A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase von Jin, Da-Yun, Chen, Xuejie, Liu, Yizhou, Williams, Craig M., Pedersen, Lars C., Stafford, Darrel W., Tie, Jian-Ke

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Naturally occurring UBIAD1 mutations differentially affect menaquinone biosynthesis and vitamin K‐dependent carboxylation von Chen, Xuejie, Furukawa, Natsuko, Jin, Da‐Yun, Liu, Yizhou, Stafford, Darrel W., Williams, Craig M., Suhara, Yoshitomo, Tie, Jian‐Ke

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A novel vitamin K derived anticoagulant tolerant to genetic variations of vitamin K epoxide reductase von Chen, Xuejie, Liu, Yizhou, Furukawa, Natsuko, Jin, Da‐Yun, Paul Savage, G., Stafford, Darrel W., Suhara, Yoshitomo, Williams, Craig M., Tie, Jian‐Ke

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Warfarin and vitamin K epoxide reductase: a molecular accounting for observed inhibition von Wu, Sangwook, Chen, Xuejie, Jin, Da-Yun, Stafford, Darrel W., Pedersen, Lee G., Tie, Jian-Ke

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Vitamin K-dependent carboxylation of coagulation factors: insights from a cell-based functional study von Hao, Zhenyu, Jin, Da-Yun, Stafford, Darrel W., Tie, Jian-Ke

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Cyclooctatetraene: A Bioactive Cubane Paradigm Complement von Xing, Hui, Houston, Sevan D., Chen, Xuejie, Ghassabian, Sussan, Fahrenhorst‐Jones, Tyler, Kuo, Andy, Murray, Cody‐Ellen P., Conn, Kyna‐Anne, Jaeschke, Kara N., Jin, Da‐Yun, Pasay, Cielo, Bernhardt, Paul V., Burns, Jed M., Tsanaktsidis, John, Savage, G. Paul, Boyle, Glen M., De Voss, James J., McCarthy, James, Walter, Gimme H., Burne, Thomas H. J., Smith, Maree T., Tie, Jian‐Ke, Williams, Craig M.

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Functional study of the vitamin K cycle in mammalian cells von Tie, Jian-Ke, Jin, Da-Yun, Straight, David L., Stafford, Darrel W.

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Human Vitamin K Epoxide Reductase and Its Bacterial Homologue Have Different Membrane Topologies and Reaction Mechanisms von Tie, Jian-Ke, Jin, Da-Yun, Stafford, Darrel W.

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Vitamin K epoxide reductase and its paralogous enzyme have different structures and functions von Sinhadri, Balaji Chandra Sekhar, Jin, Da-Yun, Stafford, Darrel W., Tie, Jian-Ke

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The Conversion of Vitamin K Epoxide to Vitamin K Quinone and Vitamin K Quinone to Vitamin K Hydroquinone Uses the Same Active Site Cysteines von Jin, Da-Yun, Tie, Jian-Ke, Stafford, Darrel W

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γ-Glutamyl carboxylase mutations differentially affect the biological function of vitamin K–dependent proteins von Hao, Zhenyu, Jin, Da-Yun, Chen, Xuejie, Schurgers, Leon J., Stafford, Darrel W., Tie, Jian-Ke

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Evaluation of oral anticoagulants with vitamin K epoxide reductase in its native milieu von Chen, Xuejie, Jin, Da-Yun, Stafford, Darrel W., Tie, Jian-Ke

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Membrane Topology Mapping of Vitamin K Epoxide Reductase by in Vitro Translation/Cotranslocation von Tie, Jian-Ke, Nicchitta, Christopher, von Heijne, Gunnar, Stafford, Darrel W.

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Molecular basis of inherited protein C deficiency results from genetic variations in the signal peptide and propeptide regions von Cao, Qing, Hao, Zhenyu, Li, Cheng, Chen, Xuejie, Gao, Meng, Jiang, Nan, Liu, Hongli, Shen, Yan, Yang, Haiping, Zhang, Shujuan, Yang, Aiying, Li, Weikai, Tie, Jian-Ke, Shen, Guomin

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Characterization of vitamin K–dependent carboxylase mutations that cause bleeding and nonbleeding disorders von Tie, Jian-Ke, Carneiro, Jorge D.A., Jin, Da-Yun, Martinhago, Ciro D., Vermeer, Cees, Stafford, Darrel W.

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A cell-based high-throughput screen identifies drugs that cause bleeding disorders by off-targeting the vitamin K cycle von Chen, Xuejie, Li, Caihong, Jin, Da-Yun, Ingram, Brian, Hao, Zhenyu, Bai, Xue, Stafford, Darrel W., Hu, Keping, Tie, Jian-Ke

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Synthesis of new vitamin K derivatives with a ketone group at the C-1′ position of the side chain and their conversion to menaquinone-4 von Furukawa, Natsuko, Chen, Xuejie, Asano, Satoshi, Matsumoto, Marina, Wu, Yuxin, Murata, Kohei, Takeuchi, Atsuko, Tode, Chisato, Homma, Taiki, Koharazawa, Ryohto, Usami, Kouki, Tie, Jian-Ke, Hirota, Yoshihisa, Suhara, Yoshitomo

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Conserved Loop Cysteines of Vitamin K Epoxide Reductase Complex Subunit 1-like 1 (VKORC1L1) Are Involved in Its Active Site Regeneration von Tie, Jian-Ke, Jin, Da-Yun, Stafford, Darrel W.

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Determining the necessity of phenyl ring π-character in warfarin von Xing, Hui, Houston, Sevan D., Chen, Xuejie, Jin, Da-Yun, Savage, G. Paul, Tie, Jian-Ke, Williams, Craig M.

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Molecular basis of the first reported clinical case of congenital combined deficiency of coagulation factors von Jin, Da-Yun, Ingram, Brian O., Stafford, Darrel W., Tie, Jian-Ke

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