A public genome-scale lentiviral expression library of human ORFs von Yang, Xiaoping, Boehm, Jesse S, Yang, Xinping, Salehi-Ashtiani, Kourosh, Hao, Tong, Shen, Yun, Lubonja, Rakela, Thomas, Sapana R, Alkan, Ozan, Bhimdi, Tashfeen, Green, Thomas M, Johannessen, Cory M, Silver, Serena J, Nguyen, Cindy, Murray, Ryan R, Hieronymus, Haley, Balcha, Dawit, Fan, Changyu, Lin, Chenwei, Ghamsari, Lila, Vidal, Marc, Hahn, William C, Hill, David E, Root, David E

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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation von Johannessen, Cory M., Boehm, Jesse S., Kim, So Young, Thomas, Sapana R., Wardwell, Leslie, Johnson, Laura A., Emery, Caroline M., Stransky, Nicolas, Cogdill, Alexandria P., Barretina, Jordi, Caponigro, Giordano, Hieronymus, Haley, Murray, Ryan R., Salehi-Ashtiani, Kourosh, Hill, David E., Vidal, Marc, Zhao, Jean J., Yang, Xiaoping, Alkan, Ozan, Kim, Sungjoon, Harris, Jennifer L., Wilson, Christopher J., Myer, Vic E., Finan, Peter M., Root, David E., Roberts, Thomas M., Golub, Todd, Flaherty, Keith T., Dummer, Reinhard, Weber, Barbara L., Sellers, William R., Schlegel, Robert, Wargo, Jennifer A., Hahn, William C., Garraway, Levi A.

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PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling von Moody, S E, Schinzel, A C, Singh, S, Izzo, F, Strickland, M R, Luo, L, Thomas, S R, Boehm, J S, Kim, S Y, Wang, Z C, Hahn, W C

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PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling von Shrestha, Y, Schafer, E J, Boehm, J S, Thomas, S R, He, F, Du, J, Wang, S, Barretina, J, Weir, B A, Zhao, J J, Polyak, K, Golub, T R, Beroukhim, R, Hahn, W C

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PRKACA Mediates Resistance to HER2-Targeted Therapy in Breast Cancer Cells and Restores Anti-Apoptotic Signaling von Moody, Susan E, Schinzel, Anna C, Singh, Shambhavi, Izzo, Francesca, Strickland, Matthew R, Luo, Leo, Thomas, Sapana R, Boehm, Jesse S, Kim, So Young, Wang, Zhigang C, Hahn, William C

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COT/MAP3K8 drives resistance to RAF inhibition through MAP kinase pathway reactivation von Johannessen, Cory M., Boehm, Jesse S., Kim, So Young, Thomas, Sapana R., Wardwell, Leslie, Johnson, Laura A., Emery, Caroline M., Stransky, Nicolas, Cogdill, Alexandria P., Barretina, Jordi, Caponigro, Giordano, Hieronymus, Haley, Murray, Ryan R., Salehi-Ashtiani, Kourosh, Hill, David E., Vidal, Marc, Zhao, Jean J., Yang, Xiaoping, Alkan, Ozan, Kim, Sungjoon, Harris, Jennifer L., Wilson, Christopher J., Myer, Vic E., Finan, Peter M., Root, David E., Roberts, Thomas M., Golub, Todd, Flaherty, Keith T., Dummer, Reinhard, Weber, Barbara, Sellers, William R., Schlegel, Robert, Wargo, Jennifer A., Hahn, William C., Garraway, Levi A.

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Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response von Haberman, Yael, Karns, Rebekah, Dexheimer, Phillip J., Schirmer, Melanie, Somekh, Judith, Jurickova, Ingrid, Braun, Tzipi, Novak, Elizabeth, Bauman, Laura, Collins, Margaret H., Mo, Angela, Rosen, Michael J., Bonkowski, Erin, Gotman, Nathan, Marquis, Alison, Nistel, Mason, Rufo, Paul A., Baker, Susan S., Sauer, Cary G., Markowitz, James, Pfefferkorn, Marian D., Rosh, Joel R., Boyle, Brendan M., Mack, David R., Baldassano, Robert N., Shah, Sapana, Leleiko, Neal S., Heyman, Melvin B., Grifiths, Anne M., Patel, Ashish S., Noe, Joshua D., Aronow, Bruce J., Kugathasan, Subra, Walters, Thomas D., Gibson, Greg, Thomas, Sonia Davis, Mollen, Kevin, Shen-Orr, Shai, Huttenhower, Curtis, Xavier, Ramnik J., Hyams, Jeffrey S., Denson, Lee A.

