Clinical validation of an artificial intelligence-based decision support system for diagnosis and risk stratification of heart failure (STRATIFYHF): a protocol for a prospective, m... von Charman, Sarah Jane, Okwose, Nduka C, Groenewegen, Amy, Del Franco, Annamaria, Tafelmeier, Maria, Preveden, Andrej, Garcia Sebastian, Cristina, Fuller, Amy S, Sinclair, David, Edwards, Duncan, Nelissen, Anne Pauline, Malitas, Petros, Zisaki, Aikaterini, Darba, Josep, Bosnic, Zoran, Vracar, Petar, Barlocco, Fausto, Fotiadis, Dimitris, Banerjee, Prithwish, MacGowan, Guy A, Fernandez, Oscar, Zamorano, José, Jiménez-Blanco Bravo, Marta, Maier, Lars S, Olivotto, Iacopo, Rutten, Frans H, Mant, Jonathan, Velicki, Lazar, Seferović, Petar M, Filipovic, Nenad, Jakovljevic, Djordje G, Fatima, Bano, Kate, Williams, Alessandra, Fornaro, Aleksandra, Milovancev, Meritxell, Ascanio, Ainoa, Aguera, Matej, Pičulin, Borut, Flis, Dimitrios, Boucharas, Dimitris, Manousos, Manolis, Tsiknakis, Thomas, Kassiotis, Tijana, Sustersic, Bogdan, Milicevic, Richard, Hobbs FD, Onno, Kaagman

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A digitally supported multimodal lifestyle program to promote brain health among older adults (the LETHE randomized controlled feasibility trial): study design, progress, and first... von Rosenberg, Anna, Untersteiner, Helena, Guazzarini, Anna Giulia, Bödenler, Markus, Bruinsma, Jeroen, Buchgraber-Schnalzer, Bianca, Colombo, Matteo, Crutzen, Rik, Diaz, Ana, Fotiadis, Dimitrios I, Hilberger, Hannes, Huber, Simone, Kaartinen, Nico, Kassiotis, Thomas, Kivipelto, Miia, Lehtisalo, Jenni, Loukas, Vasileios S, Lötjönen, Jyrki, Pirani, Mattia, Thunborg, Charlotta, Hanke, Sten, Mangialasche, Francesca, Mecocci, Patrizia, Stögmann, Elisabeth, Ngandu, Tiia

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Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA von Abbosh, Christopher, Frankell, Alexander M., Harrison, Thomas, Kisistok, Judit, Garnett, Aaron, Johnson, Laura, Veeriah, Selvaraju, Moreau, Mike, Chesh, Adrian, Chaunzwa, Tafadzwa L., Weiss, Jakob, Schroeder, Morgan R., Ward, Sophia, Grigoriadis, Kristiana, Shahpurwalla, Aamir, Litchfield, Kevin, Puttick, Clare, Biswas, Dhruva, Karasaki, Takahiro, Black, James R. M., Martínez-Ruiz, Carlos, Bakir, Maise Al, Pich, Oriol, Watkins, Thomas B. K., Lim, Emilia L., Huebner, Ariana, Moore, David A., Godin-Heymann, Nadia, L’Hernault, Anne, Bye, Hannah, Odell, Aaron, Kalavakur, Paula, Gomes, Fabio, Patel, Akshay J., Manzano, Elizabeth, Hiley, Crispin T., Carey, Nicolas, Riley, Joan, Cook, Daniel E., Hodgson, Darren, Stetson, Daniel, Barrett, J. Carl, Kortlever, Roderik M., Evan, Gerard I., Hackshaw, Allan, Daber, Robert D., Shaw, Jacqui A., Aerts, Hugo J. W. L., Licon, Abel, Stahl, Josh, Jamal-Hanjani, Mariam, Birkbak, Nicolai J., McGranahan, Nicholas, Swanton, Charles

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IL27 gene expression distinguishes multisystem inflammatory syndrome in children from febrile illness in a South African cohort von Spracklen, Timothy F, Mendelsohn, Simon C, Butters, Claire, Facey-Thomas, Heidi, Stander, Raphaella, Abrahams, Debbie, Erasmus, Mzwandile, Baguma, Richard, Day, Jonathan, Scott, Christiaan, Zühlke, Liesl J, Kassiotis, George, Scriba, Thomas J, Webb, Kate

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Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells von Śledzińska, Anna, Vila de Mucha, Maria, Bergerhoff, Katharina, Hotblack, Alastair, Demane, Dafne Franz, Ghorani, Ehsan, Akarca, Ayse U., Marzolini, Maria A.V., Solomon, Isabelle, Vargas, Frederick Arce, Pule, Martin, Ono, Masahiro, Seddon, Benedict, Kassiotis, George, Ariyan, Charlotte E., Korn, Thomas, Marafioti, Teresa, Lord, Graham M., Stauss, Hans, Jenner, Richard G., Peggs, Karl S., Quezada, Sergio A.

