Remembering your A, B, C's: Alzheimer's disease and ABCA1 von Lewandowski, Cutler T., Laham, Megan S., Thatcher, Gregory R.J.

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The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development von Ziniel, Peter D, Karumudi, Bhargava, Barnard, Andrew H, Fisher, Ethan M S, Thatcher, Gregory R J, Podust, Larissa M, Williams, David L

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Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments von Fata, Francesca, Silvestri, Ilaria, Ardini, Matteo, Ippoliti, Rodolfo, Di Leandro, Luana, Demitri, Nicola, Polentarutti, Maurizio, Di Matteo, Adele, Lyu, Haining, Thatcher, Gregory R.J, Petukhov, Pavel A, Williams, David L, Angelucci, Francesco

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Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity von Shen, Zhengnan, Ratia, Kiira, Cooper, Laura, Kong, Deyu, Lee, Hyun, Kwon, Youngjin, Li, Yangfeng, Alqarni, Saad, Huang, Fei, Dubrovskyi, Oleksii, Rong, Lijun, Thatcher, Gregory R J, Xiong, Rui

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NO-flurbiprofen reduces amyloid-β, is neuroprotective in cell culture, and enhances cognition in response to cholinergic blockade von Abdul-Hay, Samer O, Luo, Jia, Ashghodom, Rezene T, Thatcher, Gregory R.J

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Selective modulation of amyloid-β peptide degradation by flurbiprofen, fenofibrate, and related compounds regulates Aβ levels von Abdul-Hay, Samer O, Edirisinghe, Praneeth, Thatcher, Gregory R.J

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Iodocyclization of S–(homo)propargyl dithiocarbamates: Regiospecific synthesis of 2-imino(iminium)-1, 3-dithiolanes/dithianes/dithiepanes von Soleymani, Farinaz, Ziyaei Halimehjani, Azim, Asar, Farzane Jafari, Thatcher, Gregory R.J.

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Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons von Yu, Lei, Tasaki, Shinya, Schneider, Julie A, Arfanakis, Konstantinos, Duong, Duc M, Wingo, Aliza P, Wingo, Thomas S, Kearns, Nicola, Thatcher, Gregory R. J, Seyfried, Nicholas T, Levey, Allan I, De Jager, Philip L, Bennett, David A

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Novel Selective Estrogen Receptor Downregulators (SERDs) Developed against Treatment-Resistant Breast Cancer von Xiong, Rui, Zhao, Jiong, Gutgesell, Lauren M, Wang, Yueting, Lee, Sue, Karumudi, Bhargava, Zhao, Huiping, Lu, Yunlong, Tonetti, Debra A, Thatcher, Gregory R. J

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Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbocicl... von Li, Yangfeng, Zhao, Jiong, Gutgesell, Lauren M, Shen, Zhengnan, Ratia, Kiira, Dye, Katherine, Dubrovskyi, Oleksii, Zhao, Huiping, Huang, Fei, Tonetti, Debra A, Thatcher, Gregory R. J, Xiong, Rui

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MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3 von Singh, Sunil Kumar, Kumar, Sandeep, Viswakarma, Navin, Principe, Daniel R., Das, Subhasis, Sondarva, Gautam, Nair, Rakesh Sathish, Srivastava, Piush, Sinha, Subhash C., Grippo, Paul J., Thatcher, Gregory R. J., Rana, Basabi, Rana, Ajay

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Quinoids Formed from Estrogens and Antiestrogens von Bolton, Judy L, Yu, Linning, Thatcher, Gregory R.J

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TrkA expression directs the anti-neoplastic activity of MLK3 inhibitors in triple-negative breast cancer von Nair, Rakesh Sathish, Kumar, Sandeep, Das, Subhasis, Singh, Sunil Kumar, Srivastava, Piush, Sondarva, Gautam, Rao, Arundhati, Sinha, Subhash C., Xiong, Rui, Bloem, Laura, Hoskins, Kent, Thatcher, Gregory R. J., Rana, Basabi, Rana, Ajay

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Design and Synthesis of Basic Selective Estrogen Receptor Degraders for Endocrine Therapy Resistant Breast Cancer von Lu, Yunlong, Gutgesell, Lauren M, Xiong, Rui, Zhao, Jiong, Li, Yangfeng, Rosales, Carlo I, Hollas, Michael, Shen, Zhengnan, Gordon-Blake, Jesse, Dye, Katherine, Wang, Yueting, Lee, Sue, Chen, Hu, He, Donghong, Dubrovyskyii, Oleksii, Zhao, Huiping, Huang, Fei, Lasek, Amy W, Tonetti, Debra A, Thatcher, Gregory R. J

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Potential Mechanisms of Estrogen Quinone Carcinogenesis von Bolton, Judy L, Thatcher, Gregory R. J

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Synthesis, Optimization, and Structure–Activity Relationships of Nicotinamide Phosphoribosyltransferase (NAMPT) Positive Allosteric Modulators (N-PAMs) von Shen, Zhengnan, Ratia, Kiira, Krider, Isabella, Ackerman-Berrier, Martha, Penton, Christopher, Musku, Soumya Reddy, Gordon-Blake, Jesse M., Laham, Megan S., Christie, Nicholas, Ma, Nina, Fu, Jiqiang, Xiong, Rui, Courey, Jenna M., Velma, Ganga Reddy, Thatcher, Gregory R. J.

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Discovery and Structural Optimization of 4‑(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections von Gaisina, Irina N, Peet, Norton P, Wong, Letitia, Schafer, Adam M, Cheng, Han, Anantpadma, Manu, Davey, Robert A, Thatcher, Gregory R. J, Rong, Lijun

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XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer von Principe, Daniel R, Xiong, Rui, Li, Yangfeng, Pham, Thao N D, Kamath, Suneel D, Dubrovskyi, Oleksii, Ratia, Kiira, Huang, Fei, Zhao, Jiong, Shen, Zhengnan, Thummuri, Dinesh, Daohong, Zhou, Underwood, Patrick W, Trevino, Jose, Munshi, Hidayatullah G, Thatcher, Gregory R J, Rana, Ajay

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Synthesis, Optimization, and Structure–Activity Relationships of Imidazo[1,2‑a]pyrimidines as Inhibitors of Group 2 Influenza A Viruses von Alqarni, Saad, Cooper, Laura, Galvan Achi, Jazmin, Bott, Ryan, Sali, Veeresh Kumar, Brown, Andrew, Santarsiero, Bernard D., Krunic, Aleksej, Manicassamy, Balaji, Peet, Norton P., Zhang, Pin, Thatcher, Gregory R. J., Gaisina, Irina N., Rong, Lijun, Moore, Terry W.

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Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity von Kumar, Sandeep, Singh, Sunil Kumar, Viswakarma, Navin, Sondarva, Gautam, Nair, Rakesh Sathish, Sethupathi, Periannan, Sinha, Subhash C., Emmadi, Rajyasree, Hoskins, Kent, Danciu, Oana, Thatcher, Gregory R. J., Rana, Basabi, Rana, Ajay

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