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A Systematic Review of Genetic Correlates of Weight Loss After Bariatric Surgery von Gupta, Sapana R., Zhou, Yingjie, Wadden, Thomas A., Berkowitz, Robert I., Chao, Ariana M.

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Stratification of risk of progression to colectomy in ulcerative colitis via measured and predicted gene expression von Mo, Angela, Nagpal, Sini, Gettler, Kyle, Haritunians, Talin, Giri, Mamta, Haberman, Yael, Karns, Rebekah, Prince, Jarod, Arafat, Dalia, Hsu, Nai-Yun, Chuang, Ling-Shiang, Argmann, Carmen, Kasarskis, Andrew, Suarez-Farinas, Mayte, Gotman, Nathan, Mengesha, Emebet, Venkateswaran, Suresh, Rufo, Paul A., Baker, Susan S., Sauer, Cary G., Markowitz, James, Pfefferkorn, Marian D., Rosh, Joel R., Boyle, Brendan M., Mack, David R., Baldassano, Robert N., Shah, Sapana, LeLeiko, Neal S., Heyman, Melvin B., Griffiths, Anne M., Patel, Ashish S., Noe, Joshua D., Davis Thomas, Sonia, Aronow, Bruce J., Walters, Thomas D., McGovern, Dermot P.B., Hyams, Jeffrey S., Kugathasan, Subra, Cho, Judy H., Denson, Lee A., Gibson, Greg

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Targeted Assessment of Mucosal Immune Gene Expression Predicts Clinical Outcomes in Children with Ulcerative Colitis von Clarkston, Kathryn, Karns, Rebekah, Jegga, Anil G, Sharma, Mihika, Fox, Sejal, Ojo, Babajide A, Minar, Phillip, Walters, Thomas D, Griffiths, Anne M, Mack, David R, Boyle, Brendan, LeLeiko, Neal S, Markowitz, James, Rosh, Joel R, Patel, Ashish S, Shah, Sapana, Baldassano, Robert N, Pfefferkorn, Marian, Sauer, Cary, Kugathasan, Subra, Haberman, Yael, Hyams, Jeffrey S, Denson, Lee A, Rosen, Michael J

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Characterization of Stool Virome in Children Newly Diagnosed With Moderate to Severe Ulcerative Colitis von Tokarz, Rafal, Hyams, Jeffrey S, Mack, David R, Boyle, Brendan, Griffiths, Anne M, LeLeiko, Neal S, Sauer, Cary G, Shah, Sapana, Markowitz, James, Baker, Susan S, Rosh, Joel, Baldassano, Robert N, Kugathasan, Subra, Walters, Thomas, Tagliafierro, Teresa, Sameroff, Stephen, Lee, Bohyun, Che, Xiaoyu, Oleynik, Alexandra, Denson, Lee A, Lipkin, W Ian

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Successful Implementation Isn’t Enough: One Intermediary Organization’s Focus on Sustainment von Margolies, Paul J., Patel, Sapana R., Covell, Nancy H., Broadway-Wilson, Karen, Gregory, Raymond, Jewell, Thomas C., Scannevin, Gary, Dixon, Lisa B.

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PAK1 is a Breast Cancer Oncogene that Coordinately Activates MAPK and MET Signaling von Shrestha, Yashaswi, Schafer, Eric J, Boehm, Jesse S, He, Frank, Wang, Shumei, Barretina, Jordi, Thomas, Sapana Rachael, Du, Jinyan, Weir, Barbara Ann, Zhao, Jean J, Golub, Todd R, Beroukhim, Rameen, Hahn, William C, Polyak, Kornelia

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Abstract 5769: A novel, high-throughput approach to discovering drug-resistance genes identifies CRAF, CrkL, and TPL2/COT as drivers of resistance to BRAFV600E inhibition von Johannessen, Cory M., Wardwell, Leslie, Kim, So Young, Boehm, Jesse, Thomas, Sapana, Johnson, Laura A., Hieronymus, Haley, Salehi-Ashtiani, Kourosh, Hill, David E., Zhao, Jean J., Vidal, Marc, Golub, Todd R., Hahn, William C., Garraway, Levi A.

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