Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool von Sannerud, Ragna, Esselens, Cary, Ejsmont, Paulina, Mattera, Rafael, Rochin, Leila, Tharkeshwar, Arun Kumar, De Baets, Greet, De Wever, Veerle, Habets, Roger, Baert, Veerle, Vermeire, Wendy, Michiels, Christine, Groot, Arjan J., Wouters, Rosanne, Dillen, Katleen, Vints, Katlijn, Baatsen, Pieter, Munck, Sebastian, Derua, Rita, Waelkens, Etienne, Basi, Guriqbal S., Mercken, Mark, Vooijs, Marc, Bollen, Mathieu, Schymkowitz, Joost, Rousseau, Frederic, Bonifacino, Juan S., Van Niel, Guillaume, De Strooper, Bart, Annaert, Wim

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PQLC2 recruits the C9orf72 complex to lysosomes in response to cationic amino acid starvation von Amick, Joseph, Tharkeshwar, Arun Kumar, Talaia, Gabriel, Ferguson, Shawn M

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CRISPR/Cas9 screen in human iPSC‐derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity von Guo, Wenting, Wang, Haibo, Kumar Tharkeshwar, Arun, Couthouis, Julien, Braems, Elke, Masrori, Pegah, Van Schoor, Evelien, Fan, Yannan, Ahuja, Karan, Moisse, Matthieu, Jacquemyn, Maarten, Furtado Madeiro da Costa, Rodrigo, Gajjar, Madhavsai, Balusu, Sriram, Tricot, Tine, Fumagalli, Laura, Hersmus, Nicole, Janky, Rekin's, Impens, Francis, Vanden Berghe, Pieter, Ho, Ritchie, Thal, Dietmar Rudolf, Vandenberghe, Rik, Hegde, Muralidhar L., Chandran, Siddharthan, De Strooper, Bart, Daelemans, Dirk, Van Damme, Philip, Van Den Bosch, Ludo, Verfaillie, Catherine

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A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency von Tharkeshwar, Arun Kumar, Trekker, Jesse, Vermeire, Wendy, Pauwels, Jarne, Sannerud, Ragna, Priestman, David A., te Vruchte, Danielle, Vints, Katlijn, Baatsen, Pieter, Decuypere, Jean-Paul, Lu, Huiqi, Martin, Shaun, Vangheluwe, Peter, Swinnen, Johannes V., Lagae, Liesbet, Impens, Francis, Platt, Frances M., Gevaert, Kris, Annaert, Wim

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Superparamagnetic Nanoparticles for Lysosome Isolation to Identify Spatial Alterations in Lysosomal Protein and Lipid Composition von Tharkeshwar, Arun Kumar, Demedts, David, Annaert, Wim

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C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pathway at multiple levels von Beckers, Jimmy, Tharkeshwar, Arun Kumar, Van Damme, Philip

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A pathogenic mutation in the ALS/FTD gene VCP induces mitochondrial hypermetabolism by modulating the permeability transition pore von Vanderhaeghe, Silke, Prerad, Jovan, Tharkeshwar, Arun Kumar, Goethals, Elien, Vints, Katlijn, Beckers, Jimmy, Scheveneels, Wendy, Debroux, Eveline, Princen, Katrien, Van Damme, Philip, Fivaz, Marc, Griffioen, Gerard, Van Den Bosch, Ludo

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A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons von Beckers, Jimmy, Tharkeshwar, Arun Kumar, Fumagalli, Laura, Contardo, Matilde, Van Schoor, Evelien, Fazal, Raheem, Thal, Dietmar Rudolf, Chandran, Siddharthan, Mancuso, Renzo, Van Den Bosch, Ludo, Van Damme, Philip

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Organellar Omics—A Reviving Strategy to Untangle the Biomolecular Complexity of the Cell von Tharkeshwar, Arun Kumar, Gevaert, Kris, Annaert, Wim

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C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pathway at multiple levels von Beckers, Jimmy, Tharkeshwar, Arun Kumar, Van Damme, Philip

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ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling von Hancock-Cerutti, William, Wu, Zheng, Xu, Peng, Yadavalli, Narayana, Leonzino, Marianna, Tharkeshwar, Arun Kumar, Ferguson, Shawn M, Shadel, Gerald S, De Camilli, Pietro

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A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes von Thimiri Govinda Raj, Deepak B, Ghesquière, Bart, Tharkeshwar, Arun Kumar, Coen, Katrijn, Derua, Rita, Vanderschaeghe, Dieter, Rysman, Evelien, Bagadi, Murali, Baatsen, Pieter, De Strooper, Bart, Waelkens, Etienne, Borghs, Gustaaf, Callewaert, Nico, Swinnen, Johan, Gevaert, Kris, Annaert, Wim

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Organellar OmicsA Reviving Strategy to Untangle the Biomolecular Complexity of the Cell von Tharkeshwar, Arun Kumar, Gevaert, Kris, Annaert, Wim

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Front Cover: Organellar Omics – A Reviving Strategy to Untangle the Biomolecular Complexity of the Cell von Tharkeshwar, Arun Kumar, Gevaert, Kris, Annaert, Wim

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WDR41 supports lysosomal response to changes in amino acid availability von Amick, Joseph, Tharkeshwar, Arun Kumar, Amaya, Catherine, Ferguson, Shawn M

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Characterization of Influenza Virus Pseudotyped with Ebolavirus Glycoprotein von Xiao, Julie Huiyuan, Rijal, Pramila, Schimanski, Lisa, Tharkeshwar, Arun Kumar, Wright, Edward, Annaert, Wim, Townsend, Alain

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ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling von Hancock-Cerutti, William, Wu, Zheng, Xu, Peng, Yadavalli, Narayana, Leonzino, Marianna, Tharkeshwar, Arun Kumar, Ferguson, Shawn M, Shadel, Gerald S, De Camilli, Pietro

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Superparamagnetic Nanoparticles for Lysosome Isolation to Identify Spatial Alterations in Lysosomal Protein and Lipid Composition von Tharkeshwar, Arun Kumar, Demedts, David, Annaert, Wim

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Disruption of MAM integrity in mutant FUS oligodendroglial progenitors from hiPSCs von Zhu, Yingli, Burg, Thibaut, Neyrinck, Katrien, Vervliet, Tim, Nami, Fatemeharefeh, Vervoort, Ellen, Ahuja, Karan, Sassano, Maria Livia, Chai, Yoke Chin, Tharkeshwar, Arun Kumar, De Smedt, Jonathan, Hu, Haibo, Bultynck, Geert, Agostinis, Patrizia, Swinnen, Johannes V., Van Den Bosch, Ludo, da Costa, Rodrigo Furtado Madeiro, Verfaillie, Catherine

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Correction to: Disruption of MAM integrity in mutant FUS oligodendroglial progenitors from hiPSCs von Zhu, Yingli, Burg, Thibaut, Neyrinck, Katrien, Vervliet, Tim, Nami, Fatemeharefeh, Vervoort, Ellen, Ahuja, Karan, Sassano, Maria Livia, Chai, Yoke Chin, Tharkeshwar, Arun Kumar, De Smedt, Jonathan, Hu, Haibo, Bultynck, Geert, Agostinis, Patrizia, Swinnen, Johannes V., Van Den Bosch, Ludo, da Costa, Rodrigo Furtado Madeiro, Verfaillie, Catherine

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