Deep learning sequence-based ab initio prediction of variant effects on expression and disease risk von Zhou, Jian, Theesfeld, Chandra L., Yao, Kevin, Chen, Kathleen M., Wong, Aaron K., Troyanskaya, Olga G.

Volltext

Deciphering missense coding variants with AlphaMissense von Pan, Zhicheng, Theesfeld, Chandra L.

Volltext

Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder von Krishnan, Arjun, Zhang, Ran, Yao, Victoria, Theesfeld, Chandra L, Wong, Aaron K, Tadych, Alicja, Volfovsky, Natalia, Packer, Alan, Lash, Alex, Troyanskaya, Olga G

Volltext

Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid von Iserman, Christiane, Roden, Christine A., Boerneke, Mark A., Sealfon, Rachel S.G., McLaughlin, Grace A., Jungreis, Irwin, Fritch, Ethan J., Hou, Yixuan J., Ekena, Joanne, Weidmann, Chase A., Theesfeld, Chandra L., Kellis, Manolis, Troyanskaya, Olga G., Baric, Ralph S., Sheahan, Timothy P., Weeks, Kevin M., Gladfelter, Amy S.

Volltext

The BioGRID interaction database: 2017 update von Chatr-Aryamontri, Andrew, Oughtred, Rose, Boucher, Lorrie, Rust, Jennifer, Chang, Christie, Kolas, Nadine K, O'Donnell, Lara, Oster, Sara, Theesfeld, Chandra, Sellam, Adnane, Stark, Chris, Breitkreutz, Bobby-Joe, Dolinski, Kara, Tyers, Mike

Volltext

Decoding disease: from genomes to networks to phenotypes von Wong, Aaron K., Sealfon, Rachel S. G., Theesfeld, Chandra L., Troyanskaya, Olga G.

Volltext

The BioGRID interaction database: 2015 update von Chatr-Aryamontri, Andrew, Breitkreutz, Bobby-Joe, Oughtred, Rose, Boucher, Lorrie, Heinicke, Sven, Chen, Daici, Stark, Chris, Breitkreutz, Ashton, Kolas, Nadine, O'Donnell, Lara, Reguly, Teresa, Nixon, Julie, Ramage, Lindsay, Winter, Andrew, Sellam, Adnane, Chang, Christie, Hirschman, Jodi, Theesfeld, Chandra, Rust, Jennifer, Livstone, Michael S, Dolinski, Kara, Tyers, Mike

Volltext

Genome-wide landscape of RNA-binding protein target site dysregulation reveals a major impact on psychiatric disorder risk von Park, Christopher Y., Zhou, Jian, Wong, Aaron K., Chen, Kathleen M., Theesfeld, Chandra L., Darnell, Robert B., Troyanskaya, Olga G.

Volltext

Accurate genome-wide predictions of spatio-temporal gene expression during embryonic development von Zhou, Jian, Schor, Ignacio E, Yao, Victoria, Theesfeld, Chandra L, Marco-Ferreres, Raquel, Tadych, Alicja, Furlong, Eileen E M, Troyanskaya, Olga G

Volltext

An extended set of yeast-based functional assays accurately identifies human disease mutations von Sun, Song, Yang, Fan, Tan, Guihong, Costanzo, Michael, Oughtred, Rose, Hirschman, Jodi, Theesfeld, Chandra L, Bansal, Pritpal, Sahni, Nidhi, Yi, Song, Yu, Analyn, Tyagi, Tanya, Tie, Cathy, Hill, David E, Vidal, Marc, Andrews, Brenda J, Boone, Charles, Dolinski, Kara, Roth, Frederick P

Volltext

An automated framework for efficiently designing deep convolutional neural networks in genomics von Zhang, Zijun, Park, Christopher Y., Theesfeld, Chandra L., Troyanskaya, Olga G.

Volltext

SARS-CoV-2 receptor networks in diabetic and COVID-19–associated kidney disease von Menon, Rajasree, Otto, Edgar A., Sealfon, Rachel, Nair, Viji, Wong, Aaron K., Theesfeld, Chandra L., Chen, Xi, Wang, Yuan, Boppana, Avinash S., Luo, Jinghui, Yang, Yingbao, Kasson, Peter M., Schaub, Jennifer A., Berthier, Celine C., Eddy, Sean, Lienczewski, Chrysta C., Godfrey, Bradley, Dagenais, Susan L., Sohaney, Ryann, Hartman, John, Fermin, Damian, Subramanian, Lalita, Looker, Helen C., Harder, Jennifer L., Mariani, Laura H., Hodgin, Jeffrey B., Sexton, Jonathan Z., Wobus, Christiane E., Naik, Abhijit S., Nelson, Robert G., Troyanskaya, Olga G., Kretzler, Matthias

Volltext

Modeling molecular development of breast cancer in canine mammary tumors von Graim, Kiley, Gorenshteyn, Dmitriy, Robinson, David G, Carriero, Nicholas J, Cahill, James A, Chakrabarti, Rumela, Goldschmidt, Michael H, Durham, Amy C, Funk, Julien, Storey, John D, Kristensen, Vessela N, Theesfeld, Chandra L, Sorenmo, Karin U, Troyanskaya, Olga G

Volltext

Modeling transcriptional regulation of model species with deep learning von Cofer, Evan M, Raimundo, João, Tadych, Alicja, Yamazaki, Yuji, Wong, Aaron K, Theesfeld, Chandra L, Levine, Michael S, Troyanskaya, Olga G

Volltext

Tissue-specific enhancer functional networks for associating distal regulatory regions to disease von Chen, Xi, Zhou, Jian, Zhang, Ran, Wong, Aaron K., Park, Christopher Y., Theesfeld, Chandra L., Troyanskaya, Olga G.

Volltext

Whole-genome deep-learning analysis identifies contribution of noncoding mutations to autism risk von Zhou, Jian, Park, Christopher Y., Theesfeld, Chandra L., Wong, Aaron K., Yuan, Yuan, Scheckel, Claudia, Fak, John J., Funk, Julien, Yao, Kevin, Tajima, Yoko, Packer, Alan, Darnell, Robert B., Troyanskaya, Olga G.

Volltext

Insulin-induced Gene Protein (INSIG)-dependent Sterol Regulation of Hmg2 Endoplasmic Reticulum-associated Degradation (ERAD) in Yeast von Theesfeld, Chandra L., Hampton, Randolph Y.

Volltext

Atlas of primary cell-type-specific sequence models of gene expression and variant effects von Sokolova, Ksenia, Theesfeld, Chandra L., Wong, Aaron K., Zhang, Zijun, Dolinski, Kara, Troyanskaya, Olga G.

Volltext

The Sterol-sensing Domain (SSD) Directly Mediates Signal-regulated Endoplasmic Reticulum-associated Degradation (ERAD) of 3-Hydroxy-3-methylglutaryl (HMG)-CoA Reductase Isozyme Hmg... von Theesfeld, Chandra L., Pourmand, Deeba, Davis, Talib, Garza, Renee M., Hampton, Randolph Y.

Volltext

A Computational Framework for Genome-wide Characterization of the Human Disease Landscape von Lee, Young-suk, Krishnan, Arjun, Oughtred, Rose, Rust, Jennifer, Chang, Christie S., Ryu, Joseph, Kristensen, Vessela N., Dolinski, Kara, Theesfeld, Chandra L., Troyanskaya, Olga G.

Volltext