A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation von Petersen, Donna N., Hawkins, Julie, Ruangsiriluk, Wanida, Stevens, Kimberly A., Maguire, Bruce A., O’Connell, Thomas N., Rocke, Benjamin N., Boehm, Markus, Ruggeri, Roger B., Rolph, Tim, Hepworth, David, Loria, Paula M., Carpino, Philip A.

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Solution-Based Indirect Affinity Selection Mass SpectrometryA General Tool For High-Throughput Screening Of Pharmaceutical Compound Libraries von O’Connell, Thomas N, Ramsay, Jason, Rieth, Steven F, Shapiro, Michael J, Stroh, Justin G

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A chemical probe to modulate human GID4 Pro/N-degron interactions von Owens, Dominic D. G., Maitland, Matthew E. R., Khalili Yazdi, Aliakbar, Song, Xiaosheng, Reber, Viviane, Schwalm, Martin P., Machado, Raquel A. C., Bauer, Nicolas, Wang, Xu, Szewczyk, Magdalena M., Dong, Cheng, Dong, Aiping, Loppnau, Peter, Calabrese, Matthew F., Dowling, Matthew S., Lee, Jisun, Montgomery, Justin I., O’Connell, Thomas N., Subramanyam, Chakrapani, Wang, Feng, Adamson, Ella C., Schapira, Matthieu, Gstaiger, Matthias, Knapp, Stefan, Vedadi, Masoud, Min, Jinrong, Lajoie, Gilles A., Barsyte-Lovejoy, Dalia, Owen, Dafydd R., Schild-Poulter, Caroline, Arrowsmith, Cheryl H.

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Integrating Intramolecular Hydrogen Bonding (IMHB) Considerations in Drug Discovery Using ΔlogP As a Tool von Shalaeva, Marina, Caron, Giulia, Abramov, Yuriy A, O’Connell, Thomas N, Plummer, Mark S, Yalamanchi, Geeta, Farley, Kathleen A, Goetz, Gilles H, Philippe, Laurence, Shapiro, Michael J

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Discovery and Optimization of a Novel Spiropyrrolidine Inhibitor of β-Secretase (BACE1) through Fragment-Based Drug Design von Efremov, Ivan V, Vajdos, Felix F, Borzilleri, Kris A, Capetta, Steven, Chen, Hou, Dorff, Peter H, Dutra, Jason K, Goldstein, Steven W, Mansour, Mahmoud, McColl, Alexander, Noell, Stephen, Oborski, Christine E, O’Connell, Thomas N, O’Sullivan, Theresa J, Pandit, Jayvardhan, Wang, Hong, Wei, BinQing, Withka, Jane M

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PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease von Gopalsamy, Ariamala, Aulabaugh, Ann E, Barakat, Amey, Beaumont, Kevin C, Cabral, Shawn, Canterbury, Daniel P, Casimiro-Garcia, Agustin, Chang, Jeanne S, Chen, Ming Z, Choi, Chulho, Dow, Robert L, Fadeyi, Olugbeminiyi O, Feng, Xidong, France, Scott P, Howard, Roger M, Janz, Jay M, Jasti, Jayasankar, Jasuja, Reema, Jones, Lyn H, King-Ahmad, Amanda, Knee, Kelly M, Kohrt, Jeffrey T, Limberakis, Chris, Liras, Spiros, Martinez, Carlos A, McClure, Kim F, Narayanan, Arjun, Narula, Jatin, Novak, Jonathan J, O'Connell, Thomas N, Parikh, Mihir D, Piotrowski, David W, Plotnikova, Olga, Robinson, Ralph P, Sahasrabudhe, Parag V, Sharma, Raman, Thuma, Benjamin A, Vasa, Dipy, Wei, Liuqing, Wenzel, A Zane, Withka, Jane M, Xiao, Jun, Yayla, Hatice G

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Aminopyrazole Carboxamide Bruton’s Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning von Schnute, Mark E, Benoit, Stephen E, Buchler, Ingrid P, Caspers, Nicole, Grapperhaus, Margaret L, Han, Seungil, Hotchandani, Rajeev, Huang, Nelson, Hughes, Robert O, Juba, Brian M, Kim, Kyung-Hee, Liu, Erica, McCarthy, Erin, Messing, Dean, Miyashiro, Joy S, Mohan, Shashi, O’Connell, Thomas N, Ohren, Jeffrey F, Parikh, Mihir D, Schmidt, Michelle, Selness, Shaun R, Springer, John R, Thanabal, Venkataraman, Trujillo, John I, Walker, Daniel P, Wan, Zhao-Kui, Withka, Jane M, Wittwer, Arthur J, Wood, Nancy L, Xing, Li, Zapf, Christoph W, Douhan, John

