Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents von Rohloff, John C, Gelinas, Amy D, Jarvis, Thale C, Ochsner, Urs A, Schneider, Daniel J, Gold, Larry, Janjic, Nebojsa

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Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets von Davies, Douglas R, Gelinas, Amy D, Zhang, Chi, Rohloff, John C, Carter, Jeffrey D, O’Connell, Daniel, Waugh, Sheela M, Wolk, Steven K, Mayfield, Wesley S, Burgin, Alex B, Edwards, Thomas E, Stewart, Lance J, Gold, Larry, Janjic, Nebojsa, Jarvis, Thale C

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Protein signature of lung cancer tissues von Mehan, Michael R, Ayers, Deborah, Thirstrup, Derek, Xiong, Wei, Ostroff, Rachel M, Brody, Edward N, Walker, Jeffrey J, Gold, Larry, Jarvis, Thale C, Janjic, Nebojsa, Baird, Geoffrey S, Wilcox, Sheri K

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Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent von De Groote, Mary A, Jackson, Mary, Gonzalez-Juarrero, Mercedes, Li, Wei, Young, Casey L, Wong, Christina, Graham, James, Day, Joshua, Hoang, Teresa, Jarvis, Thale C, Ribble, Wendy, Sun, Xicheng, Ochsner, Urs A

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Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor von Jarvis, Thale C., Davies, Douglas R., Hisaminato, Akihiko, Resnicow, Daniel I., Gupta, Shashi, Waugh, Sheela M., Nagabukuro, Akira, Wadatsu, Takashi, Hishigaki, Haretsugu, Gawande, Bharat, Zhang, Chi, Wolk, Steven K., Mayfield, Wesley S., Nakaishi, Yuichiro, Burgin, Alex B., Stewart, Lance J., Edwards, Thomas E., Gelinas, Amy D., Schneider, Daniel J., Janjic, Nebojsa

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Structure of PolC reveals unique DNA binding and fidelity determinants von Evans, Ronald J, Davies, Douglas R, Bullard, James M, Christensen, Jeffrey, Green, Louis S, Guiles, Joseph W, Pata, Janice D, Ribble, Wendy K, Janjic, Nebojsa, Jarvis, Thale C

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Discovery and Analysis of 4H-Pyridopyrimidines, a Class of Selective Bacterial Protein Synthesis Inhibitors von RIBBLE, Wendy, HILL, Walter E, OCHSNER, Urs A, JARVIS, Thale C, GUILES, Joseph W, JANJIC, Nebojsa, BULLARD, James M

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Inhibition of Methionyl-tRNA Synthetase by REP8839 and Effects of Resistance Mutations on Enzyme Activity von GREEN, Louis S, BULLARD, James M, RIBBLE, Wendy, DEAN, Frank, AYERS, David F, OCHSNER, Urs A, JANJIC, Nebojsa, JARVIS, Thale C

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Chemically Modified DNA Aptamers Bind Interleukin-6 with High Affinity and Inhibit Signaling by Blocking Its Interaction with Interleukin-6 Receptor von Gupta, Shashi, Hirota, Masao, Waugh, Sheela M., Murakami, Ikuo, Suzuki, Tomoki, Muraguchi, Masahiro, Shibamori, Masafumi, Ishikawa, Yuichi, Jarvis, Thale C., Carter, Jeffrey D., Zhang, Chi, Gawande, Bharat, Vrkljan, Michael, Janjic, Nebojsa, Schneider, Daniel J.

