Structure-Assisted Design of Mechanism-Based Irreversible Inhibitors of Human Rhinovirus 3C Protease with Potent Antiviral Activity against Multiple Rhinovirus Serotypes von Matthews, D A, Dragovich, P S, Webber, S E, Fuhrman, S A, Patick, A K, Zalman, L S, Hendrickson, T F, Love, R A, Prins, T J, Marakovits, J T, Zhou, R, Tikhe, J, Ford, C E, Meador, J W, Ferre, R A, Brown, E L, Binford, S L, Brothers, M A, DeLisle, D M, Worland, S T

Volltext

Design, Synthesis, and Evaluation of 3,4-Dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as Inhibitors of Poly(ADP-Ribose) Polymerase von Tikhe, Jayashree G, Webber, Stephen E, Hostomsky, Zdenek, Maegley, Karen A, Ekkers, Anne, Li, Jianke, Yu, Xiao-Hong, Almassy, Robert J, Kumpf, Robert A, Boritzki, Theodore J, Zhang, Cathy, Calabrese, Chris R, Curtin, Nicola J, Kyle, Suzanne, Thomas, Huw D, Wang, Lan-Zhen, Calvert, A. Hilary, Golding, Bernard T, Griffin, Roger J, Newell, David R

Volltext

Structure-based design of irreversible, tripeptidyl human rhinovirus 3C protease inhibitors containing N-methyl amino acids von Dragovich, Peter S, Webber, Stephen E, Prins, Thomas J, Zhou, Ru, Marakovits, Joseph T, Tikhe, Jayashree G, Fuhrman, Shella A, Patick, Amy K, Matthews, David A, Ford, Clifford E, Brown, Edward L, Binford, Susan L, Meador, James W, Ferre, Rose Ann, Worland, Stephen T

Volltext

Design, Synthesis, and Evaluation of Nonpeptidic Inhibitors of Human Rhinovirus 3C Protease von Webber, Stephen E., Tikhe, Jayashree, Worland, Stephen T., Fuhrman, Shella A., Hendrickson, Thomas F., Matthews, David A., Love, Robert A., Patick, Amy K., Meador, James W., Ferre, Rose Ann, Brown, Edward L., DeLisle, Dorothy M., Ford, Clifford E., Binford, Susan L.

Volltext

Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 1. Michael Acceptor Structure−Activity Studies von Dragovich, Peter S, Webber, Stephen E, Babine, Robert E, Fuhrman, Shella A, Patick, Amy K, Matthews, David A, Lee, Caroline A, Reich, Siegfried H, Prins, Thomas J, Marakovits, Joseph T, Littlefield, Ethel S, Zhou, Ru, Tikhe, Jayashree, Ford, Clifford E, Wallace, Michael B, Meador, James W, Ferre, Rose Ann, Brown, Edward L, Binford, Susan L, Harr, James E. V, DeLisle, Dorothy M, Worland, Stephen T

Volltext

Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 2. Peptide Structure−Activity Studies von Dragovich, Peter S, Webber, Stephen E, Babine, Robert E, Fuhrman, Shella A, Patick, Amy K, Matthews, David A, Reich, Siegfried H, Marakovits, Joseph T, Prins, Thomas J, Zhou, Ru, Tikhe, Jayashree, Littlefield, Ethel S, Bleckman, Ted M, Wallace, Michael B, Little, Thomas L, Ford, Clifford E, Meador, James W, Ferre, Rose Ann, Brown, Edward L, Binford, Susan L, DeLisle, Dorothy M, Worland, Stephen T

Volltext

Phage Therapy for Mosquito Larval Control: a Proof-of-Principle Study von Tikhe, Chinmay V, Dimopoulos, George

Volltext

Pleiotropic Odorant-Binding Proteins Promote Aedes aegypti Reproduction and Flavivirus Transmission von Dong, Shengzhang, Ye, Zi, Tikhe, Chinmay Vijay, Tu, Zhijian Jake, Zwiebel, Laurence J, Dimopoulos, George

Volltext

ChemInform Abstract: Design, Synthesis, and Evaluation of Nonpeptidic Inhibitors of Human Rhinovirus 3C Protease von WEBBER, S. E., TIKHE, J., WORLAND, S. T., FUHRMAN, S. A., HENDRICKSON, T. F., MATTHEWS, D. A., LOVE, R. A., PATICK, A. K., MEADOR, J. W., FERRE, R. A., BROWN, E. L., DELISLE, D. M., FORD, C. E., BINFORD, S. L.

Volltext

Discovery of the c‑Jun N‑Terminal Kinase Inhibitor CC-90001 von Nagy, Mark A, Hilgraf, Robert, Mortensen, Deborah S, Elsner, Jan, Norris, Stephen, Tikhe, Jayashree, Yoon, Won, Paisner, David, Delgado, Mercedes, Erdman, Paul, Haelewyn, Jason, Khambatta, Godrej, Xu, Li, Romanow, William J, Condroski, Kevin, Bahmanyar, Sogole, McCarrick, Meg, Benish, Brent, Blease, Kate, LeBrun, Laurie, Moghaddam, Mehran F, Apuy, Julius, Canan, Stacie S, Bennett, Brydon L, Satoh, Yoshitaka