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The evolution of lung cancer and impact of subclonal selection in TRACERx von Frankell, Alexander M., Dietzen, Michelle, Al Bakir, Maise, Lim, Emilia L., Karasaki, Takahiro, Ward, Sophia, Veeriah, Selvaraju, Colliver, Emma, Huebner, Ariana, Bunkum, Abigail, Hill, Mark S., Grigoriadis, Kristiana, Moore, David A., Black, James R. M., Liu, Wing Kin, Thol, Kerstin, Pich, Oriol, Watkins, Thomas B. K., Naceur-Lombardelli, Cristina, Cook, Daniel E., Salgado, Roberto, Wilson, Gareth A., Bailey, Chris, Angelova, Mihaela, Bentham, Robert, Martínez-Ruiz, Carlos, Abbosh, Christopher, Nicholson, Andrew G., Le Quesne, John, Biswas, Dhruva, Rosenthal, Rachel, Puttick, Clare, Hessey, Sonya, Lee, Claudia, Prymas, Paulina, Toncheva, Antonia, Smith, Jon, Xing, Wei, Nicod, Jerome, Price, Gillian, Kerr, Keith M., Naidu, Babu, Middleton, Gary, Blyth, Kevin G., Fennell, Dean A., Forster, Martin D., Lee, Siow Ming, Falzon, Mary, Hewish, Madeleine, Shackcloth, Michael J., Lim, Eric, Benafif, Sarah, Russell, Peter, Boleti, Ekaterini, Krebs, Matthew G., Lester, Jason F., Papadatos-Pastos, Dionysis, Ahmad, Tanya, Thakrar, Ricky M., Lawrence, David, Navani, Neal, Janes, Sam M., Dive, Caroline, Blackhall, Fiona H., Summers, Yvonne, Cave, Judith, Marafioti, Teresa, Herrero, Javier, Quezada, Sergio A., Peggs, Karl S., Schwarz, Roland F., Van Loo, Peter, Miedema, Daniël M., Birkbak, Nicolai J., Hiley, Crispin T., Hackshaw, Allan, Zaccaria, Simone, Jamal-Hanjani, Mariam, McGranahan, Nicholas, Swanton, Charles

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Antibodies against endogenous retroviruses promote lung cancer immunotherapy von Ng, Kevin W., Boumelha, Jesse, Enfield, Katey S. S., Almagro, Jorge, Cha, Hongui, Pich, Oriol, Karasaki, Takahiro, Moore, David A., Salgado, Roberto, Sivakumar, Monica, Young, George, Molina-Arcas, Miriam, de Carné Trécesson, Sophie, Anastasiou, Panayiotis, Fendler, Annika, Au, Lewis, Shepherd, Scott T. C., Martínez-Ruiz, Carlos, Puttick, Clare, Black, James R. M., Watkins, Thomas B. K., Kim, Hyemin, Shim, Seohee, Faulkner, Nikhil, Attig, Jan, Veeriah, Selvaraju, Magno, Neil, Ward, Sophia, Frankell, Alexander M., Al Bakir, Maise, Lim, Emilia L., Hill, Mark S., Wilson, Gareth A., Cook, Daniel E., Birkbak, Nicolai J., Behrens, Axel, Yousaf, Nadia, Popat, Sanjay, Hackshaw, Allan, Hiley, Crispin T., Litchfield, Kevin, McGranahan, Nicholas, Jamal-Hanjani, Mariam, Larkin, James, Lee, Se-Hoon, Turajlic, Samra, Swanton, Charles, Downward, Julian, Kassiotis, George

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The evolution of non-small cell lung cancer metastases in TRACERx von Al Bakir, Maise, Huebner, Ariana, Martínez-Ruiz, Carlos, Grigoriadis, Kristiana, Watkins, Thomas B. K., Pich, Oriol, Moore, David A., Veeriah, Selvaraju, Ward, Sophia, Laycock, Joanne, Johnson, Diana, Rowan, Andrew, Razaq, Maryam, Akther, Mita, Naceur-Lombardelli, Cristina, Prymas, Paulina, Toncheva, Antonia, Hessey, Sonya, Dietzen, Michelle, Colliver, Emma, Frankell, Alexander M., Bunkum, Abigail, Lim, Emilia L., Karasaki, Takahiro, Abbosh, Christopher, Hiley, Crispin T., Hill, Mark S., Cook, Daniel E., Wilson, Gareth A., Salgado, Roberto, Nye, Emma, Stone, Richard Kevin, Fennell, Dean A., Price, Gillian, Kerr, Keith M., Naidu, Babu, Middleton, Gary, Summers, Yvonne, Lindsay, Colin R., Blackhall, Fiona H., Cave, Judith, Blyth, Kevin G., Nair, Arjun, Ahmed, Asia, Taylor, Magali N., Procter, Alexander James, Falzon, Mary, Lawrence, David, Navani, Neal, Thakrar, Ricky M., Janes, Sam M., Papadatos-Pastos, Dionysis, Forster, Martin D., Lee, Siow Ming, Ahmad, Tanya, Quezada, Sergio A., Peggs, Karl S., Van Loo, Peter, Dive, Caroline, Hackshaw, Allan, Birkbak, Nicolai J., Zaccaria, Simone, Jamal-Hanjani, Mariam, McGranahan, Nicholas, Swanton, Charles

