Instructive Role of MLL-Fusion Proteins Revealed by a Model of t(4;11) Pro-B Acute Lymphoblastic Leukemia von Lin, Shan, Luo, Roger T., Ptasinska, Anetta, Kerry, Jon, Assi, Salam A., Wunderlich, Mark, Imamura, Toshihiko, Kaberlein, Joseph J., Rayes, Ahmad, Althoff, Mark J., Anastasi, John, O’Brien, Maureen M., Meetei, Amom Ruhikanta, Milne, Thomas A., Bonifer, Constanze, Mulloy, James C., Thirman, Michael J.

Volltext

Distinct microRNA expression profiles in acute myeloid leukemia with common translocations von Li, Zejuan, Lu, Jun, Sun, Miao, Mi, Shuangli, Zhang, Hao, Luo, Roger T, Chen, Ping, Wang, Yungui, Yan, Ming, Qian, Zhijian, Neilly, Mary Beth, Jin, Jie, Zhang, Yanming, Bohlander, Stefan K, Zhang, Dong-Er, Larson, Richard A, Le Beau, Michelle M, Thirman, Michael J, Golub, Todd R, Rowley, Janet D, Chen, Jianjun

Volltext

Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis von Jeong, Jong Jin, Gu, Xiaorong, Nie, Ji, Sundaravel, Sriram, Liu, Hui, Kuo, Wen-Liang, Bhagat, Tushar D, Pradhan, Kith, Cao, John, Nischal, Sangeeta, McGraw, Kathy L, Bhattacharyya, Sanchari, Bishop, Michael R, Artz, Andrew, Thirman, Michael J, Moliterno, Alison, Ji, Peng, Levine, Ross L, Godley, Lucy A, Steidl, Ulrich, Bieker, James J, List, Alan F, Saunthararajah, Yogen, He, Chuan, Verma, Amit, Wickrema, Amittha

Volltext

MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome von Wang, Qian-fei, Wu, George, Mi, Shuangli, He, Fuhong, Wu, Jun, Dong, Jingfang, Luo, Roger T., Mattison, Ryan, Kaberlein, Joseph J., Prabhakar, Shyam, Ji, Hongkai, Thirman, Michael J.

Volltext

A phase I study of selinexor in combination with high-dose cytarabine and mitoxantrone for remission induction in patients with acute myeloid leukemia von Wang, Amy Y, Weiner, Howard, Green, Margaret, Chang, Hua, Fulton, Noreen, Larson, Richard A, Odenike, Olatoyosi, Artz, Andrew S, Bishop, Michael R, Godley, Lucy A, Thirman, Michael J, Kosuri, Satyajit, Churpek, Jane E, Curran, Emily, Pettit, Kristen, Stock, Wendy, Liu, Hongtao

Volltext

Clinical and molecular response of acute myeloid leukemia harboring non-canonical FLT3 N676K driver mutations to contemporary FLT3 inhibitors von Roloff, Gregory W, Wen, Frank, Ramsland, Aubrianna, Artz, Andrew S, Kosuri, Satyajit, Stock, Wendy, Odenike, Olatoyosi, Larson, Richard A, Liu, Hongtao, Godley, Lucy A, Thirman, Michael J, Patel, Anand A, Daugherty, Christopher K, DuVall, Adam S, Nawas, Mariam T, Dworkin, Emily, Wool, Geoffrey D, Gurbuxani, Sandeep, Fitzpatrick, Carrie, Segal, Jeremy P, Wang, Peng, Drazer, Michael W

Volltext

Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia von Mi, Shuangli, Li, Zejuan, Chen, Ping, He, Chunjiang, Cao, Donglin, Elkahloun, Abdel, Lu, Jun, Pelloso, Luis A, Wunderlich, Mark, Huang, Hao, Luo, Roger T, Sun, Miao, He, Miao, Neilly, Mary Beth, Zeleznik-Le, Nancy J, Thirman, Michael J, Mulloy, James C, Liu, Paul P, Rowley, Janet D, Chen, Jianjun

Volltext

Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia von DiNardo, Courtney D, Jonas, Brian A, Pullarkat, Vinod, Thirman, Michael J, Garcia, Jacqueline S, Wei, Andrew H, Konopleva, Marina, Döhner, Hartmut, Letai, Anthony, Fenaux, Pierre, Koller, Elizabeth, Havelange, Violaine, Leber, Brian, Esteve, Jordi, Wang, Jianxiang, Pejsa, Vlatko, Hájek, Roman, Porkka, Kimmo, Illés, Árpád, Lavie, David, Lemoli, Roberto M, Yamamoto, Kazuhito, Yoon, Sung-Soo, Jang, Jun-Ho, Yeh, Su-Peng, Turgut, Mehmet, Hong, Wan-Jen, Zhou, Ying, Potluri, Jalaja, Pratz, Keith W

Volltext

The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia von Issa, Ghayas C., Aldoss, Ibrahim, DiPersio, John, Cuglievan, Branko, Stone, Richard, Arellano, Martha, Thirman, Michael J., Patel, Manish R., Dickens, David S., Shenoy, Shalini, Shukla, Neerav, Kantarjian, Hagop, Armstrong, Scott A., Perner, Florian, Perry, Jennifer A., Rosen, Galit, Bagley, Rebecca G., Meyers, Michael L., Ordentlich, Peter, Gu, Yu, Kumar, Vinit, Smith, Steven, McGeehan, Gerard M., Stein, Eytan M.

