The use of spirocyclic scaffolds in drug discovery von Zheng, Yajun, Tice, Colin M., Singh, Suresh B.

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The Medicinal Chemistry of Liver X Receptor (LXR) Modulators von Tice, Colin M, Noto, Paul B, Fan, Kristi Yi, Zhuang, Linghang, Lala, Deepak S, Singh, Suresh B

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Selecting the right compounds for screening: does Lipinski's Rule of 5 for pharmaceuticals apply to agrochemicals? von Tice, Colin M

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Antiretroviral Drug Discovery Targeting the HIV-1 Nef Virulence Factor von Emert-Sedlak, Lori A., Shi, Haibin, Tice, Colin M., Chen, Li, Alvarado, John J., Shu, Sherry T., Du, Shoucheng, Thomas, Catherine E., Wrobel, Jay E., Reitz, Allen B., Smithgall, Thomas E.

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Conformational control in structure-based drug design von Zheng, Yajun, Tice, Colin M., Singh, Suresh B.

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PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication von Emert-Sedlak, Lori A., Tice, Colin M., Shi, Haibin, Alvarado, John J., Shu, Sherry T., Reitz, Allen B., Smithgall, Thomas E.

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Non-canonical modulators of nuclear receptors von Tice, Colin M., Zheng, Ya-Jun

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Optimization of orally bioavailable alkyl amine renin inhibitors von Xu, Zhenrong, Cacatian, Salvacion, Yuan, Jing, Simpson, Robert D., Jia, Lanqi, Zhao, Wei, Tice, Colin M., Flaherty, Patrick T., Guo, Joan, Ishchenko, Alexey, Singh, Suresh B., Wu, Zhongren, McKeever, Brian M., Scott, Boyd B., Bukhtiyarov, Yuri, Berbaum, Jennifer, Mason, Jennifer, Panemangalore, Reshma, Cappiello, Maria Grazia, Bentley, Ross, Doe, Christopher P., Harrison, Richard K., McGeehan, Gerard M., Dillard, Lawrence W., Baldwin, John J., Claremon, David A.

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Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist von Zheng, Yajun, Zhuang, Linghang, Fan, Kristi Yi, Tice, Colin M, Zhao, Wei, Dong, Chengguo, Lotesta, Stephen D, Leftheris, Katerina, Lindblom, Peter R, Liu, Zhijie, Shimada, Jun, Noto, Paul B, Meng, Shi, Hardy, Andrew, Howard, Lamont, Krosky, Paula, Guo, Joan, Lipinski, Kerri, Kandpal, Geeta, Bukhtiyarov, Yuri, Zhao, Yi, Lala, Deepak, Van Orden, Rebecca, Zhou, Jing, Chen, Guozhou, Wu, Zhongren, McKeever, Brian M, McGeehan, Gerard M, Gregg, Richard E, Claremon, David A, Singh, Suresh B

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Tight-Binding Hydroxypyrazole HIV‑1 Nef Inhibitors Suppress Viral Replication in Donor Mononuclear Cells and Reverse Nef-Mediated MHC‑I Downregulation von Shi, Haibin, Tice, Colin M, Emert-Sedlak, Lori, Chen, Li, Li, Wing Fai, Carlsen, Marianne, Wrobel, Jay E, Reitz, Allen B, Smithgall, Thomas E

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Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor von Zhuang, Linghang, Tice, Colin M., Xu, Zhenrong, Zhao, Wei, Cacatian, Salvacion, Ye, Yuan-Jie, Singh, Suresh B., Lindblom, Peter, McKeever, Brian M., Krosky, Paula M., Zhao, Yi, Lala, Deepak, Kruk, Barbara A., Meng, Shi, Howard, Lamont, Johnson, Judith A., Bukhtiyarov, Yuri, Panemangalore, Reshma, Guo, Joan, Guo, Rong, Himmelsbach, Frank, Hamilton, Bradford, Schuler-Metz, Annette, Schauerte, Heike, Gregg, Richard, McGeehan, Gerard M., Leftheris, Katerina, Claremon, David A.

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Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core von Tice, Colin M., Noto, Paul B., Fan, Kristi Yi, Zhao, Wei, Lotesta, Stephen D., Dong, Chengguo, Marcus, Andrew P., Zheng, Ya-Jun, Chen, Guozhou, Wu, Zhongren, Van Orden, Rebecca, Zhou, Jing, Bukhtiyarov, Yuri, Zhao, Yi, Lipinski, Kerri, Howard, Lamont, Guo, Joan, Kandpal, Geeta, Meng, Shi, Hardy, Andrew, Krosky, Paula, Gregg, Richard E., Leftheris, Katerina, McKeever, Brian M., Singh, Suresh B., Lala, Deepak, McGeehan, Gerard M., Zhuang, Linghang, Claremon, David A.