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Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex von Yazdi, Aliakbar Khalili, Perveen, Sumera, Dong, Cheng, Song, Xiaosheng, Dong, Aiping, Szewczyk, Magdalena M, Calabrese, Matthew F, Casimiro-Garcia, Agustin, Chakrapani, Subramanyam, Dowling, Matthew S, Ficici, Emel, Lee, Jisun, Montgomery, Justin I, O'Connell, Thomas N, Skrzypek, Grzegorz J, Tran, Tuan P, Troutman, Matthew D, Wang, Feng, Young, Jennifer A, Min, Jinrong, Barsyte-Lovejoy, Dalia, Brown, Peter J, Santhakumar, Vijayaratnam, Arrowsmith, Cheryl H, Vedadi, Masoud, Owen, Dafydd R

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Intramolecular Ring-Opening Decomposition of Aryl Azetidines von Bai, Guoyun, O’Connell, Thomas N, Brodney, Michael A, Butler, Christopher R, Czabaniuk, Lara C, Gilbert, Adam M, LaChapelle, Erik A, Li, Chao, McAllister, Laura A, Ogilvie, Kevin, Philippe, Laurence, Salomon-Ferrer, Romelia, Shapiro, Michael J, Starr, Jeremy T, Uccello, Daniel P, Withka, Jane M, Yan, Jiangli, Brown, Matthew F

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Comparison of LC-NMR and conventional NMR for structure elucidation in drug metabolism studies von Walker, Gregory S, O'Connell, Thomas N

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Species Differences in the Biotransformation of an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist: The Effects of Distinct Glucuronide Metabolites on Overall Compound Dispos... von SHAFFER, Christopher L, GUNDUZ, Mithat, RYDER, Tim F, O'CONNELL, Thomas N

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Novel Erythromycins from a Recombinant Saccharopolyspora erythraea Strain NRRL 2338 pIG1: I. Fermentation, Isolation and Biological Activity von PACEY, MICHAEL S., DIRLAM, JOHN P., GELDART, RODERICK W., LEADLAY, PETER F., MCARTHUR, HAMISH A. I., MCCORMICK, ELLEN L., MONDAY, ROBERT A., O'CONNELL, THOMAS N., STAUNTON, JAMES, WINCHESTER, TOBY J.

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Synthesis and structure–activity relationships of thiotetronic acid analogues of thiolactomycin von Sakya, Subas M, Suarez-Contreras, Melani, Dirlam, John P, O'Connell, Thomas N, Hayashi, Shigeru F, Santoro, Sheryl L, Kamicker, Barbara J, George, David M, Ziegler, Carl B

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Biotransformation of an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist in Sprague-Dawley Rats and the Dispositional Characterization of Its N-Carbamoyl Glucuronide Metabolit... von Shaffer, Christopher L., Ryder, Tim F., Venkatakrishnan, Karthik, Henne, Ilana K., O’Connell, Thomas N.

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Metabolism, pharmacokinetics, and excretion of the 5-hydroxytryptamine1b receptor antagonist elzasonan in humans von Kamel, Amin, Obach, R Scott, Colizza, Kevin, Wang, Weiwei, O'Connell, Thomas N, Coelho, Jr, Richard V, Kelley, Ryan M, Schildknegt, Klaas

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Species Differences in the Biotransformation of an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist: The Effects of Distinct Glucuronide Metabolites on Overall Compound Disp... von Christopher L. Shaffer, Mithat Gunduz, Tim F. Ryder, Thomas N. O'Connell

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Biotransformation of an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist in Sprague-Dawley Rats and the Dispositional Characterization of Its N-Carbamoyl Glucuronide Metabol... von Christopher L. Shaffer, Tim F. Ryder, Karthik Venkatakrishnan, Ilana K. Henne, Thomas N. O'Connell

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5-Hydroxytryptamine1B Receptor Antagonist Elzasonan in Humans von KAMEL, Amin, OBACH, R. Scott, COLIZZA, Kevin, WEIWEI WANG, O'CONNELL, Thomas N, COELHO, Richard V, KELLEY, Ryan M, SCHILDKNEGT, Klaas

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Biotransformation of an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist in Sprague-Dawley Rats and the Dispositional Characterization of Its N-Carbamoyl Glucuronide Metabolit... von SHAFFER, Christopher L, RYDER, Tim F, VENKATAKRISHNAN, Karthik, HENNE, Ilana K, O'CONNELL, Thomas N

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Production of 6-Deoxy-13-cyclopropyl-Erythromycin B by Saccharopolyspora erythraea NRRL 18643 von BROWN, MARIA S., DIRLAM, JOHN P., MCARTHUR, HAMISH A. I., MCCORMICK, ELLEN L., MORSE, BROOK K., MURPHY, PAUL A., O'CONNELL, THOMAS N., PACEY, MIKE, RESCEK, DIANNE M., RUDDOCK, JOHN, WAX, RICHARD G.

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