Machine learning-coupled combinatorial mutagenesis enables resource-efficient engineering of CRISPR-Cas9 genome editor activities von Thean, Dawn G. L., Chu, Hoi Yee, Fong, John H. C., Chan, Becky K. C., Zhou, Peng, Kwok, Cynthia C. S., Chan, Yee Man, Mak, Silvia Y. L., Choi, Gigi C. G., Ho, Joshua W. K., Zheng, Zongli, Wong, Alan S. L.

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High-fidelity KKH variant of Staphylococcus aureus Cas9 nucleases with improved base mismatch discrimination von Yuen, Chaya T L, Thean, Dawn G L, Chan, Becky K C, Zhou, Peng, Kwok, Cynthia C S, Chu, Hoi Yee, Cheung, Maggie S H, Wang, Bei, Chan, Yee Man, Mak, Silvia Y L, Leung, Anskar Y, Choi, Gigi C G, Zheng, Zongli, Wong, Alan S L

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Combinatorial genetics methods for discovering high-order regulatory combinations and engineering genetic drivers for neural differentiation von Thean, Dawn, Wong, Alan

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Macrocyclization of an all-d linear alpha-helical peptide imparts cellular permeability von Kannan, Srinivasaraghavan, Aronica, Pietro G. A., Ng, Simon, Lian, Dawn Thean Gek, Frosi, Yuri, Chee, Sharon, Jiang, Shimin, Yuen, Tsz Ying, Sadruddin, Ahmad, Kaan, Hung Yi Kristal, Chandramohan, Arun, Wong, Jin Huei, Tan, Yaw Sing, Chang, Zi Wei, Ferrer-Gago, Fernando J., Arumugam, Prakash, Han, Yi, Chen, Shiying, Renia, Laurent, Brown, Christopher J., Johannes, Charles W., Henry, Brian, Lane, David P., Sawyer, Tomi K., Verma, Chandra S., Partridge, Anthony W.

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Accurate top protein variant discovery via low-N pick-and-validate machine learning von Chu, Hoi Yee, Fong, John H.C., Thean, Dawn G.L., Zhou, Peng, Fung, Frederic K.C., Huang, Yuanhua, Wong, Alan S.L.

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Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides von Desai, Tanvi J., Habulihaz, Bahanu, Cannon, Joe R., Chandramohan, Arun, Kaan, Hung Yi Kristal, Sadruddin, Ahmad, Yuen, Tsz Ying, Johannes, Charles, Thean, Dawn, Brown, Chris J., Lane, David P., Partridge, Anthony W., Evers, Raymond, Sawyer, Tomi K., Hochman, Jerome

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Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex von Frosi, Yuri, Lin, Yen-Chu, Shimin, Jiang, Ramlan, Siti Radhiah, Hew, Kelly, Engman, Alf Henrik, Pillai, Anil, Yeung, Kit, Cheng, Yue Xiang, Cornvik, Tobias, Nordlund, Par, Goh, Megan, Lama, Dilraj, Gates, Zachary P., Verma, Chandra S., Thean, Dawn, Lane, David P., Asial, Ignacio, Brown, Christopher J.

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Monitoring flux in signalling pathways through measurements of 4EBP1-mediated eIF4F complex assembly von Frosi, Yuri, Usher, Rachael, Lian, Dawn Thean Gek, Lane, David P, Brown, Christopher J

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Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties von Partridge, Anthony W, Kaan, Hung Yi Kristal, Juang, Yu-Chi, Sadruddin, Ahmad, Lim, Shuhui, Brown, Christopher J, Ng, Simon, Thean, Dawn, Ferrer, Fernando, Johannes, Charles, Yuen, Tsz Ying, Kannan, Srinivasaraghavan, Aronica, Pietro, Tan, Yaw Sing, Pradhan, Mohan R, Verma, Chandra S, Hochman, Jerome, Chen, Shiying, Wan, Hui, Ha, Sookhee, Sherborne, Brad, Lane, David P, Sawyer, Tomi K

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Correction to: Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides von Desai, Tanvi J., Habulihaz, Bahanu, Cannon, Joseph R., Chandramohan, Arun, Kaan, Hung Yi Kristal, Sadruddin, Ahmad, Yuen, Tsz Ying, Johannes, Charles, Thean, Dawn, Brown, Chris J., Lane, David P., Partridge, Anthony W., Evers, Raymond, Sawyer, Tomi K., Hochman, Jerome