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Structure-Based Design and Synthesis of 1,3-Oxazinan-2-one Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 von Xu, Zhenrong, Tice, Colin M, Zhao, Wei, Cacatian, Salvacion, Ye, Yuan-Jie, Singh, Suresh B, Lindblom, Peter, McKeever, Brian M, Krosky, Paula M, Kruk, Barbara A, Berbaum, Jennifer, Harrison, Richard K, Johnson, Judith A, Bukhtiyarov, Yuri, Panemangalore, Reshma, Scott, Boyd B, Zhao, Yi, Bruno, Joseph G, Togias, Jennifer, Guo, Joan, Guo, Rong, Carroll, Patrick J, McGeehan, Gerard M, Zhuang, Linghang, He, Wei, Claremon, David A

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Selecting the right compounds for screening: use of surface-area parameters von Tice, Colin M

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Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility von Jia, Lanqi, Simpson, Robert D, Yuan, Jing, Xu, Zhenrong, Zhao, Wei, Cacatian, Salvacion, Tice, Colin M, Guo, Joan, Ishchenko, Alexey, Singh, Suresh B, Wu, Zhongren, McKeever, Brian M, Bukhtiyarov, Yuri, Johnson, Judith A, Doe, Christopher P, Harrison, Richard K, McGeehan, Gerard M, Dillard, Lawrence W, Baldwin, John J, Claremon, David A

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Spirocyclic ureas: Orally bioavailable 11β-HSD1 inhibitors identified by computer-aided drug design von Tice, Colin M., Zhao, Wei, Xu, Zhenrong, Cacatian, Salvacion T., Simpson, Robert D., Ye, Yuan-Jie, Singh, Suresh B., McKeever, Brian M., Lindblom, Peter, Guo, Joan, Krosky, Paula M., Kruk, Barbara A., Berbaum, Jennifer, Harrison, Richard K., Johnson, Judith J., Bukhtiyarov, Yuri, Panemangalore, Reshma, Scott, Boyd B., Zhao, Yi, Bruno, Joseph G., Zhuang, Linghang, McGeehan, Gerard M., He, Wei, Claremon, David A.

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Biphenyl/diphenyl ether renin inhibitors: Filling the S1 pocket of renin via the S3 pocket von Yuan, Jing, Simpson, Robert D., Zhao, Wei, Tice, Colin M., Xu, Zhenrong, Cacatian, Salvacion, Jia, Lanqi, Flaherty, Patrick T., Guo, Joan, Ishchenko, Alexey, Wu, Zhongren, McKeever, Brian M., Scott, Boyd B., Bukhtiyarov, Yuri, Berbaum, Jennifer, Panemangalore, Reshma, Bentley, Ross, Doe, Christopher P., Harrison, Richard K., McGeehan, Gerard M., Singh, Suresh B., Dillard, Lawrence W., Baldwin, John J., Claremon, David A.

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Design and optimization of renin inhibitors: Orally bioavailable alkyl amines von Tice, Colin M., Xu, Zhenrong, Yuan, Jing, Simpson, Robert D., Cacatian, Salvacion T., Flaherty, Patrick T., Zhao, Wei, Guo, Joan, Ishchenko, Alexey, Singh, Suresh B., Wu, Zhongren, Scott, Boyd B., Bukhtiyarov, Yuri, Berbaum, Jennifer, Mason, Jennifer, Panemangalore, Reshma, Cappiello, Maria Grazia, Müller, Dominik, Harrison, Richard K., McGeehan, Gerard M., Dillard, Lawrence W., Baldwin, John J., Claremon, David A.

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Discovery and optimization of adamantyl carbamate inhibitors of 11β-HSD1 von Tice, Colin M., Zhao, Wei, Krosky, Paula M., Kruk, Barbara A., Berbaum, Jennifer, Johnson, Judith A., Bukhtiyarov, Yuri, Panemangalore, Reshma, Scott, Boyd B., Zhao, Yi, Bruno, Joseph G., Howard, Lamont, Togias, Jennifer, Ye, Yuan-Jie, Singh, Suresh B., McKeever, Brian M., Lindblom, Peter R., Guo, Joan, Guo, Rong, Nar, Herbert, Schuler-Metz, Annette, Gregg, Richard E., Leftheris, Katerina, Harrison, Richard K., McGeehan, Gerard M., Zhuang, Linghang, Claremon, David A.

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Highly flexible ligand binding pocket of ecdysone receptor: a single amino acid change leads to discrimination between two groups of nonsteroidal ecdysone agonists von Kumar, Mohan B, Potter, David W, Hormann, Robert E, Edwards, Angela, Tice, Colin M, Smith, Howard C, Dipietro, Martha A, Polley, Mitch, Lawless, Michael, Wolohan, Philippa R N, Kethidi, Damodhar R, Palli, Subba R

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