Genetic Ablation of the c-Cbl Ubiquitin Ligase Domain Results in Increased Energy Expenditure and Improved Insulin Action von MOLERO, Juan C, TURNER, Nigel, THIEN, Christine B. F, LANGDON, Wallace Y, JAMES, David E, COONEY, Gregory J

Volltext

The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells von Rathinam, Chozhavendan, Thien, Christine B F, Langdon, Wallace Y, Gu, Hua, Flavell, Richard A

Volltext

Loss of c-Cbl E3 ubiquitin ligase activity enhances the development of myeloid leukemia in FLT3-ITD mutant mice von Taylor, Samuel J, Thien, Christine B.F, Dagger, Samantha A, Duyvestyn, Johanna M, Grove, Carolyn S, Lee, Benjamin H, Gilliland, D. Gary, Langdon, Wallace Y

Volltext

Dasatinib targets B-lineage cells but does not provide an effective therapy for myeloproliferative disease in c-Cbl RING finger mutant mice von Duyvestyn, Johanna M, Taylor, Samuel J, Dagger, Samantha A, Orandle, Marlene, Morse, 3rd, Herbert C, Thien, Christine B F, Langdon, Wallace Y

Volltext

RING Finger Mutations that Abolish c-Cbl-Directed Polyubiquitination and Downregulation of the EGF Receptor Are Insufficient for Cell Transformation von Thien, Christine B.F, Walker, Francesca, Langdon, Wallace Y

Volltext

c-Cbl Promotes T Cell Receptor-induced Thymocyte Apoptosis by Activating the Phosphatidylinositol 3-Kinase/Akt Pathway von Thien, Christine B.F., Dagger, Samantha A., Steer, James H., Koentgen, Frank, Jansen, Elisa S., Scott, Clare L., Langdon, Wallace Y.

Volltext

The Cbl-b RING finger domain has a limited role in regulating inflammatory cytokine production by IgE-activated mast cells von Oksvold, Morten P., Dagger, Samantha A., Thien, Christine B.F., Langdon, Wallace Y.

Volltext

Unaltered negative selection and Treg development of self-reactive thymocytes in TCR transgenic Fyn-deficient mice von Mamchak, Alusha A, Thien, Christine B.F, Dagger, Samantha A, Lyandres, Julia, Jiang, Shuwei, Langdon, Wallace Y, DeFranco, Anthony L

Volltext

c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses von Thien, Christine B F, Langdon, Wallace Y

Volltext

Essential role of E3 ubiquitin ligase activity in Cbl-b-regulated T cell functions von Paolino, Magdalena, Thien, Christine B F, Gruber, Thomas, Hinterleitner, Reinhard, Baier, Gottfried, Langdon, Wallace Y, Penninger, Josef M

Volltext

Cbl: many adaptations to regulate protein tyrosine kinases von Thien, Christine B. F, Langdon, Wallace Y

Volltext

Flt3 inhibitor AC220 is a potent therapy in a mouse model of myeloproliferative disease driven by enhanced wild-type Flt3 signaling von Taylor, Samuel J., Dagger, Samantha A., Thien, Christine B.F., Wikstrom, Matthew E., Langdon, Wallace Y.

Volltext

A TNF- and c-Cbl-dependent FLIPS-degradation pathway and its function in Mycobacterium tuberculosis–induced macrophage apoptosis von Kundu, Manikuntala, Pathak, Sushil Kumar, Kumawat, Kuldeep, Basu, Sanchita, Chatterjee, Gargi, Pathak, Shresh, Noguchi, Takuya, Takeda, Kohsuke, Ichijo, Hidenori, Thien, Christine B F, Langdon, Wallace Y, Basu, Joyoti

Volltext

Myeloid Leukemia Development in c-Cbl RING Finger Mutant Mice Is Dependent on FLT3 Signaling von Rathinam, Chozhavendan, Thien, Christine B.F., Flavell, Richard A., Langdon, Wallace Y.

Volltext

Visualizing the role of Cbl-b in control of islet-reactive CD4 T cells and susceptibility to type 1 diabetes von Hoyne, Gerard F, Flening, Eleanor, Yabas, Mehmet, Teh, Charis, Altin, John A, Randall, Katrina, Thien, Christine B F, Langdon, Wallace Y, Goodnow, Christopher C

Volltext

Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient Mice von Murphy, Maria A., Schnall, Ralf G., Venter, Deon J., Barnett, Louise, Bertoncello, Ivan, Thien, Christine B. F., Langdon, Wallace Y., Bowtell, David D. L.

Volltext

c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action von Molero, Juan C, Jensen, Thomas E, Withers, Phil C, Couzens, Michelle, Herzog, Herbert, Thien, Christine B F, Langdon, Wallace Y, Walder, Ken, Murphy, Maria A, Bowtell, David D L, James, David E, Cooney, Gregory J

Volltext

Cbl-b Is a Negative Regulator of Inflammatory Cytokines Produced by IgE-Activated Mast Cells von Gustin, Sonja E, Thien, Christine B. F, Langdon, Wallace Y

Volltext

Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion von Thien, Christine BF, Blystad, Frøydis D, Zhan, Yifan, Lew, Andrew M, Voigt, Valentina, Andoniou, Christopher E, Langdon, Wallace Y

Volltext

Negative regulation of PTK signalling by Cbl proteins von Thien, Christine B F, Langdon, Wallace Y

Volltext