A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours von Plummer, R, Wilson, R H, Calvert, H, Boddy, A V, Griffin, M, Sludden, J, Tilby, M J, Eatock, M, Pearson, D G, Ottley, C J, Matsumura, Y, Kataoka, K, Nishiya, T

Volltext

Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells von Roberts, D L, Williams, K J, Cowen, R L, Barathova, M, Eustace, A J, Brittain-Dissont, S, Tilby, M J, Pearson, D G, Ottley, C J, Stratford, I J, Dive, C

Volltext

Adaptive dosing and platinum–DNA adduct formation in children receiving high-dose carboplatin for the treatment of solid tumours von Veal, G J, Errington, J, Tilby, M J, Pearson, A D J, Foot, A B M, McDowell, H, Ellershaw, C, Pizer, B, Nowell, G M, Pearson, D G, Boddy, A V

Volltext

Decreased telomerase activity is not a reliable indicator of chemosensitivity in testicular cancer cell lines von Cressey, T.R, Tilby, M.J, Newell, D.R

Volltext

Mechanisms of action of, and modes of resistance to, alkylating agents used in the treatment of haematological malignancies von Hall, A.G., Tilby, M.J.

Volltext

Pharmacokinetics and metabolism of ifosfamide in relation to DNA damage assessed by the COMET assay in children with cancer von Willits, I, Price, L, Parry, A, Tilby, M J, Ford, D, Cholerton, S, Pearson, A D J, Boddy, A V

Volltext

Cisplatin pharmacokinetics in children with cancer von Peng, B., English, M.W., Boddy, A.V., Price, L., Wyllie, R., Pearson, A.D.J., Tilby, M.J., Newell, D.R.

Volltext

An investigation into the formation of N- [2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 6-[2-(dimethylamino)ethylamino]- 3-hydroxy-7H-indeno[2,1-C]quinolin-7-one dihydr... von Padget, Kay, Stewart, Alistair, Charlton, Peter, Tilby, Michael J, Austin, Caroline A

Volltext

Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin von Meczes, E L, Pearson, A D J, Austin, C A, Tilby, M J

Volltext

Pharmacokinetically guided dose escalation of carboplatin in epithelial ovarian cancer: Effect on drug-plasma AUC and peripheral blood drug-DNA adduct levels von Ghazal-Aswad, S., Tilby, M.J., Lind, M., Baily, N., Sinha, D. P., Calvert, A. H., Newell, D. R.

Volltext

Platinum-DNA adduct formation in leucocytes of children in relation to pharmacokinetics after cisplatin and carboplatin therapy von Peng, B, Tilby, MJ, English, MW, Price, L, Pearson, AD, Boddy, AV, Newell, DR

Volltext

Measurement of covalent drug-DNA interactions at the nucleotide level in cells at pharmacologically relevant doses von McGurk, Claire J, McHugh, Peter J, Tilby, Michael J, Grimaldi, Keith A, Hartley, John A

Volltext

Etoposide Targets Topoisomerase II alpha and II beta in Leukemic Cells: Isoform-Specific Cleavable Complexes Visualized and Quantified In Situ by a Novel Immunofluorescence Techniq... von Willmore, E, Frank, A J, Padget, K, Tilby, MJ, Austin, CA

Volltext

Detection and Quantification of Melphalan-DNA Adducts at the Single Cell Level in Hematopoietic Tumor Cells von Frank, Adrian J., Proctor, Stephen J., Tilby, Michael J.

Volltext

Influence of Cellular Factors and Pharmacokinetics on the Formation of Platinum-DNA Adducts in Leukocytes of Children Receiving Cisplatin Therapy von VEAL, Gareth J, DIAS, Cinara, PRICE, Lisa, PARRY, Annie, ERRINGTON, Julie, HALE, Juliet, PEARSON, Andrew D. J, BODDY, Alan V, NEWELL, David R, TILBY, Michael J

Volltext

Murine Transgenic Cells Lacking DNA Topoisomerase IIβ Are Resistant to Acridines and Mitoxantrone: Analysis of Cytotoxicity and Cleavable Complex Formation von Errington, F., Willmore, E., Tilby, M. J., Li, L., Li, G., Li, W., Baguley, B. C., Austin, C. A.

Volltext

Sensitive detection of DNA modifications induced by cisplatin and carboplatin in vitro and in vivo using a monoclonal antibody von TILBY, M. J, JOHNSON, C, KNOX, R. J, CORDELL, J, ROBERTS, J. J, DEAN, C. J

Volltext

LES FLEURS DU MAL IN LIMBO: THE NON-APPEARANCE OF LES LIMBES REVISITED von Tilby, M. J.

Volltext

A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia von Willmore, Elaine, de Caux, Sarah, Sunter, Nicola J., Tilby, Michael J., Jackson, Graham H., Austin, Caroline A., Durkacz, Barbara W.

Volltext

A monoclonal antibody that recognizes alkali-stabilized melphalan-DNA adducts and its application in immunofluorescence microscopy von Tilby, Michael J., McCartney, Hazel, Cordell, Jaqueline, Frank, Adrian, Dean, Christopher J.

Volltext