TATTON: a multi-arm, phase Ib trial of osimertinib combined with selumetinib, savolitinib, or durvalumab in EGFR-mutant lung cancer von Oxnard, G.R., Yang, J.C.-H., Yu, H., Kim, S.-W., Saka, H., Horn, L., Goto, K., Ohe, Y., Mann, H., Thress, K.S., Frigault, M.M., Vishwanathan, K., Ghiorghiu, D., Ramalingam, S.S., Ahn, M.-J.

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135O_PR: Plasma genotyping for predicting benefit from osimertinib in patients (pts) with advanced NSCLC von Oxnard, G R, Thress, K S, Alden, R S, Lawrance, R, Paweletz, C P, Cantarini, M, Barrett, C, Yang, J, Jänne, P

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Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation von Clurman, B E, Sheaff, R J, Thress, K, Groudine, M, Roberts, J M

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Reaper-induced dissociation of a Scythe-sequestered cytochrome c-releasing activity von Thress, K, Evans, E.K, Kornbluth, S

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Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper von Thress, Kenneth, Song, Jaewhan, Morimoto, Richard I., Kornbluth, Sally

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OA 09.02 Osimertinib Resistance Mediated by Loss of EGFR T790M Is Associated with Early Resistance and Competing Resistance Mechanisms von Oxnard, G., Hu, Y., Mileham, K., Tracy, P., Feeney, N., Sholl, L., Paweletz, C., Thress, K., Jänne, P.

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P3.01-074 Genomic Analysis of Tumor and Plasma in T790M Mutant Positive EGFR Lung Cancer Patients before and after Osimertinib Treatment von Yang, J.C., Yu, C., Shih, J., Ho, C., Liao, W., Lee, J., Tsai, T., Su, K., Shih, M., Chang, Y.L., Bai, Y., Huang, D., Thress, K., Lin, C.

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OA 10.01 Detection of EGFR mutations from plasma ctDNA in the osimertinib Phase III trial (AURA3): comparison of three plasma assays von Ahn, M., Han, J., Tsai, C., Delmonte, A., Hsia, T., Laskin, J., Kim, S., He, Y., Hida, T., Maemondo, M., Kato, T., Jenkins, S., Markovets, A., Thress, K., Mok, T.

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P2.02-052 A Clinically-Validated Universal Companion Diagnostic Platform for Cancer Patient Care von Sun, J., Li, Y., Milbury, C., Skoletsky, J., Burns, C., Yip, W., Luo, J., Dewal, N., Johnson, A., Gowen, K., Tong, J., He, Y., He, J., White, J., Roels, S., Tsuji, A., Truesdell, J., Peters, E., Gilbert, H., Wu, C., Schleifman, E., Barrett, C., Thress, K., Jenkins, S., Elvin, J., Otto, G., Lipson, D., Ross, J., Miller, V., Stephens, P.J., Doherty, M., Vietz, C.

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P3.02-062 An EGFR Follow-On Companion Diagnostic for Clinical Care of Patients with NSCLC von Li, Y., Luo, J., Yip, W., Skoletsky, J., Milbury, C., Burns, C., Tsuji, A., Truesdell, J., Peters, E., Gilbert, H., Wu, C., Schleifman, E., Barrett, C., Thress, K., Jenkins, S., Elvin, J., Otto, G., Lipson, D., Ross, J., Miller, V., Stephens, P.J., Doherty, M., Vietz, C., Sun, J.

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574 POSTER Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway von Thress, K, MacIntyre, T, Wang, H, Liu, Z.Y, Hoffmann, E, Wang, T, Whitston, D, Brown, J.L, Webster, K, Omer, C

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Scythe: a novel reaper-binding apoptotic regulator von Thress, Kenneth, Henzel, William, Shillinglaw, Wendy, Kornbluth, Sally

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1270PLEVELS OF EGFR T790M IN PLASMA DNA AS A PREDICTIVE BIOMARKER FOR RESPONSE TO AZD9291, A MUTANT-SELECTIVE EGFR KINASE INHIBITOR von Thress, K., Yang, J.C., Ahn, M., Kim, D., Kim, S., Ohe, Y., Planchard, D., Brant, R., Carr, H., Dearden, S., Jenkins, S., Cantarini, M., Ghiorghiu, S., Barrett, J.C., Janne, P.A., Oxnard, G.R.

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Levels of Egfr T790M in Plasma Dna As a Predictive Biomarker for Response to Azd9291, a Mutant-Selective Egfr Kinase Inhibitor von Thress, K., Yang, J.C., Ahn, M., Kim, D., Kim, S., Ohe, Y., Planchard, D., Brant, R., Carr, H., Dearden, S., Jenkins, S., Cantarini, M., Ghiorghiu, S., Barrett, J.C., Janne, P.A., Oxnard, G.R.

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Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper von Thress, Kenneth, Song, Jaewhan, Morimoto, Richard I., Kornbluth, Sally

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A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch von Kaye, Frederic J., Modi, Sanjay, Ivanovska, Irena, Koonin, Eugene V., Thress, Kenneth, Kubo, Akihito, Kornbluth, Sally, Rose, Mark D.

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Mitochondria at the crossroad of apoptotic cell death von Thress, K, Kornbluth, S, Smith, J J

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Plasma genotyping for predicting benefit from osimertinib in patients (pts) with advanced NSCLC: 135O_PR von Oxnard, G R, Thress, K S, Alden, R S, Lawrance, R, Paweletz, C P, Cantarini, M, Barrett, C, Yang, J, Jänne, P

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Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases Activity von Ballard, Peter, Yates, James W T, Yang, Zhenfan, Kim, Dong-Wan, Yang, James Chih-Hsin, Cantarini, Mireille, Pickup, Kathryn, Jordan, Angela, Hickey, Mike, Grist, Matthew, Box, Matthew, Johnström, Peter, Varnäs, Katarina, Malmquist, Jonas, Thress, Kenneth S, Jänne, Pasi A, Cross, Darren

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Gefitinib Plus Chemotherapy Versus Chemotherapy in Epidermal Growth Factor Receptor Mutation-Positive Non-Small-Cell Lung Cancer Resistant to First-Line Gefitinib (IMPRESS): Overal... von Mok, Tony S K, Kim, Sang-We, Wu, Yi-Long, Nakagawa, Kazuhiko, Yang, Jin-Ji, Ahn, Myung-Ju, Wang, Jie, Yang, James Chih-Hsin, Lu, You, Atagi, Shinji, Ponce, Santiago, Shi, Xiaojin, Rukazenkov, Yuri, Haddad, Vincent, Thress, Kenneth S, Soria, Jean-Charles

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