Volltext

Novel Tricyclic Poly(ADP-ribose) Polymerase-1 Inhibitors with Potent Anticancer Chemopotentiating Activity:  Design, Synthesis, and X-ray Cocrystal Structure von Canan Koch, Stacie S, Thoresen, Lars H, Tikhe, Jayashree G, Maegley, Karen A, Almassy, Robert J, Li, Jianke, Yu, Xiao-Hong, Zook, Scott E, Kumpf, Robert A, Zhang, Cathy, Boritzki, Theodore J, Mansour, Rena N, Zhang, Kanyin E, Ekker, Anne, Calabrese, Chris R, Curtin, Nicola J, Kyle, Suzanne, Thomas, Huw D, Wang, Lan-Zhen, Calvert, A. Hilary, Golding, Bernard T, Griffin, Roger J, Newell, David R, Webber, Stephen E, Hostomsky, Zdenek

Volltext

SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH von ROMANOW, William J, NAGY, Mark A, LEBRUN, Laurie Ann, DELGADO, Maria Mercedes, HILGRAF, Robert, ERDMAN, Paul, NORRIS, Stephen, YOON, Won Hyung, SLOSS, Marianne, BENNETT, Brydon, PAISNER, David A, SATOH, Yoshitaka, MCCARRICK, Meg, ELSNER, Jan, MOGHADDAM, Mehran, TIKHE, Jayashree

Volltext bestellen

Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith von Delgado, Mercedes, Sloss, Marianne, Norris, Stephen, Paisner, David A, Elsner, Jan, McCarrick, Meg, Satoh, Yoshitaka, Bennett, Brydon L, LeBrun, Laurie Ann, Moghaddam, Mehran F, Nagy, Mark A, Yoon, Won Hyung, Tikhe, Jayashree, Erdman, Paul, Romanow, William J, Hilgraf, Robert

Volltext bestellen

Design, Synthesis, and Evaluation of 3,4-Dihydro-2 H -[1,4]diazepino[6,7,1- hi ]indol-1-ones as Inhibitors of Poly(ADP-Ribose) Polymerase von Tikhe, Jayashree G., Webber, Stephen E., Hostomsky, Zdenek, Maegley, Karen A., Ekkers, Anne, Li, Jianke, Yu, Xiao-Hong, Almassy, Robert J., Kumpf, Robert A., Boritzki, Theodore J., Zhang, Cathy, Calabrese, Chris R., Curtin, Nicola J., Kyle, Suzanne, Thomas, Huw D., Wang, Lan-Zhen, Calvert, A. Hilary, Golding, Bernard T., Griffin, Roger J., Newell, David R.

Volltext

SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH von YOON, WON, HYUNG, TIKHE, JAYASHREE, DELGADO, MARIA MERCEDES, MOGHADDAM, MEHRAN, F, MCCARRICK, MEG, SATOH, YOSHITAKA, SLOSS, MARIANNE, ELSNER, JAN, HILGRAF, ROBERT, NAGY, MARK, A, NORRIS, STEPHEN, LEBRUN, LAURIE, ANN, PAISNER, DAVID, A, BENNETT, BRYDON, L, ERDMAN, PAUL, ROMANOW, WILLIAM, J

Volltext bestellen

SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH von Mccarrick, Meg, Delgado, Maria Mercedes, Lebrun, Laurie Ann, Sloss, Marianne, Norris, Stephen, Paisner, David A, Elsner, Jan, Satoh, Yoshitaka, Bennett, Brydon L, Moghaddam, Mehran F, Nagy, Mark A, Yoon, Won Hyung, Tikhe, Jayashree, Erdman, Paul, Romanow, William J, Hilgraf, Robert

Volltext bestellen

SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH von MOGHADDAM Mehran F, SLOSS Marianne, HILGRAF Robert, TIKHE Jayashree, MCCARRICK Meg, NORRIS Stephen, ELSNER Jan, ERDMAN Paul, YOON Won Hyung, LEBRUN Laurie Ann, DELGADO Maria Mercedes, NAGY Mark A, SATOH Yoshitaka, PAISNER David A, ROMANOW William J, BENNETT Brydon L

Volltext bestellen

SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH von PAISNER, DAVID A, ROMANOW, WILLIAM J, TIKHE, JAYASHREE, DELGADO, MARIA MERCEDES, LEBRUN, LAURIE ANN, MCCARRICK, MEG, SATOH, YOSHITAKA, BENNETT, BRYDON L, SLOSS, MARIANNE, NAGY, MARK A, ELSNER, JAN, HILGRAF, ROBERT, NORRIS, STEPHEN, YOON, WON HYUNG, ERDMAN, PAUL, MOGHADDAM, MEHRAN F

Volltext bestellen

SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH von ROMANOW, William J, NAGY, Mark A, BENNETT, Brydon L, LEBRUN, Laurie Ann, DELGADO, Maria Mercedes, HILGRAF, Robert, ERDMAN, Paul, NORRIS, Stephen, YOON, Won Hyung, SLOSS, Marianne, PAISNER, David A, SATOH, Yoshitaka, MOGHADDAM, Mehran F, MCCARRICK, Meg, ELSNER, Jan, TIKHE, Jayashree

Volltext bestellen

SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH von ROMANOW, William J, NAGY, Mark A, LEBRUN, Laurie Ann, DELGADO, Maria Mercedes, HILGRAF, Robert, ERDMAN, Paul, NORRIS, Stephen, YOON, Won Hyung, SLOSS, Marianne, BENNETT, Brydon, PAISNER, David A, SATOH, Yoshitaka, MCCARRICK, Meg, ELSNER, Jan, MOGHADDAM, Mehran, TIKHE, Jayashree

Volltext bestellen