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T cell regulation as a side effect of homeostasis and competition von Barthlott, Thomas, Kassiotis, George, Stockinger, Brigitta

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Evolutionary characterization of lung adenocarcinoma morphology in TRACERx von Karasaki, Takahiro, Moore, David A., Veeriah, Selvaraju, Naceur-Lombardelli, Cristina, Toncheva, Antonia, Magno, Neil, Ward, Sophia, Bakir, Maise Al, Watkins, Thomas B. K., Grigoriadis, Kristiana, Huebner, Ariana, Hill, Mark S., Frankell, Alexander M., Abbosh, Christopher, Puttick, Clare, Zhai, Haoran, Gimeno-Valiente, Francisco, Saghafinia, Sadegh, Kanu, Nnennaya, Dietzen, Michelle, Pich, Oriol, Lim, Emilia L., Martínez-Ruiz, Carlos, Black, James R. M., Biswas, Dhruva, Campbell, Brittany B., Lee, Claudia, Colliver, Emma, Enfield, Katey S. S., Hessey, Sonya, Hiley, Crispin T., Zaccaria, Simone, Litchfield, Kevin, Birkbak, Nicolai J., Cadieux, Elizabeth Larose, Demeulemeester, Jonas, Van Loo, Peter, Adusumilli, Prasad S., Tan, Kay See, Cheema, Waseem, Sanchez-Vega, Francisco, Jones, David R., Rekhtman, Natasha, Travis, William D., Hackshaw, Allan, Marafioti, Teresa, Salgado, Roberto, Le Quesne, John, Nicholson, Andrew G., McGranahan, Nicholas, Swanton, Charles, Jamal-Hanjani, Mariam

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E3 ubiquitin ligase HECTD2 mediates melanoma progression and immune evasion von Ottina, Eleonora, Panova, Veera, Doglio, Laura, Kazachenka, Anastasiya, Cornish, Georgina, Kirkpatrick, Joanna, Attig, Jan, Young, George R., Litchfield, Kevin, Lesluyes, Tom, Van Loo, Peter, Swanton, Charles, MacRae, James, Tüting, Thomas, Kassiotis, George

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Representation of genomic intratumor heterogeneity in multi-region non-small cell lung cancer patient-derived xenograft models von Hynds, Robert E., Huebner, Ariana, Pearce, David R., Hill, Mark S., Akarca, Ayse U., Moore, David A., Ward, Sophia, Gowers, Kate H. C., Karasaki, Takahiro, Al Bakir, Maise, Wilson, Gareth A., Pich, Oriol, Martínez-Ruiz, Carlos, Hossain, A. S. Md Mukarram, Pearce, Simon P., Sivakumar, Monica, Ben Aissa, Assma, Grönroos, Eva, Chandrasekharan, Deepak, Kolluri, Krishna K., Towns, Rebecca, Wang, Kaiwen, Cook, Daniel E., Bosshard-Carter, Leticia, Naceur-Lombardelli, Cristina, Rowan, Andrew J., Veeriah, Selvaraju, Litchfield, Kevin, Crosbie, Philip A. J., Dive, Caroline, Quezada, Sergio A., Janes, Sam M., Jamal-Hanjani, Mariam, Marafioti, Teresa, McGranahan, Nicholas, Swanton, Charles

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Restoration of Endogenous Retrovirus Infectivity Impacts Mouse Cancer Models von Ottina, Eleonora, Levy, Prisca, Eksmond, Urszula, Merkenschlager, Julia, Young, George R, Roels, Juliette, Stoye, Jonathan P, Tüting, Thomas, Calado, Dinis P, Kassiotis, George

