Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma von Jansky, Selina, Sharma, Ashwini Kumar, Körber, Verena, Quintero, Andrés, Toprak, Umut H., Wecht, Elisa M., Gartlgruber, Moritz, Greco, Alessandro, Chomsky, Elad, Grünewald, Thomas G. P., Henrich, Kai-Oliver, Tanay, Amos, Herrmann, Carl, Höfer, Thomas, Westermann, Frank

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Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota von Akagbosu, Blossom, Tayyebi, Zakieh, Shibu, Gayathri, Paucar Iza, Yoselin A., Deep, Deeksha, Parisotto, Yollanda Franco, Fisher, Logan, Pasolli, H. Amalia, Thevin, Valentin, Elmentaite, Rasa, Knott, Maximilian, Hemmers, Saskia, Jahn, Lorenz, Friedrich, Christin, Verter, Jacob, Wang, Zhong-Min, van den Brink, Marcel, Gasteiger, Georg, Grünewald, Thomas G. P., Marie, Julien C., Leslie, Christina, Rudensky, Alexander Y., Brown, Chrysothemis C.

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Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells von Elia, Ilaria, Broekaert, Dorien, Christen, Stefan, Boon, Ruben, Radaelli, Enrico, Orth, Martin F., Verfaillie, Catherine, Grünewald, Thomas G. P., Fendt, Sarah-Maria

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Ewing sarcoma von Grünewald, Thomas G. P., Cidre-Aranaz, Florencia, Surdez, Didier, Tomazou, Eleni M., de Álava, Enrique, Kovar, Heinrich, Sorensen, Poul H., Delattre, Olivier, Dirksen, Uta

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Epithelial-to-Mesenchymal and Mesenchymal-to-Epithelial Transition in Mesenchymal Tumors: A Paradox in Sarcomas? von Sannino, Giuseppina, Marchetto, Aruna, Kirchner, Thomas, Grünewald, Thomas G P

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Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours von Jones, David T. W., Banito, Ana, Grünewald, Thomas G. P., Haber, Michelle, Jäger, Natalie, Kool, Marcel, Milde, Till, Molenaar, Jan J., Nabbi, Arash, Pugh, Trevor J., Schleiermacher, Gudrun, Smith, Malcolm A., Westermann, Frank, Pfister, Stefan M.

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Targeting the undruggable: exploiting neomorphic features of fusion oncoproteins in childhood sarcomas for innovative therapies von Knott, Maximilian M. L., Hölting, Tilman L. B., Ohmura, Shunya, Kirchner, Thomas, Cidre-Aranaz, Florencia, Grünewald, Thomas G. P.

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PHGDH heterogeneity potentiates cancer cell dissemination and metastasis von Rossi, Matteo, Altea-Manzano, Patricia, Demicco, Margherita, Doglioni, Ginevra, Bornes, Laura, Fukano, Marina, Vandekeere, Anke, Cuadros, Alejandro M., Fernández-García, Juan, Riera-Domingo, Carla, Jauset, Cristina, Planque, Mélanie, Alkan, H. Furkan, Nittner, David, Zuo, Dongmei, Broadfield, Lindsay A., Parik, Sweta, Pane, Antonino Alejandro, Rizzollo, Francesca, Rinaldi, Gianmarco, Zhang, Tao, Teoh, Shao Thing, Aurora, Arin B., Karras, Panagiotis, Vermeire, Ines, Broekaert, Dorien, Elsen, Joke Van, Knott, Maximilian M. L., Orth, Martin F., Demeyer, Sofie, Eelen, Guy, Dobrolecki, Lacey E., Bassez, Ayse, Brussel, Thomas Van, Sotlar, Karl, Lewis, Michael T., Bartsch, Harald, Wuhrer, Manfred, Veelen, Peter van, Carmeliet, Peter, Cools, Jan, Morrison, Sean J., Marine, Jean-Christophe, Lambrechts, Diether, Mazzone, Massimiliano, Hannon, Gregory J., Lunt, Sophia Y., Grünewald, Thomas G. P., Park, Morag, Rheenen, Jacco van, Fendt, Sarah-Maria

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Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity von Vriens, Kim, Christen, Stefan, Parik, Sweta, Broekaert, Dorien, Yoshinaga, Kazuaki, Talebi, Ali, Dehairs, Jonas, Escalona-Noguero, Carmen, Schmieder, Roberta, Cornfield, Thomas, Charlton, Catriona, Romero-Pérez, Laura, Rossi, Matteo, Rinaldi, Gianmarco, Orth, Martin F., Boon, Ruben, Kerstens, Axelle, Kwan, Suet Ying, Faubert, Brandon, Méndez-Lucas, Andrés, Kopitz, Charlotte C., Chen, Ting, Fernandez-Garcia, Juan, Duarte, João A. G., Schmitz, Arndt A., Steigemann, Patrick, Najimi, Mustapha, Hägebarth, Andrea, Van Ginderachter, Jo A., Sokal, Etienne, Gotoh, Naohiro, Wong, Kwok-Kin, Verfaillie, Catherine, Derua, Rita, Munck, Sebastian, Yuneva, Mariia, Beretta, Laura, DeBerardinis, Ralph J., Swinnen, Johannes V., Hodson, Leanne, Cassiman, David, Verslype, Chris, Christian, Sven, Grünewald, Sylvia, Grünewald, Thomas G. P., Fendt, Sarah-Maria

