Assessing the performance of QSP models: biology as the driver for validation von Singh, Fulya Akpinar, Afzal, Nasrin, Smithline, Shepard J., Thalhauser, Craig J.

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High degree of heterogeneity in Alzheimer's disease progression patterns von Komarova, Natalia L, Thalhauser, Craig J

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Advancing cancer drug development with mechanistic mathematical modeling: bridging the gap between theory and practice von Kulesza, Alexander, Couty, Claire, Lemarre, Paul, Thalhauser, Craig J., Cao, Yanguang

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An asymptotic description of a basic FcRn-regulated clearance mechanism and its implications for PBPK modelling of large antibodies von Kátai, Csaba B., Smithline, Shepard J., Thalhauser, Craig J., Bosgra, Sieto, Elassaiss-Schaap, Jeroen

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QSP Toolbox: Computational Implementation of Integrated Workflow Components for Deploying Multi-Scale Mechanistic Models von Cheng, Yougan, Thalhauser, Craig J., Smithline, Shepard, Pagidala, Jyotsna, Miladinov, Marko, Vezina, Heather E., Gupta, Manish, Leil, Tarek A., Schmidt, Brian J.

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A Survey of Software Tool Utilization and Capabilities for Quantitative Systems Pharmacology: What We Have and What We Need von Ermakov, Sergey, Schmidt, Brian J., Musante, Cynthia J., Thalhauser, Craig J.

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Evaluating a Multiscale Mechanistic Model of the Immune System to Predict Human Immunogenicity for a Biotherapeutic in Phase 1 von Hamuro, Lora, Tirucherai, Giridhar S., Crawford, Sean M., Nayeem, Akbar, Pillutla, Renuka C., DeSilva, Binodh S., Leil, Tarek A., Thalhauser, Craig J.

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Tumor-immune interaction, surgical treatment, and cancer recurrence in a mathematical model of melanoma von Eikenberry, Steffen, Thalhauser, Craig, Kuang, Yang

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A Flexible Approach for Context‐Dependent Assessment of Quantitative Systems Pharmacology Models von Ramanujan, Saroja, Chan, Jason R., Friedrich, Christina M., Thalhauser, Craig J.

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Alzheimer's disease: rapid and slow progression von Thalhauser, Craig J., Komarova, Natalia L.

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Immunogenicity in Clinical Practice and Drug Development: When is it Significant? von Shakhnovich, Valentina, Meibohm, Bernd, Rosenberg, Amy, Kierzek, Andrzej M., Hasenkamp, Rachel, Funk, Ryan S., Thalhauser, Craig J., Graaf, Piet H., Wang, Yow‐Ming C., Hamuro, Lora

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1280 Modeling of direct (EGFR- based) and ADCC cytotoxic effect of Cetuximab on the basis of literature available in vitro data von Demin, Oleg, Smirnov, Sergey, Diakonova, Alexandra, Roskoshnaia, Anna, Bajaj, Gaurav, Adams, Homer, Gupta, Manish, Thalhauser, Craig

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Signal response sensitivity in the yeast mitogen-activated protein kinase cascade von Thalhauser, Craig J, Komarova, Natalia L

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Calculating stage duration statistics in multistage diseases von Komarova, Natalia L, Thalhauser, Craig J

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Selection in spatial stochastic models of cancer: migration as a key modulator of fitness von Thalhauser, Craig J, Lowengrub, John S, Stupack, Dwayne, Komarova, Natalia L

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874 A quantitative systems pharmacology model of head and neck squamous cell carcinoma: a tool for evaluating treatment outcomes for combination therapies von Diakonova, Alexandra, Smirnov, Sergey, Roskoshnaia, Anna, Borisov, Ivan, Demin, Oleg, Bajaj, Gaurav, Adams, Homer, Jure-Kunkel, Maria, Gupta, Manish, Thalhauser, Craig

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A Quantitative Systems Pharmacology Consortium Approach to Managing Immunogenicity of Therapeutic Proteins von Kierzek, Andrzej M., Hickling, Timothy P., Figueroa, Isabel, Kalvass, J. Cory, Nijsen, Marjoleen, Mohan, Krithika, Veldman, Geertruida M., Yamada, Akihiro, Sayama, Hiroyuki, Yokoo, Sachiko, Gulati, Abhishek, Dhanikula, Renu S., Gokemeijer, Jochem, Leil, Tarek A., Thalhauser, Craig J., Giorgi, Mario, Swat, Maciej J., Chelliah, Vijayalakshmi, Small, Ben G., Benson, Neil, Walker, Michael, Gadkar, Kapil, Quarmby, Valerie, Deng, Rong, Ferrante, Andrea, Dickinson, Gemma L., Van Der Walt, Jan‐Stefan, Zhou, Lian, Chen, Xiaoying, Jones, Hannah M., Narula, Jatin, Tourdot, Sophie, Lavé, Thierry, Ribba, Benjamin, Graaf, Piet H.

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786 Dose selection for DuoBody®-PD-L1×4-1BB (GEN1046) using a semimechanistic pharmacokinetics/pharmacodynamics model that leverages preclinical and clinical data von Bajaj, Gaurav, Nazari, Fereshteh, Presler, Marc, Thalhauser, Craig, Forssmann, Ulf, Jure-Kunkel, Maria, Muik, Alexander, Lagkadinou, Eleni, Tureci, Özlem, Sahin, Ugur, Ahmadi, Tahamtan, Gupta, Manish

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Specificity and Robustness of the Mammalian MAPK-IEG Network von Thalhauser, Craig J., Komarova, Natalia L.

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Explicit Separation of Growth and Motility in a New Tumor Cord Model von Thalhauser, Craig J, Sankar, Tejas, Preul, Mark C, Kuang, Yang

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