microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease von Thome, Aaron D, Harms, Ashley S, Volpicelli-Daley, Laura A, Standaert, David G

Volltext

Fractalkine Signaling Regulates the Inflammatory Response in an α-Synuclein Model of Parkinson Disease von Thome, Aaron D, Standaert, David G, Harms, Ashley S

Volltext

Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease von Harms, Ashley S., Thome, Aaron D., Yan, Zhaoqi, Schonhoff, Aubrey M., Williams, Gregory P., Li, Xinru, Liu, Yudong, Qin, Hongwei, Benveniste, Etty N., Standaert, David G.

Volltext

Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson's disease von Williams, Gregory P, Schonhoff, Aubrey M, Jurkuvenaite, Asta, Thome, Aaron D, Standaert, David G, Harms, Ashley S

Volltext

α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration von Harms, Ashley S, Delic, Vedad, Thome, Aaron D, Bryant, Nicole, Liu, Zhiyong, Chandra, Sidhanth, Jurkuvenaite, Asta, West, Andrew B

Volltext

MHCII is required for α-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration von Harms, Ashley S, Cao, Shuwen, Rowse, Amber L, Thome, Aaron D, Li, Xinru, Mangieri, Leandra R, Cron, Randy Q, Shacka, John J, Raman, Chander, Standaert, David G

Volltext

Tregs Attenuate Peripheral Oxidative Stress and Acute Phase Proteins in ALS von Beers, David R., Thonhoff, Jason R., Faridar, Alireza, Thome, Aaron D., Zhao, Weihua, Wen, Shixiang, Appel, Stanley H.

Volltext

Elevated acute phase proteins reflect peripheral inflammation and disease severity in patients with amyotrophic lateral sclerosis von Beers, David R., Zhao, Weihua, Neal, Daniel W., Thonhoff, Jason R., Thome, Aaron D., Faridar, Alireza, Wen, Shixiang, Wang, Jinghong, Appel, Stanley H.

Volltext

Functional alterations of myeloid cells during the course of Alzheimer's disease von Thome, Aaron D, Faridar, Alireza, Beers, David R, Thonhoff, Jason R, Zhao, Weihua, Wen, Shixiang, Pascual, Belen, Masdeu, Joseph C, Appel, Stanley H

Volltext

Extracellular Vesicles Derived From Ex Vivo Expanded Regulatory T Cells Modulate In Vitro and In Vivo Inflammation von Thome, Aaron D., Thonhoff, Jason R., Zhao, Weihua, Faridar, Alireza, Wang, Jinghong, Beers, David R., Appel, Stanley H.

Volltext

Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer's disease von Faridar, Alireza, Vasquez, Matthew, Thome, Aaron D, Yin, Zheng, Xuan, Hui, Wang, Jing Hong, Wen, Shixiang, Li, Xuping, Thonhoff, Jason R, Zhao, Weihua, Zhao, Hong, Beers, David R, Wong, Stephen T C, Masdeu, Joseph C, Appel, Stanley H

Volltext

Ex vivo expansion of dysfunctional regulatory T lymphocytes restores suppressive function in Parkinson’s disease von Thome, Aaron D., Atassi, Farah, Wang, Jinghong, Faridar, Alireza, Zhao, Weihua, Thonhoff, Jason R., Beers, David R., Lai, Eugene C., Appel, Stanley H.

Volltext

Restoring regulatory T-cell dysfunction in Alzheimer’s disease through ex vivo expansion von Faridar, Alireza, Thome, Aaron D, Zhao, Weihua, Thonhoff, Jason R, Beers, David R, Pascual, Belen, Masdeu, Joseph C, Appel, Stanley H

Volltext

A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer's disease von Faridar, Alireza, Eid, Abdulmunaim M, Thome, Aaron D, Zhao, Weihua, Beers, David R, Pascual, Maria B, Nakawah, Mohammad O, Roman, Gustavo C, Davis, Charles S, Grundman, Michael, Masdeu, Joseph C, Appel, Stanley H

Volltext

The Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator ADX88178 Inhibits Inflammatory Responses in Primary Microglia von Ponnazhagan, Ranjani, Harms, Ashley S., Thome, Aaron D., Jurkuvenaite, Asta, Gogliotti, Rocco, Niswender, Colleen M., Conn, P. Jeffrey, Standaert, David G.

Volltext

A phase 1 proof-of-concept study evaluating safety, tolerability, and biological marker responses with combination therapy of CTLA4-Ig and interleukin-2 in amyotrophic lateral scle... von Thonhoff, Jason R, Beers, David R, Zhao, Weihua, Faridar, Alireza, Thome, Aaron, Wen, Shixiang, Zhang, Aijun, Wang, Jinghong, Appel, Stanley H

Volltext

Combined Regulatory T-Lymphocyte and IL-2 Treatment Is Safe, Tolerable, and Biologically Active for 1 Year in Persons With Amyotrophic Lateral Sclerosis von Thonhoff, Jason R., Berry, James D., Macklin, Eric A., Beers, David R., Mendoza, Patricia A., Zhao, Weihua, Thome, Aaron D., Triolo, Fabio, Moon, James J., Paganoni, Sabrina, Cudkowicz, Merit, Appel, Stanley H.

Volltext

Immunosuppressive Functions of M2 Macrophages Derived from iPSCs of Patients with ALS and Healthy Controls von Zhao, Weihua, Beers, David R., Thonhoff, Jason R., Thome, Aaron D., Faridar, Alireza, Wang, Jinghong, Wen, Shixiang, Ornelas, Loren, Sareen, Dhruv, Goodridge, Helen S., Svendsen, Clive N., Appel, Stanley H.

Volltext

Serum programmed cell death proteins in amyotrophic lateral sclerosis von Beers, David R., Zhao, Weihua, Thonhoff, Jason R., Faridar, Alireza, Thome, Aaron D., Wen, Shixiang, Wang, Jinghong, Appel, Stanley H.

Volltext

A partial MECP2 duplication in a mildly affected adult male: a putative role for the 3' untranslated region in the MECP2 duplication phenotype von Hanchard, Neil A, Carvalho, Claudia M B, Bader, Patricia, Thome, Aaron, Omo-Griffith, Lisa, del Gaudio, Daniela, Pehlivan, Davut, Fang, Ping, Schaaf, Christian P, Ramocki, Melissa B, Lupski, James R, Cheung, Sau Wai

Volltext