Antisense‐mediated reduction of proprotein convertase subtilisin/kexin type 9 (PCSK9): a first‐in‐human randomized, placebo‐controlled trial von Poelgeest, Eveline P., Hodges, Michael R., Moerland, Matthijs, Tessier, Yann, Levin, Arthur A., Persson, Robert, Lindholm, Marie W., Dumong Erichsen, Kamille, Ørum, Henrik, Cohen, Adam F., Burggraaf, Jacobus

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Assessing single-stranded oligonucleotide drug-induced effects in vitro reveals key risk factors for thrombocytopenia von Sewing, Sabine, Roth, Adrian B, Winter, Michael, Dieckmann, Andreas, Bertinetti-Lapatki, Cristina, Tessier, Yann, McGinnis, Claudia, Huber, Sylwia, Koller, Erich, Ploix, Corinne, Reed, John C, Singer, Thomas, Rothfuss, Andreas

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Establishment of a Predictive In Vitro Assay for Assessment of the Hepatotoxic Potential of Oligonucleotide Drugs von Sewing, Sabine, Boess, Franziska, Moisan, Annie, Bertinetti-Lapatki, Cristina, Minz, Tanja, Hedtjaern, Maj, Tessier, Yann, Schuler, Franz, Singer, Thomas, Roth, Adrian B

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Platelet Activation by Antisense Oligonucleotides (ASOs) in the Göttingen Minipig, including an Evaluation of Glycoprotein VI (GPVI) and Platelet Factor 4 (PF4) Ontogeny von Valenzuela, Allan, Ayuso, Miriam, Buyssens, Laura, Bars, Chloé, Van Ginneken, Chris, Tessier, Yann, Van Cruchten, Steven

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Acute Kidney Injury During Therapy With an Antisense Oligonucleotide Directed Against PCSK9 von van Poelgeest, Eveline P., MD, Swart, Reinout M., MD, Betjes, Michiel G.H., MD, Moerland, Matthijs, PhD, Weening, Jan J., MD, Tessier, Yann, DVM, Hodges, Michael R., MD, Levin, Arthur A., PhD, Burggraaf, Jacobus, MD, PhD

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Safety Testing of an Antisense Oligonucleotide Intended for Pediatric Indications in the Juvenile Gottingen Minipig, including an Evaluation of the Ontogeny of Key Nucleases von Valenzuela, Allan, Tardiveau, Claire, Ayuso, Miriam, Buyssens, Laura, Bars, Chloe, Van Ginneken, Chris, Fant, Pierluigi, Leconte, Isabelle, Braendli-Baiocco, Annamaria, Parrott, Neil, Schmitt, Georg, Tessier, Yann, Barrow, Paul, Van Cruchten, Steven

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Inhibition of EGF Uptake by Nephrotoxic Antisense Drugs In Vitro and Implications for Preclinical Safety Profiling von Moisan, Annie, Gubler, Marcel, Zhang, Jitao David, Tessier, Yann, Dumong Erichsen, Kamille, Sewing, Sabine, Gérard, Régine, Avignon, Blandine, Huber, Sylwia, Benmansour, Fethallah, Chen, Xing, Villaseñor, Roberto, Braendli-Baiocco, Annamaria, Festag, Matthias, Maunz, Andreas, Singer, Thomas, Schuler, Franz, Roth, Adrian B.

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A Low-Cost and Simple Imaging Technique of the Anterior and Posterior Segments: Eye Fundus, Ciliary Bodies, Iridocorneal Angle von Guyomard, Jean-Laurent, Rosolen, Serge G, Paques, Michel, Delyfer, Marie-Noelle, Simonutti, Manuel, Tessier, Yann, Sahel, Jose A, Legargasson, Jean-Francois, Picaud, Serge

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Platelet Activation by Antisense Oligonucleotides Ontogeny von Valenzuela, Allan, Ayuso, Miriam, Buyssens, Laura, Bars, Chloé, Van Ginneken, Chris, Tessier, Yann, Van Cruchten, Steven

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Outcomes of the European Federation of Pharmaceutical Industries and Associations Oligonucleotide Working Group Survey on Nonclinical Practices and Regulatory Expectations for Ther... von Tessier, Yann, Achanzar, William, Mihalcik, Lauren, Amuzie, Chidozie, Andersson, Patrik, Parry, Joel D., Moggs, Jonathan, Whiteley, Laurence O.

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Safety, Tissue Distribution, and Metabolism of LNA-Containing Antisense Oligonucleotides in Rats von Romero-Palomo, Fernando, Festag, Matthias, Lenz, Barbara, Schadt, Simone, Brink, Andreas, Kipar, Anja, Steinhuber, Bernd, Husser, Christophe, Koller, Erich, Sewing, Sabine, Tessier, Yann, Dzygiel, Pawel, Fischer, Guy, Winter, Michael, Hetzel, Udo, Mihatsch, Michael J., Braendli-Baiocco, Annamaria

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Safety, tissue distribution, and metabolism of LNA-containing antisense oligonucleotides in rats von Romero-Palomo, Fernando, Festag, Matthias, Lenz, Barbara, Schadt, Simone, Brink, Andreas, Kipar, Anja, Steinhuber, Bernd, Husser, Christophe, Koller, Erich, Sewing, Sabine, Tessier, Yann, Dzygiel, Pawel, Fischer, Guy, Winter, Michael, Hetzel, Udo, Mihatsch, Michael J, Braendli-Baiocco, Annamaria

