Functionalized Organozinc Reagents in Medicinal Chemistry: Discovery of Novel Drug Candidates von Sidduri, Achyutharao, Tilley, Jefferson W., Fotouhi, Nader

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Potent MCH-1 receptor antagonists from cis-1,4-diaminocyclohexane-derived indane analogs von Qian, Yimin, Conde-Knape, Karin, Erickson, Shawn D., Falcioni, Fiorenza, Gillespie, Paul, Hakimi, Irina, Mennona, Francis, Ren, Yonglin, Salari, Hamid, So, Sung-Sau, Tilley, Jefferson W.

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Very late antigen-4 integrin antagonists von Tilley, Jefferson W

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Glucokinase activators as new type 2 diabetes therapeutic agents von Sarabu, Ramakanth, Berthel, Steven J, Kester, Robert F, Tilley, Jefferson W

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Identification of N-acyl 4-(5-pyrimidine-2,4-dionyl)phenylalanine derivatives and their orally active prodrug esters as dual-acting alpha4–beta1 and alpha4–beta7 receptor antagonis... von Sidduri, Achyutharao, Tilley, Jefferson W., Lou, Jianping, Tare, Nadine, Cavallo, Gary, Frank, Karl, Pamidimukkala, Anjula, Choi, Duk Soon, Gerber, Louise, Railkar, Aruna, Renzetti, Louis

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Glucokinase activators: Novo Nordisk's WO2008084044 and Array Biopharma's WO2008091770 von Tilley, Jefferson W

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Identification of N-acyl 4-(3-pyridonyl)phenylalanine derivatives and their orally active prodrug esters as dual acting α4β1 and α4β7 receptor antagonists von Tilley, Jefferson W., Sidduri, Achyutharao, Lou, Jianping, Kaplan, Gerry, Tare, Nadine, Cavallo, Gary, Frank, Karl, Pamidimukkala, Anjula, Choi, Duk Soon, Gerber, Louise, Railkar, Aruna, Renzetti, Louis

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Discovery of camphor-derived pyrazolones as 11β-hydroxysteroid dehydrogenase type 1 inhibitors von Gillespie, Paul, Pietranico-Cole, Sherrie, Myers, Michael, Bilotta, Joseph A., Conde-Knape, Karin, Fotouhi, Nader, Goodnow, Robert A., Guertin, Kevin R., Hamilton, Matthew M., Haynes, Nancy-Ellen, Liu, Baolian, Qi, Lida, Ren, Yonglin, Scott, Nathan R., So, Sung-Sau, Spence, Cheryl, Taub, Rebecca, Thakkar, Kshitij, Tilley, Jefferson W., Zwingelstein, Catherine

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VLA-4 antagonists von Tilley, Jefferson W

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Discovery of 2‑[3,5-Dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thy... von Kelly, Martha J, Pietranico-Cole, Sherrie, Larigan, J. Douglas, Haynes, Nancy-Ellen, Reynolds, Charles H, Scott, Nathan, Vermeulen, John, Dvorozniak, Mark, Conde-Knape, Karin, Huang, Kuo-Sen, So, Sung-Sau, Thakkar, Kshitij, Qian, Yimin, Banner, Bruce, Mennona, Frank, Danzi, Sara, Klein, Irwin, Taub, Rebecca, Tilley, Jefferson

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Potent, selective MCH-1 receptor antagonists von Erickson, Shawn D., Banner, Bruce, Berthel, Steven, Conde-Knape, Karin, Falcioni, Fiorenza, Hakimi, Irina, Hennessy, Bernard, Kester, Robert F., Kim, Kyungjin, Ma, Chun, McComas, Warren, Mennona, Francis, Mischke, Steven, Orzechowski, Lucy, Qian, Yimin, Salari, Hamid, Tengi, John, Thakkar, Kshitij, Taub, Rebecca, Tilley, Jefferson W., Wang, Hong

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Identification of a Small Molecule Inhibitor of the IL-2/IL-2Rα Receptor Interaction Which Binds to IL-2 von Tilley, Jefferson W, Chen, Li, Fry, David C, Emerson, S. Donald, Powers, Gordon D, Biondi, Denise, Varnell, Tracey, Trilles, Richard, Guthrie, Robert, Mennona, Francis, Kaplan, Gerry, LeMahieu, Ronald A, Carson, Mathew, Han, Ru-Jen, Liu, C.-M, Palermo, Robert, Ju, Grace

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Metabolic/endocrine system von Sarabu, Ramakanth, Tilley, Jefferson W

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Imide and lactam derivatives of N-benzylpyroglutamyl- l-phenylalanine as VCAM/VLA-4 antagonists von Tilley, Jefferson W, Kaplan, Gerry, Rowan, Karen, Schwinge, Virginia, Wolitzky, Barry

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The design and synthesis of potent cyclic peptide VCAM-VLA-4 antagonists incorporating an achiral Asp-Pro mimetic von FOTOUHI, N, JOSHI, P, FRY, D, COOK, C, TILLEY, J. W, KAPLAN, G, HANGLOW, A, ROWAN, K, SCHWINGE, V, WOLITZKY, B

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Abstract 2643: Design and discovery of novel oral INV-88 macrophage migration inhibitory factor (MIF) inhibitors: Potent anti-tumor activity in vitro and in vivo von Gaweco, Anderson, Chung, Vincent, Tilley, Jefferson, Windsor, William, Stouch, Terry, Ellingboe, John, Crichlow, Gregg, Sabanas, Philipp, Sebesta, Christian

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Focused library approach for identification of new N-acylphenylalanines as VCAM/VLA-4 antagonists von Chen, Li, Trilles, Richard, Miklowski, Dorota, Huang, Tai-Nan, Fry, David, Campbell, Robert, Rowan, Karen, Schwinge, Virginia, Tilley, Jefferson W.

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N-Aroyl- l-Phenylalanine Derivatives as VCAM/VLA-4 Antagonists von Sidduri, Achyutharao, Tilley, Jefferson W., Lou, Jian Ping, Chen, Li, Kaplan, Gerry, Mennona, Frank, Campbell, Robert, Guthrie, Robert, Huang, Tai-Nan, Rowan, Karen, Schwinge, Virginia, Renzetti, Louis M.

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N-Benzylpyroglutamyl-L-phenylalanine derivatives as VCAM/VLA-4 antagonists von LI CHEN, TILLEY, J. W, WOLITZKY, B, ROWAN, K, GUTHRIE, R. W, MENNONA, F, HUANG, T.-N, KAPLAN, G, TRILLES, R, MIKLOWSKI, D, HUBY, N, SCHWINGE, V

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Synthesis of constrained l -phenylalanine derivatives incorporating a benzazepinone or an azepinone ring as VCAM/VLA-4 antagonists von Sidduri, Achyutharao, Lou, Jian Ping, Campbell, Robert, Rowan, Karen, Tilley, Jefferson W

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