Volltext

Quercetin Therapy for Selected Patients with PIM1 Kinase-Positive Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Pilot Study von Baron, Beverly W., Thirman, Michael J., Giurcanu, Mihai C., Baron, Joseph M.

Volltext

Paradoxical Effects of MLL Paralogs in MLL-Rearranged Leukemia von Thirman, Michael J.

Volltext

Measurable Residual Disease Response and Prognosis in Treatment-Naïve Acute Myeloid Leukemia With Venetoclax and Azacitidine von Pratz, Keith W, Jonas, Brian A, Pullarkat, Vinod, Recher, Christian, Schuh, Andre C, Thirman, Michael J, Garcia, Jacqueline S, DiNardo, Courtney D, Vorobyev, Vladimir, Fracchiolla, Nicola S, Yeh, Su-Peng, Jang, Jun Ho, Ozcan, Muhit, Yamamoto, Kazuhito, Illes, Arpad, Zhou, Ying, Dail, Monique, Chyla, Brenda, Potluri, Jalaja, Döhner, Hartmut

Volltext

Venetoclax with azacitidine or decitabine in patients with newly diagnosed acute myeloid leukemia: Long term follow‐up from a phase 1b study von Pollyea, Daniel A., Pratz, Keith, Letai, Anthony, Jonas, Brian A., Wei, Andrew H., Pullarkat, Vinod, Konopleva, Marina, Thirman, Michael J., Arellano, Martha, Becker, Pamela S., Chyla, Brenda, Hong, Wan‐Jen, Jiang, Qi, Potluri, Jalaja, DiNardo, Courtney D.

Volltext

Impact of FLT3 Mutation on Outcomes after Venetoclax and Azacitidine for Patients with Treatment-Naïve Acute Myeloid Leukemia von Konopleva, Marina, Thirman, Michael J, Pratz, Keith W, Garcia, Jacqueline S, Recher, Christian, Pullarkat, Vinod, Kantarjian, Hagop M, DiNardo, Courtney D, Dail, Monique, Duan, Yinghui, Chyla, Brenda, Potluri, Jalaja, Miller, Catherine L, Wei, Andrew H

Volltext

Consistent Deregulation of Gene Expression between Human and Murine MLL Rearrangement Leukemias von ZEJUAN LI, LUO, Roger T, LAVAU, Catherine, YANMING ZHANG, TSENG, Charles, XIUQING ZHANG, JIAN WANG, JUN YU, HUANMING YANG, SAN MING WANG, ROWLEY, Janet D, JIANJUN CHEN, SHUANGLI MI, THIRMAN, Michael J, MIAO SUN, PING CHEN, JINGYUE BAO, BETH NEILLY, Mary, JAYATHILAKA, Nimanthi, JOHNSON, Deborah S, LILI WANG

Volltext

Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes von Byun, Jung S, Wong, Madeline M, Cui, Wenwu, Idelman, Gila, Li, Quentin, De Siervi, Adriana, Bilke, Sven, Haggerty, Cynthia M, Player, Audrey, Wang, Yong Hong, Thirman, Michael J, Kaberlein, Joseph J, Petrovas, Constantinos, Koup, Richard A, Longo, Dan, Ozato, Keiko, Gardner, Kevin

Volltext

Unexplained anemia predominates despite an intensive evaluation in a racially diverse cohort of older adults from a referral anemia clinic von Artz, Andrew S, Thirman, Michael J

Volltext

PIM1 gene cooperates with human BCL6 gene to promote the development of lymphomas von Baron, Beverly W, Anastasi, John, Hyjek, Elizabeth M, Bies, Juraj, Reddy, Poluru L, Dong, Jingfang, Joseph, Loren, Thirman, Michael J, Wroblewski, Kristen, Wolff, Linda, Baron, Joseph M

Volltext

The full transforming capacity of MLL-Af4 is interlinked with lymphoid lineage commitment von Lin, Shan, Luo, Roger T., Shrestha, Mahesh, Thirman, Michael J., Mulloy, James C.

Volltext

The Elongation Factor ELL (Eleven-Nineteen Lysine-Rich Leukemia) Is a Selective Coregulator for Steroid Receptor Functions von Pascual-Le Tallec, Laurent, Simone, Federico, Viengchareun, Say, Meduri, Geri, Thirman, Michael J, Lombès, Marc

Volltext