The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies von Vangamudi, Bhavatarini, Paul, Thomas A, Shah, Parantu K, Kost-Alimova, Maria, Nottebaum, Lisa, Shi, Xi, Zhan, Yanai, Leo, Elisabetta, Mahadeshwar, Harshad S, Protopopov, Alexei, Futreal, Andrew, Tieu, Trang N, Peoples, Mike, Heffernan, Timothy P, Marszalek, Joseph R, Toniatti, Carlo, Petrocchi, Alessia, Verhelle, Dominique, Owen, Dafydd R, Draetta, Giulio, Jones, Philip, Palmer, Wylie S, Sharma, Shikhar, Andersen, Jannik N

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Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor von Palmer, Wylie S, Poncet-Montange, Guillaume, Liu, Gang, Petrocchi, Alessia, Reyna, Naphtali, Subramanian, Govindan, Theroff, Jay, Yau, Anne, Kost-Alimova, Maria, Bardenhagen, Jennifer P, Leo, Elisabetta, Shepard, Hannah E, Tieu, Trang N, Shi, Xi, Zhan, Yanai, Zhao, Shuping, Barton, Michelle C, Draetta, Giulio, Toniatti, Carlo, Jones, Philip, Geck Do, Mary, Andersen, Jannik N

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The Effect of Topoisomerase I Inhibitors on the Efficacy of T-Cell-Based Cancer Immunotherapy von McKenzie, Jodi A, Mbofung, Rina M, Malu, Shruti, Zhang, Min, Ashkin, Emily, Devi, Seram, Williams, Leila, Tieu, Trang, Peng, Weiyi, Pradeep, Sunila, Xu, Chunyu, Zorro Manrique, Soraya, Liu, Chengwen, Huang, Lu, Chen, Yuan, Forget, Marie-Andree, Haymaker, Cara, Bernatchez, Chantale, Satani, Nikunj, Muller, Florian, Roszik, Jason, Kalra, Ashish, Heffernan, Timothy, Sood, Anil, Hu, Jianhua, Amaria, Rodabe, Davis, R Eric, Hwu, Patrick

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HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes von Mbofung, Rina M., McKenzie, Jodi A., Malu, Shruti, Zhang, Min, Peng, Weiyi, Liu, Chengwen, Kuiatse, Isere, Tieu, Trang, Williams, Leila, Devi, Seram, Ashkin, Emily, Xu, Chunyu, Huang, Lu, Zhang, Minying, Talukder, Amjad H., Tripathi, Satyendra C., Khong, Hiep, Satani, Nikunj, Muller, Florian L., Roszik, Jason, Heffernan, Timothy, Allison, James P., Lizee, Gregory, Hanash, Sam M., Proia, David, Amaria, Rodabe, Davis, R. Eric, Hwu, Patrick

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The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression von Huang, Lu, Malu, Shruti, McKenzie, Jodi A, Andrews, Miles C, Talukder, Amjad H, Tieu, Trang, Karpinets, Tatiana, Haymaker, Cara, Forget, Marie-Andrée, Williams, Leila J, Wang, Zhe, Mbofung, Rina M, Wang, Zhi-Qiang, Davis, Richard Eric, Lo, Roger S, Wargo, Jennifer A, Davies, Michael A, Bernatchez, Chantale, Heffernan, Timothy, Amaria, Rodabe N, Korkut, Anil, Peng, Weiyi, Roszik, Jason, Lizée, Gregory, Woodman, Scott E, Hwu, Patrick

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Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity von Punt, Simone, Malu, Shruti, McKenzie, Jodi A., Manrique, Soraya Zorro, Doorduijn, Elien M., Mbofung, Rina M., Williams, Leila, Silverman, Deborah A., Ashkin, Emily L., Dominguez, Ana Lucía, Wang, Zhe, Chen, Jie Qing, Maiti, Sourindra N., Tieu, Trang N., Liu, Chengwen, Xu, Chunyu, Forget, Marie-Andrée, Haymaker, Cara, Khalili, Jahan S., Satani, Nikunj, Muller, Florian, Cooper, Laurence J. N., Overwijk, Willem W., Amaria, Rodabe N., Bernatchez, Chantale, Heffernan, Timothy P., Peng, Weiyi, Roszik, Jason, Hwu, Patrick