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Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles von Yuen, Tsz Ying, Brown, Christopher J, Xue, Yuezhen, Tan, Yaw Sing, Ferrer Gago, Fernando J, Lee, Xue Er, Neo, Jin Yong, Thean, Dawn, Kaan, Hung Yi Kristal, Partridge, Anthony W, Verma, Chandra S, Lane, David P, Johannes, Charles W

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Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids von Chee, Sharon Min Qi, Wongsantichon, Jantana, Siau, Jiawei, Thean, Dawn, Ferrer, Fernando, Robinson, Robert C, Lane, David P, Brown, Christopher J, Ghadessy, Farid J

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Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9 von Choi, Gigi C. G., Zhou, Peng, Yuen, Chaya T. L., Chan, Becky K. C., Xu, Feng, Bao, Siyu, Chu, Hoi Yee, Thean, Dawn, Tan, Kaeling, Wong, Koon Ho, Zheng, Zongli, Wong, Alan S. L.

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Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides (Mar, 10.1007/s11095-021-03005-z, 2021) von Desai, Tanvi J., Habulihaz, Bahanu, Cannon, Joseph R., Chandramohan, Arun, Kaan, Hung Yi Kristal, Sadruddin, Ahmad, Yuen, Tsz Ying, Johannes, Charles, Thean, Dawn, Brown, Chris J., Lane, David P., Partridge, Anthony W., Evers, Raymond, Sawyer, Tomi K., Hochman, Jerome

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NanoClick: A High Throughput, Target-Agnostic Peptide Cell Permeability Assay von Peier, Andrea, Ge, Lan, Boyer, Nicolas, Frost, John, Duggal, Ruchia, Biswas, Kaustav, Edmondson, Scott, Hermes, Jeffrey D, Yan, Lin, Zimprich, Chad, Sadruddin, Ahmad, Kristal Kaan, Hung Yi, Chandramohan, Arun, Brown, Christopher J, Thean, Dawn, Lee, Xue Er, Yuen, Tsz Ying, Ferrer-Gago, Fernando J, Johannes, Charles W, Lane, David P, Sherborne, Brad, Corona, Cesear, Robers, Matthew B, Sawyer, Tomi K, Partridge, Anthony W

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Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design von Tan, Yaw Sing, Reeks, Judith, Brown, Christopher J, Thean, Dawn, Ferrer Gago, Fernando Jose, Yuen, Tsz Ying, Goh, Eunice Tze Leng, Lee, Xue Er Cheryl, Jennings, Claire E, Joseph, Thomas L, Lakshminarayanan, Rajamani, Lane, David P, Noble, Martin E. M, Verma, Chandra S

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Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles† †Electronic supplementary information (ESI)... von Yuen, Tsz Ying, Brown, Christopher J., Xue, Yuezhen, Tan, Yaw Sing, Ferrer Gago, Fernando J., Lee, Xue Er, Neo, Jin Yong, Thean, Dawn, Kaan, Hung Yi Kristal, Partridge, Anthony W., Verma, Chandra S., Lane, David P., Johannes, Charles W.

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Publisher Correction: Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9 von Choi, Gigi C. G., Zhou, Peng, Yuen, Chaya T. L., Chan, Becky K. C., Xu, Feng, Bao, Siyu, Chu, Hoi Yee, Thean, Dawn, Tan, Kaeling, Wong, Koon Ho, Zheng, Zongli, Wong, Alan S. L.

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Rigorous Computational and Experimental Investigations on MDM2/MDMX-Targeted Linear and Macrocyclic Peptides von Diller, David J, Swanson, Jon, Bayden, Alexander S, Brown, Chris J, Thean, Dawn, Lane, David P, Partridge, Anthony W, Sawyer, Tomi K, Audie, Joseph

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Macrocyclization of an all-d linear α-helical peptide imparts cellular permeability† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc06383h von Kannan, Srinivasaraghavan, Aronica, Pietro G. A., Ng, Simon, Gek Lian, Dawn Thean, Frosi, Yuri, Chee, Sharon, Shimin, Jiang, Yuen, Tsz Ying, Sadruddin, Ahmad, Kaan, Hung Yi Kristal, Chandramohan, Arun, Wong, Jin Huei, Tan, Yaw Sing, Chang, Zi Wei, Ferrer-Gago, Fernando J., Arumugam, Prakash, Han, Yi, Chen, Shiying, Rénia, Laurent, Brown, Christopher J., Johannes, Charles W., Henry, Brian, Lane, David P., Sawyer, Tomi K., Verma, Chandra S., Partridge, Anthony W.

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