Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC von Thomas, Lance R., Wang, Qingguo, Grieb, Brian C., Phan, Jason, Foshage, Audra M., Sun, Qi, Olejniczak, Edward T., Clark, Travis, Dey, Soumyadeep, Lorey, Shelly, Alicie, Bethany, Howard, Gregory C., Cawthon, Bryan, Ess, Kevin C., Eischen, Christine M., Zhao, Zhongming, Fesik, Stephen W., Tansey, William P.

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The MYC-WDR5 Nexus and Cancer von Thomas, Lance R, Foshage, Audra M, Weissmiller, April M, Tansey, William P

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MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor-1 von Popay, Tessa M., Wang, Jing, Adams, Clare M., Howard, Gregory Caleb, Codreanu, Simona G., Sherrod, Stacy D., McLean, John A., Thomas, Lance R., Lorey, Shelly L., Machida, Yuichi J., Weissmiller, April M., Eischen, Christine M., Liu, Qi, Tansey, William P.

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Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity von Aho, Erin R., Wang, Jing, Gogliotti, Rocco D., Howard, Gregory C., Phan, Jason, Acharya, Pankaj, Macdonald, Jonathan D., Cheng, Ken, Lorey, Shelly L., Lu, Bin, Wenzel, Sabine, Foshage, Audra M., Alvarado, Joseph, Wang, Feng, Shaw, J. Grace, Zhao, Bin, Weissmiller, April M., Thomas, Lance R., Vakoc, Christopher R., Hall, Matthew D., Hiebert, Scott W., Liu, Qi, Stauffer, Shaun R., Fesik, Stephen W., Tansey, William P.

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Proteolytic Control of the Oncoprotein Transcription Factor Myc von Thomas, Lance R., Tansey, William P.

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WIN site inhibition disrupts a subset of WDR5 function von Siladi, Andrew J., Wang, Jing, Florian, Andrea C., Thomas, Lance R., Creighton, Joy H., Matlock, Brittany K., Flaherty, David K., Lorey, Shelly L., Howard, Gregory C., Fesik, Stephen W., Weissmiller, April M., Liu, Qi, Tansey, William P.

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Comparison of triple-negative breast cancer molecular subtyping using RNA from matched fresh-frozen versus formalin-fixed paraffin-embedded tissue von Jovanović, Bojana, Sheng, Quanhu, Seitz, Robert S, Lawrence, Kasey D, Morris, Stephan W, Thomas, Lance R, Hout, David R, Schweitzer, Brock L, Guo, Yan, Pietenpol, Jennifer A, Lehmann, Brian D

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Targeting MYC through WDR5 von Thomas, Lance R., Adams, Clare M., Fesik, Stephen W., Eischen, Christine M., Tansey, William P.

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Tumor-derived Mutations in the TRAIL Receptor DR5 Inhibit TRAIL Signaling through the DR4 Receptor by Competing for Ligand Binding von Bin, Lianghua, Thorburn, Jacqueline, Thomas, Lance R., Clark, Peter E., Humphreys, Robin, Thorburn, Andrew

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Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance von Thomas, Lance R., Adams, Clare M., Wang, Jing, Weissmiller, April M., Creighton, Joy, Lorey, Shelly L., Liu, Qi, Fesik, Stephen W., Eischen, Christine M., Tansey, William P.

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Selective inactivation of a Fas-associated death domain protein (FADD)-dependent apoptosis and autophagy pathway in immortal epithelial cells von Thorburn, Jacqueline, Moore, Franklin, Rao, Anuradha, Barclay, Wendy W, Thomas, Lance R, Grant, Ken W, Cramer, Scott D, Thorburn, Andrew

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Discovery of WD Repeat-Containing Protein 5 (WDR5)–MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design von Chacón Simon, Selena, Wang, Feng, Thomas, Lance R, Phan, Jason, Zhao, Bin, Olejniczak, Edward T, Macdonald, Jonathan D, Shaw, J. Grace, Schlund, Caden, Payne, William, Creighton, Joy, Stauffer, Shaun R, Waterson, Alex G, Tansey, William P, Fesik, Stephen W

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Direct Binding of Fas-associated Death Domain (FADD) to the Tumor Necrosis Factor-related Apoptosis-inducing Ligand Receptor DR5 Is Regulated by the Death Effector Domain of FADD von Thomas, Lance R, Henson, Adrianna, Reed, John C, Salsbury, Freddie R, Thorburn, Andrew

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Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core von Tian, Jianhua, Teuscher, Kevin B, Aho, Erin R, Alvarado, Joseph R, Mills, Jonathan J, Meyers, Kenneth M, Gogliotti, Rocco D, Han, Changho, Macdonald, Jonathan D, Sai, Jiqing, Shaw, J. Grace, Sensintaffar, John L, Zhao, Bin, Rietz, Tyson A, Thomas, Lance R, Payne, William G, Moore, William J, Stott, Gordon M, Kondo, Jumpei, Inoue, Masahiro, Coffey, Robert J, Tansey, William P, Stauffer, Shaun R, Lee, Taekyu, Fesik, Stephen W

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Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5–MYC Protein–Protein Interaction von Macdonald, Jonathan D, Chacón Simon, Selena, Han, Changho, Wang, Feng, Shaw, J. Grace, Howes, Jennifer E, Sai, Jiqing, Yuh, Joannes P, Camper, Demarco, Alicie, Bethany M, Alvarado, Joseph, Nikhar, Sameer, Payne, William, Aho, Erin R, Bauer, Joshua A, Zhao, Bin, Phan, Jason, Thomas, Lance R, Rossanese, Olivia W, Tansey, William P, Waterson, Alex G, Stauffer, Shaun R, Fesik, Stephen W

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The C-terminal Tails of Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) and Fas Receptors Have Opposing Functions in Fas-associated Death Domain (FADD) Recruitment... von Thomas, Lance R, Johnson, Ronald L, Reed, John C, Thorburn, Andrew

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Control of thymocyte development and recombination-activating gene expression by the zinc finger protein Zfp608 von Aune, Thomas M, Zhang, Feng, Thomas, Lance R, Oltz, Eugene M

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5-Oxo-ETE analogs and the proliferation of cancer cells von O'Flaherty, Joseph T., Rogers, LeAnn C., Paumi, Christian M., Hantgan, Roy R., Thomas, Lance R., Clay, Carl E., High, Kevin, Chen, Yong Q., Willingham, Mark C., Smitherman, Pamela K., Kute, Timothy E., Rao, Anuradha, Cramer, Scott D., Morrow, Charles S.

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Regulation of Fas-associated Death Domain Interactions by the Death Effector Domain Identified by a Modified Reverse Two-hybrid Screen von Thomas, Lance R., Stillman, David J., Thorburn, Andrew

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Functional Analysis of Histone Methyltransferase G9a in B and T Lymphocytes von Thomas, Lance R, Miyashita, Hiroki, Cobb, Robin Milley, Pierce, Steven, Tachibana, Makoto, Hobeika, Elias, Reth, Michael, Shinkai, Yoichi, Oltz, Eugene M

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