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Abstract 4002: Enhancing the antitumor efficacy of immunotherapy by using the topoisomerase I inhibitor MM398 von McKenzie, Jodi A., Mbofung, Rina M., Malu, Shruti, Amaria, Rodabe N., Davis, Richard E., Zhang, Li, Tieu, Trang N., Heffernan, Tim P., Hwu, Patrick

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Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery von Zhan, Yanai, Kost-Alimova, Maria, Shi, Xi, Leo, Elisabetta, Bardenhagen, Jennifer P, Shepard, Hannah E, Appikonda, Srikanth, Vangamudi, Bhavatarini, Zhao, Shuping, Tieu, Trang N, Jiang, Shiming, Heffernan, Timothy P, Marszalek, Joseph R, Toniatti, Carlo, Draetta, Giulio, Tyler, Jessica, Barton, Michelle, Jones, Philip, Palmer, Wylie S, Geck Do, Mary K, Andersen, Jannik N

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The impacts of consumer value and brand identification on brand loyalty and electronic word of mouth: the case of smartphone market in Ho Chi Minh City von Tran, The Nam, Tieu, Van Trang

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Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy von Peng, Weiyi, Chen, Jie Qing, Liu, Chengwen, Malu, Shruti, Creasy, Caitlin, Tetzlaff, Michael T, Xu, Chunyu, McKenzie, Jodi A, Zhang, Chunlei, Liang, Xiaoxuan, Williams, Leila J, Deng, Wanleng, Chen, Guo, Mbofung, Rina, Lazar, Alexander J, Torres-Cabala, Carlos A, Cooper, Zachary A, Chen, Pei-Ling, Tieu, Trang N, Spranger, Stefani, Yu, Xiaoxing, Bernatchez, Chantale, Forget, Marie-Andree, Haymaker, Cara, Amaria, Rodabe, McQuade, Jennifer L, Glitza, Isabella C, Cascone, Tina, Li, Haiyan S, Kwong, Lawrence N, Heffernan, Timothy P, Hu, Jianhua, Bassett, Jr, Roland L, Bosenberg, Marcus W, Woodman, Scott E, Overwijk, Willem W, Lizée, Gregory, Roszik, Jason, Gajewski, Thomas F, Wargo, Jennifer A, Gershenwald, Jeffrey E, Radvanyi, Laszlo, Davies, Michael A, Hwu, Patrick

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Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression von Wang, Guocan, Lu, Xin, Dey, Prasenjit, Deng, Pingna, Wu, Chia Chin, Jiang, Shan, Fang, Zhuangna, Zhao, Kun, Konaparthi, Ramakrishna, Hua, Sujun, Zhang, Jianhua, Li-Ning-Tapia, Elsa M, Kapoor, Avnish, Wu, Chang-Jiun, Patel, Neelay Bhaskar, Guo, Zhenglin, Ramamoorthy, Vandhana, Tieu, Trang N, Heffernan, Tim, Zhao, Di, Shang, Xiaoying, Khadka, Sunada, Hou, Pingping, Hu, Baoli, Jin, Eun-Jung, Yao, Wantong, Pan, Xiaolu, Ding, Zhihu, Shi, Yanxia, Li, Liren, Chang, Qing, Troncoso, Patricia, Logothetis, Christopher J, McArthur, Mark J, Chin, Lynda, Wang, Y Alan, DePinho, Ronald A

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Emotional exhaustion: How does it relate to work engagement? von Pham, The Nam Tran, Van Trang Tieu

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STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts von Buckbinder, Leonard, St Jean, Jr, David J, Tieu, Trang, Ladd, Brendon, Hilbert, Brendan, Wang, Weixue, Alltucker, Jacob T, Manimala, Samantha, Kryukov, Gregory V, Brooijmans, Natasja, Dowdell, Gregory, Jonsson, Philip, Huff, Michael, Guzman-Perez, Angel, Jackson, Erica L, Goncalves, Marcus D, Stuart, Darrin D