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Reimagining scientific conferences-a Keystone Symposia report von Weiman, Shannon, Cable, Jennifer, Greenleaf, Walter, Rundel, Felix, Whitfield, Kate E, Wingate, Lory, Gallagher, Richard, Pesanelli, Jennifer, Orr, Dereck, Jarvis, Thale C, Cadar, Raluca, Uva, Matthew D', Ruediger, Dylan, Vaez, Robert, Frisby, Adam, Ahmed, Sami, Donoviel, Dorit, Klinman, Judith, Johnson, Debbie

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Crystal Structure of Interleukin-6 in Complex with a Modified Nucleic Acid Ligand von Gelinas, Amy D., Davies, Douglas R., Edwards, Thomas E., Rohloff, John C., Carter, Jeffrey D., Zhang, Chi, Gupta, Shashi, Ishikawa, Yuichi, Hirota, Masao, Nakaishi, Yuichiro, Jarvis, Thale C., Janjic, Nebojsa

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Multiple-Ascending-Dose Phase 1 Clinical Study of the Safety, Tolerability, and Pharmacokinetics of CRS3123, a Narrow-Spectrum Agent with Minimal Disruption of Normal Gut Microbiot... von Lomeli, Barbara K, Galbraith, Hal, Schettler, Jared, Saviolakis, George A, El-Amin, Wael, Osborn, Blaire, Ravel, Jacques, Hazleton, Keith, Lozupone, Catherine A, Evans, Ronald J, Bell, Stacie J, Ochsner, Urs A, Jarvis, Thale C, Baqar, Shahida, Janjic, Nebojsa

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Safety, Tolerability, Systemic Exposure, and Metabolism of CRS3123, a Methionyl-tRNA Synthetase Inhibitor Developed for Treatment of Clostridium difficile, in a Phase 1 Study von Nayak, Seema U, Griffiss, J McLeod, Blumer, Jeffrey, O'Riordan, Mary Ann, Gray, Wesley, McKenzie, Robin, Jurao, Robert A, An, Amanda T, Le, Melissa, Bell, Stacie J, Ochsner, Urs A, Jarvis, Thale C, Janjic, Nebojsa, Zenilman, Jonathan M

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Microbiological profile, preclinical pharmacokinetics and efficacy of CRS0393, a novel antimycobacterial agent targeting MmpL3 von Ochsner, Urs A., De Groote, Mary A., Jarvis, Thale C., Liu, Hang, Youmans, Tessa, Hoang, Teresa, Ribble, Wendy, Day, Joshua, Li, Wei, Pearce, Camron, Walz, Amanda, Panthi, Chandra M., Rimal, Binayak, Stevens, Casey M., Zgurskaya, Helen I., Jackson, Mary, Ordway, Diane, Gonzalez-Juarrero, Mercedes, Sun, Xicheng, Lamichhane, Gyanu, Mason, Clifford

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Spectrum of activity and mode of action of REP3123, a new antibiotic to treat Clostridium difficile infections von Critchley, Ian A., Green, Louis S., Young, Casey L., Bullard, James M., Evans, Ron J., Price, Melissa, Jarvis, Thale C., Guiles, Joseph W., Janjic, Nebojsa, Ochsner, Urs A.

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Reconstitution of a Minimal DNA Replicase from Pseudomonas aeruginosa and Stimulation by Non-cognate Auxiliary Factors von Jarvis, Thale C, Beaudry, Amber A, Bullard, James M, Janjic, Nebojsa, McHenry, Charles S

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Discovery and Characterization of the Cryptic Ψ Subunit of the Pseudomonad DNA Replicase von Jarvis, Thale C., Beaudry, Amber A., Bullard, James M., Ochsner, Urs, Dallmann, H. Garry, McHenry, Charles S.

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The polymerase in its labyrinth: mechanisms and implications of RNA recombination von Jarvis, Thale C., Kirkegaard, Karla

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Nuclease-Resistant Ribozymes Decrease Stromelysin mRNA Levels in Rabbit Synovium Following Exogenous Delivery to the Knee Joint von Flory, Craig M., Pavco, Pamela A., Jarvis, Thale C., Lesch, Mark E., Wincott, Francine E., Beigelman, Leonid, Hunt, Stephen W., Schrier, Denis J.

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Ribozymes as Tools for Therapeutic Target Validation in Arthritis von Jarvis, Thale C, Bouhana, Karyn S, Lesch, Mark E, Brown, Suzy A, Parry, Tom J, Schrier, Denis J, Hunt, Stephen W., III, Pavco, Pamela A, Flory, Craig M

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