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The Angers CT Score is a Risk Factor for the Failure of the Conservative Management of Adhesive Small Bowel Obstruction: A Prospective Observational Multicentric Study von Paisant, Anita, Burgmaier, Jeanne, Calame, Paul, Loison, Mélanie, Molière, Sébastien, Brigand, Cécile, Belabbas, Dihia, Duchalais, Emilie, Regimbeau, Jean-Marc, Yzet, Thierry, Alves, Arnaud, Fohlen, Audrey, Bergeat, Damien, Vauclair, Estelle, Pellegrini, Julie, Ragot, Emilia, Lansier, Alexandre, Abet, Emeric, Nevot, Alexandre, Rousset, Pascal, Ouaissi, Mehdi, Besson, Marie, Ronot, Maxime, Giacca, Massimo, Girard, Edouard, Tessier, Yann, Massalou, Damien, Poirier, Florent, Lakkis, Zaher, Aubé, Christophe, Hamel, Jean Francois, Passot, Guillaume, Venara, Aurélien

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Cardiovascular effects of RTR2996, a single stranded oligonucleotide, in the minipig von Roberts, Sonia, Greiter-Wilke, Andrea, Waiz, David, Jenni, Roland, Weile, Christian, Zihlmann, Marco, Tessier, Yann, Braendli-Baiocco, Annamaria, Festag, Matthias

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Gene expression profiling of key nucleases in the juvenile Göttingen minipig von Valenzuela, Allan Paulo, Buyssens, Laura, Bars, Chloé, Ayuso, Miriam, Van Ginneken, Chris, Parrott, Neil, Tessier, Yann, Schmitt, Georg, Barrow, Paul, Van Cruchten, Steven

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The Minipig is a Suitable Non-Rodent Model in the Safety Assessment of Single Stranded Oligonucleotides von Braendli-Baiocco, A, Festag, M, Dumong-Erichsen, K, Persson, R, Mihatsch, MJ, Fisker, N, Funk, J, Mohr, S, Constien, R, Ploix, C, Brady, K, Berrera, M, Altmann, B, Lenz, B, Albassam, M, Schmitt, G, Weiser, T, Schuler, F, Singer, T, Tessier, Y

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Locked nucleic acid (LNA)‐based single‐stranded oligonucleotides are not genotoxic von Guérard, Melanie, Andreas, Zeller, Erich, Koller, Christine, Marchand, Martina, Müller B., Christian, Weile, Franz, Schuler, Thomas, Singer, Yann, Tessier

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From the Cover: The Minipig is a Suitable Non-Rodent Model in the Safety Assessment of Single Stranded Oligonucleotides von Braendli-Baiocco, Annamaria, Festag, Matthias, Dumong Erichsen, Kamille, Persson, Robert, Mihatsch, Michael J, Fisker, Niels, Funk, Juergen, Mohr, Susanne, Constien, Rainer, Ploix, Corinne, Brady, Kevin, Berrera, Marco, Altmann, Bernd, Lenz, Barbara, Albassam, Mudher, Schmitt, Georg, Weiser, Thomas, Schuler, Franz, Singer, Thomas, Tessier, Yann

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Abstracts8th Annual Meeting of the Oligonucleotide Therapeutics SocietyBoston, MassachusettsOctober 28–31, 2012 von Sharp, Phillip A., Maraganore, John, Crooke, Stanley T., Babar, Imran, Janowski, Bethany A., Matsui, Masayuki, Zhang, Huiying, Gagnon, Keith, Shaikh, Sarfraz, Meister, Gunter, Hirsch, Markus, Juliano, Rudy, Fisher, Michael, MacRae, Ian, Butora, Gabor, Matsuda, Akira, Minakawa, Noriaki, Tuschl, Thomas, Williams, Zev, Renwick, Neil, Hafner, Markus, Jiang, Tian, Dela-Moss, Indee, Kierzek, Ryszard, Kierzek, Elzbieta, Ellington, Andy, Seth, Punit, Peng, Chang Geng, Chan, Amy, Charisse, Klaus, Maier, Martin, Fitzgerald, Kevin, Jadhav, Vasant, Jayaraman, Muthusamy, Landesman, Yosef, Zhang, Xuemei, Hutabarat, Renta, Kumar, Varun, Rajeev, Kallanthottathil G., Mui, Barbara L., Du, Xinyao, Hope, Michael J., Madden, Thomas D., Cullis, Pieter, Akinc, Akin, Lewis, David, Hossbach, Markus, Chu, Qili, Klein, Jason J., Wakefield, Darren H., Oropeza, Claudia E., Roehl, Ingo, Vornlocher, Hans-Peter, Sarnow, Peter, Machlin, Erica, Sagan, Selena, Guo, Shuling, Booten, Sheri L., Hung, Gene, Blomenkamp, Keith, Teckman, Jeffery H., McCaleb, Michael L., Monia, Brett P., Akinc, Akin, Sehgal, Alfica, Brodsky, Josh, Qin, June, Foster, Don, Mirkin, Chad, Mitrpant, Charlermchai, McGovern, Vicki, Bevan, Adam, Thornton, Charles, Wheeler, Thurman M., Leger, Andrew J., Pandey, Sanjay K., Wentworth, Bruce M., Lieberman, J., Wheeler, LA, Basar, E, Seung, E, Deruaz, M, Luster, AD, Tager, AM, Patick, Amy, Tessier, Yann, Perssonv, Robert, Sandberg, Bente C., Nochur, Sara, Ftizgerlad, Kevin, Gollob, Jared, Monia, Brett, Müller, Philipp, Jensen, Jeff J., Henry, Scott P., Levin, Art, Lindow, Morten, Lawrence, Christine, Sciabola, Simone, Rotstein, Sergio

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Mecanizado avanzado de piezas recubiertas mediante plasma von López de la Calle, L.N, Sánchez, M. M, Barroeta, A, Gutiérrez, Alberto, Pupat, Sophie, Tessier, Yann

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