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Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation von Sun, Yuting, Bandi, Madhavi, Lofton, Timothy, Smith, Melinda, Bristow, Christopher A., Carugo, Alessandro, Rogers, Norma, Leonard, Paul, Chang, Qing, Mullinax, Robert, Han, Jing, Shi, Xi, Seth, Sahil, Meyers, Brooke A., Miller, Meredith, Miao, Lili, Ma, Xiaoyan, Feng, Ningping, Giuliani, Virginia, Geck Do, Mary, Czako, Barbara, Palmer, Wylie S., Mseeh, Faika, Asara, John M., Jiang, Yongying, Morlacchi, Pietro, Zhao, Shuping, Peoples, Michael, Tieu, Trang N., Warmoes, Marc O., Lorenzi, Philip L., Muller, Florian L., DePinho, Ronald A., Draetta, Giulio F., Toniatti, Carlo, Jones, Philip, Heffernan, Timothy P., Marszalek, Joseph R.

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Abstract P4-07-04: STX-478, a mutant-selective PI3Kα H1047X inhibitor clinical candidate with a best-in-class profile: Pharmacology and therapeutic activity as monotherapy and in c... von Buckbinder, Leonard, St. Jean, David J., Ladd, Brendon, Tieu, Trang, Jonsson, Philip, Alltucker, Jacob, Manimala, Samantha, Wang, Weixue, Guzman-Perez, Angel, Stuart, Darrin D., Dowdell, Gregory

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High-Throughput Quantitative Assay Technologies for Accelerating the Discovery and Optimization of Targeted Protein Degradation Therapeutics von Simard, Jeffrey R., Lee, Linda, Vieux, Ellen, Improgo, Reina, Tieu, Trang, Phillips, Andrew J., Fisher, Stewart L., Pollock, Roy M., Park, Eunice

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Abstract LB194: Discovery and characterization of a mutant selective PI3KαH1047Xinhibitor with a best-in-class profile von Buckbinder, Leonard, St. Jean, David J., Tieu, Trang, Wang, Weixue, Kryukov, Gregory, Jonsson, Philip, Alltucker, Jacob, Manimala, Samantha, Ladd, Brendon, Guzman-Perez, Angel, Stuart, Darrin

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The impacts of consumer value and brand identification on brand loyalty and electronic word of mouth: the case of smartphone market in Ho Chi Minh City von Tran The Nam, Tieu Van Trang

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Abstract 4360: Inhibition of HSP90 enhances T cell-mediated antitumor immune responses through expression of interferon-alpha response Genes von Mbofung, Rina M., McKenzie, Jodi A., Malu, Shruti, Liu, Chengwen, Williams, Leila, Peng, Weiyi, Wang, Zhe, Tripathi, Satyendra, Tieu, Trang, Zhao, Shuping, Devi, Seram, Kuiatse, Isere, Ashkin, Emily, Bailey, Leah, Roszik, Jason, Hanash, Samir, Heffernan, Timothy, Davis, Richard E., Amaria, Rodabe N., Hwu, Patrick

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Abstract 3528: The SMARCA2/4 catalytic activity, but not the bromodomain, is a drug target in SWI/SNF mutant cancers von Vangamudi, Bhavatarini, Paul, Thomas, Shah, Parantu K., Alimova, Maria K., Nottebaum, Lisa, Shi, Xi, Zhan, Yanai, Leo, Elisabetta, Mahadeshwar, Harshad S., Protopopov, Alexei, Futreal, Andrew, Tieu, Trang N., Peoples, Mike, Petrocchi, Alessia, Marszalek, Joseph R., Toniatti, Carlo, Heffernan, Timothy P., Verhelle, Dominique, Draetta, Giulio, Owen, Dafydd, Jones, Philip, Palmer, Wylie, Sharma, Shikhar, Andersen, Jannik N.

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