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Antibodies against endogenous retroviruses promote lung cancer immunotherapy von Ng, Kevin, Boumelha, Jesse, Enfield, Katey S.S, Almagro, Jorge L, Cha, Hongui M, Pich, Oriol, Karasaki, Takahiro, Moore, David, Salgado, Roberto, Sivakumar, Monica, Young, George, Molina-Arcas, Miriam L, de Carne Trecesson, Sophie, Anastasiou, Panayiotis, Fendler, Annika C, Au, Lewis, Shepherd, Scott T.C, Martinez-Ruiz, Carlos, Puttick, Clare, Black, James R.M, Watkins, Thomas B.K, Kim, Hyemin, Shim, Seohee, Faulkner, Nikhil, Attig, Jan A, Veeriah, Selvaraju, Magno, Neil J, Ward, Sophia T, Frankell, Alexander, Al Bakir, Maise, Lim, Emilia, Hill, Mark, Wilson, Gareth, Cook, Daniel, Birkbak, Nicolai, Behrens, Axel, Yousaf, Nadia, Popat, Sanjay, Hackshaw, Allan, TRACERx, Consortium, CAPTURE, Consortium, Hiley, Crispin T, Litchfield, Kevin, McGranahan, Nicholas, Jamal-Hanjani, Mariam, Larkin, James, Lee, Se-Hoon, Turajlic, Samra, Swanton, Charles, Downward, Julian, Kassiotis, George

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Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers von Houlihan, Catherine F, Vora, Nina, Byrne, Thomas, Lewer, Dan, Kelly, Gavin, Heaney, Judith, Gandhi, Sonia, Spyer, Moira J, Beale, Rupert, Cherepanov, Peter, Moore, David, Gilson, Richard, Gamblin, Steve, Kassiotis, George, McCoy, Laura E, Swanton, Charles, Crick COVID-19 Consortium, Hayward, Andrew, Nastouli, Eleni, SAFER Investigators

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343 Identification of tumor-reactive T cells targeting melanoma Dark Antigens™ validates this novel class of targets for development of immunotherapies von Abbott, Rachel, Hofland, Tom, Hulen, Thomas, Elizabeth (Els) Verdegaal, Crowther, Michael, Dukes, Joseph, Khan, Shawez, Pita de Kok, Masi, Giulia, Özcan Met, Schina, Aimilia, Selvadurai, Hayden, Visser, Marten, Ward, Katarzyna, van der Burg, Sjoerd, Kassiotis, George, Svane, Inge

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The concept of space and competition in immune regulation von Stockinger, Brigitta, Barthlott, Thomas, Kassiotis, George

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Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma von Biswas, Dhruva, Liu, Yun-Hsin, Herrero, Javier, Wu, Yin, Moore, David A, Karasaki, Takahiro, Grigoriadis, Kristiana, Lu, Wei-Ting, Veeriah, Selvaraju, Naceur-Lombardelli, Cristina, Magno, Neil, Ward, Sophia, Frankell, Alexander M, Hill, Mark S, Colliver, Emma, de Carné Trécesson, Sophie, East, Philip, Malhi, Aman, Snell, Daniel M, O'Neill, Olga, Leonce, Daniel, Mattsson, Johanna, Lindberg, Amanda, Micke, Patrick, Moldvay, Judit, Megyesfalvi, Zsolt, Dome, Balazs, Fillinger, János, Nicod, Jerome, Downward, Julian, Szallasi, Zoltan, Hackshaw, Allan, Jamal-Hanjani, Mariam, Kanu, Nnennaya, Birkbak, Nicolai J, Swanton, Charles

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T cell regulation: a special job or everyone's responsibility? von Stockinger, Brigitta, Barthlott, Thomas, Kassiotis, George

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Antibodies against endogenous retroviruses promote lung cancer immunotherapy von Ng, Kevin W, Boumelha, Jesse, Enfield, Katey SS, Almagro, Jorge, Cha, Hongui, Pich, Oriol, Karasaki, Takahiro, Moore, David A, Salgado, Roberto, Sivakumar, Monica, Young, George, Molina-Arcas, Miriam, de Carné Trécesson, Sophie, Anastasiou, Panayiotis, Fendler, Annika, Au, Lewis, Shepherd, Scott TC, Martínez-Ruiz, Carlos, Puttick, Clare, Black, James RM, Watkins, Thomas BK, Kim, Hyemin, Shim, Seohee, Faulkner, Nikhil, Attig, Jan, Veeriah, Selvaraju, Magno, Neil, Ward, Sophia, Frankell, Alexander M, Al Bakir, Maise, Lim, Emilia L, Hill, Mark S, Wilson, Gareth A, Cook, Daniel E, Birkbak, Nicolai J, Behrens, Axel, Yousaf, Nadia, Popat, Sanjay, Hackshaw, Allan, TRACERx Consortium, CAPTURE Consortium, Hiley, Crispin T, Litchfield, Kevin, McGranahan, Nicholas, Jamal-Hanjani, Mariam, Larkin, James, Lee, Se-Hoon, Turajlic, Samra, Swanton, Charles, Downward, Julian, Kassiotis, George

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