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Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries von Boeva, Valentina, Louis-Brennetot, Caroline, Peltier, Agathe, Durand, Simon, Pierre-Eugène, Cécile, Raynal, Virginie, Etchevers, Heather C, Thomas, Sophie, Lermine, Alban, Daudigeos-Dubus, Estelle, Geoerger, Birgit, Orth, Martin F, Grünewald, Thomas G P, Diaz, Elise, Ducos, Bertrand, Surdez, Didier, Carcaboso, Angel M, Medvedeva, Irina, Deller, Thomas, Combaret, Valérie, Lapouble, Eve, Pierron, Gaelle, Grossetête-Lalami, Sandrine, Baulande, Sylvain, Schleiermacher, Gudrun, Barillot, Emmanuel, Rohrer, Hermann, Delattre, Olivier, Janoueix-Lerosey, Isabelle

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Teacher-student collaborated multiple instance learning for pan-cancer PDL1 expression prediction from histopathology slides von Jin, Darui, Liang, Shangying, Shmatko, Artem, Arnold, Alexander, Horst, David, Grünewald, Thomas G. P., Gerstung, Moritz, Bai, Xiangzhi

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A comparative view on the expression patterns of PD-L1 and PD-1 in soft tissue sarcomas von Orth, Martin F., Buecklein, Veit Leonhard, Kampmann, Eric, Subklewe, Marion, Noessner, Elfriede, Cidre-Aranaz, Florencia, Romero-Pérez, Laura, Wehweck, Fabienne Sophie, Lindner, Lars, Issels, Rolf, Kirchner, Thomas, Altendorf-Hofmann, Annelore, Grünewald, Thomas G. P., Knösel, Thomas

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Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma von Ohmura, Shunya, Marchetto, Aruna, Orth, Martin F, Li, Jing, Jabar, Susanne, Ranft, Andreas, Vinca, Endrit, Ceranski, Katharina, Carreño-Gonzalez, Martha J, Romero-Pérez, Laura, Wehweck, Fabienne S, Musa, Julian, Bestvater, Felix, Knott, Maximilian M L, Hölting, Tilman L B, Hartmann, Wolfgang, Dirksen, Uta, Kirchner, Thomas, Cidre-Aranaz, Florencia, Grünewald, Thomas G P

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Endogenous TCR promotes in vivo persistence of CD19-CAR-T cells compared to a CRISPR/Cas9-mediated TCR knockout CAR von Stenger, Dana, Stief, Tanja A., Kaeuferle, Theresa, Willier, Semjon, Rataj, Felicitas, Schober, Kilian, Vick, Binje, Lotfi, Ramin, Wagner, Beate, Grünewald, Thomas G.P., Kobold, Sebastian, Busch, Dirk H., Jeremias, Irmela, Blaeschke, Franziska, Feuchtinger, Tobias

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Single-cell division tracing and transcriptomics reveal cell types and differentiation paths in the regenerating lung von Martins, Leila R., Sieverling, Lina, Michelhans, Michelle, Schiller, Chiara, Erkut, Cihan, Grünewald, Thomas G. P., Triana, Sergio, Fröhling, Stefan, Velten, Lars, Glimm, Hanno, Scholl, Claudia

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Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma von Marchetto, Aruna, Ohmura, Shunya, Orth, Martin F., Knott, Maximilian M. L., Colombo, Maria V., Arrigoni, Chiara, Bardinet, Victor, Saucier, David, Wehweck, Fabienne S., Li, Jing, Stein, Stefanie, Gerke, Julia S., Baldauf, Michaela C., Musa, Julian, Dallmayer, Marlene, Romero-Pérez, Laura, Hölting, Tilman L. B., Amatruda, James F., Cossarizza, Andrea, Henssen, Anton G., Kirchner, Thomas, Moretti, Matteo, Cidre-Aranaz, Florencia, Sannino, Giuseppina, Grünewald, Thomas G. P.

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MYBL2 (B-Myb): a central regulator of cell proliferation, cell survival and differentiation involved in tumorigenesis von Musa, Julian, Aynaud, Marie-Ming, Mirabeau, Olivier, Delattre, Olivier, Grünewald, Thomas GP

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Unraveling Ewing Sarcoma Tumorigenesis Originating from Patient-Derived Mesenchymal Stem Cells von Sole, Anna, Grossetête, Sandrine, Heintzé, Maxime, Babin, Loelia, Zaïdi, Sakina, Revy, Patrick, Renouf, Benjamin, De Cian, Anne, Giovannangeli, Carine, Pierre-Eugène, Cécile, Janoueix-Lerosey, Isabelle, Couronné, Lucile, Kaltenbach, Sophie, Tomishima, Mark, Jasin, Maria, Grünewald, Thomas G P, Delattre, Olivier, Surdez, Didier, Brunet, Erika

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Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer von Li, Jing, Ohmura, Shunya, Marchetto, Aruna, Orth, Martin F., Imle, Roland, Dallmayer, Marlene, Musa, Julian, Knott, Maximilian M. L., Hölting, Tilman L. B., Stein, Stefanie, Funk, Cornelius M., Sastre, Ana, Alonso, Javier, Bestvater, Felix, Kasan, Merve, Romero-Pérez, Laura, Hartmann, Wolfgang, Ranft, Andreas, Banito, Ana, Dirksen, Uta, Kirchner, Thomas, Cidre-Aranaz, Florencia, Grünewald, Thomas G. P.

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Prion-like domain mediated phase separation of ARID1A promotes oncogenic potential of Ewing’s sarcoma von Kim, Yong Ryoul, Joo, Jaegeon, Lee, Hee Jung, Kim, Chaelim, Park, Ju-Chan, Yu, Young Suk, Kim, Chang Rok, Lee, Do Hui, Cha, Joowon, Kwon, Hyemin, Hanssen, Kimberley M., Grünewald, Thomas G. P., Choi, Murim, Han, Ilkyu, Bae, Sangsu, Jung, Inkyung, Shin, Yongdae, Baek, Sung Hee

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