, Nguyen-Khac, Florence, Davi, Frederic, Veronese, Lauren, Combes, Patricia, Le Garff-Tavernier, Magali, Leblond, Veronique, Merle-Béral, Hélène, Alsolami, Reem, Weller, Susanne, Hamblin, Angela, Mason, Joanne, Pettitt, Andrew R, Hillmen, Peter, Taylor, Jenny, Knight, Samantha JL, Schuh, Anna, Tournilhac, Olivier

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SAMHD1, A Putative Tumour Suppressor, Is Recurrently Mutated in Chronic Lymphocytic Leukaemia, and Is Associated with Poor Risk Features von Clifford, Ruth, Ackroyd, Sam, Burns, Adam, Timbs, Adele, Maelfait, Jonathan, Dreau, Helene, Henderson, Shirley, Ross, Mark, Bentley, David, Hillmen, Peter, Knight, Samantha, Taylor, Jenny, Hatton, Chris S.R, Rehwinkel, Jan, Crow, Yanick, Schuh, Anna

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Quantitative Whole Genome Analysis of Sequential Samples From Patients with B-CLL Identifies Novel Recurrent Copy Number Alterations Involving Critical B-Cell Transcription Factors von Timbs, Adele, Knight, Sam, SadighiAkha, Elham, Burns, Adam, Dreau, Helene, Hewitt, Anne-Marie, Hatton, Chris, Yau, Chris, Holmes, Chris, Taylor, Jenny, Schuh, Anna

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Identification of Novel Recurrent Copy Number Variations and Regions of Copy-Neutral Loss of Heterozygosity by High Resolution Genomic Array in Pre-Treatment and Relapsed B-CLL von Knight, Samantha JL, Sadighi Akha, Elham, Timbs, Adele, Enver, Tariq, Pettitt, Andrew R, Taylor, Jenny, Hatton, Chris S, Schuh, Anna

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